Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Metallo-beta-lactamase superfamily/Beta-lactamase superfamily domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HZY3_LEIIN

TriTrypDb:

LINF_220017200

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.302
CLV_C14_Caspase3-7	96	100	PF00656	0.687
CLV_NRD_NRD_1	273	275	PF00675	0.285
CLV_PCSK_KEX2_1	273	275	PF00082	0.285
CLV_PCSK_SKI1_1	412	416	PF00082	0.419
DEG_APCC_DBOX_1	73	81	PF00400	0.542
DOC_CKS1_1	234	239	PF01111	0.249
DOC_MAPK_DCC_7	74	82	PF00069	0.378
DOC_MAPK_gen_1	273	280	PF00069	0.292
DOC_MAPK_gen_1	287	295	PF00069	0.416
DOC_MAPK_MEF2A_6	287	295	PF00069	0.451
DOC_MAPK_MEF2A_6	63	72	PF00069	0.381
DOC_MAPK_MEF2A_6	74	82	PF00069	0.481
DOC_MAPK_NFAT4_5	63	71	PF00069	0.316
DOC_USP7_MATH_1	119	123	PF00917	0.725
DOC_USP7_MATH_1	336	340	PF00917	0.331
DOC_USP7_MATH_1	365	369	PF00917	0.437
DOC_USP7_MATH_1	435	439	PF00917	0.353
DOC_USP7_MATH_1	55	59	PF00917	0.513
DOC_USP7_UBL2_3	214	218	PF12436	0.283
DOC_WW_Pin1_4	206	211	PF00397	0.394
DOC_WW_Pin1_4	233	238	PF00397	0.431
DOC_WW_Pin1_4	384	389	PF00397	0.413
DOC_WW_Pin1_4	390	395	PF00397	0.388
LIG_14-3-3_CanoR_1	118	124	PF00244	0.624
LIG_14-3-3_CanoR_1	225	229	PF00244	0.313
LIG_14-3-3_CanoR_1	273	281	PF00244	0.288
LIG_14-3-3_CanoR_1	63	69	PF00244	0.375
LIG_Actin_WH2_2	433	448	PF00022	0.477
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BRCT_BRCA1_1	1	5	PF00533	0.462
LIG_BRCT_BRCA1_1	119	123	PF00533	0.426
LIG_BRCT_BRCA1_1	367	371	PF00533	0.417
LIG_Clathr_ClatBox_1	280	284	PF01394	0.425
LIG_Clathr_ClatBox_1	375	379	PF01394	0.333
LIG_deltaCOP1_diTrp_1	197	203	PF00928	0.425
LIG_FHA_1	133	139	PF00498	0.302
LIG_FHA_1	165	171	PF00498	0.425
LIG_FHA_2	146	152	PF00498	0.272
LIG_FHA_2	234	240	PF00498	0.322
LIG_FHA_2	274	280	PF00498	0.322
LIG_LIR_Apic_2	206	210	PF02991	0.386
LIG_LIR_LC3C_4	404	407	PF02991	0.181
LIG_LIR_Nem_3	151	156	PF02991	0.299
LIG_LIR_Nem_3	264	270	PF02991	0.364
LIG_LIR_Nem_3	310	316	PF02991	0.311
LIG_SH2_CRK	24	28	PF00017	0.327
LIG_SH2_CRK	314	318	PF00017	0.319
LIG_SH2_STAT5	132	135	PF00017	0.496
LIG_SH2_STAT5	153	156	PF00017	0.310
LIG_SH2_STAT5	207	210	PF00017	0.267
LIG_SH2_STAT5	222	225	PF00017	0.233
LIG_SH2_STAT5	324	327	PF00017	0.378
LIG_SH2_STAT5	357	360	PF00017	0.289
LIG_SH2_STAT5	397	400	PF00017	0.333
LIG_SH3_3	14	20	PF00018	0.405
LIG_SH3_3	459	465	PF00018	0.448
LIG_SH3_3	51	57	PF00018	0.487
LIG_SH3_3	75	81	PF00018	0.534
LIG_SUMO_SIM_par_1	166	171	PF11976	0.437
LIG_UBA3_1	402	410	PF00899	0.275
LIG_WRC_WIRS_1	200	205	PF05994	0.418
LIG_WW_1	21	24	PF00397	0.399
MOD_CDK_SPxxK_3	384	391	PF00069	0.275
