LeishMANIAdb
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Stealth_CR2 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR2 domain-containing protein
Gene product:
Protein of unknown function (DUF3184) - putative
Species:
Leishmania infantum
UniProt:
A4HZW0_LEIIN
TriTrypDb:
LINF_220014600 *
Length:
947

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Annotations by Jardim et al.

Protein kinase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 4
GO:0016020 membrane 2 11
GO:0043226 organelle 2 4
GO:0043227 membrane-bounded organelle 3 4
GO:0043229 intracellular organelle 3 4
GO:0043231 intracellular membrane-bounded organelle 4 4
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4HZW0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZW0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016740 transferase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 22 26 PF00656 0.638
CLV_C14_Caspase3-7 90 94 PF00656 0.606
CLV_C14_Caspase3-7 905 909 PF00656 0.484
CLV_NRD_NRD_1 248 250 PF00675 0.644
CLV_NRD_NRD_1 363 365 PF00675 0.643
CLV_NRD_NRD_1 414 416 PF00675 0.461
CLV_NRD_NRD_1 419 421 PF00675 0.478
CLV_NRD_NRD_1 461 463 PF00675 0.724
CLV_NRD_NRD_1 499 501 PF00675 0.641
CLV_NRD_NRD_1 596 598 PF00675 0.432
CLV_NRD_NRD_1 661 663 PF00675 0.657
CLV_NRD_NRD_1 716 718 PF00675 0.475
CLV_NRD_NRD_1 738 740 PF00675 0.586
CLV_NRD_NRD_1 759 761 PF00675 0.522
CLV_NRD_NRD_1 809 811 PF00675 0.624
CLV_NRD_NRD_1 887 889 PF00675 0.570
CLV_PCSK_FUR_1 714 718 PF00082 0.491
CLV_PCSK_FUR_1 757 761 PF00082 0.515
CLV_PCSK_FUR_1 807 811 PF00082 0.617
CLV_PCSK_KEX2_1 248 250 PF00082 0.644
CLV_PCSK_KEX2_1 363 365 PF00082 0.670
CLV_PCSK_KEX2_1 414 416 PF00082 0.461
CLV_PCSK_KEX2_1 486 488 PF00082 0.562
CLV_PCSK_KEX2_1 501 503 PF00082 0.511
CLV_PCSK_KEX2_1 596 598 PF00082 0.449
CLV_PCSK_KEX2_1 661 663 PF00082 0.647
CLV_PCSK_KEX2_1 682 684 PF00082 0.475
CLV_PCSK_KEX2_1 716 718 PF00082 0.475
CLV_PCSK_KEX2_1 738 740 PF00082 0.586
CLV_PCSK_KEX2_1 759 761 PF00082 0.522
CLV_PCSK_KEX2_1 809 811 PF00082 0.624
CLV_PCSK_KEX2_1 887 889 PF00082 0.570
CLV_PCSK_PC1ET2_1 486 488 PF00082 0.562
CLV_PCSK_PC1ET2_1 501 503 PF00082 0.511
CLV_PCSK_PC1ET2_1 682 684 PF00082 0.475
CLV_PCSK_SKI1_1 106 110 PF00082 0.624
CLV_PCSK_SKI1_1 194 198 PF00082 0.528
CLV_PCSK_SKI1_1 204 208 PF00082 0.518
CLV_PCSK_SKI1_1 36 40 PF00082 0.505
CLV_PCSK_SKI1_1 363 367 PF00082 0.636
CLV_PCSK_SKI1_1 453 457 PF00082 0.661
CLV_PCSK_SKI1_1 627 631 PF00082 0.442
CLV_PCSK_SKI1_1 67 71 PF00082 0.558
