LeishMANIAdb
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WD_REPEATS_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
WD_REPEATS_REGION domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZX1_LEIIN
TriTrypDb:
LINF_220015800
Length:
706

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, SEC10 exocyst complex component Sec10, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005681 spliceosomal complex 3 1
GO:0010494 cytoplasmic stress granule 5 1
GO:0032991 protein-containing complex 1 4
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043226 organelle 2 4
GO:0043228 non-membrane-bounded organelle 3 4
GO:0043229 intracellular organelle 3 4
GO:0043232 intracellular non-membrane-bounded organelle 4 4
GO:0071013 catalytic step 2 spliceosome 3 1
GO:0099080 supramolecular complex 2 1
GO:0110165 cellular anatomical entity 1 4
GO:0140513 nuclear protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990904 ribonucleoprotein complex 2 4
GO:0005840 ribosome 5 3

Expansion

Sequence features

A4HZX1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZX1

Function

Biological processes
Term Name Level Count
GO:0000375 RNA splicing, via transesterification reactions 8 1
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 1
GO:0000398 mRNA splicing, via spliceosome 8 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006397 mRNA processing 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008380 RNA splicing 7 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 127 131 PF00656 0.435
CLV_C14_Caspase3-7 309 313 PF00656 0.518
CLV_C14_Caspase3-7 68 72 PF00656 0.666
CLV_NRD_NRD_1 253 255 PF00675 0.443
CLV_NRD_NRD_1 270 272 PF00675 0.266
CLV_NRD_NRD_1 400 402 PF00675 0.617
CLV_PCSK_KEX2_1 253 255 PF00082 0.541
CLV_PCSK_KEX2_1 270 272 PF00082 0.499
CLV_PCSK_KEX2_1 631 633 PF00082 0.430
CLV_PCSK_PC1ET2_1 631 633 PF00082 0.386
CLV_PCSK_SKI1_1 151 155 PF00082 0.431
CLV_PCSK_SKI1_1 187 191 PF00082 0.405
CLV_PCSK_SKI1_1 253 257 PF00082 0.555
CLV_PCSK_SKI1_1 259 263 PF00082 0.553
CLV_PCSK_SKI1_1 649 653 PF00082 0.434
DEG_APCC_DBOX_1 150 158 PF00400 0.365
DEG_APCC_DBOX_1 186 194 PF00400 0.365
DEG_Nend_Nbox_1 1 3 PF02207 0.726
DEG_SPOP_SBC_1 415 419 PF00917 0.561
DOC_CYCLIN_yClb1_LxF_4 523 528 PF00134 0.448
DOC_MAPK_DCC_7 354 364 PF00069 0.629
DOC_MAPK_DCC_7 365 374 PF00069 0.481
DOC_MAPK_FxFP_2 635 638 PF00069 0.395
DOC_MAPK_gen_1 251 258 PF00069 0.481
DOC_MAPK_gen_1 365 372 PF00069 0.505
DOC_MAPK_HePTP_8 362 374 PF00069 0.445
DOC_MAPK_MEF2A_6 182 190 PF00069 0.370
DOC_MAPK_MEF2A_6 205 213 PF00069 0.363
DOC_MAPK_MEF2A_6 281 288 PF00069 0.370
DOC_MAPK_MEF2A_6 365 374 PF00069 0.453
DOC_MAPK_MEF2A_6 656 663 PF00069 0.432
DOC_PP1_RVXF_1 523 529 PF00149 0.446
DOC_PP2B_LxvP_1 357 360 PF13499 0.632
DOC_PP4_FxxP_1 61 64 PF00568 0.617
DOC_PP4_FxxP_1 635 638 PF00568 0.395
DOC_PP4_MxPP_1 477 480 PF00568 0.397
DOC_SPAK_OSR1_1 281 285 PF12202 0.336
DOC_USP7_MATH_1 140 144 PF00917 0.441
DOC_USP7_MATH_1 22 26 PF00917 0.784
DOC_USP7_MATH_1 345 349 PF00917 0.557
DOC_USP7_MATH_1 35 39 PF00917 0.527
DOC_USP7_MATH_1 360 364 PF00917 0.429
DOC_USP7_MATH_1 397 401 PF00917 0.532
DOC_USP7_UBL2_3 402 406 PF12436 0.508
DOC_WW_Pin1_4 293 298 PF00397 0.597
DOC_WW_Pin1_4 578 583 PF00397 0.490
LIG_14-3-3_CanoR_1 525 529 PF00244 0.431
LIG_14-3-3_CanoR_1 656 662 PF00244 0.399
LIG_BIR_III_4 76 80 PF00653 0.543
LIG_deltaCOP1_diTrp_1 120 124 PF00928 0.386
LIG_EH1_1 182 190 PF00400 0.370
LIG_FHA_1 121 127 PF00498 0.393
LIG_FHA_1 225 231 PF00498 0.358
LIG_FHA_1 579 585 PF00498 0.448
LIG_FHA_1 588 594 PF00498 0.336
LIG_FHA_1 609 615 PF00498 0.442
LIG_FHA_1 653 659 PF00498 0.435
LIG_FHA_1 677 683 PF00498 0.488
LIG_FHA_1 92 98 PF00498 0.460
LIG_FHA_2 144 150 PF00498 0.475
LIG_FHA_2 460 466 PF00498 0.383
LIG_FHA_2 550 556 PF00498 0.460
LIG_FHA_2 63 69 PF00498 0.572
LIG_FHA_2 97 103 PF00498 0.472
LIG_GBD_Chelix_1 184 192 PF00786 0.435
LIG_LIR_Apic_2 340 345 PF02991 0.538
LIG_LIR_Apic_2 58 64 PF02991 0.621
LIG_LIR_Gen_1 120 126 PF02991 0.385
LIG_LIR_Gen_1 166 175 PF02991 0.524
LIG_LIR_Gen_1 204 214 PF02991 0.456
LIG_LIR_Gen_1 299 306 PF02991 0.432
LIG_LIR_Gen_1 387 398 PF02991 0.411
LIG_LIR_Gen_1 527 536 PF02991 0.504
LIG_LIR_Gen_1 604 615 PF02991 0.443
LIG_LIR_Nem_3 120 125 PF02991 0.462
LIG_LIR_Nem_3 166 170 PF02991 0.516
LIG_LIR_Nem_3 204 209 PF02991 0.462
LIG_LIR_Nem_3 299 304 PF02991 0.433
LIG_LIR_Nem_3 387 393 PF02991 0.414
LIG_LIR_Nem_3 527 531 PF02991 0.477
LIG_LIR_Nem_3 556 562 PF02991 0.406
LIG_LIR_Nem_3 604 610 PF02991 0.455
LIG_LYPXL_SIV_4 636 644 PF13949 0.426
LIG_PDZ_Class_1 701 706 PF00595 0.394
LIG_SH2_CRK 122 126 PF00017 0.373
LIG_SH2_CRK 301 305 PF00017 0.575
LIG_SH2_CRK 607 611 PF00017 0.432
LIG_SH2_GRB2like 163 166 PF00017 0.398
LIG_SH2_NCK_1 607 611 PF00017 0.432
LIG_SH2_PTP2 206 209 PF00017 0.358
LIG_SH2_PTP2 559 562 PF00017 0.408
LIG_SH2_STAP1 122 126 PF00017 0.373
LIG_SH2_STAP1 88 92 PF00017 0.394
LIG_SH2_STAT5 122 125 PF00017 0.354
LIG_SH2_STAT5 206 209 PF00017 0.358
LIG_SH2_STAT5 301 304 PF00017 0.459
LIG_SH2_STAT5 323 326 PF00017 0.417
LIG_SH2_STAT5 390 393 PF00017 0.358
LIG_SH2_STAT5 407 410 PF00017 0.680
LIG_SH2_STAT5 547 550 PF00017 0.393
LIG_SH2_STAT5 559 562 PF00017 0.359
LIG_SH3_3 367 373 PF00018 0.498
LIG_SH3_3 42 48 PF00018 0.701
LIG_SH3_3 473 479 PF00018 0.551
LIG_SH3_4 402 409 PF00018 0.509
LIG_SUMO_SIM_anti_2 285 290 PF11976 0.415
LIG_SUMO_SIM_anti_2 493 500 PF11976 0.351
LIG_SUMO_SIM_anti_2 527 533 PF11976 0.414
LIG_SUMO_SIM_anti_2 549 558 PF11976 0.419
LIG_SUMO_SIM_par_1 457 462 PF11976 0.443
LIG_SUMO_SIM_par_1 493 500 PF11976 0.418
LIG_SUMO_SIM_par_1 659 665 PF11976 0.392
LIG_TRAF2_1 65 68 PF00917 0.574
LIG_TYR_ITSM 297 304 PF00017 0.432
LIG_TYR_ITSM 603 610 PF00017 0.352
LIG_UBA3_1 97 101 PF00899 0.459
MOD_CK1_1 143 149 PF00069 0.407
MOD_CK1_1 38 44 PF00069 0.623
MOD_CK1_1 416 422 PF00069 0.687
MOD_CK1_1 500 506 PF00069 0.507
MOD_CK1_1 601 607 PF00069 0.477
MOD_CK1_1 662 668 PF00069 0.279
MOD_CK2_1 1 7 PF00069 0.547
MOD_CK2_1 143 149 PF00069 0.396
MOD_CK2_1 459 465 PF00069 0.363
MOD_CK2_1 52 58 PF00069 0.663
MOD_CK2_1 549 555 PF00069 0.378
MOD_CK2_1 62 68 PF00069 0.544
MOD_GlcNHglycan 127 130 PF01048 0.421
MOD_GlcNHglycan 158 161 PF01048 0.330
MOD_GlcNHglycan 334 338 PF01048 0.452
MOD_GlcNHglycan 351 354 PF01048 0.460
MOD_GlcNHglycan 37 40 PF01048 0.598
MOD_GlcNHglycan 418 421 PF01048 0.632
MOD_GlcNHglycan 453 456 PF01048 0.510
MOD_GlcNHglycan 499 502 PF01048 0.391
MOD_GlcNHglycan 516 519 PF01048 0.476
MOD_GlcNHglycan 520 523 PF01048 0.463
MOD_GlcNHglycan 532 535 PF01048 0.420
MOD_GlcNHglycan 562 565 PF01048 0.344
MOD_GSK3_1 18 25 PF00069 0.629
MOD_GSK3_1 217 224 PF00069 0.504
MOD_GSK3_1 245 252 PF00069 0.348
MOD_GSK3_1 296 303 PF00069 0.521
MOD_GSK3_1 306 313 PF00069 0.496
MOD_GSK3_1 329 336 PF00069 0.446
MOD_GSK3_1 345 352 PF00069 0.529
MOD_GSK3_1 35 42 PF00069 0.582
MOD_GSK3_1 416 423 PF00069 0.704
MOD_GSK3_1 514 521 PF00069 0.622
MOD_GSK3_1 574 581 PF00069 0.457
MOD_GSK3_1 583 590 PF00069 0.423
MOD_GSK3_1 59 66 PF00069 0.630
MOD_GSK3_1 594 601 PF00069 0.348
MOD_N-GLC_1 518 523 PF02516 0.510
MOD_NEK2_1 1 6 PF00069 0.655
MOD_NEK2_1 249 254 PF00069 0.541
MOD_NEK2_1 306 311 PF00069 0.586
MOD_NEK2_1 490 495 PF00069 0.464
MOD_NEK2_1 532 537 PF00069 0.546
MOD_NEK2_1 554 559 PF00069 0.417
MOD_NEK2_1 652 657 PF00069 0.357
MOD_NEK2_1 701 706 PF00069 0.512
MOD_NEK2_2 217 222 PF00069 0.356
MOD_NEK2_2 360 365 PF00069 0.443
MOD_PIKK_1 140 146 PF00454 0.548
MOD_PIKK_1 306 312 PF00454 0.564
MOD_PIKK_1 63 69 PF00454 0.773
MOD_PIKK_1 91 97 PF00454 0.496
MOD_PKA_2 413 419 PF00069 0.661
MOD_PKA_2 490 496 PF00069 0.470
MOD_PKA_2 524 530 PF00069 0.438
MOD_Plk_1 245 251 PF00069 0.348
MOD_Plk_1 464 470 PF00069 0.489
MOD_Plk_1 554 560 PF00069 0.518
MOD_Plk_1 595 601 PF00069 0.453
MOD_Plk_1 640 646 PF00069 0.371
MOD_Plk_2-3 81 87 PF00069 0.509
MOD_Plk_4 120 126 PF00069 0.592
MOD_Plk_4 296 302 PF00069 0.445
MOD_Plk_4 337 343 PF00069 0.481
MOD_Plk_4 39 45 PF00069 0.568
MOD_Plk_4 490 496 PF00069 0.383
MOD_Plk_4 524 530 PF00069 0.423
MOD_Plk_4 532 538 PF00069 0.492
MOD_Plk_4 549 555 PF00069 0.370
MOD_Plk_4 640 646 PF00069 0.371
MOD_ProDKin_1 293 299 PF00069 0.591
MOD_ProDKin_1 578 584 PF00069 0.484
TRG_DiLeu_BaEn_2 119 125 PF01217 0.385
TRG_DiLeu_BaLyEn_6 677 682 PF01217 0.379
TRG_ENDOCYTIC_2 122 125 PF00928 0.391
TRG_ENDOCYTIC_2 206 209 PF00928 0.358
TRG_ENDOCYTIC_2 301 304 PF00928 0.578
TRG_ENDOCYTIC_2 323 326 PF00928 0.525
TRG_ENDOCYTIC_2 390 393 PF00928 0.337
TRG_ENDOCYTIC_2 559 562 PF00928 0.386
TRG_ENDOCYTIC_2 607 610 PF00928 0.440
TRG_ENDOCYTIC_2 615 618 PF00928 0.421
TRG_ER_diArg_1 253 255 PF00400 0.443
TRG_ER_diArg_1 265 268 PF00400 0.305
TRG_ER_diArg_1 270 272 PF00400 0.266
TRG_ER_diArg_1 364 367 PF00400 0.557
TRG_ER_diArg_1 575 578 PF00400 0.542
TRG_ER_FFAT_2 545 552 PF00635 0.362
TRG_Pf-PMV_PEXEL_1 270 274 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 680 685 PF00026 0.365

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8E7 Leptomonas seymouri 44% 72%
A0A3S7WX75 Leishmania donovani 100% 100%
A0A422N3Q2 Trypanosoma rangeli 28% 100%
A4HCB8 Leishmania braziliensis 74% 97%
C9ZSK5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9AVT0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QBP9 Leishmania major 95% 100%
V5DMK2 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS