Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZW2_LEIIN

TriTrypDb:

LINF_220014800

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	369	373	PF00656	0.495
CLV_NRD_NRD_1	113	115	PF00675	0.572
CLV_NRD_NRD_1	330	332	PF00675	0.462
CLV_NRD_NRD_1	374	376	PF00675	0.459
CLV_NRD_NRD_1	4	6	PF00675	0.593
CLV_NRD_NRD_1	527	529	PF00675	0.561
CLV_NRD_NRD_1	591	593	PF00675	0.761
CLV_NRD_NRD_1	613	615	PF00675	0.616
CLV_NRD_NRD_1	631	633	PF00675	0.596
CLV_NRD_NRD_1	692	694	PF00675	0.545
CLV_PCSK_FUR_1	611	615	PF00082	0.630
CLV_PCSK_KEX2_1	113	115	PF00082	0.572
CLV_PCSK_KEX2_1	330	332	PF00082	0.462
CLV_PCSK_KEX2_1	374	376	PF00082	0.459
CLV_PCSK_KEX2_1	526	528	PF00082	0.572
CLV_PCSK_KEX2_1	591	593	PF00082	0.661
CLV_PCSK_KEX2_1	6	8	PF00082	0.594
CLV_PCSK_KEX2_1	613	615	PF00082	0.620
CLV_PCSK_KEX2_1	692	694	PF00082	0.545
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.594
CLV_PCSK_SKI1_1	114	118	PF00082	0.612
CLV_PCSK_SKI1_1	17	21	PF00082	0.579
CLV_PCSK_SKI1_1	453	457	PF00082	0.614
CLV_PCSK_SKI1_1	633	637	PF00082	0.663
CLV_PCSK_SKI1_1	658	662	PF00082	0.555
DEG_APCC_DBOX_1	23	31	PF00400	0.537
DEG_COP1_1	209	219	PF00400	0.625
DEG_SCF_FBW7_1	394	401	PF00400	0.609
DEG_SPOP_SBC_1	106	110	PF00917	0.620
DEG_SPOP_SBC_1	407	411	PF00917	0.674
DOC_CKS1_1	395	400	PF01111	0.608
DOC_CYCLIN_RxL_1	354	362	PF00134	0.457
DOC_CYCLIN_RxL_1	655	664	PF00134	0.557
DOC_MAPK_gen_1	113	119	PF00069	0.627
DOC_MAPK_gen_1	568	576	PF00069	0.720
DOC_PP2B_LxvP_1	236	239	PF13499	0.603
DOC_PP2B_LxvP_1	96	99	PF13499	0.602
DOC_PP2B_PxIxI_1	218	224	PF00149	0.630
DOC_PP4_FxxP_1	128	131	PF00568	0.621
DOC_PP4_FxxP_1	38	41	PF00568	0.521
DOC_USP7_MATH_1	10	14	PF00917	0.497
DOC_USP7_MATH_1	107	111	PF00917	0.603
DOC_USP7_MATH_1	199	203	PF00917	0.602
DOC_USP7_MATH_1	211	215	PF00917	0.656
DOC_USP7_MATH_1	217	221	PF00917	0.629
DOC_USP7_MATH_1	287	291	PF00917	0.635
DOC_USP7_MATH_1	366	370	PF00917	0.482
DOC_USP7_MATH_1	407	411	PF00917	0.654
DOC_USP7_MATH_1	425	429	PF00917	0.551
DOC_USP7_MATH_1	491	495	PF00917	0.574
DOC_USP7_MATH_1	522	526	PF00917	0.578
DOC_USP7_MATH_1	54	58	PF00917	0.535
DOC_USP7_UBL2_3	100	104	PF12436	0.593
DOC_WW_Pin1_4	118	123	PF00397	0.562
DOC_WW_Pin1_4	209	214	PF00397	0.670
DOC_WW_Pin1_4	215	220	PF00397	0.613
DOC_WW_Pin1_4	394	399	PF00397	0.611
DOC_WW_Pin1_4	438	443	PF00397	0.600
DOC_WW_Pin1_4	487	492	PF00397	0.621
DOC_WW_Pin1_4	507	512	PF00397	0.615
LIG_14-3-3_CanoR_1	17	22	PF00244	0.585
LIG_14-3-3_CanoR_1	357	362	PF00244	0.481
LIG_14-3-3_CanoR_1	379	383	PF00244	0.396
LIG_14-3-3_CanoR_1	528	534	PF00244	0.551
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BIR_III_4	276	280	PF00653	0.544
LIG_BRCT_BRCA1_1	34	38	PF00533	0.544
LIG_Clathr_ClatBox_1	27	31	PF01394	0.548
LIG_deltaCOP1_diTrp_1	341	345	PF00928	0.446
LIG_deltaCOP1_diTrp_1	696	701	PF00928	0.457
LIG_DLG_GKlike_1	357	365	PF00625	0.470
LIG_EVH1_1	394	398	PF00568	0.607
LIG_FHA_1	44	50	PF00498	0.499
LIG_FHA_1	569	575	PF00498	0.544
LIG_FHA_1	634	640	PF00498	0.768
LIG_FHA_1	661	667	PF00498	0.567
LIG_FHA_2	142	148	PF00498	0.573
LIG_FHA_2	18	24	PF00498	0.582
LIG_FHA_2	291	297	PF00498	0.624
LIG_FHA_2	399	405	PF00498	0.597
LIG_FHA_2	409	415	PF00498	0.564
LIG_FHA_2	478	484	PF00498	0.604
LIG_FHA_2	669	675	PF00498	0.724
LIG_FHA_2	679	685	PF00498	0.536
LIG_LIR_Apic_2	126	131	PF02991	0.615
LIG_LIR_Apic_2	35	41	PF02991	0.533
LIG_LIR_Gen_1	483	491	PF02991	0.569
LIG_LIR_Gen_1	52	63	PF02991	0.534
LIG_LIR_Gen_1	530	538	PF02991	0.653
LIG_LIR_Nem_3	483	488	PF02991	0.565
LIG_LIR_Nem_3	52	58	PF02991	0.586
LIG_LIR_Nem_3	530	534	PF02991	0.653
LIG_PDZ_Class_1	700	705	PF00595	0.474
LIG_SH2_CRK	288	292	PF00017	0.559
LIG_SH2_CRK	531	535	PF00017	0.522
LIG_SH2_CRK	55	59	PF00017	0.499
LIG_SH2_GRB2like	62	65	PF00017	0.605
LIG_SH2_NCK_1	288	292	PF00017	0.559
LIG_SH2_STAP1	288	292	PF00017	0.559
LIG_SH2_STAP1	541	545	PF00017	0.536
LIG_SH2_STAP1	55	59	PF00017	0.499
LIG_SH2_STAP1	622	626	PF00017	0.584
LIG_SH2_STAT3	541	544	PF00017	0.528
LIG_SH2_STAT5	288	291	PF00017	0.560
LIG_SH2_STAT5	36	39	PF00017	0.537
LIG_SH2_STAT5	476	479	PF00017	0.676
LIG_SH2_STAT5	484	487	PF00017	0.572
LIG_SH3_2	235	240	PF14604	0.602
LIG_SH3_2	395	400	PF14604	0.652
LIG_SH3_3	128	134	PF00018	0.640
LIG_SH3_3	213	219	PF00018	0.732
LIG_SH3_3	232	238	PF00018	0.531
LIG_SH3_3	38	44	PF00018	0.500
LIG_SH3_3	392	398	PF00018	0.608
LIG_SH3_3	460	466	PF00018	0.680
LIG_SH3_CIN85_PxpxPR_1	235	240	PF14604	0.602
LIG_SUMO_SIM_par_1	357	362	PF11976	0.455
LIG_TRAF2_1	13	16	PF00917	0.502
LIG_TYR_ITIM	53	58	PF00017	0.499
LIG_WW_3	237	241	PF00397	0.594
MOD_CDK_SPxK_1	394	400	PF00069	0.605
MOD_CK1_1	120	126	PF00069	0.588
MOD_CK1_1	193	199	PF00069	0.593
MOD_CK1_1	212	218	PF00069	0.637
MOD_CK1_1	248	254	PF00069	0.489
MOD_CK1_1	290	296	PF00069	0.653
MOD_CK1_1	348	354	PF00069	0.479
MOD_CK1_1	403	409	PF00069	0.664
MOD_CK1_1	421	427	PF00069	0.550
MOD_CK1_1	430	436	PF00069	0.558
MOD_CK1_1	487	493	PF00069	0.579
MOD_CK1_1	507	513	PF00069	0.514
MOD_CK1_1	546	552	PF00069	0.584
MOD_CK1_1	627	633	PF00069	0.556
MOD_CK1_1	75	81	PF00069	0.639
MOD_CK2_1	10	16	PF00069	0.501
MOD_CK2_1	159	165	PF00069	0.801
MOD_CK2_1	17	23	PF00069	0.531
MOD_CK2_1	240	246	PF00069	0.638
MOD_CK2_1	290	296	PF00069	0.623
MOD_CK2_1	36	42	PF00069	0.422
MOD_CK2_1	668	674	PF00069	0.648
MOD_CK2_1	678	684	PF00069	0.466
MOD_CMANNOS	342	345	PF00535	0.452
MOD_CMANNOS	386	389	PF00535	0.395
MOD_CMANNOS	698	701	PF00535	0.457
MOD_Cter_Amidation	111	114	PF01082	0.572
MOD_Cter_Amidation	630	633	PF01082	0.653
MOD_GlcNHglycan	109	112	PF01048	0.743
MOD_GlcNHglycan	12	15	PF01048	0.490
MOD_GlcNHglycan	161	164	PF01048	0.657
MOD_GlcNHglycan	168	171	PF01048	0.684
MOD_GlcNHglycan	197	200	PF01048	0.545
MOD_GlcNHglycan	252	255	PF01048	0.521
MOD_GlcNHglycan	270	273	PF01048	0.366
MOD_GlcNHglycan	293	296	PF01048	0.679
MOD_GlcNHglycan	299	302	PF01048	0.742
MOD_GlcNHglycan	314	317	PF01048	0.504
MOD_GlcNHglycan	368	372	PF01048	0.536
MOD_GlcNHglycan	404	408	PF01048	0.671
MOD_GlcNHglycan	420	423	PF01048	0.549
MOD_GlcNHglycan	493	496	PF01048	0.639
MOD_GlcNHglycan	497	500	PF01048	0.658
MOD_GlcNHglycan	506	509	PF01048	0.694
MOD_GlcNHglycan	583	586	PF01048	0.667
MOD_GlcNHglycan	641	644	PF01048	0.747
MOD_GlcNHglycan	83	86	PF01048	0.640
MOD_GlcNHglycan	92	95	PF01048	0.636
MOD_GSK3_1	195	202	PF00069	0.611
MOD_GSK3_1	211	218	PF00069	0.627
MOD_GSK3_1	248	255	PF00069	0.478
MOD_GSK3_1	286	293	PF00069	0.586
MOD_GSK3_1	32	39	PF00069	0.545
MOD_GSK3_1	341	348	PF00069	0.445
MOD_GSK3_1	394	401	PF00069	0.639
MOD_GSK3_1	403	410	PF00069	0.588
MOD_GSK3_1	421	428	PF00069	0.548
MOD_GSK3_1	436	443	PF00069	0.512
MOD_GSK3_1	487	494	PF00069	0.570
MOD_GSK3_1	512	519	PF00069	0.776
MOD_GSK3_1	605	612	PF00069	0.616
MOD_GSK3_1	635	642	PF00069	0.706
MOD_GSK3_1	660	667	PF00069	0.596
MOD_N-GLC_1	430	435	PF02516	0.604
MOD_N-GLC_1	512	517	PF02516	0.632
MOD_N-GLC_1	581	586	PF02516	0.667
MOD_NEK2_1	1	6	PF00069	0.593
MOD_NEK2_1	105	110	PF00069	0.628
MOD_NEK2_1	117	122	PF00069	0.619
MOD_NEK2_1	159	164	PF00069	0.651
MOD_NEK2_1	250	255	PF00069	0.476
MOD_NEK2_1	268	273	PF00069	0.406
MOD_NEK2_1	436	441	PF00069	0.585
MOD_NEK2_1	477	482	PF00069	0.695
MOD_NEK2_1	512	517	PF00069	0.774
MOD_NEK2_1	545	550	PF00069	0.689
MOD_NEK2_1	652	657	PF00069	0.585
MOD_NEK2_1	660	665	PF00069	0.519
MOD_NEK2_2	378	383	PF00069	0.396
MOD_NEK2_2	54	59	PF00069	0.501
MOD_PIKK_1	252	258	PF00454	0.433
MOD_PIKK_1	278	284	PF00454	0.655
MOD_PIKK_1	343	349	PF00454	0.449
MOD_PIKK_1	43	49	PF00454	0.496
MOD_PIKK_1	664	670	PF00454	0.548
MOD_PIKK_1	78	84	PF00454	0.557
MOD_PK_1	190	196	PF00069	0.593
MOD_PK_1	240	246	PF00069	0.660
MOD_PKA_1	527	533	PF00069	0.606
MOD_PKA_1	591	597	PF00069	0.661
MOD_PKA_1	692	698	PF00069	0.529
MOD_PKA_2	159	165	PF00069	0.572
MOD_PKA_2	378	384	PF00069	0.405
MOD_PKA_2	527	533	PF00069	0.649
MOD_PKA_2	546	552	PF00069	0.451
MOD_PKA_2	591	597	PF00069	0.653
MOD_PKA_2	692	698	PF00069	0.529
MOD_Plk_1	245	251	PF00069	0.550
MOD_Plk_1	32	38	PF00069	0.547
MOD_Plk_2-3	678	684	PF00069	0.597
MOD_Plk_4	190	196	PF00069	0.612
MOD_Plk_4	217	223	PF00069	0.611
MOD_Plk_4	245	251	PF00069	0.550
MOD_Plk_4	378	384	PF00069	0.405
MOD_Plk_4	516	522	PF00069	0.606
MOD_Plk_4	529	535	PF00069	0.529
MOD_Plk_4	54	60	PF00069	0.503
MOD_Plk_4	661	667	PF00069	0.659
MOD_Plk_4	678	684	PF00069	0.668
MOD_ProDKin_1	118	124	PF00069	0.562
MOD_ProDKin_1	209	215	PF00069	0.670
MOD_ProDKin_1	394	400	PF00069	0.620
MOD_ProDKin_1	438	444	PF00069	0.598
MOD_ProDKin_1	487	493	PF00069	0.624
MOD_ProDKin_1	507	513	PF00069	0.613
MOD_SUMO_for_1	200	203	PF00179	0.641
TRG_DiLeu_BaEn_1	23	28	PF01217	0.597
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.504
TRG_ENDOCYTIC_2	288	291	PF00928	0.560
TRG_ENDOCYTIC_2	531	534	PF00928	0.518
TRG_ENDOCYTIC_2	55	58	PF00928	0.496
TRG_ENDOCYTIC_2	8	11	PF00928	0.549
TRG_ER_diArg_1	5	8	PF00400	0.598
TRG_ER_diArg_1	526	528	PF00400	0.572
TRG_ER_diArg_1	590	592	PF00400	0.648
TRG_ER_diArg_1	611	614	PF00400	0.699
TRG_ER_diArg_1	691	693	PF00400	0.552
TRG_NLS_MonoExtC_3	4	9	PF00514	0.589
TRG_NLS_MonoExtN_4	5	10	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	357	362	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL70	Leptomonas seymouri	42%	94%
A0A3Q8IBF7	Leishmania donovani	99%	100%
A4HCD8	Leishmania braziliensis	75%	99%
E9AVS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QBQ9	Leishmania major	89%	100%