Protein RER1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein RER1

Gene product:

rer1 family-like protein

Species:

Leishmania infantum

UniProt:

A4HZT5_LEIIN

TriTrypDb:

LINF_220011200

Length:

183

Annotations

Annotations by Jardim et al.

Metal Binding, Rer1 family-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0016020	membrane	2	9
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1

Expansion

Sequence features

A4HZT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZT5

Function

Biological processes
Term	Name	Level	Count
GO:0051179	localization	1	10
GO:0006621	protein retention in ER lumen	6	1
GO:0006810	transport	3	1
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0032507	maintenance of protein location in cell	3	1
GO:0035437	maintenance of protein localization in endoplasmic reticulum	5	1
GO:0045185	maintenance of protein location	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051234	establishment of localization	2	1
GO:0051235	maintenance of location	2	1
GO:0051651	maintenance of location in cell	2	1
GO:0072595	maintenance of protein localization in organelle	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.420
CLV_NRD_NRD_1	17	19	PF00675	0.213
CLV_PCSK_KEX2_1	25	27	PF00082	0.288
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.288
CLV_PCSK_PC7_1	21	27	PF00082	0.288
CLV_PCSK_SKI1_1	116	120	PF00082	0.273
CLV_PCSK_SKI1_1	52	56	PF00082	0.310
DEG_SPOP_SBC_1	179	183	PF00917	0.593
DOC_CKS1_1	77	82	PF01111	0.232
DOC_PP1_RVXF_1	33	40	PF00149	0.402
DOC_PP1_RVXF_1	50	57	PF00149	0.269
DOC_PP2B_LxvP_1	134	137	PF13499	0.210
DOC_USP7_MATH_1	84	88	PF00917	0.437
DOC_USP7_UBL2_3	176	180	PF12436	0.593
DOC_WW_Pin1_4	76	81	PF00397	0.239
DOC_WW_Pin1_4	87	92	PF00397	0.442
LIG_14-3-3_CanoR_1	21	25	PF00244	0.491
LIG_14-3-3_CanoR_1	52	57	PF00244	0.310
LIG_CaM_IQ_9	150	166	PF13499	0.232
LIG_EH_1	13	17	PF12763	0.464
LIG_eIF4E_1	72	78	PF01652	0.274
LIG_FHA_1	61	67	PF00498	0.336
LIG_FHA_2	93	99	PF00498	0.490
LIG_LIR_Gen_1	120	131	PF02991	0.280
LIG_LIR_Gen_1	132	141	PF02991	0.210
LIG_LIR_Nem_3	100	105	PF02991	0.399
LIG_LIR_Nem_3	120	126	PF02991	0.226
LIG_LIR_Nem_3	129	134	PF02991	0.232
LIG_LIR_Nem_3	23	27	PF02991	0.410
LIG_LIR_Nem_3	55	59	PF02991	0.309
LIG_NRBOX	69	75	PF00104	0.253
LIG_Pex14_1	115	119	PF04695	0.268
LIG_Pex14_2	119	123	PF04695	0.269
LIG_Pex14_2	127	131	PF04695	0.199
LIG_Pex14_2	147	151	PF04695	0.109
LIG_SH2_SRC	27	30	PF00017	0.491
LIG_SH2_STAT5	146	149	PF00017	0.232
LIG_SH2_STAT5	167	170	PF00017	0.397
LIG_SH2_STAT5	27	30	PF00017	0.434
LIG_SH2_STAT5	49	52	PF00017	0.299
LIG_SH2_STAT5	60	63	PF00017	0.243
LIG_SH2_STAT5	72	75	PF00017	0.245
LIG_SH3_3	101	107	PF00018	0.397
LIG_SH3_3	135	141	PF00018	0.197
LIG_SUMO_SIM_par_1	73	79	PF11976	0.251
LIG_TYR_ITIM	70	75	PF00017	0.250
LIG_WRC_WIRS_1	130	135	PF05994	0.327
LIG_WRC_WIRS_1	53	58	PF05994	0.297
LIG_WRPW_2	102	105	PF00400	0.397
MOD_CK1_1	87	93	PF00069	0.443
MOD_GlcNHglycan	10	13	PF01048	0.374
MOD_GSK3_1	87	94	PF00069	0.505
MOD_NEK2_1	126	131	PF00069	0.238
MOD_NEK2_1	150	155	PF00069	0.255
MOD_NEK2_1	28	33	PF00069	0.446
MOD_PIKK_1	150	156	PF00454	0.250
MOD_PKA_2	20	26	PF00069	0.491
MOD_Plk_1	28	34	PF00069	0.402
MOD_Plk_4	126	132	PF00069	0.270
MOD_ProDKin_1	76	82	PF00069	0.239
MOD_ProDKin_1	87	93	PF00069	0.442
TRG_DiLeu_BaEn_2	100	106	PF01217	0.452
TRG_ENDOCYTIC_2	102	105	PF00928	0.491
TRG_ENDOCYTIC_2	146	149	PF00928	0.232
TRG_ENDOCYTIC_2	72	75	PF00928	0.294
TRG_NLS_MonoExtN_4	15	22	PF00514	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2L3	Leptomonas seymouri	80%	100%
A0A0S4INL9	Bodo saltans	56%	100%
A0A1X0NTI3	Trypanosomatidae	62%	99%
A0A3R7MCZ0	Trypanosoma rangeli	63%	99%
A0A3S7WX19	Leishmania donovani	100%	100%
A5PJ65	Bos taurus	35%	93%
C9ZRM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AVP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O15258	Homo sapiens	35%	93%
O48670	Arabidopsis thaliana	39%	96%
O48671	Arabidopsis thaliana	39%	94%
P25560	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	97%
P52879	Caenorhabditis elegans	36%	96%
P79003	Saccharomyces pastorianus	35%	97%
Q10358	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	99%
Q498C8	Rattus norvegicus	35%	93%
Q4QBT9	Leishmania major	94%	100%
Q54D10	Dictyostelium discoideum	39%	97%
Q5R5U4	Pongo abelii	35%	93%
Q5ZHM5	Gallus gallus	36%	93%
Q9CQU3	Mus musculus	35%	93%
Q9ZPV7	Arabidopsis thaliana	37%	83%
Q9ZWI7	Arabidopsis thaliana	37%	86%