CLV_PCSK_SKI1_1 707 711 PF00082 0.513
CLV_PCSK_SKI1_1 743 747 PF00082 0.638
CLV_PCSK_SKI1_1 759 763 PF00082 0.512
CLV_PCSK_SKI1_1 810 814 PF00082 0.476
CLV_PCSK_SKI1_1 831 835 PF00082 0.590
CLV_Separin_Metazoa 7 11 PF03568 0.541
DEG_APCC_DBOX_1 362 370 PF00400 0.623
DEG_APCC_DBOX_1 626 634 PF00400 0.492
DEG_APCC_DBOX_1 809 817 PF00400 0.462
DEG_SCF_FBW7_1 338 345 PF00400 0.546
DEG_SPOP_SBC_1 337 341 PF00917 0.611
DOC_CKS1_1 269 274 PF01111 0.611
DOC_CKS1_1 634 639 PF01111 0.586
DOC_CYCLIN_yCln2_LP_2 129 132 PF00134 0.543
DOC_CYCLIN_yCln2_LP_2 227 233 PF00134 0.670
DOC_CYCLIN_yCln2_LP_2 507 510 PF00134 0.662
DOC_CYCLIN_yCln2_LP_2 518 524 PF00134 0.371
DOC_CYCLIN_yCln2_LP_2 722 725 PF00134 0.483
DOC_CYCLIN_yCln2_LP_2 840 846 PF00134 0.487
DOC_MAPK_DCC_7 682 692 PF00069 0.468
DOC_MAPK_gen_1 149 158 PF00069 0.526
DOC_MAPK_gen_1 460 468 PF00069 0.668
DOC_MAPK_gen_1 486 494 PF00069 0.583
DOC_MAPK_gen_1 500 507 PF00069 0.553
DOC_MAPK_gen_1 682 689 PF00069 0.459
DOC_MAPK_gen_1 714 723 PF00069 0.467
DOC_MAPK_gen_1 778 786 PF00069 0.517
DOC_MAPK_HePTP_8 484 496 PF00069 0.565
DOC_MAPK_MEF2A_6 151 160 PF00069 0.523
DOC_MAPK_MEF2A_6 486 494 PF00069 0.589
DOC_MAPK_MEF2A_6 682 691 PF00069 0.471
DOC_MAPK_MEF2A_6 714 723 PF00069 0.498
DOC_MAPK_MEF2A_6 831 840 PF00069 0.481
DOC_MAPK_NFAT4_5 682 690 PF00069 0.379
DOC_PP1_RVXF_1 668 675 PF00149 0.601
DOC_PP2B_LxvP_1 129 132 PF13499 0.543
DOC_PP2B_LxvP_1 334 337 PF13499 0.598
DOC_PP2B_LxvP_1 373 376 PF13499 0.649
DOC_PP2B_LxvP_1 507 510 PF13499 0.662
DOC_PP2B_LxvP_1 722 725 PF13499 0.491
DOC_PP2B_LxvP_1 840 843 PF13499 0.509
DOC_PP2B_PxIxI_1 687 693 PF00149 0.451
DOC_PP4_FxxP_1 634 637 PF00568 0.579
DOC_USP7_MATH_1 236 240 PF00917 0.643
DOC_USP7_MATH_1 265 269 PF00917 0.658
DOC_USP7_MATH_1 282 286 PF00917 0.481
DOC_USP7_MATH_1 314 318 PF00917 0.712
DOC_USP7_MATH_1 342 346 PF00917 0.655
DOC_USP7_MATH_1 423 427 PF00917 0.593
DOC_USP7_MATH_1 523 527 PF00917 0.518
DOC_USP7_MATH_1 749 753 PF00917 0.559
DOC_USP7_MATH_1 764 768 PF00917 0.581
DOC_USP7_MATH_1 85 89 PF00917 0.685
DOC_USP7_MATH_1 860 864 PF00917 0.534
DOC_WW_Pin1_4 217 222 PF00397 0.621
DOC_WW_Pin1_4 268 273 PF00397 0.619
DOC_WW_Pin1_4 338 343 PF00397 0.607
DOC_WW_Pin1_4 544 549 PF00397 0.667
DOC_WW_Pin1_4 550 555 PF00397 0.623
DOC_WW_Pin1_4 633 638 PF00397 0.564
LIG_14-3-3_CanoR_1 151 157 PF00244 0.501
LIG_14-3-3_CanoR_1 253 257 PF00244 0.622
LIG_14-3-3_CanoR_1 266 270 PF00244 0.494
LIG_14-3-3_CanoR_1 315 324 PF00244 0.682
LIG_14-3-3_CanoR_1 32 36 PF00244 0.400
LIG_14-3-3_CanoR_1 368 376 PF00244 0.730
