Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZY9_LEIIN

TriTrypDb:

LINF_220017800

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HZY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.651
CLV_C14_Caspase3-7	258	262	PF00656	0.785
CLV_C14_Caspase3-7	308	312	PF00656	0.734
CLV_NRD_NRD_1	169	171	PF00675	0.397
CLV_NRD_NRD_1	177	179	PF00675	0.382
CLV_NRD_NRD_1	211	213	PF00675	0.567
CLV_NRD_NRD_1	305	307	PF00675	0.542
CLV_NRD_NRD_1	31	33	PF00675	0.421
CLV_NRD_NRD_1	410	412	PF00675	0.487
CLV_NRD_NRD_1	422	424	PF00675	0.427
CLV_PCSK_FUR_1	198	202	PF00082	0.434
CLV_PCSK_KEX2_1	160	162	PF00082	0.384
CLV_PCSK_KEX2_1	168	170	PF00082	0.372
CLV_PCSK_KEX2_1	176	178	PF00082	0.338
CLV_PCSK_KEX2_1	200	202	PF00082	0.448
CLV_PCSK_KEX2_1	211	213	PF00082	0.498
CLV_PCSK_KEX2_1	304	306	PF00082	0.642
CLV_PCSK_KEX2_1	31	33	PF00082	0.421
CLV_PCSK_KEX2_1	410	412	PF00082	0.493
CLV_PCSK_KEX2_1	422	424	PF00082	0.514
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.398
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.419
CLV_PCSK_PC7_1	172	178	PF00082	0.408
CLV_PCSK_SKI1_1	100	104	PF00082	0.348
CLV_PCSK_SKI1_1	177	181	PF00082	0.510
CLV_PCSK_SKI1_1	255	259	PF00082	0.495
CLV_PCSK_SKI1_1	370	374	PF00082	0.550
CLV_PCSK_SKI1_1	410	414	PF00082	0.485
CLV_PCSK_SKI1_1	444	448	PF00082	0.522
CLV_PCSK_SKI1_1	89	93	PF00082	0.347
DEG_COP1_1	469	478	PF00400	0.674
DOC_AGCK_PIF_1	12	17	PF00069	0.264
DOC_ANK_TNKS_1	211	218	PF00023	0.723
DOC_MAPK_gen_1	31	38	PF00069	0.595
DOC_MAPK_RevD_3	18	32	PF00069	0.430
DOC_PP2B_LxvP_1	162	165	PF13499	0.578
DOC_SPAK_OSR1_1	411	415	PF12202	0.731
DOC_USP7_MATH_1	110	114	PF00917	0.362
DOC_USP7_MATH_1	134	138	PF00917	0.362
DOC_USP7_MATH_1	221	225	PF00917	0.657
DOC_USP7_MATH_1	286	290	PF00917	0.665
DOC_USP7_MATH_1	328	332	PF00917	0.704
DOC_USP7_MATH_1	464	468	PF00917	0.732
DOC_USP7_UBL2_3	454	458	PF12436	0.737
DOC_WW_Pin1_4	231	236	PF00397	0.671
DOC_WW_Pin1_4	270	275	PF00397	0.747
DOC_WW_Pin1_4	292	297	PF00397	0.752
DOC_WW_Pin1_4	339	344	PF00397	0.736
DOC_WW_Pin1_4	387	392	PF00397	0.730
DOC_WW_Pin1_4	414	419	PF00397	0.794
DOC_WW_Pin1_4	444	449	PF00397	0.716
DOC_WW_Pin1_4	466	471	PF00397	0.821
DOC_WW_Pin1_4	80	85	PF00397	0.366
LIG_14-3-3_CanoR_1	255	263	PF00244	0.694
LIG_14-3-3_CanoR_1	31	37	PF00244	0.648
LIG_14-3-3_CanoR_1	395	400	PF00244	0.792
LIG_14-3-3_CanoR_1	89	99	PF00244	0.362
LIG_BIR_II_1	1	5	PF00653	0.349
LIG_CtBP_PxDLS_1	396	400	PF00389	0.727
LIG_FHA_1	298	304	PF00498	0.690
LIG_FHA_1	383	389	PF00498	0.732
LIG_FHA_1	441	447	PF00498	0.737
LIG_FHA_1	467	473	PF00498	0.687
LIG_FHA_1	62	68	PF00498	0.345
LIG_FHA_1	73	79	PF00498	0.272
LIG_FHA_2	211	217	PF00498	0.653
LIG_FHA_2	256	262	PF00498	0.818
LIG_FHA_2	349	355	PF00498	0.733
LIG_FHA_2	475	481	PF00498	0.733
LIG_GBD_Chelix_1	50	58	PF00786	0.362
LIG_HCF-1_HBM_1	433	436	PF13415	0.689
LIG_LIR_Gen_1	16	25	PF02991	0.299
LIG_LIR_Gen_1	30	41	PF02991	0.501
LIG_LIR_Gen_1	4	13	PF02991	0.265
LIG_LIR_Gen_1	433	440	PF02991	0.681
LIG_LIR_Gen_1	93	103	PF02991	0.488
LIG_LIR_Nem_3	114	120	PF02991	0.499
LIG_LIR_Nem_3	130	135	PF02991	0.254
LIG_LIR_Nem_3	16	20	PF02991	0.299
LIG_LIR_Nem_3	224	228	PF02991	0.740
LIG_LIR_Nem_3	30	36	PF02991	0.499
LIG_LIR_Nem_3	4	8	PF02991	0.265
LIG_LIR_Nem_3	433	439	PF02991	0.677
LIG_LIR_Nem_3	93	98	PF02991	0.432
LIG_LYPXL_yS_3	225	228	PF13949	0.710
LIG_Pex14_2	10	14	PF04695	0.264
LIG_Pex14_2	82	86	PF04695	0.299
LIG_Pex14_2	91	95	PF04695	0.299
LIG_SH2_CRK	132	136	PF00017	0.265
LIG_SH2_CRK	33	37	PF00017	0.597
LIG_SH2_CRK	436	440	PF00017	0.691
LIG_SH2_CRK	5	9	PF00017	0.268
LIG_SH2_NCK_1	436	440	PF00017	0.711
LIG_SH2_STAP1	40	44	PF00017	0.362
LIG_SH2_STAT5	147	150	PF00017	0.372
LIG_SH2_STAT5	152	155	PF00017	0.322
LIG_SH2_STAT5	156	159	PF00017	0.393
LIG_SH2_STAT5	163	166	PF00017	0.573
LIG_SH2_STAT5	436	439	PF00017	0.728
LIG_SH2_STAT5	65	68	PF00017	0.386
LIG_SH3_3	220	226	PF00018	0.708
LIG_SH3_3	293	299	PF00018	0.701
LIG_SH3_3	385	391	PF00018	0.722
LIG_SH3_3	445	451	PF00018	0.744
LIG_SUMO_SIM_anti_2	19	24	PF11976	0.294
LIG_SUMO_SIM_anti_2	53	59	PF11976	0.362
LIG_SUMO_SIM_par_1	134	139	PF11976	0.299
LIG_SUMO_SIM_par_1	19	24	PF11976	0.294
LIG_TRAF2_1	189	192	PF00917	0.699
LIG_TRAF2_1	417	420	PF00917	0.680
LIG_TRAF2_1	44	47	PF00917	0.362
LIG_TYR_ITIM	223	228	PF00017	0.708
LIG_TYR_ITIM	3	8	PF00017	0.385
LIG_TYR_ITIM	97	102	PF00017	0.424
LIG_TYR_ITSM	128	135	PF00017	0.348
LIG_WRC_WIRS_1	14	19	PF05994	0.362
LIG_WRC_WIRS_1	88	93	PF05994	0.358
MOD_CDK_SPK_2	387	392	PF00069	0.675
MOD_CDK_SPxxK_3	231	238	PF00069	0.680
MOD_CDK_SPxxK_3	270	277	PF00069	0.745
MOD_CK1_1	121	127	PF00069	0.484
MOD_CK1_1	224	230	PF00069	0.755
MOD_CK1_1	24	30	PF00069	0.470
MOD_CK1_1	253	259	PF00069	0.687
MOD_CK1_1	280	286	PF00069	0.825
MOD_CK1_1	297	303	PF00069	0.722
MOD_CK1_1	438	444	PF00069	0.689
MOD_CK1_1	452	458	PF00069	0.704
MOD_CK2_1	338	344	PF00069	0.757
MOD_CK2_1	348	354	PF00069	0.688
MOD_CK2_1	414	420	PF00069	0.692
MOD_CK2_1	468	474	PF00069	0.740
MOD_GlcNHglycan	108	111	PF01048	0.362
MOD_GlcNHglycan	148	151	PF01048	0.362
MOD_GlcNHglycan	252	255	PF01048	0.614
MOD_GlcNHglycan	288	291	PF01048	0.567
MOD_GlcNHglycan	300	303	PF01048	0.530
MOD_GlcNHglycan	315	319	PF01048	0.495
MOD_GlcNHglycan	335	338	PF01048	0.624
MOD_GlcNHglycan	466	469	PF01048	0.513
MOD_GSK3_1	106	113	PF00069	0.510
MOD_GSK3_1	229	236	PF00069	0.656
MOD_GSK3_1	275	282	PF00069	0.818
MOD_GSK3_1	294	301	PF00069	0.709
MOD_GSK3_1	307	314	PF00069	0.802
MOD_GSK3_1	318	325	PF00069	0.746
MOD_GSK3_1	329	336	PF00069	0.715
MOD_GSK3_1	344	351	PF00069	0.655
MOD_GSK3_1	378	385	PF00069	0.723
MOD_GSK3_1	410	417	PF00069	0.787
MOD_GSK3_1	434	441	PF00069	0.671
MOD_GSK3_1	464	471	PF00069	0.772
MOD_GSK3_1	61	68	PF00069	0.341
MOD_LATS_1	368	374	PF00433	0.687
MOD_N-GLC_1	280	285	PF02516	0.524
MOD_N-GLC_1	311	316	PF02516	0.482
MOD_N-GLC_1	444	449	PF02516	0.536
MOD_NEK2_1	1	6	PF00069	0.360
MOD_NEK2_1	13	18	PF00069	0.299
MOD_NEK2_1	180	185	PF00069	0.607
MOD_NEK2_1	279	284	PF00069	0.750
MOD_NEK2_1	412	417	PF00069	0.748
MOD_NEK2_1	87	92	PF00069	0.405
MOD_PIKK_1	329	335	PF00454	0.754
MOD_PIKK_1	438	444	PF00454	0.731
MOD_PKA_1	410	416	PF00069	0.678
MOD_PKA_2	105	111	PF00069	0.465
MOD_PKA_2	127	133	PF00069	0.410
MOD_PKA_2	210	216	PF00069	0.672
MOD_PKA_2	410	416	PF00069	0.789
MOD_PKB_1	176	184	PF00069	0.607
MOD_Plk_1	275	281	PF00069	0.734
MOD_Plk_4	224	230	PF00069	0.668
MOD_Plk_4	395	401	PF00069	0.761
MOD_Plk_4	45	51	PF00069	0.473
MOD_Plk_4	61	67	PF00069	0.396
MOD_Plk_4	74	80	PF00069	0.248
MOD_ProDKin_1	231	237	PF00069	0.667
MOD_ProDKin_1	270	276	PF00069	0.748
MOD_ProDKin_1	292	298	PF00069	0.754
MOD_ProDKin_1	339	345	PF00069	0.734
MOD_ProDKin_1	387	393	PF00069	0.730
MOD_ProDKin_1	414	420	PF00069	0.792
MOD_ProDKin_1	444	450	PF00069	0.716
MOD_ProDKin_1	466	472	PF00069	0.823
MOD_ProDKin_1	80	86	PF00069	0.366
TRG_DiLeu_BaEn_1	315	320	PF01217	0.679
TRG_DiLeu_BaEn_4	419	425	PF01217	0.673
TRG_ENDOCYTIC_2	132	135	PF00928	0.312
TRG_ENDOCYTIC_2	225	228	PF00928	0.710
TRG_ENDOCYTIC_2	33	36	PF00928	0.585
TRG_ENDOCYTIC_2	40	43	PF00928	0.262
TRG_ENDOCYTIC_2	436	439	PF00928	0.688
TRG_ENDOCYTIC_2	5	8	PF00928	0.268
TRG_ENDOCYTIC_2	99	102	PF00928	0.521
TRG_ER_diArg_1	168	170	PF00400	0.630
TRG_ER_diArg_1	176	178	PF00400	0.621
TRG_ER_diArg_1	303	306	PF00400	0.740
TRG_ER_diArg_1	31	33	PF00400	0.621
TRG_ER_diArg_1	410	412	PF00400	0.690
TRG_ER_diArg_1	422	424	PF00400	0.669
TRG_NES_CRM1_1	47	60	PF08389	0.362
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E2	Leptomonas seymouri	39%	76%
A0A3S7WX94	Leishmania donovani	100%	100%
E9AVV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QBM9	Leishmania major	88%	100%