Zf-LSD1 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZV2_LEIIN

TriTrypDb:

LINF_220013900

Length:

268

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.462
CLV_C14_Caspase3-7	125	129	PF00656	0.507
CLV_NRD_NRD_1	43	45	PF00675	0.424
CLV_NRD_NRD_1	56	58	PF00675	0.426
CLV_PCSK_KEX2_1	250	252	PF00082	0.415
CLV_PCSK_KEX2_1	43	45	PF00082	0.424
CLV_PCSK_KEX2_1	56	58	PF00082	0.426
CLV_PCSK_KEX2_1	7	9	PF00082	0.477
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.415
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.477
CLV_PCSK_SKI1_1	36	40	PF00082	0.421
CLV_PCSK_SKI1_1	8	12	PF00082	0.559
DEG_APCC_DBOX_1	43	51	PF00400	0.394
DEG_APCC_DBOX_1	7	15	PF00400	0.480
DEG_SPOP_SBC_1	151	155	PF00917	0.454
DOC_MAPK_gen_1	34	41	PF00069	0.420
DOC_MAPK_gen_1	7	13	PF00069	0.563
DOC_PP1_RVXF_1	248	255	PF00149	0.459
DOC_PP1_RVXF_1	34	41	PF00149	0.420
DOC_PP4_FxxP_1	26	29	PF00568	0.459
DOC_USP7_MATH_1	126	130	PF00917	0.542
DOC_USP7_MATH_1	151	155	PF00917	0.660
DOC_USP7_MATH_1	161	165	PF00917	0.457
DOC_USP7_MATH_1	97	101	PF00917	0.600
DOC_USP7_UBL2_3	193	197	PF12436	0.448
DOC_USP7_UBL2_3	3	7	PF12436	0.475
LIG_14-3-3_CanoR_1	130	138	PF00244	0.711
LIG_14-3-3_CanoR_1	186	192	PF00244	0.511
LIG_14-3-3_CanoR_1	43	48	PF00244	0.426
LIG_14-3-3_CanoR_1	56	64	PF00244	0.406
LIG_DLG_GKlike_1	43	50	PF00625	0.408
LIG_FHA_1	16	22	PF00498	0.533
LIG_FHA_1	227	233	PF00498	0.448
LIG_FHA_1	242	248	PF00498	0.417
LIG_FHA_1	262	268	PF00498	0.457
LIG_FHA_2	58	64	PF00498	0.495
LIG_LIR_Apic_2	25	29	PF02991	0.461
LIG_LIR_Gen_1	46	55	PF02991	0.404
LIG_LIR_Nem_3	46	51	PF02991	0.396
LIG_NRBOX	46	52	PF00104	0.385
LIG_Pex14_2	26	30	PF04695	0.470
LIG_Pex14_2	41	45	PF04695	0.409
LIG_PTB_Apo_2	167	174	PF02174	0.449
LIG_PTB_Phospho_1	167	173	PF10480	0.441
LIG_REV1ctd_RIR_1	38	48	PF16727	0.409
LIG_SH2_STAP1	109	113	PF00017	0.585
LIG_SH2_STAT3	109	112	PF00017	0.443
LIG_SH3_2	2	7	PF14604	0.475
LIG_SH3_3	135	141	PF00018	0.487
LIG_SH3_3	14	20	PF00018	0.456
LIG_SH3_3	85	91	PF00018	0.632
LIG_SUMO_SIM_par_1	49	54	PF11976	0.402
LIG_TRAF2_1	100	103	PF00917	0.562
MOD_CK1_1	129	135	PF00069	0.588
MOD_CK1_1	152	158	PF00069	0.536
MOD_CK1_1	213	219	PF00069	0.565
MOD_CK1_1	95	101	PF00069	0.557
MOD_CK2_1	216	222	PF00069	0.589
MOD_CK2_1	57	63	PF00069	0.550
MOD_CK2_1	97	103	PF00069	0.584
MOD_GlcNHglycan	173	176	PF01048	0.538
MOD_GlcNHglycan	216	219	PF01048	0.597
MOD_GlcNHglycan	83	86	PF01048	0.552
MOD_GlcNHglycan	94	97	PF01048	0.696
MOD_GSK3_1	171	178	PF00069	0.664
MOD_GSK3_1	210	217	PF00069	0.557
MOD_LATS_1	148	154	PF00433	0.378
MOD_N-GLC_1	169	174	PF02516	0.622
MOD_N-GLC_1	30	35	PF02516	0.426
MOD_N-GLC_1	81	86	PF02516	0.539
MOD_NEK2_1	211	216	PF00069	0.529
MOD_NEK2_1	30	35	PF00069	0.434
MOD_NEK2_1	51	56	PF00069	0.571
MOD_PKA_1	43	49	PF00069	0.397
MOD_PKA_2	129	135	PF00069	0.536
MOD_PKA_2	43	49	PF00069	0.426
MOD_Plk_1	169	175	PF00069	0.471
MOD_Plk_4	141	147	PF00069	0.438
MOD_Plk_4	235	241	PF00069	0.412
MOD_SUMO_for_1	58	61	PF00179	0.487
MOD_SUMO_rev_2	128	137	PF00179	0.542
TRG_ENDOCYTIC_2	208	211	PF00928	0.442
TRG_ER_diArg_1	42	44	PF00400	0.426
TRG_ER_diArg_1	55	57	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M2	Leptomonas seymouri	56%	100%
A0A3Q8ICB8	Leishmania donovani	99%	100%
A0A3R7RDF2	Trypanosoma rangeli	35%	100%
A4HCD4	Leishmania braziliensis	72%	100%
E9AVR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QBR7	Leishmania major	83%	100%