TFIIS N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TFIIS helical bundle-like domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HZS8_LEIIN

TriTrypDb:

LINF_220010500

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HZS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZS8

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0016973	poly(A)+ mRNA export from nucleus	7	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.656
CLV_C14_Caspase3-7	217	221	PF00656	0.662
CLV_C14_Caspase3-7	223	227	PF00656	0.556
CLV_C14_Caspase3-7	236	240	PF00656	0.567
CLV_C14_Caspase3-7	411	415	PF00656	0.541
CLV_C14_Caspase3-7	60	64	PF00656	0.539
CLV_C14_Caspase3-7	65	69	PF00656	0.601
CLV_C14_Caspase3-7	87	91	PF00656	0.725
CLV_NRD_NRD_1	192	194	PF00675	0.701
CLV_NRD_NRD_1	201	203	PF00675	0.737
CLV_NRD_NRD_1	269	271	PF00675	0.686
CLV_NRD_NRD_1	406	408	PF00675	0.560
CLV_PCSK_KEX2_1	142	144	PF00082	0.524
CLV_PCSK_KEX2_1	146	148	PF00082	0.520
CLV_PCSK_KEX2_1	150	152	PF00082	0.464
CLV_PCSK_KEX2_1	201	203	PF00082	0.798
CLV_PCSK_KEX2_1	406	408	PF00082	0.566
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.522
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.508
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.441
CLV_PCSK_SKI1_1	139	143	PF00082	0.553
CLV_PCSK_SKI1_1	182	186	PF00082	0.723
CLV_PCSK_SKI1_1	250	254	PF00082	0.582
CLV_PCSK_SKI1_1	262	266	PF00082	0.655
CLV_PCSK_SKI1_1	313	317	PF00082	0.498
DEG_APCC_DBOX_1	312	320	PF00400	0.483
DEG_Nend_UBRbox_2	1	3	PF02207	0.742
DOC_CYCLIN_yCln2_LP_2	231	237	PF00134	0.647
DOC_MAPK_MEF2A_6	360	368	PF00069	0.394
DOC_PP4_FxxP_1	474	477	PF00568	0.642
DOC_USP7_MATH_1	158	162	PF00917	0.457
DOC_USP7_MATH_1	189	193	PF00917	0.782
DOC_USP7_MATH_1	315	319	PF00917	0.476
DOC_USP7_MATH_1	74	78	PF00917	0.829
DOC_USP7_UBL2_3	138	142	PF12436	0.495
DOC_USP7_UBL2_3	146	150	PF12436	0.484
DOC_USP7_UBL2_3	153	157	PF12436	0.443
DOC_USP7_UBL2_3	163	167	PF12436	0.523
DOC_USP7_UBL2_3	176	180	PF12436	0.707
DOC_USP7_UBL2_3	195	199	PF12436	0.764
DOC_USP7_UBL2_3	262	266	PF12436	0.614
DOC_USP7_UBL2_3	445	449	PF12436	0.685
DOC_USP7_UBL2_3	472	476	PF12436	0.496
DOC_WW_Pin1_4	34	39	PF00397	0.683
DOC_WW_Pin1_4	455	460	PF00397	0.636
LIG_14-3-3_CanoR_1	270	280	PF00244	0.625
LIG_14-3-3_CanoR_1	302	306	PF00244	0.593
LIG_Actin_WH2_2	241	256	PF00022	0.589
LIG_APCC_ABBA_1	15	20	PF00400	0.706
LIG_BRCT_BRCA1_1	466	470	PF00533	0.659
LIG_BRCT_BRCA1_1	49	53	PF00533	0.498
LIG_BRCT_BRCA1_2	466	472	PF00533	0.580
LIG_eIF4E_1	328	334	PF01652	0.494
LIG_FHA_1	359	365	PF00498	0.448
LIG_FHA_1	377	383	PF00498	0.626
LIG_FHA_2	463	469	PF00498	0.522
LIG_FHA_2	58	64	PF00498	0.470
LIG_GBD_Chelix_1	280	288	PF00786	0.513
LIG_LIR_Apic_2	473	477	PF02991	0.639
LIG_LIR_Gen_1	213	222	PF02991	0.697
LIG_LIR_Gen_1	424	433	PF02991	0.562
LIG_LIR_Gen_1	458	464	PF02991	0.662
LIG_LIR_Gen_1	50	61	PF02991	0.554
LIG_LIR_Nem_3	341	347	PF02991	0.439
LIG_LIR_Nem_3	383	388	PF02991	0.548
LIG_LIR_Nem_3	424	429	PF02991	0.533
LIG_LIR_Nem_3	458	463	PF02991	0.666
LIG_LIR_Nem_3	483	488	PF02991	0.556
LIG_LIR_Nem_3	50	56	PF02991	0.565
LIG_NRP_CendR_1	517	518	PF00754	0.733
LIG_Pex14_2	305	309	PF04695	0.410
LIG_Pex14_2	470	474	PF04695	0.680
LIG_SH2_CRK	485	489	PF00017	0.632
LIG_SH2_STAT5	30	33	PF00017	0.594
LIG_SH2_STAT5	328	331	PF00017	0.382
LIG_SH2_STAT5	508	511	PF00017	0.591
LIG_SH3_1	476	482	PF00018	0.566
LIG_SH3_3	32	38	PF00018	0.582
LIG_SH3_3	365	371	PF00018	0.558
LIG_SH3_3	453	459	PF00018	0.534
LIG_SH3_3	476	482	PF00018	0.541
LIG_SH3_3	487	493	PF00018	0.517
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.517
LIG_SUMO_SIM_par_1	131	137	PF11976	0.606
LIG_TYR_ITSM	481	488	PF00017	0.685
LIG_UBA3_1	131	139	PF00899	0.559
LIG_WRC_WIRS_1	423	428	PF05994	0.527
MOD_CK1_1	174	180	PF00069	0.755
MOD_CK1_1	21	27	PF00069	0.715
MOD_CK1_1	431	437	PF00069	0.720
MOD_CK1_1	49	55	PF00069	0.723
MOD_CK2_1	106	112	PF00069	0.802
MOD_CK2_1	270	276	PF00069	0.612
MOD_CK2_1	455	461	PF00069	0.596
MOD_CK2_1	462	468	PF00069	0.490
MOD_Cter_Amidation	144	147	PF01082	0.597
MOD_GlcNHglycan	108	111	PF01048	0.746
MOD_GlcNHglycan	117	120	PF01048	0.681
MOD_GlcNHglycan	189	192	PF01048	0.744
MOD_GlcNHglycan	27	30	PF01048	0.806
MOD_GlcNHglycan	273	276	PF01048	0.585
MOD_GlcNHglycan	299	302	PF01048	0.538
MOD_GlcNHglycan	430	433	PF01048	0.543
MOD_GlcNHglycan	501	504	PF01048	0.650
MOD_GlcNHglycan	76	79	PF01048	0.813
MOD_GSK3_1	189	196	PF00069	0.686
MOD_GSK3_1	21	28	PF00069	0.716
MOD_GSK3_1	210	217	PF00069	0.540
MOD_GSK3_1	253	260	PF00069	0.549
MOD_GSK3_1	297	304	PF00069	0.513
MOD_GSK3_1	372	379	PF00069	0.616
MOD_GSK3_1	42	49	PF00069	0.799
MOD_GSK3_1	424	431	PF00069	0.539
MOD_N-GLC_1	499	504	PF02516	0.677
MOD_NEK2_1	131	136	PF00069	0.555
MOD_NEK2_1	214	219	PF00069	0.654
MOD_NEK2_1	253	258	PF00069	0.579
MOD_NEK2_1	372	377	PF00069	0.508
MOD_NEK2_1	422	427	PF00069	0.459
MOD_NEK2_1	470	475	PF00069	0.637
MOD_NEK2_1	57	62	PF00069	0.583
MOD_NEK2_2	210	215	PF00069	0.688
MOD_PIKK_1	156	162	PF00454	0.444
MOD_PIKK_1	171	177	PF00454	0.486
MOD_PKA_1	187	193	PF00069	0.687
MOD_PKA_1	270	276	PF00069	0.613
MOD_PKA_2	253	259	PF00069	0.541
MOD_PKA_2	269	275	PF00069	0.666
MOD_PKA_2	301	307	PF00069	0.603
MOD_PKA_2	57	63	PF00069	0.591
MOD_Plk_1	21	27	PF00069	0.501
MOD_Plk_1	3	9	PF00069	0.767
MOD_Plk_1	340	346	PF00069	0.374
MOD_Plk_1	380	386	PF00069	0.648
MOD_Plk_1	409	415	PF00069	0.558
MOD_Plk_4	21	27	PF00069	0.501
MOD_Plk_4	210	216	PF00069	0.686
MOD_Plk_4	3	9	PF00069	0.767
MOD_Plk_4	315	321	PF00069	0.485
MOD_Plk_4	340	346	PF00069	0.378
MOD_Plk_4	470	476	PF00069	0.562
MOD_ProDKin_1	34	40	PF00069	0.684
MOD_ProDKin_1	455	461	PF00069	0.638
MOD_SUMO_rev_2	134	141	PF00179	0.554
MOD_SUMO_rev_2	435	444	PF00179	0.701
TRG_DiLeu_BaEn_2	210	216	PF01217	0.686
TRG_DiLeu_BaEn_3	2	8	PF01217	0.727
TRG_DiLeu_BaEn_4	3	9	PF01217	0.726
TRG_ENDOCYTIC_2	485	488	PF00928	0.569
TRG_ER_diArg_1	405	407	PF00400	0.583
TRG_ER_diArg_1	516	518	PF00400	0.752
TRG_NLS_Bipartite_1	138	154	PF00514	0.523
TRG_NLS_MonoExtC_3	149	154	PF00514	0.451
TRG_NLS_MonoExtN_4	147	154	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAB7	Leptomonas seymouri	60%	100%
A0A3Q8IAL9	Leishmania donovani	99%	100%
A0A422N2J9	Trypanosoma rangeli	35%	100%
A4HC96	Leishmania braziliensis	76%	97%
C9ZRL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AVN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QBU6	Leishmania major	90%	99%
V5BLH2	Trypanosoma cruzi	34%	100%