Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZV6_LEIIN

TriTrypDb:

LINF_220013500

Length:

120

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.529
DEG_Nend_Nbox_1	1	3	PF02207	0.530
DOC_MAPK_gen_1	100	108	PF00069	0.402
DOC_PP4_FxxP_1	11	14	PF00568	0.504
LIG_14-3-3_CanoR_1	55	60	PF00244	0.431
LIG_deltaCOP1_diTrp_1	107	113	PF00928	0.493
LIG_FHA_1	5	11	PF00498	0.593
LIG_FHA_1	61	67	PF00498	0.404
LIG_FHA_1	85	91	PF00498	0.460
LIG_LIR_Gen_1	112	119	PF02991	0.527
LIG_LIR_Nem_3	112	116	PF02991	0.514
LIG_PCNA_yPIPBox_3	37	49	PF02747	0.456
LIG_Pex14_1	109	113	PF04695	0.486
LIG_SH2_STAP1	97	101	PF00017	0.557
LIG_SH2_STAT3	19	22	PF00017	0.501
LIG_SH2_STAT5	19	22	PF00017	0.535
LIG_SH2_STAT5	49	52	PF00017	0.506
LIG_SH3_4	13	20	PF00018	0.502
LIG_TRAF2_1	93	96	PF00917	0.521
MOD_CK1_1	70	76	PF00069	0.596
MOD_GlcNHglycan	71	75	PF01048	0.558
MOD_GSK3_1	73	80	PF00069	0.548
MOD_NEK2_1	2	7	PF00069	0.514
MOD_NEK2_1	84	89	PF00069	0.493
MOD_PIKK_1	114	120	PF00454	0.571
MOD_PKA_2	60	66	PF00069	0.469
MOD_Plk_4	55	61	PF00069	0.582
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.525
TRG_ER_FFAT_2	43	54	PF00635	0.563
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC12	Leptomonas seymouri	76%	100%
A0A0S4IJG2	Bodo saltans	35%	100%
A0A1X0NTJ6	Trypanosomatidae	56%	100%
A0A3Q8IE81	Leishmania donovani	99%	100%
A0A422N4D9	Trypanosoma rangeli	57%	100%
C9ZSH6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AVR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QBS1	Leishmania major	96%	100%