Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin - putative

Species:

Leishmania infantum

UniProt:

A4HZT3_LEIIN

TriTrypDb:

LINF_220011000

Length:

889

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4HZT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZT3

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	17
GO:0007018	microtubule-based movement	3	17
GO:0009987	cellular process	1	17
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003774	cytoskeletal motor activity	1	17
GO:0003777	microtubule motor activity	2	17
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	17
GO:0005515	protein binding	2	17
GO:0005524	ATP binding	5	17
GO:0008017	microtubule binding	5	17
GO:0008092	cytoskeletal protein binding	3	17
GO:0015631	tubulin binding	4	17
GO:0016787	hydrolase activity	2	10
GO:0017076	purine nucleotide binding	4	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:0140657	ATP-dependent activity	1	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17
GO:0008574	plus-end-directed microtubule motor activity	3	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.568
CLV_NRD_NRD_1	300	302	PF00675	0.552
CLV_NRD_NRD_1	458	460	PF00675	0.472
CLV_NRD_NRD_1	476	478	PF00675	0.503
CLV_NRD_NRD_1	773	775	PF00675	0.645
CLV_PCSK_FUR_1	428	432	PF00082	0.372
CLV_PCSK_KEX2_1	300	302	PF00082	0.607
CLV_PCSK_KEX2_1	430	432	PF00082	0.401
CLV_PCSK_KEX2_1	773	775	PF00082	0.673
CLV_PCSK_KEX2_1	815	817	PF00082	0.367
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.395
CLV_PCSK_PC1ET2_1	815	817	PF00082	0.371
CLV_PCSK_SKI1_1	147	151	PF00082	0.275
CLV_PCSK_SKI1_1	313	317	PF00082	0.355
CLV_PCSK_SKI1_1	335	339	PF00082	0.268
CLV_PCSK_SKI1_1	354	358	PF00082	0.439
CLV_PCSK_SKI1_1	430	434	PF00082	0.268
CLV_PCSK_SKI1_1	459	463	PF00082	0.453
CLV_PCSK_SKI1_1	472	476	PF00082	0.409
CLV_PCSK_SKI1_1	532	536	PF00082	0.511
DEG_SCF_FBW7_2	409	414	PF00400	0.372
DOC_CYCLIN_RxL_1	456	466	PF00134	0.426
DOC_MAPK_gen_1	428	438	PF00069	0.344
DOC_MAPK_gen_1	813	822	PF00069	0.365
DOC_MAPK_gen_1	823	831	PF00069	0.359
DOC_MAPK_MEF2A_6	104	113	PF00069	0.393
DOC_MAPK_MEF2A_6	240	249	PF00069	0.246
DOC_MAPK_MEF2A_6	815	824	PF00069	0.359
DOC_MIT_MIM_1	694	702	PF04212	0.514
DOC_PP1_RVXF_1	789	795	PF00149	0.346
DOC_USP7_MATH_1	173	177	PF00917	0.388
DOC_USP7_MATH_1	412	416	PF00917	0.313
DOC_USP7_MATH_1	498	502	PF00917	0.676
DOC_USP7_MATH_1	760	764	PF00917	0.468
DOC_USP7_UBL2_3	316	320	PF12436	0.242
DOC_USP7_UBL2_3	854	858	PF12436	0.401
DOC_WW_Pin1_4	102	107	PF00397	0.351
DOC_WW_Pin1_4	174	179	PF00397	0.369
DOC_WW_Pin1_4	184	189	PF00397	0.308
DOC_WW_Pin1_4	407	412	PF00397	0.311
DOC_WW_Pin1_4	494	499	PF00397	0.646
LIG_14-3-3_CanoR_1	170	178	PF00244	0.425
LIG_14-3-3_CanoR_1	227	234	PF00244	0.256
LIG_14-3-3_CanoR_1	246	250	PF00244	0.355
LIG_14-3-3_CanoR_1	284	292	PF00244	0.689
LIG_14-3-3_CanoR_1	365	373	PF00244	0.388
LIG_14-3-3_CanoR_1	420	424	PF00244	0.238
LIG_14-3-3_CanoR_1	567	571	PF00244	0.525
LIG_14-3-3_CanoR_1	617	626	PF00244	0.491
LIG_14-3-3_CanoR_1	701	709	PF00244	0.568
LIG_APCC_ABBA_1	139	144	PF00400	0.292
LIG_APCC_ABBA_1	381	386	PF00400	0.255
LIG_APCC_ABBAyCdc20_2	127	133	PF00400	0.372
LIG_BIR_III_4	154	158	PF00653	0.267
LIG_FHA_1	179	185	PF00498	0.256
LIG_FHA_1	373	379	PF00498	0.340
LIG_FHA_1	388	394	PF00498	0.301
LIG_FHA_1	401	407	PF00498	0.292
LIG_FHA_1	408	414	PF00498	0.269
LIG_FHA_1	456	462	PF00498	0.464
LIG_FHA_1	464	470	PF00498	0.428
LIG_FHA_1	555	561	PF00498	0.459
LIG_FHA_1	57	63	PF00498	0.243
LIG_FHA_1	571	577	PF00498	0.501
LIG_FHA_1	650	656	PF00498	0.554
LIG_FHA_1	694	700	PF00498	0.466
LIG_FHA_2	272	278	PF00498	0.640
LIG_FHA_2	359	365	PF00498	0.388
LIG_FHA_2	534	540	PF00498	0.430
LIG_FHA_2	56	62	PF00498	0.357
LIG_FHA_2	706	712	PF00498	0.655
LIG_FHA_2	749	755	PF00498	0.437
LIG_Integrin_RGD_1	659	661	PF01839	0.458
LIG_LIR_Gen_1	115	122	PF02991	0.285
LIG_LIR_Gen_1	132	142	PF02991	0.277
LIG_LIR_Gen_1	401	409	PF02991	0.243
LIG_LIR_Gen_1	48	57	PF02991	0.285
LIG_LIR_Gen_1	680	688	PF02991	0.434
LIG_LIR_Gen_1	94	102	PF02991	0.303
LIG_LIR_Nem_3	115	120	PF02991	0.280
LIG_LIR_Nem_3	132	138	PF02991	0.332
LIG_LIR_Nem_3	195	201	PF02991	0.334
LIG_LIR_Nem_3	380	384	PF02991	0.261
LIG_LIR_Nem_3	401	405	PF02991	0.243
LIG_LIR_Nem_3	48	52	PF02991	0.285
LIG_LIR_Nem_3	680	684	PF02991	0.455
LIG_LIR_Nem_3	725	731	PF02991	0.404
LIG_LIR_Nem_3	94	98	PF02991	0.283
LIG_NRBOX	145	151	PF00104	0.275
LIG_NRBOX	388	394	PF00104	0.283
LIG_NRBOX	726	732	PF00104	0.386
LIG_PCNA_yPIPBox_3	143	151	PF02747	0.384
LIG_SH2_CRK	681	685	PF00017	0.548
LIG_SH2_NCK_1	221	225	PF00017	0.372
LIG_SH2_NCK_1	53	57	PF00017	0.228
LIG_SH2_SRC	221	224	PF00017	0.204
LIG_SH2_SRC	53	56	PF00017	0.390
LIG_SH2_STAP1	221	225	PF00017	0.256
LIG_SH2_STAP1	479	483	PF00017	0.575
LIG_SH2_STAP1	53	57	PF00017	0.339
LIG_SH2_STAP1	63	67	PF00017	0.288
LIG_SH2_STAT3	142	145	PF00017	0.220
LIG_SH2_STAT3	479	482	PF00017	0.533
LIG_SH2_STAT5	201	204	PF00017	0.250
LIG_SH2_STAT5	254	257	PF00017	0.609
LIG_SH2_STAT5	468	471	PF00017	0.389
LIG_SH2_STAT5	663	666	PF00017	0.475
LIG_SH2_STAT5	95	98	PF00017	0.265
LIG_SH3_3	879	885	PF00018	0.473
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.179
LIG_SUMO_SIM_par_1	189	195	PF11976	0.275
LIG_SxIP_EBH_1	375	385	PF03271	0.228
LIG_TRAF2_1	212	215	PF00917	0.324
LIG_TRAF2_1	273	276	PF00917	0.661
LIG_TRAF2_1	628	631	PF00917	0.474
LIG_TRAF2_2	742	747	PF00917	0.444
LIG_UBA3_1	844	851	PF00899	0.462
