Pre-mRNA-splicing factor 18

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Prp18 domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HZW5_LEIIN

TriTrypDb:

LINF_220015100

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:1990904	ribonucleoprotein complex	2	7
GO:0005682	U5 snRNP	5	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0071020	post-spliceosomal complex	4	1
GO:0071021	U2-type post-spliceosomal complex	5	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0120114	Sm-like protein family complex	2	1

Expansion

Sequence features

A4HZW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZW5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006396	RNA processing	6	6
GO:0006397	mRNA processing	7	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0008380	RNA splicing	7	6
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	6
GO:0016071	mRNA metabolic process	6	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0000350	generation of catalytic spliceosome for second transesterification step	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.558
CLV_C14_Caspase3-7	304	308	PF00656	0.648
CLV_NRD_NRD_1	448	450	PF00675	0.338
CLV_NRD_NRD_1	496	498	PF00675	0.278
CLV_PCSK_KEX2_1	114	116	PF00082	0.582
CLV_PCSK_KEX2_1	496	498	PF00082	0.275
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.582
CLV_PCSK_SKI1_1	51	55	PF00082	0.612
CLV_PCSK_SKI1_1	524	528	PF00082	0.260
DEG_APCC_DBOX_1	448	456	PF00400	0.475
DEG_ODPH_VHL_1	367	380	PF01847	0.473
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.566
DOC_MAPK_gen_1	410	418	PF00069	0.380
DOC_MAPK_gen_1	449	457	PF00069	0.529
DOC_MAPK_MEF2A_6	470	478	PF00069	0.529
DOC_PP2B_LxvP_1	161	164	PF13499	0.507
DOC_PP2B_LxvP_1	250	253	PF13499	0.430
DOC_PP4_FxxP_1	264	267	PF00568	0.475
DOC_PP4_FxxP_1	442	445	PF00568	0.428
DOC_PP4_FxxP_1	541	544	PF00568	0.422
DOC_USP7_MATH_1	139	143	PF00917	0.701
DOC_USP7_MATH_1	151	155	PF00917	0.650
DOC_USP7_MATH_1	157	161	PF00917	0.523
DOC_USP7_MATH_1	206	210	PF00917	0.508
DOC_USP7_MATH_1	245	249	PF00917	0.533
DOC_USP7_MATH_1	305	309	PF00917	0.647
DOC_USP7_MATH_1	33	37	PF00917	0.627
DOC_USP7_MATH_1	430	434	PF00917	0.532
DOC_USP7_MATH_1	49	53	PF00917	0.588
DOC_USP7_MATH_1	86	90	PF00917	0.547
DOC_WW_Pin1_4	152	157	PF00397	0.632
DOC_WW_Pin1_4	372	377	PF00397	0.371
DOC_WW_Pin1_4	431	436	PF00397	0.559
DOC_WW_Pin1_4	51	56	PF00397	0.803
DOC_WW_Pin1_4	536	541	PF00397	0.500
LIG_14-3-3_CanoR_1	148	157	PF00244	0.667
LIG_14-3-3_CanoR_1	201	207	PF00244	0.514
LIG_14-3-3_CanoR_1	496	500	PF00244	0.482
LIG_APCC_ABBA_1	526	531	PF00400	0.529
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_BRCT_BRCA1_1	538	542	PF00533	0.489
LIG_FHA_1	156	162	PF00498	0.550
LIG_FHA_1	215	221	PF00498	0.710
LIG_FHA_1	37	43	PF00498	0.611
LIG_FHA_1	452	458	PF00498	0.529
LIG_FHA_1	515	521	PF00498	0.518
LIG_FHA_1	525	531	PF00498	0.439
LIG_FHA_2	189	195	PF00498	0.459
LIG_FHA_2	279	285	PF00498	0.483
LIG_FHA_2	76	82	PF00498	0.569
LIG_Integrin_isoDGR_2	351	353	PF01839	0.614
LIG_LIR_Apic_2	538	544	PF02991	0.431
LIG_LIR_Gen_1	284	295	PF02991	0.398
LIG_LIR_Gen_1	463	474	PF02991	0.475
LIG_LIR_Nem_3	2	6	PF02991	0.562
LIG_LIR_Nem_3	284	290	PF02991	0.384
LIG_LIR_Nem_3	403	408	PF02991	0.588
LIG_LIR_Nem_3	463	469	PF02991	0.475
LIG_LIR_Nem_3	472	476	PF02991	0.616
LIG_LIR_Nem_3	77	83	PF02991	0.637
LIG_MLH1_MIPbox_1	538	542	PF16413	0.489
LIG_NRBOX	245	251	PF00104	0.426
LIG_NRBOX	325	331	PF00104	0.395
LIG_NRBOX	5	11	PF00104	0.546
LIG_SH2_PTP2	473	476	PF00017	0.529
LIG_SH2_SRC	473	476	PF00017	0.529
LIG_SH2_STAP1	212	216	PF00017	0.527
LIG_SH2_STAP1	426	430	PF00017	0.424
LIG_SH2_STAP1	83	87	PF00017	0.453
LIG_SH2_STAT5	259	262	PF00017	0.386
LIG_SH2_STAT5	335	338	PF00017	0.333
LIG_SH2_STAT5	379	382	PF00017	0.370
LIG_SH2_STAT5	421	424	PF00017	0.354
LIG_SH2_STAT5	473	476	PF00017	0.529
LIG_SH3_1	363	369	PF00018	0.520
LIG_SH3_3	161	167	PF00018	0.643
LIG_SH3_3	218	224	PF00018	0.671
LIG_SH3_3	363	369	PF00018	0.520
LIG_UBA3_1	289	294	PF00899	0.471
MOD_CK1_1	107	113	PF00069	0.658
MOD_CK1_1	133	139	PF00069	0.679
MOD_CK1_1	149	155	PF00069	0.642
MOD_CK1_1	168	174	PF00069	0.529
MOD_CK1_1	239	245	PF00069	0.548
MOD_CK1_1	248	254	PF00069	0.398
MOD_CK1_1	308	314	PF00069	0.550
MOD_CK1_1	36	42	PF00069	0.631
MOD_CK1_1	433	439	PF00069	0.617
MOD_CK1_1	75	81	PF00069	0.618
MOD_CK2_1	134	140	PF00069	0.631
MOD_CK2_1	188	194	PF00069	0.377
MOD_CK2_1	486	492	PF00069	0.497
MOD_GlcNHglycan	136	139	PF01048	0.754
MOD_GlcNHglycan	148	151	PF01048	0.618
MOD_GlcNHglycan	231	234	PF01048	0.728
MOD_GlcNHglycan	307	310	PF01048	0.705
MOD_GlcNHglycan	35	38	PF01048	0.653
MOD_GlcNHglycan	427	431	PF01048	0.428
MOD_GlcNHglycan	44	47	PF01048	0.571
MOD_GlcNHglycan	488	491	PF01048	0.275
MOD_GlcNHglycan	51	54	PF01048	0.565
MOD_GlcNHglycan	69	72	PF01048	0.628
MOD_GlcNHglycan	74	77	PF01048	0.622
MOD_GSK3_1	102	109	PF00069	0.550
MOD_GSK3_1	129	136	PF00069	0.679
MOD_GSK3_1	151	158	PF00069	0.584
MOD_GSK3_1	206	213	PF00069	0.558
MOD_GSK3_1	244	251	PF00069	0.613
MOD_GSK3_1	307	314	PF00069	0.757
MOD_GSK3_1	351	358	PF00069	0.547
MOD_GSK3_1	417	424	PF00069	0.371
MOD_GSK3_1	426	433	PF00069	0.423
MOD_GSK3_1	49	56	PF00069	0.796
MOD_GSK3_1	72	79	PF00069	0.642
MOD_N-GLC_1	133	138	PF02516	0.671
MOD_N-GLC_1	33	38	PF02516	0.628
MOD_NEK2_1	106	111	PF00069	0.636
MOD_NEK2_1	188	193	PF00069	0.347
MOD_NEK2_1	207	212	PF00069	0.402
MOD_NEK2_1	408	413	PF00069	0.567
MOD_NEK2_1	42	47	PF00069	0.692
MOD_NEK2_1	535	540	PF00069	0.577
MOD_PIKK_1	36	42	PF00454	0.631
MOD_PIKK_1	514	520	PF00454	0.495
MOD_PKA_2	200	206	PF00069	0.558
MOD_PKA_2	272	278	PF00069	0.547
MOD_PKA_2	495	501	PF00069	0.475
MOD_Plk_1	278	284	PF00069	0.492
MOD_Plk_1	474	480	PF00069	0.475
MOD_Plk_1	524	530	PF00069	0.482
MOD_Plk_4	245	251	PF00069	0.511
MOD_Plk_4	278	284	PF00069	0.492
MOD_Plk_4	417	423	PF00069	0.420
MOD_Plk_4	451	457	PF00069	0.529
MOD_Plk_4	524	530	PF00069	0.463
MOD_ProDKin_1	152	158	PF00069	0.631
MOD_ProDKin_1	372	378	PF00069	0.369
MOD_ProDKin_1	431	437	PF00069	0.564
MOD_ProDKin_1	51	57	PF00069	0.806
MOD_ProDKin_1	536	542	PF00069	0.492
MOD_SUMO_for_1	293	296	PF00179	0.494
MOD_SUMO_rev_2	286	295	PF00179	0.339
MOD_SUMO_rev_2	307	316	PF00179	0.559
TRG_DiLeu_BaEn_2	524	530	PF01217	0.475
TRG_DiLeu_BaEn_4	321	327	PF01217	0.426
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.396
TRG_ENDOCYTIC_2	379	382	PF00928	0.405
TRG_ENDOCYTIC_2	473	476	PF00928	0.529
TRG_ER_diArg_1	495	497	PF00400	0.475
TRG_ER_diArg_1	504	507	PF00400	0.478
TRG_NES_CRM1_1	180	194	PF08389	0.407
TRG_NES_CRM1_1	279	292	PF08389	0.474
TRG_NES_CRM1_1	328	342	PF08389	0.404
TRG_NES_CRM1_1	447	461	PF08389	0.483
TRG_NES_CRM1_1	518	531	PF08389	0.495
TRG_NLS_MonoCore_2	10	15	PF00514	0.501
TRG_NLS_MonoExtC_3	10	16	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I883	Leptomonas seymouri	42%	100%
A0A3Q8ICC8	Leishmania donovani	99%	100%
A4HCE1	Leishmania braziliensis	73%	99%
E9AVS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QBQ6	Leishmania major	90%	99%