Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZW6_LEIIN

TriTrypDb:

LINF_220015200

Length:

884

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990246	uniplex complex	4	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HZW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZW6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006811	monoatomic ion transport	4	7
GO:0006812	monoatomic cation transport	5	7
GO:0006816	calcium ion transport	7	7
GO:0006851	mitochondrial calcium ion transmembrane transport	4	7
GO:0009987	cellular process	1	7
GO:0030001	metal ion transport	6	7
GO:0034220	monoatomic ion transmembrane transport	3	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0055085	transmembrane transport	2	7
GO:0070588	calcium ion transmembrane transport	6	7
GO:0098655	monoatomic cation transmembrane transport	4	7
GO:0098660	inorganic ion transmembrane transport	4	7
GO:0098662	inorganic cation transmembrane transport	5	7
GO:1990542	mitochondrial transmembrane transport	3	7
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006874	intracellular calcium ion homeostasis	7	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0036444	calcium import into the mitochondrion	5	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051560	mitochondrial calcium ion homeostasis	8	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055074	calcium ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.575
CLV_C14_Caspase3-7	774	778	PF00656	0.636
CLV_C14_Caspase3-7	837	841	PF00656	0.532
CLV_NRD_NRD_1	230	232	PF00675	0.619
CLV_NRD_NRD_1	373	375	PF00675	0.552
CLV_NRD_NRD_1	427	429	PF00675	0.696
CLV_NRD_NRD_1	433	435	PF00675	0.627
CLV_NRD_NRD_1	44	46	PF00675	0.566
CLV_NRD_NRD_1	477	479	PF00675	0.555
CLV_NRD_NRD_1	636	638	PF00675	0.471
CLV_NRD_NRD_1	644	646	PF00675	0.454
CLV_PCSK_KEX2_1	197	199	PF00082	0.397
CLV_PCSK_KEX2_1	230	232	PF00082	0.619
CLV_PCSK_KEX2_1	327	329	PF00082	0.426
CLV_PCSK_KEX2_1	373	375	PF00082	0.552
CLV_PCSK_KEX2_1	427	429	PF00082	0.696
CLV_PCSK_KEX2_1	433	435	PF00082	0.627
CLV_PCSK_KEX2_1	44	46	PF00082	0.566
CLV_PCSK_KEX2_1	636	638	PF00082	0.471
CLV_PCSK_KEX2_1	644	646	PF00082	0.454
CLV_PCSK_KEX2_1	869	871	PF00082	0.599
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.397
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.441
CLV_PCSK_PC1ET2_1	869	871	PF00082	0.599
CLV_PCSK_PC7_1	640	646	PF00082	0.517
CLV_PCSK_SKI1_1	214	218	PF00082	0.373
CLV_PCSK_SKI1_1	327	331	PF00082	0.433
CLV_PCSK_SKI1_1	456	460	PF00082	0.399
CLV_PCSK_SKI1_1	479	483	PF00082	0.541
CLV_PCSK_SKI1_1	5	9	PF00082	0.551
CLV_PCSK_SKI1_1	537	541	PF00082	0.541
CLV_PCSK_SKI1_1	636	640	PF00082	0.426
CLV_PCSK_SKI1_1	645	649	PF00082	0.525
CLV_PCSK_SKI1_1	689	693	PF00082	0.412
CLV_PCSK_SKI1_1	792	796	PF00082	0.551
CLV_PCSK_SKI1_1	827	831	PF00082	0.509
CLV_PCSK_SKI1_1	854	858	PF00082	0.562
CLV_Separin_Metazoa	453	457	PF03568	0.471
CLV_Separin_Metazoa	722	726	PF03568	0.479
DEG_APCC_DBOX_1	536	544	PF00400	0.526
DEG_APCC_DBOX_1	610	618	PF00400	0.371
DEG_APCC_DBOX_1	688	696	PF00400	0.452
DEG_SCF_FBW7_1	319	325	PF00400	0.455
DEG_SCF_FBW7_1	543	549	PF00400	0.603
DEG_SCF_TRCP1_1	239	244	PF00400	0.573
DEG_SCF_TRCP1_1	337	342	PF00400	0.327
DOC_CDC14_PxL_1	597	605	PF14671	0.390
DOC_CKS1_1	319	324	PF01111	0.494
DOC_CKS1_1	407	412	PF01111	0.590
DOC_CKS1_1	543	548	PF01111	0.602
DOC_CYCLIN_RxL_1	531	541	PF00134	0.535
DOC_CYCLIN_RxL_1	827	837	PF00134	0.509
DOC_CYCLIN_yClb1_LxF_4	35	40	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	454	460	PF00134	0.481
DOC_MAPK_gen_1	440	448	PF00069	0.526
DOC_MAPK_MEF2A_6	683	692	PF00069	0.476
DOC_MAPK_RevD_3	216	231	PF00069	0.513
DOC_PP1_RVXF_1	454	461	PF00149	0.375
DOC_PP1_RVXF_1	613	620	PF00149	0.372
DOC_PP2B_LxvP_1	217	220	PF13499	0.406
DOC_PP4_FxxP_1	865	868	PF00568	0.573
DOC_USP7_MATH_1	130	134	PF00917	0.646
DOC_USP7_MATH_1	16	20	PF00917	0.568
DOC_USP7_MATH_1	237	241	PF00917	0.626
DOC_USP7_MATH_1	365	369	PF00917	0.560
DOC_USP7_MATH_1	380	384	PF00917	0.730
DOC_USP7_MATH_1	385	389	PF00917	0.677
DOC_USP7_MATH_1	416	420	PF00917	0.704
DOC_USP7_MATH_1	429	433	PF00917	0.645
DOC_USP7_MATH_1	43	47	PF00917	0.530
DOC_USP7_MATH_1	546	550	PF00917	0.710
DOC_USP7_MATH_1	563	567	PF00917	0.487
DOC_USP7_MATH_1	577	581	PF00917	0.473
DOC_USP7_MATH_1	825	829	PF00917	0.515
DOC_WW_Pin1_4	126	131	PF00397	0.637
DOC_WW_Pin1_4	244	249	PF00397	0.600
DOC_WW_Pin1_4	27	32	PF00397	0.632
DOC_WW_Pin1_4	318	323	PF00397	0.482
DOC_WW_Pin1_4	378	383	PF00397	0.678
DOC_WW_Pin1_4	387	392	PF00397	0.622
DOC_WW_Pin1_4	406	411	PF00397	0.683
DOC_WW_Pin1_4	510	515	PF00397	0.682
DOC_WW_Pin1_4	542	547	PF00397	0.623
DOC_WW_Pin1_4	55	60	PF00397	0.591
DOC_WW_Pin1_4	763	768	PF00397	0.747
DOC_WW_Pin1_4	840	845	PF00397	0.421
LIG_14-3-3_CanoR_1	275	281	PF00244	0.513
LIG_14-3-3_CanoR_1	328	333	PF00244	0.432
LIG_14-3-3_CanoR_1	340	346	PF00244	0.469
LIG_14-3-3_CanoR_1	44	50	PF00244	0.590
LIG_14-3-3_CanoR_1	515	523	PF00244	0.612
LIG_14-3-3_CanoR_1	581	587	PF00244	0.491
LIG_14-3-3_CanoR_1	644	648	PF00244	0.545
LIG_14-3-3_CanoR_1	70	75	PF00244	0.565
LIG_14-3-3_CanoR_1	725	729	PF00244	0.539
LIG_14-3-3_CanoR_1	849	854	PF00244	0.412
LIG_Actin_WH2_2	312	329	PF00022	0.397
LIG_Actin_WH2_2	600	617	PF00022	0.366
LIG_Actin_WH2_2	688	706	PF00022	0.528
LIG_BIR_II_1	1	5	PF00653	0.446
LIG_BIR_III_2	693	697	PF00653	0.514
LIG_BRCT_BRCA1_1	248	252	PF00533	0.656
LIG_BRCT_BRCA1_1	382	386	PF00533	0.568
LIG_CSL_BTD_1	543	546	PF09270	0.538
LIG_deltaCOP1_diTrp_1	343	346	PF00928	0.453
LIG_EH_1	260	264	PF12763	0.456
LIG_FHA_1	120	126	PF00498	0.595
LIG_FHA_1	168	174	PF00498	0.555
LIG_FHA_1	176	182	PF00498	0.506
LIG_FHA_1	200	206	PF00498	0.426
LIG_FHA_1	253	259	PF00498	0.509
LIG_FHA_1	350	356	PF00498	0.465
LIG_FHA_1	412	418	PF00498	0.662
LIG_FHA_1	559	565	PF00498	0.737
LIG_FHA_1	625	631	PF00498	0.494
LIG_FHA_1	715	721	PF00498	0.469
LIG_FHA_1	747	753	PF00498	0.653
LIG_FHA_1	76	82	PF00498	0.571
LIG_FHA_1	94	100	PF00498	0.400
LIG_FHA_2	158	164	PF00498	0.612
LIG_FHA_2	472	478	PF00498	0.623
LIG_FHA_2	772	778	PF00498	0.635
LIG_FHA_2	850	856	PF00498	0.402
LIG_Integrin_RGD_1	640	642	PF01839	0.501
LIG_LIR_Gen_1	20	31	PF02991	0.629
LIG_LIR_Gen_1	311	319	PF02991	0.381
LIG_LIR_Gen_1	343	354	PF02991	0.380
LIG_LIR_Gen_1	805	814	PF02991	0.479
LIG_LIR_Gen_1	846	853	PF02991	0.431
LIG_LIR_Nem_3	190	195	PF02991	0.419
LIG_LIR_Nem_3	20	26	PF02991	0.627
LIG_LIR_Nem_3	311	315	PF02991	0.373
LIG_LIR_Nem_3	343	349	PF02991	0.526
LIG_LIR_Nem_3	534	539	PF02991	0.555
LIG_LIR_Nem_3	541	547	PF02991	0.532
LIG_LIR_Nem_3	599	603	PF02991	0.370
LIG_LIR_Nem_3	667	671	PF02991	0.407
LIG_LIR_Nem_3	805	809	PF02991	0.387
LIG_LIR_Nem_3	828	833	PF02991	0.574
LIG_LIR_Nem_3	846	850	PF02991	0.330
LIG_LYPXL_yS_3	600	603	PF13949	0.393
LIG_MYND_1	400	404	PF01753	0.612
LIG_Pex14_2	292	296	PF04695	0.362
LIG_Pex14_2	312	316	PF04695	0.246
LIG_SH2_NCK_1	363	367	PF00017	0.442
LIG_SH2_STAP1	309	313	PF00017	0.349
LIG_SH2_STAP1	476	480	PF00017	0.552
LIG_SH2_STAP1	731	735	PF00017	0.571
LIG_SH2_STAT5	23	26	PF00017	0.585
LIG_SH2_STAT5	609	612	PF00017	0.408
LIG_SH2_STAT5	731	734	PF00017	0.600
LIG_SH3_3	28	34	PF00018	0.566
LIG_SH3_3	401	407	PF00018	0.572
LIG_SH3_3	540	546	PF00018	0.588
LIG_SH3_3	595	601	PF00018	0.366
LIG_SH3_3	693	699	PF00018	0.437
LIG_SH3_3	764	770	PF00018	0.641
LIG_Sin3_3	495	502	PF02671	0.532
LIG_SUMO_SIM_anti_2	810	816	PF11976	0.404
LIG_SUMO_SIM_par_1	204	210	PF11976	0.383
LIG_SUMO_SIM_par_1	351	356	PF11976	0.470
LIG_SUMO_SIM_par_1	560	566	PF11976	0.565
LIG_SUMO_SIM_par_1	627	634	PF11976	0.415
LIG_SUMO_SIM_par_1	812	818	PF11976	0.436
LIG_SUMO_SIM_par_1	90	96	PF11976	0.430
LIG_TRAF2_1	435	438	PF00917	0.546
LIG_TRAF2_1	588	591	PF00917	0.409
LIG_TRAF2_1	59	62	PF00917	0.539
LIG_TRAF2_1	653	656	PF00917	0.522
LIG_TYR_ITIM	598	603	PF00017	0.387
LIG_WRC_WIRS_1	315	320	PF05994	0.375
MOD_CDK_SPK_2	510	515	PF00069	0.581
MOD_CK1_1	126	132	PF00069	0.619
MOD_CK1_1	169	175	PF00069	0.551
MOD_CK1_1	247	253	PF00069	0.541
MOD_CK1_1	27	33	PF00069	0.607
MOD_CK1_1	381	387	PF00069	0.627
MOD_CK1_1	432	438	PF00069	0.635
MOD_CK1_1	485	491	PF00069	0.642
MOD_CK1_1	52	58	PF00069	0.599
MOD_CK1_1	580	586	PF00069	0.506
MOD_CK1_1	599	605	PF00069	0.362
MOD_CK1_1	73	79	PF00069	0.695
MOD_CK1_1	766	772	PF00069	0.636
MOD_CK2_1	157	163	PF00069	0.622
MOD_CK2_1	339	345	PF00069	0.361
MOD_CK2_1	432	438	PF00069	0.621
MOD_CK2_1	55	61	PF00069	0.585
MOD_CK2_1	563	569	PF00069	0.504
MOD_CK2_1	73	79	PF00069	0.648
MOD_CK2_1	780	786	PF00069	0.580
MOD_CK2_1	820	826	PF00069	0.460
MOD_CK2_1	840	846	PF00069	0.292
MOD_CK2_1	849	855	PF00069	0.436
MOD_CMANNOS	529	532	PF00535	0.591
MOD_Cter_Amidation	371	374	PF01082	0.549
MOD_GlcNHglycan	10	13	PF01048	0.494
MOD_GlcNHglycan	132	135	PF01048	0.567
MOD_GlcNHglycan	144	148	PF01048	0.572
MOD_GlcNHglycan	233	236	PF01048	0.664
MOD_GlcNHglycan	239	242	PF01048	0.625
MOD_GlcNHglycan	252	255	PF01048	0.462
MOD_GlcNHglycan	26	29	PF01048	0.592
MOD_GlcNHglycan	336	340	PF01048	0.352
MOD_GlcNHglycan	367	370	PF01048	0.718
MOD_GlcNHglycan	383	386	PF01048	0.580
MOD_GlcNHglycan	387	390	PF01048	0.633
MOD_GlcNHglycan	418	421	PF01048	0.760
MOD_GlcNHglycan	45	48	PF01048	0.757
MOD_GlcNHglycan	467	470	PF01048	0.535
MOD_GlcNHglycan	500	503	PF01048	0.607
MOD_GlcNHglycan	51	54	PF01048	0.615
MOD_GSK3_1	119	126	PF00069	0.599
MOD_GSK3_1	162	169	PF00069	0.577
MOD_GSK3_1	231	238	PF00069	0.672
MOD_GSK3_1	244	251	PF00069	0.536
MOD_GSK3_1	252	259	PF00069	0.673
MOD_GSK3_1	271	278	PF00069	0.461
MOD_GSK3_1	314	321	PF00069	0.373
MOD_GSK3_1	335	342	PF00069	0.338
MOD_GSK3_1	381	388	PF00069	0.730
MOD_GSK3_1	428	435	PF00069	0.610
MOD_GSK3_1	45	52	PF00069	0.686
MOD_GSK3_1	482	489	PF00069	0.535
MOD_GSK3_1	538	545	PF00069	0.618
MOD_GSK3_1	573	580	PF00069	0.696
MOD_GSK3_1	624	631	PF00069	0.499
MOD_GSK3_1	66	73	PF00069	0.667
MOD_GSK3_1	746	753	PF00069	0.669
MOD_GSK3_1	75	82	PF00069	0.488
MOD_GSK3_1	836	843	PF00069	0.445
MOD_N-GLC_1	118	123	PF02516	0.625
MOD_N-GLC_1	503	508	PF02516	0.601
MOD_N-GLC_1	55	60	PF02516	0.543
MOD_NEK2_1	100	105	PF00069	0.491
MOD_NEK2_1	166	171	PF00069	0.586
MOD_NEK2_1	24	29	PF00069	0.492
MOD_NEK2_1	335	340	PF00069	0.530
MOD_NEK2_1	349	354	PF00069	0.459
MOD_NEK2_1	465	470	PF00069	0.445
MOD_NEK2_1	482	487	PF00069	0.517
MOD_NEK2_1	729	734	PF00069	0.590
MOD_NEK2_1	794	799	PF00069	0.483
MOD_NEK2_1	8	13	PF00069	0.614
MOD_NEK2_1	815	820	PF00069	0.404
MOD_NEK2_1	92	97	PF00069	0.520
MOD_NEK2_2	322	327	PF00069	0.389
MOD_NEK2_2	699	704	PF00069	0.493
MOD_NEK2_2	80	85	PF00069	0.446
MOD_NEK2_2	825	830	PF00069	0.444
MOD_OFUCOSY	550	555	PF10250	0.656
MOD_PIKK_1	167	173	PF00454	0.577
MOD_PIKK_1	438	444	PF00454	0.511
MOD_PIKK_1	515	521	PF00454	0.616
MOD_PIKK_1	580	586	PF00454	0.489
MOD_PIKK_1	609	615	PF00454	0.372
MOD_PIKK_1	714	720	PF00454	0.544
MOD_PIKK_1	752	758	PF00454	0.694
MOD_PIKK_1	817	823	PF00454	0.426
MOD_PK_1	328	334	PF00069	0.445
MOD_PK_1	70	76	PF00069	0.562
MOD_PKA_2	229	235	PF00069	0.546
MOD_PKA_2	339	345	PF00069	0.515
MOD_PKA_2	421	427	PF00069	0.628
MOD_PKA_2	43	49	PF00069	0.636
MOD_PKA_2	432	438	PF00069	0.549
MOD_PKA_2	580	586	PF00069	0.510
MOD_PKA_2	643	649	PF00069	0.542
MOD_PKA_2	678	684	PF00069	0.464
MOD_PKA_2	724	730	PF00069	0.559
MOD_PKA_2	799	805	PF00069	0.409
MOD_Plk_1	162	168	PF00069	0.543
MOD_Plk_1	175	181	PF00069	0.531
MOD_Plk_1	256	262	PF00069	0.487
MOD_Plk_1	521	527	PF00069	0.483
MOD_Plk_1	590	596	PF00069	0.492
MOD_Plk_1	661	667	PF00069	0.509
MOD_Plk_1	699	705	PF00069	0.496
MOD_Plk_1	825	831	PF00069	0.483
MOD_Plk_2-3	157	163	PF00069	0.602
MOD_Plk_2-3	780	786	PF00069	0.600
MOD_Plk_4	169	175	PF00069	0.572
MOD_Plk_4	276	282	PF00069	0.470
MOD_Plk_4	349	355	PF00069	0.383
MOD_Plk_4	482	488	PF00069	0.546
MOD_Plk_4	590	596	PF00069	0.528
MOD_Plk_4	599	605	PF00069	0.413
MOD_Plk_4	661	667	PF00069	0.381
MOD_Plk_4	724	730	PF00069	0.501
MOD_Plk_4	794	800	PF00069	0.476
MOD_Plk_4	80	86	PF00069	0.548
MOD_ProDKin_1	126	132	PF00069	0.636
MOD_ProDKin_1	244	250	PF00069	0.599
MOD_ProDKin_1	27	33	PF00069	0.631
MOD_ProDKin_1	318	324	PF00069	0.487
MOD_ProDKin_1	378	384	PF00069	0.677
MOD_ProDKin_1	387	393	PF00069	0.622
MOD_ProDKin_1	406	412	PF00069	0.683
MOD_ProDKin_1	510	516	PF00069	0.679
MOD_ProDKin_1	542	548	PF00069	0.623
MOD_ProDKin_1	55	61	PF00069	0.588
MOD_ProDKin_1	763	769	PF00069	0.747
MOD_ProDKin_1	840	846	PF00069	0.421
MOD_SUMO_for_1	647	650	PF00179	0.671
MOD_SUMO_rev_2	473	481	PF00179	0.542
MOD_SUMO_rev_2	777	784	PF00179	0.656
TRG_DiLeu_BaEn_1	345	350	PF01217	0.368
TRG_DiLeu_BaLyEn_6	454	459	PF01217	0.385
TRG_DiLeu_BaLyEn_6	634	639	PF01217	0.485
TRG_ENDOCYTIC_2	23	26	PF00928	0.661
TRG_ENDOCYTIC_2	309	312	PF00928	0.350
TRG_ENDOCYTIC_2	600	603	PF00928	0.366
TRG_ENDOCYTIC_2	671	674	PF00928	0.380
TRG_ER_diArg_1	229	231	PF00400	0.615
TRG_ER_diArg_1	636	638	PF00400	0.463
TRG_ER_diArg_1	643	645	PF00400	0.452
TRG_NES_CRM1_1	324	337	PF08389	0.421
TRG_Pf-PMV_PEXEL_1	637	642	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	831	835	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M5	Leptomonas seymouri	38%	100%
A0A3S7WX62	Leishmania donovani	99%	100%
A4HCE3	Leishmania braziliensis	63%	97%
E9AVS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	97%
Q4QBQ5	Leishmania major	89%	100%