N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) domain/Acetyltransferase (GNAT) family - putative

Species:

Leishmania infantum

UniProt:

A4HZT7_LEIIN

TriTrypDb:

LINF_220011400

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZT7

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.525
CLV_NRD_NRD_1	131	133	PF00675	0.738
CLV_NRD_NRD_1	248	250	PF00675	0.583
CLV_NRD_NRD_1	295	297	PF00675	0.303
CLV_NRD_NRD_1	336	338	PF00675	0.346
CLV_NRD_NRD_1	405	407	PF00675	0.622
CLV_NRD_NRD_1	413	415	PF00675	0.534
CLV_PCSK_FUR_1	129	133	PF00082	0.600
CLV_PCSK_KEX2_1	131	133	PF00082	0.738
CLV_PCSK_KEX2_1	214	216	PF00082	0.569
CLV_PCSK_KEX2_1	248	250	PF00082	0.583
CLV_PCSK_KEX2_1	295	297	PF00082	0.299
CLV_PCSK_KEX2_1	335	337	PF00082	0.346
CLV_PCSK_KEX2_1	405	407	PF00082	0.622
CLV_PCSK_KEX2_1	413	415	PF00082	0.534
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.572
CLV_PCSK_SKI1_1	222	226	PF00082	0.524
CLV_PCSK_SKI1_1	248	252	PF00082	0.581
CLV_PCSK_SKI1_1	25	29	PF00082	0.510
CLV_PCSK_SKI1_1	385	389	PF00082	0.517
CLV_PCSK_SKI1_1	487	491	PF00082	0.615
DEG_APCC_DBOX_1	31	39	PF00400	0.424
DEG_APCC_DBOX_1	5	13	PF00400	0.620
DEG_Nend_UBRbox_3	1	3	PF02207	0.601
DEG_ODPH_VHL_1	317	329	PF01847	0.567
DOC_CDC14_PxL_1	49	57	PF14671	0.457
DOC_CKS1_1	310	315	PF01111	0.620
DOC_CYCLIN_RxL_1	219	228	PF00134	0.552
DOC_CYCLIN_RxL_1	22	30	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	251	257	PF00134	0.429
DOC_MAPK_gen_1	385	395	PF00069	0.577
DOC_MAPK_HePTP_8	246	258	PF00069	0.367
DOC_MAPK_MEF2A_6	249	258	PF00069	0.426
DOC_MAPK_MEF2A_6	321	329	PF00069	0.620
DOC_PP1_RVXF_1	376	382	PF00149	0.486
DOC_PP2B_LxvP_1	103	106	PF13499	0.463
DOC_PP2B_LxvP_1	172	175	PF13499	0.543
DOC_PP4_FxxP_1	170	173	PF00568	0.700
DOC_PP4_FxxP_1	283	286	PF00568	0.462
DOC_PP4_MxPP_1	148	151	PF00568	0.501
DOC_USP7_MATH_1	157	161	PF00917	0.746
DOC_USP7_MATH_1	163	167	PF00917	0.662
DOC_USP7_MATH_1	175	179	PF00917	0.704
DOC_USP7_MATH_1	302	306	PF00917	0.536
DOC_USP7_MATH_1	420	424	PF00917	0.665
DOC_USP7_MATH_1	74	78	PF00917	0.517
DOC_USP7_MATH_2	199	205	PF00917	0.582
DOC_WW_Pin1_4	159	164	PF00397	0.660
DOC_WW_Pin1_4	195	200	PF00397	0.705
DOC_WW_Pin1_4	294	299	PF00397	0.593
DOC_WW_Pin1_4	305	310	PF00397	0.489
DOC_WW_Pin1_4	4	9	PF00397	0.650
DOC_WW_Pin1_4	455	460	PF00397	0.748
LIG_14-3-3_CanoR_1	11	17	PF00244	0.620
LIG_14-3-3_CanoR_1	191	199	PF00244	0.728
LIG_14-3-3_CanoR_1	202	207	PF00244	0.646
LIG_14-3-3_CanoR_1	296	304	PF00244	0.593
LIG_14-3-3_CanoR_1	32	36	PF00244	0.496
LIG_APCC_ABBA_1	372	377	PF00400	0.537
LIG_APCC_ABBA_1	381	386	PF00400	0.515
LIG_APCC_ABBA_1	387	392	PF00400	0.549
LIG_BRCT_BRCA1_1	319	323	PF00533	0.533
LIG_Clathr_ClatBox_1	263	267	PF01394	0.567
LIG_EH1_1	322	330	PF00400	0.546
LIG_FHA_1	188	194	PF00498	0.720
LIG_FHA_1	320	326	PF00498	0.516
LIG_FHA_1	356	362	PF00498	0.533
LIG_FHA_1	367	373	PF00498	0.484
LIG_FHA_1	374	380	PF00498	0.475
LIG_FHA_1	98	104	PF00498	0.474
LIG_FHA_2	183	189	PF00498	0.728
LIG_FHA_2	190	196	PF00498	0.710
LIG_FHA_2	399	405	PF00498	0.524
LIG_FHA_2	73	79	PF00498	0.559
LIG_HCF-1_HBM_1	40	43	PF13415	0.392
LIG_LIR_Apic_2	169	173	PF02991	0.670
LIG_LIR_Apic_2	472	477	PF02991	0.579
LIG_LIR_Gen_1	100	109	PF02991	0.480
LIG_LIR_Nem_3	100	104	PF02991	0.453
LIG_MYND_1	309	313	PF01753	0.541
LIG_MYND_1	53	57	PF01753	0.545
LIG_MYND_3	149	153	PF01753	0.644
LIG_Pex14_2	206	210	PF04695	0.559
LIG_RPA_C_Fungi	332	344	PF08784	0.404
LIG_SH2_PTP2	255	258	PF00017	0.437
LIG_SH2_SRC	216	219	PF00017	0.623
LIG_SH2_SRC	43	46	PF00017	0.357
LIG_SH2_STAP1	350	354	PF00017	0.412
LIG_SH2_STAT5	255	258	PF00017	0.437
LIG_SH2_STAT5	43	46	PF00017	0.410
LIG_SH2_STAT5	54	57	PF00017	0.508
LIG_SH3_1	54	60	PF00018	0.546
LIG_SH3_3	174	180	PF00018	0.731
LIG_SH3_3	230	236	PF00018	0.590
LIG_SH3_3	30	36	PF00018	0.540
LIG_SH3_3	307	313	PF00018	0.514
LIG_SH3_3	448	454	PF00018	0.843
LIG_SH3_3	47	53	PF00018	0.432
LIG_SH3_3	54	60	PF00018	0.432
LIG_SUMO_SIM_anti_2	324	329	PF11976	0.412
LIG_SUMO_SIM_anti_2	46	53	PF11976	0.518
LIG_SUMO_SIM_par_1	75	85	PF11976	0.522
LIG_TRAF2_1	151	154	PF00917	0.661
LIG_TRAF2_1	81	84	PF00917	0.514
LIG_WRC_WIRS_1	167	172	PF05994	0.698
MOD_CDK_SPK_2	195	200	PF00069	0.601
MOD_CDK_SPxxK_3	195	202	PF00069	0.702
MOD_CDK_SPxxK_3	4	11	PF00069	0.651
MOD_CK1_1	15	21	PF00069	0.567
MOD_CK1_1	166	172	PF00069	0.675
MOD_CK1_1	182	188	PF00069	0.708
MOD_CK1_1	227	233	PF00069	0.653
MOD_CK1_1	297	303	PF00069	0.482
MOD_CK1_1	305	311	PF00069	0.401
MOD_CK1_1	398	404	PF00069	0.625
MOD_CK1_1	423	429	PF00069	0.704
MOD_CK1_1	467	473	PF00069	0.541
MOD_CK2_1	189	195	PF00069	0.726
MOD_CK2_1	284	290	PF00069	0.436
MOD_CK2_1	398	404	PF00069	0.521
MOD_CK2_1	72	78	PF00069	0.547
MOD_GlcNHglycan	114	117	PF01048	0.667
MOD_GlcNHglycan	12	15	PF01048	0.606
MOD_GlcNHglycan	17	20	PF01048	0.536
MOD_GlcNHglycan	230	233	PF01048	0.701
MOD_GlcNHglycan	299	302	PF01048	0.410
MOD_GlcNHglycan	314	317	PF01048	0.340
MOD_GlcNHglycan	455	458	PF01048	0.779
MOD_GSK3_1	15	22	PF00069	0.490
MOD_GSK3_1	155	162	PF00069	0.630
MOD_GSK3_1	175	182	PF00069	0.720
MOD_GSK3_1	183	190	PF00069	0.590
MOD_GSK3_1	191	198	PF00069	0.591
MOD_GSK3_1	223	230	PF00069	0.584
MOD_GSK3_1	305	312	PF00069	0.380
MOD_GSK3_1	364	371	PF00069	0.391
MOD_GSK3_1	455	462	PF00069	0.849
MOD_GSK3_1	74	81	PF00069	0.518
MOD_GSK3_1	88	95	PF00069	0.339
MOD_LATS_1	189	195	PF00433	0.590
MOD_LATS_1	294	300	PF00433	0.404
MOD_NEK2_1	10	15	PF00069	0.612
MOD_NEK2_1	21	26	PF00069	0.499
MOD_NEK2_1	469	474	PF00069	0.544
MOD_PIKK_1	216	222	PF00454	0.623
MOD_PIKK_1	231	237	PF00454	0.522
MOD_PIKK_1	459	465	PF00454	0.763
MOD_PIKK_1	487	493	PF00454	0.640
MOD_PKA_2	10	16	PF00069	0.646
MOD_PKA_2	120	126	PF00069	0.697
MOD_PKA_2	201	207	PF00069	0.779
MOD_PKA_2	31	37	PF00069	0.478
MOD_PKA_2	412	418	PF00069	0.593
MOD_PKA_2	445	451	PF00069	0.738
MOD_PKB_1	200	208	PF00069	0.724
MOD_Plk_2-3	78	84	PF00069	0.548
MOD_Plk_4	12	18	PF00069	0.600
MOD_Plk_4	179	185	PF00069	0.608
MOD_Plk_4	469	475	PF00069	0.504
MOD_Plk_4	88	94	PF00069	0.484
MOD_Plk_4	97	103	PF00069	0.483
MOD_ProDKin_1	159	165	PF00069	0.659
MOD_ProDKin_1	195	201	PF00069	0.704
MOD_ProDKin_1	294	300	PF00069	0.478
MOD_ProDKin_1	305	311	PF00069	0.332
MOD_ProDKin_1	4	10	PF00069	0.650
MOD_ProDKin_1	455	461	PF00069	0.750
TRG_DiLeu_BaEn_1	40	45	PF01217	0.544
TRG_DiLeu_BaEn_1	47	52	PF01217	0.424
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.626
TRG_DiLeu_LyEn_5	5	10	PF01217	0.620
TRG_ENDOCYTIC_2	255	258	PF00928	0.395
TRG_ER_diArg_1	129	132	PF00400	0.643
TRG_ER_diArg_1	334	337	PF00400	0.412
TRG_ER_diArg_1	413	416	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y0	Leptomonas seymouri	42%	100%
A0A3S7WX61	Leishmania donovani	100%	100%
A4HCA5	Leishmania braziliensis	68%	100%
E9AVP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QBT7	Leishmania major	89%	100%