LIG_14-3-3_CanoR_1 453 459 PF00244 0.715
LIG_14-3-3_CanoR_1 500 506 PF00244 0.667
LIG_14-3-3_CanoR_1 600 605 PF00244 0.415
LIG_14-3-3_CanoR_1 750 754 PF00244 0.615
LIG_14-3-3_CanoR_1 759 764 PF00244 0.524
LIG_14-3-3_CanoR_1 831 840 PF00244 0.542
LIG_Actin_WH2_2 169 187 PF00022 0.362
LIG_Actin_WH2_2 765 780 PF00022 0.483
LIG_Actin_WH2_2 799 816 PF00022 0.415
LIG_APCC_ABBA_1 494 499 PF00400 0.605
LIG_BIR_III_4 327 331 PF00653 0.700
LIG_BRCT_BRCA1_1 153 157 PF00533 0.478
LIG_BRCT_BRCA1_1 65 69 PF00533 0.521
LIG_deltaCOP1_diTrp_1 346 349 PF00928 0.675
LIG_deltaCOP1_diTrp_1 438 444 PF00928 0.427
LIG_EH1_1 32 40 PF00400 0.502
LIG_FHA_1 111 117 PF00498 0.605
LIG_FHA_1 171 177 PF00498 0.527
LIG_FHA_1 329 335 PF00498 0.709
LIG_FHA_1 368 374 PF00498 0.597
LIG_FHA_1 449 455 PF00498 0.647
LIG_FHA_1 502 508 PF00498 0.656
LIG_FHA_1 634 640 PF00498 0.552
LIG_FHA_1 652 658 PF00498 0.489
LIG_FHA_1 667 673 PF00498 0.431
LIG_FHA_2 2 8 PF00498 0.531
LIG_FHA_2 218 224 PF00498 0.627
LIG_FHA_2 236 242 PF00498 0.508
LIG_FHA_2 316 322 PF00498 0.623
LIG_FHA_2 501 507 PF00498 0.668
LIG_FHA_2 77 83 PF00498 0.391
LIG_FHA_2 867 873 PF00498 0.546
LIG_LIR_Apic_2 631 637 PF02991 0.531
LIG_LIR_Apic_2 787 792 PF02991 0.569
LIG_LIR_Apic_2 796 801 PF02991 0.435
LIG_LIR_Gen_1 115 124 PF02991 0.522
LIG_LIR_Gen_1 154 165 PF02991 0.488
LIG_LIR_Gen_1 173 183 PF02991 0.301
LIG_LIR_Gen_1 255 263 PF02991 0.626
LIG_LIR_Gen_1 581 591 PF02991 0.631
LIG_LIR_Gen_1 607 617 PF02991 0.345
LIG_LIR_Gen_1 671 681 PF02991 0.546
LIG_LIR_Nem_3 115 121 PF02991 0.542
LIG_LIR_Nem_3 173 178 PF02991 0.348
LIG_LIR_Nem_3 255 259 PF02991 0.620
LIG_LIR_Nem_3 525 531 PF02991 0.576
LIG_LIR_Nem_3 553 559 PF02991 0.571
LIG_LIR_Nem_3 581 587 PF02991 0.624
LIG_LIR_Nem_3 607 613 PF02991 0.440
LIG_LIR_Nem_3 671 677 PF02991 0.595
LIG_LIR_Nem_3 678 684 PF02991 0.456
LIG_LIR_Nem_3 696 702 PF02991 0.315
LIG_LIR_Nem_3 744 748 PF02991 0.625
LIG_MAD2 717 725 PF02301 0.474
LIG_Pex14_1 440 444 PF04695 0.430
LIG_Pex14_2 617 621 PF04695 0.378
LIG_PTB_Apo_2 158 165 PF02174 0.520
LIG_PTB_Phospho_1 158 164 PF10480 0.528
LIG_REV1ctd_RIR_1 67 76 PF16727 0.545
LIG_RPA_C_Fungi 399 411 PF08784 0.411
LIG_SH2_CRK 118 122 PF00017 0.546
LIG_SH2_CRK 179 183 PF00017 0.365
LIG_SH2_CRK 56 60 PF00017 0.542
LIG_SH2_GRB2like 159 162 PF00017 0.537
LIG_SH2_NCK_1 75 79 PF00017 0.560
LIG_SH2_STAT3 211 214 PF00017 0.511
LIG_SH2_STAT5 118 121 PF00017 0.554
LIG_SH2_STAT5 164 167 PF00017 0.480
LIG_SH2_STAT5 379 382 PF00017 0.695
LIG_SH2_STAT5 483 486 PF00017 0.580
LIG_SH2_STAT5 528 531 PF00017 0.595
LIG_SH3_3 128 134 PF00018 0.557
LIG_SH3_3 183 189 PF00018 0.473
LIG_SH3_3 266 272 PF00018 0.597
LIG_SH3_3 389 395 PF00018 0.549
LIG_SH3_3 49 55 PF00018 0.510
LIG_SH3_3 551 557 PF00018 0.649
LIG_SH3_3 718 724 PF00018 0.471
LIG_SH3_3 758 764 PF00018 0.512
LIG_SH3_3 862 868 PF00018 0.538
LIG_SUMO_SIM_anti_2 900 906 PF11976 0.496
LIG_SUMO_SIM_par_1 687 693 PF11976 0.451
LIG_SUMO_SIM_par_1 900 906 PF11976 0.496
LIG_TRAF2_1 385 388 PF00917 0.542
LIG_TRAF2_1 881 884 PF00917 0.610
LIG_TRFH_1 332 336 PF08558 0.626
LIG_TYR_ITIM 116 121 PF00017 0.562
MOD_CK1_1 268 274 PF00069 0.713
MOD_CK1_1 285 291 PF00069 0.461
MOD_CK1_1 345 351 PF00069 0.573
MOD_CK1_1 511 517 PF00069 0.586
MOD_CK2_1 1 7 PF00069 0.539
MOD_CK2_1 235 241 PF00069 0.625
MOD_CK2_1 315 321 PF00069 0.610
MOD_CK2_1 690 696 PF00069 0.496
MOD_CK2_1 76 82 PF00069 0.380
MOD_CK2_1 866 872 PF00069 0.546
MOD_Cter_Amidation 361 364 PF01082 0.640
MOD_Cter_Amidation 714 717 PF01082 0.502
MOD_Cter_Amidation 807 810 PF01082 0.628
MOD_Cter_Amidation 885 888 PF01082 0.580
MOD_GlcNHglycan 287 290 PF01048 0.604
MOD_GlcNHglycan 426 429 PF01048 0.524
MOD_GlcNHglycan 645 648 PF01048 0.707
MOD_GlcNHglycan 666 669 PF01048 0.671
MOD_GlcNHglycan 86 90 PF01048 0.623
MOD_GlcNHglycan 892 895 PF01048 0.503
MOD_GlcNHglycan 926 929 PF01048 0.694
MOD_GSK3_1 112 119 PF00069 0.612
MOD_GSK3_1 133 140 PF00069 0.573
MOD_GSK3_1 264 271 PF00069 0.684
MOD_GSK3_1 278 285 PF00069 0.473
MOD_GSK3_1 337 344 PF00069 0.688
MOD_GSK3_1 600 607 PF00069 0.466
MOD_GSK3_1 608 615 PF00069 0.497
MOD_GSK3_1 856 863 PF00069 0.502
MOD_N-GLC_1 151 156 PF02516 0.532
MOD_N-GLC_1 285 290 PF02516 0.621
MOD_N-GLC_1 550 555 PF02516 0.641
MOD_N-GLC_1 605 610 PF02516 0.345
MOD_N-GLC_1 63 68 PF02516 0.561
MOD_NEK2_1 1 6 PF00069 0.512
MOD_NEK2_1 116 121 PF00069 0.580
MOD_NEK2_1 184 189 PF00069 0.415
MOD_NEK2_1 197 202 PF00069 0.473
MOD_NEK2_1 207 212 PF00069 0.487
MOD_NEK2_1 31 36 PF00069 0.455
MOD_NEK2_1 39 44 PF00069 0.519
MOD_NEK2_1 63 68 PF00069 0.547
MOD_NEK2_1 657 662 PF00069 0.735
MOD_NEK2_1 70 75 PF00069 0.481
MOD_NEK2_1 702 707 PF00069 0.582
MOD_NEK2_1 856 861 PF00069 0.383
MOD_NEK2_1 897 902 PF00069 0.479
MOD_PIKK_1 315 321 PF00454 0.621
MOD_PIKK_1 454 460 PF00454 0.649
MOD_PIKK_1 523 529 PF00454 0.536
MOD_PKA_1 500 506 PF00069 0.612
MOD_PKA_1 759 765 PF00069 0.513
MOD_PKA_2 184 190 PF00069 0.570
MOD_PKA_2 252 258 PF00069 0.649
MOD_PKA_2 265 271 PF00069 0.524
MOD_PKA_2 276 282 PF00069 0.515
MOD_PKA_2 307 313 PF00069 0.637
MOD_PKA_2 31 37 PF00069 0.389
MOD_PKA_2 314 320 PF00069 0.607
MOD_PKA_2 367 373 PF00069 0.629
MOD_PKA_2 501 507 PF00069 0.663
MOD_PKA_2 604 610 PF00069 0.330
MOD_PKA_2 657 663 PF00069 0.665
MOD_PKA_2 749 755 PF00069 0.561
MOD_PKA_2 759 765 PF00069 0.513
MOD_PKA_2 911 917 PF00069 0.547
MOD_PKB_1 149 157 PF00069 0.526
MOD_PKB_1 465 473 PF00069 0.594
MOD_PKB_1 757 765 PF00069 0.513
MOD_Plk_1 151 157 PF00069 0.526
MOD_Plk_1 345 351 PF00069 0.647
MOD_Plk_1 605 611 PF00069 0.342
MOD_Plk_1 94 100 PF00069 0.599
MOD_Plk_2-3 651 657 PF00069 0.661
MOD_Plk_4 152 158 PF00069 0.375
MOD_Plk_4 860 866 PF00069 0.528
MOD_Plk_4 897 903 PF00069 0.476
MOD_ProDKin_1 217 223 PF00069 0.617
MOD_ProDKin_1 268 274 PF00069 0.621
MOD_ProDKin_1 338 344 PF00069 0.606
MOD_ProDKin_1 544 550 PF00069 0.670
MOD_ProDKin_1 633 639 PF00069 0.575
MOD_SUMO_for_1 648 651 PF00179 0.596
MOD_SUMO_rev_2 387 393 PF00179 0.554
MOD_SUMO_rev_2 417 423 PF00179 0.512
MOD_SUMO_rev_2 577 582 PF00179 0.411
TRG_DiLeu_BaEn_1 790 795 PF01217 0.632
TRG_DiLeu_BaEn_1 799 804 PF01217 0.402
TRG_DiLeu_BaLyEn_6 685 690 PF01217 0.465
TRG_DiLeu_BaLyEn_6 698 703 PF01217 0.342
TRG_ENDOCYTIC_2 118 121 PF00928 0.554
TRG_ENDOCYTIC_2 164 167 PF00928 0.445
TRG_ENDOCYTIC_2 56 59 PF00928 0.546
TRG_ENDOCYTIC_2 584 587 PF00928 0.520
TRG_ENDOCYTIC_2 742 745 PF00928 0.631
TRG_ENDOCYTIC_2 933 936 PF00928 0.654
TRG_ER_diArg_1 148 151 PF00400 0.530
TRG_ER_diArg_1 247 249 PF00400 0.646
TRG_ER_diArg_1 363 365 PF00400 0.690
TRG_ER_diArg_1 413 415 PF00400 0.468
TRG_ER_diArg_1 459 462 PF00400 0.719
TRG_ER_diArg_1 464 467 PF00400 0.694
TRG_ER_diArg_1 47 50 PF00400 0.583
TRG_ER_diArg_1 596 598 PF00400 0.374
TRG_ER_diArg_1 661 663 PF00400 0.657
TRG_ER_diArg_1 713 716 PF00400 0.502
TRG_ER_diArg_1 757 760 PF00400 0.520
TRG_ER_diArg_1 806 809 PF00400 0.622
TRG_NLS_MonoExtN_4 459 466 PF00514 0.680
TRG_Pf-PMV_PEXEL_1 10 15 PF00026 0.567
TRG_Pf-PMV_PEXEL_1 36 40 PF00026 0.484

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WY38 Leishmania donovani 85% 69%
A0A3S7WY59 Leishmania donovani 88% 69%
A4HDA4 Leishmania braziliensis 73% 100%
A4I0N4 Leishmania infantum 85% 69%
A4I0N5 Leishmania infantum 86% 100%
E9AVR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AWN4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
E9AWN5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QAT6 Leishmania major 85% 100%
Q4QAT7 Leishmania major 83% 100%
Q4QBR1 Leishmania major 92% 100%
Q4QER4 Leishmania major 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS