LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
CRAL/TRIO domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HZY1_LEIIN
TriTrypDb:
LINF_220016900
Length:
712

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZY1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZY1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 30 34 PF00656 0.493
CLV_C14_Caspase3-7 70 74 PF00656 0.387
CLV_NRD_NRD_1 183 185 PF00675 0.408
CLV_NRD_NRD_1 408 410 PF00675 0.508
CLV_NRD_NRD_1 609 611 PF00675 0.474
CLV_NRD_NRD_1 659 661 PF00675 0.445
CLV_NRD_NRD_1 97 99 PF00675 0.423
CLV_PCSK_FUR_1 180 184 PF00082 0.340
CLV_PCSK_FUR_1 607 611 PF00082 0.466
CLV_PCSK_FUR_1 95 99 PF00082 0.395
CLV_PCSK_KEX2_1 180 182 PF00082 0.385
CLV_PCSK_KEX2_1 183 185 PF00082 0.308
CLV_PCSK_KEX2_1 408 410 PF00082 0.508
CLV_PCSK_KEX2_1 607 609 PF00082 0.474
CLV_PCSK_KEX2_1 661 663 PF00082 0.466
CLV_PCSK_KEX2_1 95 97 PF00082 0.426
CLV_PCSK_PC1ET2_1 661 663 PF00082 0.466
CLV_PCSK_PC7_1 604 610 PF00082 0.462
CLV_PCSK_SKI1_1 132 136 PF00082 0.312
CLV_PCSK_SKI1_1 166 170 PF00082 0.393
CLV_PCSK_SKI1_1 456 460 PF00082 0.580
CLV_PCSK_SKI1_1 97 101 PF00082 0.365
DEG_COP1_1 530 539 PF00400 0.631
DEG_SCF_FBW7_1 472 478 PF00400 0.716
DEG_SPOP_SBC_1 283 287 PF00917 0.340
DEG_SPOP_SBC_1 32 36 PF00917 0.602
DEG_SPOP_SBC_1 703 707 PF00917 0.555
DOC_CKS1_1 472 477 PF01111 0.719
DOC_CYCLIN_RxL_1 163 173 PF00134 0.359
DOC_CYCLIN_yCln2_LP_2 262 268 PF00134 0.255
DOC_CYCLIN_yCln2_LP_2 392 398 PF00134 0.545
DOC_CYCLIN_yCln2_LP_2 459 465 PF00134 0.642
DOC_MAPK_gen_1 22 29 PF00069 0.432
DOC_MAPK_gen_1 408 419 PF00069 0.534
DOC_MAPK_gen_1 607 619 PF00069 0.547
DOC_MAPK_gen_1 78 87 PF00069 0.359
DOC_MAPK_gen_1 9 18 PF00069 0.382
DOC_MAPK_MEF2A_6 102 109 PF00069 0.362
DOC_MAPK_MEF2A_6 132 139 PF00069 0.312
DOC_MAPK_MEF2A_6 154 162 PF00069 0.291
DOC_MAPK_MEF2A_6 22 29 PF00069 0.423
DOC_MAPK_MEF2A_6 620 628 PF00069 0.498
DOC_MAPK_NFAT4_5 22 30 PF00069 0.431
DOC_MAPK_RevD_3 647 662 PF00069 0.329
DOC_PP2B_LxvP_1 25 28 PF13499 0.395
DOC_PP2B_LxvP_1 396 399 PF13499 0.488
DOC_PP2B_PxIxI_1 104 110 PF00149 0.378
DOC_PP4_FxxP_1 142 145 PF00568 0.388
DOC_USP7_MATH_1 116 120 PF00917 0.302
DOC_USP7_MATH_1 190 194 PF00917 0.367
DOC_USP7_MATH_1 32 36 PF00917 0.612
DOC_USP7_MATH_1 338 342 PF00917 0.358
DOC_USP7_MATH_1 386 390 PF00917 0.629
DOC_USP7_MATH_1 466 470 PF00917 0.658
DOC_USP7_MATH_1 544 548 PF00917 0.661
DOC_USP7_MATH_1 703 707 PF00917 0.527
DOC_WW_Pin1_4 107 112 PF00397 0.376
DOC_WW_Pin1_4 205 210 PF00397 0.280
DOC_WW_Pin1_4 435 440 PF00397 0.639
DOC_WW_Pin1_4 45 50 PF00397 0.778
DOC_WW_Pin1_4 458 463 PF00397 0.622
DOC_WW_Pin1_4 471 476 PF00397 0.655
DOC_WW_Pin1_4 683 688 PF00397 0.518
LIG_14-3-3_CanoR_1 291 295 PF00244 0.340
LIG_14-3-3_CanoR_1 468 475 PF00244 0.667
LIG_BIR_II_1 1 5 PF00653 0.465
LIG_BIR_III_4 382 386 PF00653 0.577
LIG_BRCT_BRCA1_1 118 122 PF00533 0.364
LIG_BRCT_BRCA1_1 191 195 PF00533 0.255
LIG_CtBP_PxDLS_1 312 316 PF00389 0.312
LIG_FHA_1 139 145 PF00498 0.364
LIG_FHA_1 226 232 PF00498 0.363
LIG_FHA_1 308 314 PF00498 0.291
LIG_FHA_1 487 493 PF00498 0.742
LIG_FHA_1 536 542 PF00498 0.673
LIG_FHA_1 62 68 PF00498 0.367
LIG_FHA_2 28 34 PF00498 0.485
LIG_FHA_2 472 478 PF00498 0.585
LIG_FHA_2 676 682 PF00498 0.518
LIG_FHA_2 68 74 PF00498 0.476
LIG_LIR_Apic_2 141 145 PF02991 0.340
LIG_LIR_Gen_1 119 129 PF02991 0.340
LIG_LIR_Gen_1 678 687 PF02991 0.481
LIG_LIR_LC3C_4 82 87 PF02991 0.316
LIG_LIR_Nem_3 119 125 PF02991 0.472
LIG_LIR_Nem_3 538 542 PF02991 0.676
LIG_LIR_Nem_3 60 65 PF02991 0.422
LIG_LIR_Nem_3 678 683 PF02991 0.453
LIG_LYPXL_yS_3 259 262 PF13949 0.312
LIG_MYND_3 144 148 PF01753 0.312
LIG_NRBOX 155 161 PF00104 0.291
LIG_NRBOX 668 674 PF00104 0.464
LIG_PCNA_PIPBox_1 69 78 PF02747 0.352
LIG_Pex3_1 669 680 PF04882 0.448
LIG_SH2_GRB2like 136 139 PF00017 0.312
LIG_SH2_NCK_1 542 546 PF00017 0.664
LIG_SH2_NCK_1 577 581 PF00017 0.558
LIG_SH2_PTP2 136 139 PF00017 0.388
LIG_SH2_PTP2 397 400 PF00017 0.488
LIG_SH2_SRC 136 139 PF00017 0.388
LIG_SH2_SRC 397 400 PF00017 0.488
LIG_SH2_STAT5 136 139 PF00017 0.299
LIG_SH2_STAT5 397 400 PF00017 0.488
LIG_SH2_STAT5 542 545 PF00017 0.657
LIG_SH2_STAT5 618 621 PF00017 0.541
LIG_SH2_STAT5 75 78 PF00017 0.336
LIG_SH2_STAT5 79 82 PF00017 0.347
LIG_SH3_2 441 446 PF14604 0.656
LIG_SH3_3 395 401 PF00018 0.495
LIG_SH3_3 433 439 PF00018 0.646
LIG_SH3_3 46 52 PF00018 0.596
LIG_SH3_3 469 475 PF00018 0.666
LIG_SUMO_SIM_anti_2 249 256 PF11976 0.425
LIG_SUMO_SIM_anti_2 423 431 PF11976 0.525
LIG_SUMO_SIM_par_1 105 110 PF11976 0.393
LIG_SUMO_SIM_par_1 145 151 PF11976 0.350
LIG_SUMO_SIM_par_1 155 161 PF11976 0.355
LIG_SUMO_SIM_par_1 227 234 PF11976 0.285
LIG_SUMO_SIM_par_1 671 676 PF11976 0.518
LIG_TRAF2_1 51 54 PF00917 0.605
LIG_TRAF2_1 585 588 PF00917 0.462
LIG_TYR_ITIM 134 139 PF00017 0.388
LIG_UBA3_1 251 257 PF00899 0.385
LIG_UBA3_1 76 83 PF00899 0.345
LIG_WRC_WIRS_1 139 144 PF05994 0.340
MOD_CAAXbox 709 712 PF01239 0.540
MOD_CDK_SPK_2 45 50 PF00069 0.753
MOD_CDK_SPxK_1 205 211 PF00069 0.236
MOD_CK1_1 34 40 PF00069 0.754
MOD_CK1_1 363 369 PF00069 0.763
MOD_CK1_1 425 431 PF00069 0.559
MOD_CK1_1 507 513 PF00069 0.630
MOD_CK1_1 575 581 PF00069 0.670
MOD_CK2_1 282 288 PF00069 0.323
MOD_CK2_1 338 344 PF00069 0.409
MOD_CK2_1 48 54 PF00069 0.600
MOD_CK2_1 582 588 PF00069 0.479
MOD_CK2_1 629 635 PF00069 0.437
MOD_CK2_1 675 681 PF00069 0.513
MOD_GlcNHglycan 1 4 PF01048 0.470
MOD_GlcNHglycan 118 121 PF01048 0.345
MOD_GlcNHglycan 192 195 PF01048 0.333
MOD_GlcNHglycan 323 326 PF01048 0.440
MOD_GlcNHglycan 36 39 PF01048 0.755
MOD_GlcNHglycan 362 365 PF01048 0.628
MOD_GlcNHglycan 424 427 PF01048 0.534
MOD_GlcNHglycan 450 453 PF01048 0.634
MOD_GlcNHglycan 506 509 PF01048 0.610
MOD_GlcNHglycan 533 536 PF01048 0.615
MOD_GlcNHglycan 560 563 PF01048 0.644
MOD_GlcNHglycan 580 583 PF01048 0.474
MOD_GSK3_1 105 112 PF00069 0.406
MOD_GSK3_1 186 193 PF00069 0.413
MOD_GSK3_1 246 253 PF00069 0.340
MOD_GSK3_1 27 34 PF00069 0.568
MOD_GSK3_1 353 360 PF00069 0.713
MOD_GSK3_1 421 428 PF00069 0.655
MOD_GSK3_1 431 438 PF00069 0.593
MOD_GSK3_1 466 473 PF00069 0.671
MOD_GSK3_1 527 534 PF00069 0.683
MOD_GSK3_1 540 547 PF00069 0.555
MOD_GSK3_1 578 585 PF00069 0.503
MOD_GSK3_1 61 68 PF00069 0.372
MOD_GSK3_1 681 688 PF00069 0.494
MOD_GSK3_1 703 710 PF00069 0.496
MOD_LATS_1 529 535 PF00433 0.639
MOD_N-GLC_1 246 251 PF02516 0.388
MOD_N-GLC_1 326 331 PF02516 0.371
MOD_N-GLC_1 466 471 PF02516 0.638
MOD_N-GLC_1 629 634 PF02516 0.437
MOD_N-GLC_1 681 686 PF02516 0.481
MOD_NEK2_1 100 105 PF00069 0.405
MOD_NEK2_1 240 245 PF00069 0.343
MOD_NEK2_1 306 311 PF00069 0.352
MOD_NEK2_1 337 342 PF00069 0.377
MOD_NEK2_1 403 408 PF00069 0.560
MOD_NEK2_1 422 427 PF00069 0.558
MOD_NEK2_1 548 553 PF00069 0.628
MOD_NEK2_1 558 563 PF00069 0.560
MOD_NEK2_1 572 577 PF00069 0.631
MOD_NEK2_1 67 72 PF00069 0.350
MOD_NEK2_1 673 678 PF00069 0.444
MOD_PIKK_1 338 344 PF00454 0.388
MOD_PIKK_1 403 409 PF00454 0.559
MOD_PIKK_1 478 484 PF00454 0.663
MOD_PK_1 629 635 PF00069 0.450
MOD_PKA_1 408 414 PF00069 0.503
MOD_PKA_2 290 296 PF00069 0.388
MOD_PKA_2 408 414 PF00069 0.503
MOD_PKA_2 467 473 PF00069 0.669
MOD_Plk_1 100 106 PF00069 0.386
MOD_Plk_1 246 252 PF00069 0.388
MOD_Plk_1 306 312 PF00069 0.319
MOD_Plk_1 629 635 PF00069 0.437
MOD_Plk_1 673 679 PF00069 0.436
MOD_Plk_2-3 498 504 PF00069 0.578
MOD_Plk_4 240 246 PF00069 0.352
MOD_Plk_4 247 253 PF00069 0.352
MOD_Plk_4 425 431 PF00069 0.611
MOD_Plk_4 572 578 PF00069 0.581
MOD_Plk_4 629 635 PF00069 0.450
MOD_ProDKin_1 107 113 PF00069 0.370
MOD_ProDKin_1 205 211 PF00069 0.280
MOD_ProDKin_1 435 441 PF00069 0.639
MOD_ProDKin_1 45 51 PF00069 0.769
MOD_ProDKin_1 458 464 PF00069 0.622
MOD_ProDKin_1 471 477 PF00069 0.656
MOD_ProDKin_1 683 689 PF00069 0.524
MOD_SUMO_for_1 654 657 PF00179 0.505
MOD_SUMO_rev_2 350 359 PF00179 0.640
TRG_DiLeu_BaEn_1 151 156 PF01217 0.285
TRG_DiLeu_BaLyEn_6 257 262 PF01217 0.340
TRG_DiLeu_LyEn_5 151 156 PF01217 0.285
TRG_ENDOCYTIC_2 136 139 PF00928 0.312
TRG_ENDOCYTIC_2 258 261 PF00928 0.479
TRG_ER_diArg_1 180 183 PF00400 0.385
TRG_ER_diArg_1 408 410 PF00400 0.508
TRG_ER_diArg_1 607 610 PF00400 0.479
TRG_ER_diArg_1 94 97 PF00400 0.380
TRG_NES_CRM1_1 637 651 PF08389 0.431
TRG_NLS_MonoExtC_3 659 664 PF00514 0.454
TRG_NLS_MonoExtN_4 660 665 PF00514 0.510
TRG_Pf-PMV_PEXEL_1 97 101 PF00026 0.318

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P818 Leptomonas seymouri 52% 100%
A0A3Q8IAR1 Leishmania donovani 99% 100%
A4HCF0 Leishmania braziliensis 69% 99%
E9AVU1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QBN8 Leishmania major 89% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS