Uncharacterized protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZW3_LEIIN

TriTrypDb:

LINF_220014900

Length:

122

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 55, 57, 58

Expansion

Sequence features

A4HZW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	75	79	PF00656	0.516
DEG_SPOP_SBC_1	87	91	PF00917	0.688
DOC_USP7_MATH_1	102	106	PF00917	0.577
DOC_USP7_MATH_1	87	91	PF00917	0.552
DOC_USP7_UBL2_3	97	101	PF12436	0.679
DOC_WW_Pin1_4	11	16	PF00397	0.636
DOC_WW_Pin1_4	55	60	PF00397	0.633
LIG_14-3-3_CanoR_1	103	109	PF00244	0.357
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BRCT_BRCA1_1	67	71	PF00533	0.582
LIG_FHA_1	75	81	PF00498	0.571
LIG_FHA_1	89	95	PF00498	0.697
LIG_LIR_Gen_1	107	117	PF02991	0.552
LIG_LIR_Nem_3	67	73	PF02991	0.625
LIG_MLH1_MIPbox_1	67	71	PF16413	0.636
LIG_SH2_STAT3	20	23	PF00017	0.730
LIG_SH3_3	96	102	PF00018	0.639
LIG_SH3_4	97	104	PF00018	0.673
LIG_TRAF2_1	105	108	PF00917	0.649
MOD_CDK_SPK_2	11	16	PF00069	0.665
MOD_CK1_1	2	8	PF00069	0.608
MOD_CK1_1	55	61	PF00069	0.743
MOD_CK2_1	102	108	PF00069	0.656
MOD_CK2_1	87	93	PF00069	0.620
MOD_GlcNHglycan	104	107	PF01048	0.560
MOD_GlcNHglycan	2	5	PF01048	0.672
MOD_GlcNHglycan	31	34	PF01048	0.758
MOD_GlcNHglycan	7	10	PF01048	0.653
MOD_GSK3_1	25	32	PF00069	0.691
MOD_GSK3_1	74	81	PF00069	0.527
MOD_PIKK_1	52	58	PF00454	0.751
MOD_PKA_2	102	108	PF00069	0.364
MOD_Plk_1	87	93	PF00069	0.692
MOD_Plk_2-3	88	94	PF00069	0.697
MOD_ProDKin_1	11	17	PF00069	0.638
MOD_ProDKin_1	55	61	PF00069	0.634
MOD_SUMO_rev_2	39	47	PF00179	0.665
MOD_SUMO_rev_2	62	71	PF00179	0.658
TRG_DiLeu_BaEn_3	107	113	PF01217	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN5	Leptomonas seymouri	73%	100%
A0A3Q8ILK3	Leishmania donovani	98%	100%
A4HCE0	Leishmania braziliensis	93%	100%
E9AVS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QBQ8	Leishmania major	97%	100%
V5BLM9	Trypanosoma cruzi	34%	100%