LeishMANIAdb
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A2 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
A2 protein
Gene product:
A2 protein
Species:
Leishmania infantum
UniProt:
A4HZU7_LEIIN
TriTrypDb:
LINF_220012800 *
Length:
487

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 5, no: 0
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZU7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZU7

Putative motif mimicry

Leishmania From To Domain/Motif Score
DEG_Nend_UBRbox_1 1 4 PF02207 0.668
DOC_MAPK_DCC_7 2 11 PF00069 0.623
DOC_MAPK_DCC_7 30 40 PF00069 0.686
DOC_MAPK_gen_1 2 11 PF00069 0.623
DOC_MAPK_MEF2A_6 4 13 PF00069 0.609
DOC_WW_Pin1_4 481 486 PF00397 0.617
LIG_HP1_1 8 12 PF01393 0.596
LIG_SUMO_SIM_par_1 117 122 PF11976 0.522
LIG_SUMO_SIM_par_1 18 23 PF11976 0.606
LIG_SUMO_SIM_par_1 184 189 PF11976 0.486
LIG_SUMO_SIM_par_1 256 261 PF11976 0.413
LIG_SUMO_SIM_par_1 328 333 PF11976 0.393
LIG_SUMO_SIM_par_1 36 41 PF11976 0.682
LIG_SUMO_SIM_par_1 370 375 PF11976 0.365
LIG_SUMO_SIM_par_1 63 68 PF11976 0.546
LIG_SUMO_SIM_par_1 80 85 PF11976 0.637
MOD_CK1_1 167 173 PF00069 0.440
MOD_GlcNHglycan 22 25 PF01048 0.631
MOD_NEK2_1 20 25 PF00069 0.622
MOD_PK_1 2 8 PF00069 0.635
MOD_ProDKin_1 481 487 PF00069 0.629

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IC81 Leishmania donovani 86% 75%
A0A3Q8IFH2 Leishmania donovani 86% 79%
A0A3S5H7A7 Leishmania donovani 85% 92%
A0A3S7WX44 Leishmania donovani 84% 74%
P9WHX6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 24% 84%
P9WHX7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 24% 84%
P9WHZ6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 22% 79%
P9WHZ7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 22% 79%
P9WI20 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 23% 72%
P9WI21 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 24% 72%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS