LeishMANIAdb
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Putative proteasome regulatory ATPase subunit 5

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative proteasome regulatory ATPase subunit 5
Gene product:
proteasome regulatory ATPase subunit 5 - putative
Species:
Leishmania infantum
UniProt:
A4HZT9_LEIIN
TriTrypDb:
LINF_220011600
Length:
444

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Annotations by Jardim et al.

Proteasome, proteasome regulatory ATPase subunit 5

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0000502 proteasome complex 3 11
GO:0005634 nucleus 5 7
GO:0005737 cytoplasm 2 12
GO:0008540 proteasome regulatory particle, base subcomplex 2 1
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0043229 intracellular organelle 3 7
GO:0043231 intracellular membrane-bounded organelle 4 7
GO:0110165 cellular anatomical entity 1 12
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZT9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZT9

Function

Biological processes
TermNameLevelCount
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0009057 macromolecule catabolic process 4 12
GO:0009987 cellular process 1 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 12
GO:0019941 modification-dependent protein catabolic process 6 1
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 12
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 12
GO:0016887 ATP hydrolysis activity 7 12
GO:0017076 purine nucleotide binding 4 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 291 295 PF00656 0.268
CLV_C14_Caspase3-7 320 324 PF00656 0.268
CLV_NRD_NRD_1 116 118 PF00675 0.227
CLV_NRD_NRD_1 121 123 PF00675 0.225
CLV_NRD_NRD_1 23 25 PF00675 0.646
CLV_NRD_NRD_1 354 356 PF00675 0.268
CLV_NRD_NRD_1 376 378 PF00675 0.395
CLV_NRD_NRD_1 434 436 PF00675 0.435
CLV_PCSK_KEX2_1 23 25 PF00082 0.641
CLV_PCSK_KEX2_1 299 301 PF00082 0.281
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P5B8 Leptomonas seymouri 95% 100%
A0A0N1IGY9 Leptomonas seymouri 45% 100%
A0A0N1IM81 Leptomonas seymouri 50% 100%
A0A0S4ITX1 Bodo saltans 76% 100%
A0A0S4JSD8 Bodo saltans 40% 100%
A0A1X0NMZ3 Trypanosomatidae 50% 100%
A0A1X0NNS1 Trypanosomatidae 46% 100%
A0A1X0NT86 Trypanosomatidae 79% 100%
A0A1X0P1T5 Trypanosomatidae 42% 100%
A0A3Q8IJS0 Leishmania donovani 53% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS