Peptidyl-prolyl cis-trans isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase - putative

Species:

Leishmania infantum

UniProt:

A4HZT1_LEIIN

TriTrypDb:

LINF_220010800

Length:

160

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZT1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	2
GO:0003824	catalytic activity	1	2
GO:0016853	isomerase activity	2	2
GO:0016859	cis-trans isomerase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.174
CLV_NRD_NRD_1	139	141	PF00675	0.174
CLV_NRD_NRD_1	82	84	PF00675	0.174
CLV_PCSK_FUR_1	137	141	PF00082	0.174
CLV_PCSK_KEX2_1	115	117	PF00082	0.174
CLV_PCSK_KEX2_1	139	141	PF00082	0.174
CLV_PCSK_KEX2_1	81	83	PF00082	0.174
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.174
CLV_PCSK_SKI1_1	133	137	PF00082	0.174
CLV_PCSK_SKI1_1	74	78	PF00082	0.174
DEG_APCC_DBOX_1	115	123	PF00400	0.174
DOC_CKS1_1	94	99	PF01111	0.174
DOC_MAPK_gen_1	113	121	PF00069	0.174
DOC_MAPK_MEF2A_6	83	92	PF00069	0.174
DOC_USP7_MATH_1	25	29	PF00917	0.433
DOC_WW_Pin1_4	17	22	PF00397	0.456
DOC_WW_Pin1_4	90	95	PF00397	0.174
LIG_Actin_WH2_2	124	141	PF00022	0.174
LIG_BIR_II_1	1	5	PF00653	0.429
LIG_BIR_III_1	1	5	PF00653	0.429
LIG_BIR_III_3	1	5	PF00653	0.429
LIG_BIR_III_4	15	19	PF00653	0.457
LIG_CSL_BTD_1	94	97	PF09270	0.174
LIG_eIF4E_1	33	39	PF01652	0.263
LIG_FHA_2	124	130	PF00498	0.174
LIG_FHA_2	94	100	PF00498	0.174
LIG_Integrin_RGD_1	116	118	PF01839	0.174
LIG_LIR_Gen_1	105	112	PF02991	0.174
LIG_LIR_Nem_3	32	36	PF02991	0.296
LIG_SH2_CRK	33	37	PF00017	0.281
LIG_SH2_SRC	33	36	PF00017	0.288
LIG_SH2_STAT5	107	110	PF00017	0.174
LIG_SH2_STAT5	75	78	PF00017	0.174
LIG_SH3_1	82	88	PF00018	0.174
LIG_SH3_3	140	146	PF00018	0.174
LIG_SH3_3	45	51	PF00018	0.288
LIG_SH3_3	82	88	PF00018	0.174
LIG_SH3_3	91	97	PF00018	0.174
LIG_TRAF2_1	96	99	PF00917	0.174
LIG_UBA3_1	38	46	PF00899	0.230
MOD_CK1_1	93	99	PF00069	0.174
MOD_CK2_1	17	23	PF00069	0.455
MOD_CK2_1	93	99	PF00069	0.174
MOD_GlcNHglycan	109	113	PF01048	0.174
MOD_GlcNHglycan	142	146	PF01048	0.174
MOD_GlcNHglycan	27	30	PF01048	0.421
MOD_GSK3_1	10	17	PF00069	0.454
MOD_PIKK_1	146	152	PF00454	0.174
MOD_Plk_2-3	123	129	PF00069	0.174
MOD_Plk_4	5	11	PF00069	0.435
MOD_ProDKin_1	17	23	PF00069	0.455
MOD_ProDKin_1	90	96	PF00069	0.174
TRG_ENDOCYTIC_2	107	110	PF00928	0.174
TRG_ENDOCYTIC_2	33	36	PF00928	0.288
TRG_ER_diArg_1	136	139	PF00400	0.174
TRG_ER_diArg_1	81	83	PF00400	0.174
TRG_NLS_MonoCore_2	112	117	PF00514	0.174
TRG_NLS_MonoExtC_3	112	118	PF00514	0.174

Homologs


Protein	Taxonomy	Sequence identity	Coverage
O74448	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	91%
P0C1J8	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	32%	100%
P0DMT5	Theileria annulata	32%	100%
P22696	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	94%
Q13526	Homo sapiens	26%	98%
Q4R383	Macaca fascicularis	26%	98%
Q4UG71	Theileria annulata	32%	100%
Q5BIN5	Bos taurus	25%	98%
Q9QUR7	Mus musculus	28%	97%