LIG_WRC_WIRS_1	378	383	PF05994	0.179
MOD_CK1_1	165	171	PF00069	0.452
MOD_CK1_1	174	180	PF00069	0.373
MOD_CK1_1	226	232	PF00069	0.291
MOD_CK1_1	238	244	PF00069	0.297
MOD_CK1_1	287	293	PF00069	0.736
MOD_CK1_1	3	9	PF00069	0.465
MOD_CK1_1	355	361	PF00069	0.317
MOD_CK1_1	368	374	PF00069	0.203
MOD_CK1_1	387	393	PF00069	0.315
MOD_CK1_1	419	425	PF00069	0.243
MOD_CK1_1	494	500	PF00069	0.638
MOD_CK1_1	501	507	PF00069	0.671
MOD_CK1_1	569	575	PF00069	0.525
MOD_CK1_1	665	671	PF00069	0.347
MOD_CK1_1	705	711	PF00069	0.438
MOD_CK1_1	781	787	PF00069	0.598
MOD_CK1_1	91	97	PF00069	0.308
MOD_CK2_1	134	140	PF00069	0.282
MOD_CK2_1	189	195	PF00069	0.269
MOD_CK2_1	209	215	PF00069	0.266
MOD_CK2_1	270	276	PF00069	0.671
MOD_CK2_1	33	39	PF00069	0.243
MOD_CK2_1	412	418	PF00069	0.338
MOD_CK2_1	489	495	PF00069	0.653
MOD_CK2_1	5	11	PF00069	0.410
MOD_CK2_1	533	539	PF00069	0.521
MOD_CK2_1	55	61	PF00069	0.310
MOD_CK2_1	587	593	PF00069	0.497
MOD_CK2_1	617	623	PF00069	0.421
MOD_CK2_1	781	787	PF00069	0.482
MOD_Cter_Amidation	298	301	PF01082	0.529
MOD_GlcNHglycan	164	167	PF01048	0.440
MOD_GlcNHglycan	173	176	PF01048	0.218
MOD_GlcNHglycan	184	187	PF01048	0.150
MOD_GlcNHglycan	228	231	PF01048	0.272
MOD_GlcNHglycan	292	295	PF01048	0.651
MOD_GlcNHglycan	414	417	PF01048	0.334
MOD_GlcNHglycan	500	503	PF01048	0.632
MOD_GlcNHglycan	731	734	PF01048	0.456
MOD_GlcNHglycan	780	783	PF01048	0.586
MOD_GlcNHglycan	90	93	PF01048	0.319
MOD_GSK3_1	173	180	PF00069	0.455
MOD_GSK3_1	245	252	PF00069	0.358
MOD_GSK3_1	283	290	PF00069	0.712
MOD_GSK3_1	354	361	PF00069	0.296
MOD_GSK3_1	368	375	PF00069	0.334
MOD_GSK3_1	412	419	PF00069	0.353
MOD_GSK3_1	494	501	PF00069	0.638
MOD_GSK3_1	562	569	PF00069	0.579
MOD_GSK3_1	693	700	PF00069	0.367
MOD_GSK3_1	718	725	PF00069	0.604
MOD_GSK3_1	748	755	PF00069	0.559
MOD_GSK3_1	98	105	PF00069	0.306
MOD_N-GLC_1	102	107	PF02516	0.321
MOD_N-GLC_1	352	357	PF02516	0.292
MOD_N-GLC_1	489	494	PF02516	0.462
MOD_N-GLC_1	705	710	PF02516	0.446
MOD_N-GLC_1	79	84	PF02516	0.282
MOD_NEK2_1	292	297	PF00069	0.528
MOD_NEK2_1	392	397	PF00069	0.265
MOD_NEK2_1	455	460	PF00069	0.476
MOD_NEK2_1	570	575	PF00069	0.516
MOD_NEK2_1	584	589	PF00069	0.427
MOD_NEK2_1	642	647	PF00069	0.433
MOD_NEK2_1	677	682	PF00069	0.556
MOD_NEK2_1	702	707	PF00069	0.438
MOD_NEK2_1	722	727	PF00069	0.304
MOD_NEK2_1	98	103	PF00069	0.278
MOD_NEK2_2	189	194	PF00069	0.372
MOD_NEK2_2	748	753	PF00069	0.443
MOD_NEK2_2	79	84	PF00069	0.346
MOD_NEK2_2	862	867	PF00069	0.398
MOD_PIKK_1	271	277	PF00454	0.702
MOD_PIKK_1	285	291	PF00454	0.715
MOD_PIKK_1	570	576	PF00454	0.527
MOD_PIKK_1	584	590	PF00454	0.548
MOD_PIKK_1	642	648	PF00454	0.471
MOD_PIKK_1	679	685	PF00454	0.382
MOD_PIKK_1	693	699	PF00454	0.357
MOD_PIKK_1	735	741	PF00454	0.535
