Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Metallo-beta-lactamase superfamily/Beta-lactamase superfamily domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HZY4_LEIIN

TriTrypDb:

LINF_220017300

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.489
CLV_NRD_NRD_1	348	350	PF00675	0.435
CLV_NRD_NRD_1	44	46	PF00675	0.350
CLV_NRD_NRD_1	5	7	PF00675	0.553
CLV_PCSK_KEX2_1	145	147	PF00082	0.504
CLV_PCSK_KEX2_1	348	350	PF00082	0.451
CLV_PCSK_KEX2_1	44	46	PF00082	0.352
CLV_PCSK_KEX2_1	5	7	PF00082	0.553
CLV_PCSK_SKI1_1	403	407	PF00082	0.476
DEG_APCC_DBOX_1	379	387	PF00400	0.482
DEG_APCC_DBOX_1	5	13	PF00400	0.336
DEG_ODPH_VHL_1	84	97	PF01847	0.427
DEG_SPOP_SBC_1	123	127	PF00917	0.213
DEG_SPOP_SBC_1	195	199	PF00917	0.570
DOC_CDC14_PxL_1	150	158	PF14671	0.354
DOC_MAPK_gen_1	216	225	PF00069	0.497
DOC_MAPK_gen_1	376	385	PF00069	0.516
DOC_MAPK_gen_1	44	52	PF00069	0.350
DOC_MAPK_gen_1	5	11	PF00069	0.487
DOC_MAPK_gen_1	74	83	PF00069	0.309
DOC_MAPK_HePTP_8	375	387	PF00069	0.377
DOC_MAPK_MEF2A_6	216	225	PF00069	0.555
DOC_MAPK_MEF2A_6	313	321	PF00069	0.311
DOC_MAPK_MEF2A_6	378	387	PF00069	0.530
DOC_MAPK_MEF2A_6	44	52	PF00069	0.394
DOC_PP1_RVXF_1	400	407	PF00149	0.350
DOC_PP1_RVXF_1	6	12	PF00149	0.325
DOC_PP2B_LxvP_1	151	154	PF13499	0.333
DOC_USP7_MATH_1	123	127	PF00917	0.223
DOC_USP7_MATH_1	182	186	PF00917	0.571
DOC_USP7_MATH_1	195	199	PF00917	0.630
DOC_USP7_MATH_1	230	234	PF00917	0.608
DOC_USP7_MATH_1	272	276	PF00917	0.468
DOC_USP7_MATH_1	301	305	PF00917	0.493
DOC_USP7_MATH_1	328	332	PF00917	0.525
DOC_USP7_MATH_1	37	41	PF00917	0.591
DOC_USP7_MATH_1	388	392	PF00917	0.471
DOC_WW_Pin1_4	124	129	PF00397	0.443
DOC_WW_Pin1_4	160	165	PF00397	0.554
DOC_WW_Pin1_4	226	231	PF00397	0.548
LIG_14-3-3_CanoR_1	348	352	PF00244	0.454
LIG_14-3-3_CanoR_1	409	414	PF00244	0.472
LIG_14-3-3_CanoR_1	45	51	PF00244	0.412
LIG_14-3-3_CanoR_1	6	12	PF00244	0.410
LIG_BRCT_BRCA1_1	303	307	PF00533	0.486
LIG_BRCT_BRCA1_1	52	56	PF00533	0.342
LIG_Clathr_ClatBox_1	311	315	PF01394	0.386
LIG_eIF4E_1	91	97	PF01652	0.380
LIG_FHA_1	348	354	PF00498	0.299
LIG_FHA_1	367	373	PF00498	0.462
LIG_FHA_2	204	210	PF00498	0.437
LIG_IRF3_LxIS_1	48	53	PF10401	0.426
LIG_LIR_Gen_1	64	70	PF02991	0.352
LIG_LIR_Gen_1	78	87	PF02991	0.331
LIG_LIR_Nem_3	246	252	PF02991	0.398
LIG_LIR_Nem_3	64	68	PF02991	0.344
LIG_LIR_Nem_3	78	83	PF02991	0.328
LIG_Pex14_2	352	356	PF04695	0.455
LIG_RPA_C_Fungi	404	416	PF08784	0.322
LIG_SH2_CRK	250	254	PF00017	0.373
LIG_SH2_CRK	80	84	PF00017	0.427
LIG_SH2_SRC	91	94	PF00017	0.380
LIG_SH2_STAT3	417	420	PF00017	0.489
LIG_SH2_STAT5	260	263	PF00017	0.439
LIG_SH2_STAT5	293	296	PF00017	0.347
LIG_SH2_STAT5	333	336	PF00017	0.383
LIG_SH2_STAT5	351	354	PF00017	0.228
LIG_SH2_STAT5	91	94	PF00017	0.393
LIG_SH3_2	39	44	PF14604	0.462
LIG_SH3_3	221	227	PF00018	0.467
LIG_SH3_3	36	42	PF00018	0.499
LIG_SH3_3	382	388	PF00018	0.397
LIG_SH3_3	80	86	PF00018	0.380
LIG_SUMO_SIM_anti_2	315	320	PF11976	0.285
LIG_SUMO_SIM_anti_2	381	387	PF11976	0.365
LIG_SUMO_SIM_par_1	315	320	PF11976	0.294
LIG_UBA3_1	210	217	PF00899	0.499
LIG_WRC_WIRS_1	147	152	PF05994	0.479
MOD_CK1_1	126	132	PF00069	0.414
MOD_CK1_1	197	203	PF00069	0.553
MOD_CK1_1	275	281	PF00069	0.662
MOD_CK1_1	295	301	PF00069	0.350
MOD_CK2_1	196	202	PF00069	0.657
MOD_CK2_1	58	64	PF00069	0.488
MOD_GlcNHglycan	129	132	PF01048	0.464
MOD_GlcNHglycan	17	20	PF01048	0.420
MOD_GlcNHglycan	184	187	PF01048	0.557
MOD_GlcNHglycan	199	202	PF01048	0.667
MOD_GlcNHglycan	232	235	PF01048	0.679
MOD_GlcNHglycan	328	331	PF01048	0.550
MOD_GlcNHglycan	39	42	PF01048	0.578
MOD_GlcNHglycan	60	63	PF01048	0.539
MOD_GlcNHglycan	77	80	PF01048	0.344
MOD_GSK3_1	122	129	PF00069	0.395
MOD_GSK3_1	131	138	PF00069	0.392
MOD_GSK3_1	187	194	PF00069	0.627
MOD_GSK3_1	226	233	PF00069	0.640
MOD_GSK3_1	238	245	PF00069	0.585
MOD_GSK3_1	268	275	PF00069	0.430
MOD_GSK3_1	46	53	PF00069	0.394
MOD_GSK3_1	7	14	PF00069	0.306
MOD_N-GLC_1	238	243	PF02516	0.631
MOD_N-GLC_1	46	51	PF02516	0.405
MOD_NEK2_1	50	55	PF00069	0.406
MOD_NEK2_1	7	12	PF00069	0.406
MOD_NEK2_1	95	100	PF00069	0.430
MOD_NEK2_2	72	77	PF00069	0.316
MOD_PIKK_1	165	171	PF00454	0.342
MOD_PIKK_1	275	281	PF00454	0.688
MOD_PKA_2	268	274	PF00069	0.485
MOD_PKA_2	275	281	PF00069	0.618
MOD_PKA_2	347	353	PF00069	0.448
MOD_PKA_2	7	13	PF00069	0.403
MOD_Plk_1	295	301	PF00069	0.392
MOD_Plk_1	46	52	PF00069	0.400
MOD_Plk_4	135	141	PF00069	0.427
MOD_Plk_4	146	152	PF00069	0.451
MOD_Plk_4	203	209	PF00069	0.513
MOD_Plk_4	46	52	PF00069	0.315
MOD_Plk_4	7	13	PF00069	0.399
MOD_ProDKin_1	124	130	PF00069	0.443
MOD_ProDKin_1	160	166	PF00069	0.547
MOD_ProDKin_1	226	232	PF00069	0.548
MOD_SUMO_rev_2	209	218	PF00179	0.450
MOD_SUMO_rev_2	371	377	PF00179	0.495
MOD_SUMO_rev_2	399	405	PF00179	0.371
TRG_ENDOCYTIC_2	260	263	PF00928	0.385
TRG_ENDOCYTIC_2	80	83	PF00928	0.360
TRG_ER_diArg_1	144	146	PF00400	0.511
TRG_ER_diArg_1	347	349	PF00400	0.439
TRG_ER_diArg_1	4	6	PF00400	0.533
TRG_NES_CRM1_1	202	215	PF08389	0.390
TRG_NES_CRM1_1	309	320	PF08389	0.381
TRG_NES_CRM1_1	366	381	PF08389	0.291
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M2	Leptomonas seymouri	39%	94%
A0A0N1PFX0	Leptomonas seymouri	58%	94%
A0A0S4J8Q0	Bodo saltans	35%	100%
A0A0S4JLW1	Bodo saltans	25%	96%
A0A1X0NTE2	Trypanosomatidae	41%	100%
A0A1X0NX03	Trypanosomatidae	24%	100%
A0A3Q8IFK3	Leishmania donovani	49%	91%
A0A3S7WXD8	Leishmania donovani	100%	100%
A0A422NHR8	Trypanosoma rangeli	41%	100%
A4HCF4	Leishmania braziliensis	46%	100%
A4HZY3	Leishmania infantum	44%	100%
C9ZSM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AVU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	91%
E9AVU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBN4	Leishmania major	93%	99%
Q4QBN5	Leishmania major	42%	100%
V5BVW3	Trypanosoma cruzi	41%	100%