LeishMANIAdb
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Putative adaptor complex AP-1 medium subunit

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative adaptor complex AP-1 medium subunit
Gene product:
adaptor complex AP-1 medium subunit - putative
Species:
Leishmania infantum
UniProt:
A4HZY5_LEIIN
TriTrypDb:
LINF_220017400 *
Length:
319

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, adaptor complex AP-1 medium subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0030119 AP-type membrane coat adaptor complex 3 11
GO:0030131 clathrin adaptor complex 4 11
GO:0032991 protein-containing complex 1 11
GO:0098796 membrane protein complex 2 11
GO:0005737 cytoplasm 2 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HZY5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZY5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 11
GO:0006886 intracellular protein transport 4 11
GO:0008104 protein localization 4 11
GO:0009987 cellular process 1 11
GO:0015031 protein transport 4 11
GO:0016192 vesicle-mediated transport 4 11
GO:0033036 macromolecule localization 2 11
GO:0045184 establishment of protein localization 3 11
GO:0046907 intracellular transport 3 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0051641 cellular localization 2 11
GO:0051649 establishment of localization in cell 3 11
GO:0070727 cellular macromolecule localization 3 11
GO:0071702 organic substance transport 4 11
GO:0071705 nitrogen compound transport 4 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 112 116 PF00082 0.332
CLV_PCSK_SKI1_1 289 293 PF00082 0.313
CLV_PCSK_SKI1_1 306 310 PF00082 0.313
DEG_Nend_UBRbox_4 1 3 PF02207 0.340
DOC_CKS1_1 300 305 PF01111 0.424
DOC_MAPK_FxFP_2 4 7 PF00069 0.544
DOC_MAPK_MEF2A_6 265 274 PF00069 0.327
DOC_PP1_RVXF_1 110 116 PF00149 0.424
DOC_PP1_RVXF_1 143 150 PF00149 0.313
DOC_PP1_RVXF_1 271 277 PF00149 0.424
DOC_PP4_FxxP_1 149 152 PF00568 0.313
DOC_PP4_FxxP_1 254 257 PF00568 0.313
DOC_PP4_FxxP_1 276 279 PF00568 0.313
DOC_PP4_FxxP_1 4 7 PF00568 0.455
DOC_SPAK_OSR1_1 275 279 PF12202 0.424
DOC_USP7_MATH_1 209 213 PF00917 0.334
DOC_USP7_MATH_1 47 51 PF00917 0.555
DOC_USP7_UBL2_3 269 273 PF12436 0.394
DOC_USP7_UBL2_3 292 296 PF12436 0.385
DOC_WW_Pin1_4 299 304 PF00397 0.424
DOC_WW_Pin1_4 48 53 PF00397 0.436
LIG_14-3-3_CanoR_1 120 126 PF00244 0.424
LIG_14-3-3_CanoR_1 145 150 PF00244 0.313
LIG_14-3-3_CanoR_1 196 206 PF00244 0.328
LIG_14-3-3_CanoR_1 246 254 PF00244 0.379
LIG_14-3-3_CanoR_1 260 267 PF00244 0.226
LIG_14-3-3_CanoR_1 306 314 PF00244 0.313
LIG_BRCT_BRCA1_1 173 177 PF00533 0.433
LIG_BRCT_BRCA1_1 250 254 PF00533 0.365
LIG_FHA_1 102 108 PF00498 0.314