MOD_PIKK_1	752	758	PF00454	0.345
MOD_PIKK_1	852	858	PF00454	0.561
MOD_PKA_1	773	779	PF00069	0.513
MOD_PKA_2	226	232	PF00069	0.273
MOD_PKA_2	23	29	PF00069	0.597
MOD_PKA_2	245	251	PF00069	0.223
MOD_PKA_2	283	289	PF00069	0.719
MOD_PKA_2	384	390	PF00069	0.292
MOD_PKA_2	419	425	PF00069	0.261
MOD_PKA_2	455	461	PF00069	0.501
MOD_PKA_2	566	572	PF00069	0.528
MOD_PKA_2	697	703	PF00069	0.591
MOD_PKA_2	718	724	PF00069	0.633
MOD_PKA_2	752	758	PF00069	0.473
MOD_PKA_2	773	779	PF00069	0.513
MOD_Plk_1	249	255	PF00069	0.314
MOD_Plk_1	32	38	PF00069	0.418
MOD_Plk_1	352	358	PF00069	0.279
MOD_Plk_1	489	495	PF00069	0.509
MOD_Plk_1	665	671	PF00069	0.418
MOD_Plk_1	705	711	PF00069	0.417
MOD_Plk_2-3	257	263	PF00069	0.576
MOD_Plk_2-3	33	39	PF00069	0.372
MOD_Plk_4	134	140	PF00069	0.290
MOD_Plk_4	358	364	PF00069	0.260
MOD_Plk_4	377	383	PF00069	0.253
MOD_Plk_4	463	469	PF00069	0.406
MOD_Plk_4	501	507	PF00069	0.648
MOD_Plk_4	511	517	PF00069	0.569
MOD_Plk_4	718	724	PF00069	0.450
MOD_Plk_4	79	85	PF00069	0.298
MOD_Plk_4	93	99	PF00069	0.255
MOD_ProDKin_1	102	108	PF00069	0.351
MOD_ProDKin_1	174	180	PF00069	0.369
MOD_ProDKin_1	184	190	PF00069	0.308
MOD_ProDKin_1	407	413	PF00069	0.311
MOD_ProDKin_1	494	500	PF00069	0.619
MOD_SUMO_rev_2	529	536	PF00179	0.538
MOD_SUMO_rev_2	600	607	PF00179	0.585
MOD_SUMO_rev_2	807	814	PF00179	0.376
TRG_DiLeu_BaEn_1	621	626	PF01217	0.421
TRG_DiLeu_BaEn_4	529	535	PF01217	0.550
TRG_DiLeu_BaEn_4	631	637	PF01217	0.485
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.440
TRG_DiLeu_BaLyEn_6	726	731	PF01217	0.372
TRG_ENDOCYTIC_2	681	684	PF00928	0.555
TRG_ENDOCYTIC_2	95	98	PF00928	0.255
TRG_ER_diArg_1	14	17	PF00400	0.371
TRG_ER_diArg_1	788	791	PF00400	0.483
TRG_ER_diArg_1	875	878	PF00400	0.560
TRG_NES_CRM1_1	662	675	PF08389	0.389
TRG_NES_CRM1_1	818	833	PF08389	0.365
TRG_NLS_Bipartite_1	300	322	PF00514	0.473
TRG_NLS_MonoExtN_4	316	322	PF00514	0.242
TRG_NLS_MonoExtN_4	428	434	PF00514	0.372
TRG_Pf-PMV_PEXEL_1	793	797	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM1	Leptomonas seymouri	65%	96%
A0A0S4INA4	Bodo saltans	41%	100%
A0A1X0NUN6	Trypanosomatidae	41%	95%
A0A3Q8IG88	Leishmania donovani	30%	100%
A0A3R7NW09	Trypanosoma rangeli	30%	85%
A0A3S7WX05	Leishmania donovani	100%	100%
A0A422N2N4	Trypanosoma rangeli	42%	100%
A4H4I4	Leishmania braziliensis	25%	100%
A4H8S6	Leishmania braziliensis	25%	86%
A4HCA1	Leishmania braziliensis	78%	100%
A4IBA7	Leishmania infantum	30%	100%
E9AF32	Leishmania major	29%	100%
E9AVN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B687	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q0DV28	Oryza sativa subsp. japonica	25%	94%
Q4QBU1	Leishmania major	92%	100%
V5BLH7	Trypanosoma cruzi	42%	100%