MOD_CK1_1	209	215	PF00069	0.288
MOD_CK1_1	227	233	PF00069	0.300
MOD_CK1_1	235	241	PF00069	0.350
MOD_CK1_1	32	38	PF00069	0.312
MOD_CK1_1	339	345	PF00069	0.423
MOD_CK1_1	359	365	PF00069	0.300
MOD_CK2_1	233	239	PF00069	0.319
MOD_GlcNHglycan	112	115	PF01048	0.667
MOD_GlcNHglycan	2	5	PF01048	0.579
MOD_GlcNHglycan	229	232	PF01048	0.430
MOD_GlcNHglycan	31	34	PF01048	0.355
MOD_GlcNHglycan	388	391	PF01048	0.463
MOD_GlcNHglycan	56	60	PF01048	0.513
MOD_GSK3_1	164	171	PF00069	0.417
MOD_GSK3_1	199	206	PF00069	0.365
MOD_GSK3_1	208	215	PF00069	0.332
MOD_GSK3_1	25	32	PF00069	0.311
MOD_GSK3_1	298	305	PF00069	0.430
MOD_GSK3_1	332	339	PF00069	0.337
MOD_GSK3_1	386	393	PF00069	0.390
MOD_GSK3_1	64	71	PF00069	0.354
MOD_GSK3_1	7	14	PF00069	0.511
MOD_GSK3_1	82	89	PF00069	0.648
MOD_N-GLC_1	257	262	PF02516	0.439
MOD_N-GLC_1	64	69	PF02516	0.367
MOD_NEK2_1	168	173	PF00069	0.421
MOD_NEK2_1	25	30	PF00069	0.396
MOD_NEK2_1	68	73	PF00069	0.368
MOD_NEK2_2	119	124	PF00069	0.522
MOD_NEK2_2	145	150	PF00069	0.289
MOD_PIKK_1	11	17	PF00454	0.406
MOD_PIKK_1	339	345	PF00454	0.456
MOD_PIKK_1	435	441	PF00454	0.348
MOD_PKA_1	273	279	PF00069	0.345
MOD_PKA_2	117	123	PF00069	0.519
MOD_PKA_2	224	230	PF00069	0.250
MOD_PKA_2	272	278	PF00069	0.281
MOD_PKA_2	332	338	PF00069	0.403
MOD_PKA_2	339	345	PF00069	0.372
MOD_Plk_1	216	222	PF00069	0.384
MOD_Plk_1	359	365	PF00069	0.330
MOD_Plk_1	453	459	PF00069	0.445
MOD_Plk_1	64	70	PF00069	0.361
MOD_Plk_4	119	125	PF00069	0.427
MOD_Plk_4	164	170	PF00069	0.364
MOD_Plk_4	199	205	PF00069	0.392
MOD_Plk_4	25	31	PF00069	0.388
MOD_ProDKin_1	206	212	PF00069	0.394
MOD_ProDKin_1	233	239	PF00069	0.431
MOD_ProDKin_1	384	390	PF00069	0.413
TRG_ENDOCYTIC_2	153	156	PF00928	0.351
TRG_ENDOCYTIC_2	24	27	PF00928	0.333
TRG_ENDOCYTIC_2	324	327	PF00928	0.319
TRG_ENDOCYTIC_2	457	460	PF00928	0.388
TRG_ER_diArg_1	272	274	PF00400	0.345
TRG_NES_CRM1_1	373	384	PF08389	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M2	Leptomonas seymouri	62%	100%
A0A0N1PFX0	Leptomonas seymouri	36%	100%
A0A0S4J8Q0	Bodo saltans	39%	100%
A0A0S4JLW1	Bodo saltans	25%	100%
A0A1X0NTE2	Trypanosomatidae	39%	100%
A0A1X0NX03	Trypanosomatidae	23%	100%
A0A3Q8IFK3	Leishmania donovani	100%	100%
A0A3S7WXD8	Leishmania donovani	44%	100%
A0A422NHR8	Trypanosoma rangeli	38%	100%
A4HCF4	Leishmania braziliensis	86%	100%
A4HZY4	Leishmania infantum	44%	100%
C9ZSM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AVU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AVU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
Q4QBN4	Leishmania major	46%	100%
Q4QBN5	Leishmania major	92%	99%
V5BVW3	Trypanosoma cruzi	40%	100%