LIG_FHA_1 180 186 PF00498 0.422
LIG_FHA_1 221 227 PF00498 0.424
LIG_FHA_1 300 306 PF00498 0.424
LIG_FHA_2 198 204 PF00498 0.387
LIG_LIR_Apic_2 148 152 PF02991 0.313
LIG_LIR_Apic_2 251 257 PF02991 0.384
LIG_LIR_Apic_2 3 7 PF02991 0.457
LIG_LIR_Apic_2 50 56 PF02991 0.316
LIG_LIR_Gen_1 153 163 PF02991 0.313
LIG_LIR_Nem_3 153 159 PF02991 0.424
LIG_LIR_Nem_3 205 210 PF02991 0.332
LIG_LIR_Nem_3 3 9 PF02991 0.361
LIG_LIR_Nem_3 302 307 PF02991 0.332
LIG_SH2_GRB2like 61 64 PF00017 0.456
LIG_SH2_PTP2 207 210 PF00017 0.374
LIG_SH2_PTP2 290 293 PF00017 0.424
LIG_SH2_SRC 207 210 PF00017 0.374
LIG_SH2_STAT3 18 21 PF00017 0.433
LIG_SH2_STAT3 228 231 PF00017 0.424
LIG_SH2_STAT3 307 310 PF00017 0.313
LIG_SH2_STAT5 18 21 PF00017 0.464
LIG_SH2_STAT5 207 210 PF00017 0.374
LIG_SH2_STAT5 280 283 PF00017 0.344
LIG_SH2_STAT5 290 293 PF00017 0.196
LIG_SH2_STAT5 299 302 PF00017 0.313
LIG_SH2_STAT5 307 310 PF00017 0.313
LIG_SH3_3 203 209 PF00018 0.389
LIG_SH3_3 297 303 PF00018 0.401
LIG_TYR_ITIM 288 293 PF00017 0.313
LIG_WRC_WIRS_1 146 151 PF05994 0.313
MOD_CDK_SPxK_1 48 54 PF00069 0.427
MOD_CDK_SPxxK_3 299 306 PF00069 0.424
MOD_CK1_1 121 127 PF00069 0.456
MOD_CK1_1 258 264 PF00069 0.315
MOD_CK1_1 294 300 PF00069 0.410
MOD_CK1_1 97 103 PF00069 0.372
MOD_CK2_1 197 203 PF00069 0.424
MOD_GlcNHglycan 120 123 PF01048 0.424
MOD_GlcNHglycan 250 253 PF01048 0.383
MOD_GlcNHglycan 283 286 PF01048 0.313
MOD_GlcNHglycan 310 313 PF01048 0.313
MOD_GlcNHglycan 99 102 PF01048 0.313
MOD_GSK3_1 171 178 PF00069 0.422
MOD_GSK3_1 19 26 PF00069 0.578
MOD_GSK3_1 190 197 PF00069 0.214
MOD_GSK3_1 216 223 PF00069 0.410
MOD_GSK3_1 255 262 PF00069 0.328
MOD_GSK3_1 31 38 PF00069 0.650
MOD_GSK3_1 97 104 PF00069 0.332
MOD_N-GLC_1 197 202 PF02516 0.291
MOD_N-GLC_1 30 35 PF02516 0.596
MOD_NEK2_1 115 120 PF00069 0.312
MOD_NEK2_1 20 25 PF00069 0.597
MOD_NEK2_1 281 286 PF00069 0.299
MOD_PIKK_1 218 224 PF00454 0.456
MOD_PIKK_1 306 312 PF00454 0.313
MOD_PKA_2 259 265 PF00069 0.332
MOD_PKA_2 97 103 PF00069 0.332
MOD_Plk_1 128 134 PF00069 0.424
MOD_Plk_1 154 160 PF00069 0.424
MOD_Plk_1 30 36 PF00069 0.597
MOD_Plk_4 20 26 PF00069 0.554
MOD_ProDKin_1 299 305 PF00069 0.424
MOD_ProDKin_1 48 54 PF00069 0.427
TRG_ENDOCYTIC_2 207 210 PF00928 0.374
TRG_ENDOCYTIC_2 290 293 PF00928 0.302
TRG_NES_CRM1_1 83 96 PF08389 0.424
TRG_Pf-PMV_PEXEL_1 13 17 PF00026 0.465

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6F2 Leptomonas seymouri 27% 67%
A0A0N1I7F0 Leptomonas seymouri 86% 74%
A0A0N1ILY9 Leptomonas seymouri 29% 73%
A0A0N1PAY6 Leptomonas seymouri 24% 71%
A0A0S4INT9 Bodo saltans 26% 70%
A0A0S4JHW9 Bodo saltans 32% 69%
A0A1X0NJW3 Trypanosomatidae 23% 70%
A0A1X0NL86 Trypanosomatidae 29% 77%
A0A1X0NTD3 Trypanosomatidae 54% 74%
A0A1X0P9U6 Trypanosomatidae 27% 73%
A0A3Q8IB94 Leishmania donovani 100% 74%
A0A3Q8IKF7 Leishmania donovani 30% 73%
A0A3R7KIH0 Trypanosoma rangeli 29% 68%
A0A3R7NKK1 Trypanosoma rangeli 24% 70%
A0A3S7X806 Leishmania donovani 24% 68%
A0A422NHS3 Trypanosoma rangeli 54% 74%
A4HAX6 Leishmania braziliensis 25% 100%
A4HCF3 Leishmania braziliensis 92% 100%
A4HPG9 Leishmania braziliensis 29% 100%
A4IA35 Leishmania infantum 24% 68%
A4ID91 Leishmania infantum 31% 73%
C9ZM64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 75%
C9ZSM4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 74%
C9ZWJ5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 70%
D3ZRP6 Rattus norvegicus 44% 75%
E2RED8 Canis lupus familiaris 22% 71%
E9AT81 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AVU6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
F4I562 Arabidopsis thaliana 31% 77%
O00189 Homo sapiens 23% 70%
O22715 Arabidopsis thaliana 41% 75%
O23140 Arabidopsis thaliana 37% 73%
P35585 Mus musculus 44% 75%
P35602 Caenorhabditis elegans 45% 76%
P35603 Caenorhabditis elegans 37% 72%
P47795 Diplobatis ommata 29% 76%
P53676 Rattus norvegicus 29% 76%
P53677 Homo sapiens 30% 76%
P53678 Rattus norvegicus 30% 76%
P54672 Dictyostelium discoideum 36% 73%
P84091 Mus musculus 38% 73%
P84092 Rattus norvegicus 38% 73%
Q00776 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 67%
Q09718 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 72%
Q24K11 Bos taurus 30% 76%
Q29RY8 Bos taurus 23% 71%
Q2KJ81 Bos taurus 44% 75%
Q2PWT8 Rattus norvegicus 23% 70%
Q32Q06 Rattus norvegicus 44% 75%
Q3SYW1 Bos taurus 43% 75%
Q3ZC13 Bos taurus 38% 73%
Q4Q1B6 Leishmania major 30% 100%
Q4Q2T6 Leishmania major 24% 100%
Q4QBN3 Leishmania major 97% 100%
Q4R706 Macaca fascicularis 38% 73%
Q54HS9 Dictyostelium discoideum 46% 75%
Q5NVF7 Pongo abelii 38% 73%
Q5R478 Pongo abelii 30% 76%
Q5ZMP6 Gallus gallus 38% 74%
Q5ZMP7 Gallus gallus 29% 76%
Q6NWK2 Danio rerio 37% 73%
Q6P856 Xenopus tropicalis 38% 73%
Q7ZW98 Danio rerio 37% 73%
Q801Q8 Xenopus laevis 38% 73%
Q8R2R9 Mus musculus 29% 76%
Q96CW1 Homo sapiens 38% 73%
Q9BXS5 Homo sapiens 44% 75%
Q9GPF1 Dictyostelium discoideum 30% 76%
Q9HFE5 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 45% 75%
Q9JKC7 Mus musculus 23% 71%
Q9JKC8 Mus musculus 30% 76%
Q9SAC9 Arabidopsis thaliana 42% 75%
Q9SB50 Arabidopsis thaliana 30% 71%
Q9WVP1 Mus musculus 43% 75%
Q9Y2T2 Homo sapiens 30% 76%
Q9Y6Q5 Homo sapiens 43% 75%
V5BKQ8 Trypanosoma cruzi 26% 75%
V5BLL2 Trypanosoma cruzi 53% 74%
V5DGM7 Trypanosoma cruzi 31% 77%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS