Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4HZS7_LEIIN

TriTrypDb:

LINF_220010400

Length:

844

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZS7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004707	MAP kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.791
CLV_C14_Caspase3-7	427	431	PF00656	0.500
CLV_C14_Caspase3-7	760	764	PF00656	0.471
CLV_NRD_NRD_1	125	127	PF00675	0.652
CLV_NRD_NRD_1	52	54	PF00675	0.473
CLV_NRD_NRD_1	717	719	PF00675	0.355
CLV_PCSK_FUR_1	123	127	PF00082	0.617
CLV_PCSK_KEX2_1	125	127	PF00082	0.652
CLV_PCSK_KEX2_1	193	195	PF00082	0.363
CLV_PCSK_KEX2_1	52	54	PF00082	0.473
CLV_PCSK_KEX2_1	564	566	PF00082	0.305
CLV_PCSK_KEX2_1	717	719	PF00082	0.355
CLV_PCSK_KEX2_1	742	744	PF00082	0.296
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.363
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.305
CLV_PCSK_PC1ET2_1	742	744	PF00082	0.296
CLV_PCSK_SKI1_1	101	105	PF00082	0.479
CLV_PCSK_SKI1_1	11	15	PF00082	0.360
CLV_PCSK_SKI1_1	17	21	PF00082	0.412
CLV_PCSK_SKI1_1	41	45	PF00082	0.465
CLV_PCSK_SKI1_1	438	442	PF00082	0.296
CLV_PCSK_SKI1_1	462	466	PF00082	0.336
CLV_PCSK_SKI1_1	540	544	PF00082	0.322
CLV_PCSK_SKI1_1	645	649	PF00082	0.355
CLV_PCSK_SKI1_1	679	683	PF00082	0.243
CLV_PCSK_SKI1_1	717	721	PF00082	0.296
CLV_PCSK_SKI1_1	72	76	PF00082	0.483
CLV_PCSK_SKI1_1	742	746	PF00082	0.355
CLV_Separin_Metazoa	533	537	PF03568	0.296
DEG_APCC_DBOX_1	16	24	PF00400	0.421
DEG_SCF_FBW7_1	89	95	PF00400	0.448
DEG_SCF_FBW7_2	697	704	PF00400	0.355
DEG_SPOP_SBC_1	23	27	PF00917	0.439
DEG_SPOP_SBC_1	242	246	PF00917	0.580
DEG_SPOP_SBC_1	250	254	PF00917	0.604
DEG_SPOP_SBC_1	371	375	PF00917	0.738
DEG_SPOP_SBC_1	92	96	PF00917	0.440
DOC_CDC14_PxL_1	505	513	PF14671	0.296
DOC_CKS1_1	89	94	PF01111	0.451
DOC_CYCLIN_RxL_1	712	724	PF00134	0.296
DOC_CYCLIN_RxL_1	8	16	PF00134	0.358
DOC_MAPK_DCC_7	106	116	PF00069	0.457
DOC_MAPK_gen_1	120	130	PF00069	0.535
DOC_MAPK_gen_1	462	471	PF00069	0.296
DOC_MAPK_gen_1	504	513	PF00069	0.296
DOC_MAPK_gen_1	603	612	PF00069	0.355
DOC_MAPK_HePTP_8	501	513	PF00069	0.296
DOC_MAPK_MEF2A_6	504	513	PF00069	0.296
DOC_MAPK_MEF2A_6	606	614	PF00069	0.355
DOC_MAPK_RevD_3	112	126	PF00069	0.494
DOC_PP1_RVXF_1	439	446	PF00149	0.338
DOC_PP1_RVXF_1	447	454	PF00149	0.260
DOC_PP2B_LxvP_1	559	562	PF13499	0.355
DOC_PP2B_LxvP_1	796	799	PF13499	0.383
DOC_PP4_FxxP_1	104	107	PF00568	0.473
DOC_PP4_FxxP_1	109	112	PF00568	0.458
DOC_PP4_FxxP_1	21	24	PF00568	0.443
DOC_PP4_FxxP_1	682	685	PF00568	0.323
DOC_USP7_MATH_1	135	139	PF00917	0.632
DOC_USP7_MATH_1	154	158	PF00917	0.649
DOC_USP7_MATH_1	22	26	PF00917	0.442
DOC_USP7_MATH_1	240	244	PF00917	0.664
DOC_USP7_MATH_1	250	254	PF00917	0.575
DOC_USP7_MATH_1	776	780	PF00917	0.588
DOC_USP7_UBL2_3	189	193	PF12436	0.330
DOC_USP7_UBL2_3	82	86	PF12436	0.463
DOC_WW_Pin1_4	152	157	PF00397	0.569
DOC_WW_Pin1_4	24	29	PF00397	0.441
DOC_WW_Pin1_4	372	377	PF00397	0.772
DOC_WW_Pin1_4	378	383	PF00397	0.646
DOC_WW_Pin1_4	402	407	PF00397	0.760
DOC_WW_Pin1_4	656	661	PF00397	0.296
DOC_WW_Pin1_4	663	668	PF00397	0.296
DOC_WW_Pin1_4	697	702	PF00397	0.330
DOC_WW_Pin1_4	721	726	PF00397	0.296
DOC_WW_Pin1_4	77	82	PF00397	0.460
DOC_WW_Pin1_4	781	786	PF00397	0.638
DOC_WW_Pin1_4	88	93	PF00397	0.438
LIG_14-3-3_CanoR_1	125	131	PF00244	0.574
LIG_14-3-3_CanoR_1	136	143	PF00244	0.603
LIG_14-3-3_CanoR_1	147	156	PF00244	0.516
LIG_14-3-3_CanoR_1	241	248	PF00244	0.639
LIG_14-3-3_CanoR_1	33	37	PF00244	0.479
LIG_14-3-3_CanoR_1	544	552	PF00244	0.336
LIG_14-3-3_CanoR_1	586	591	PF00244	0.369
LIG_14-3-3_CanoR_1	70	75	PF00244	0.496
LIG_14-3-3_CanoR_1	743	750	PF00244	0.296
LIG_14-3-3_CanoR_1	816	824	PF00244	0.439
LIG_Actin_WH2_2	452	467	PF00022	0.296
LIG_Actin_WH2_2	523	538	PF00022	0.296
LIG_AP2alpha_1	755	759	PF02296	0.353
LIG_BRCT_BRCA1_1	15	19	PF00533	0.393
LIG_BRCT_BRCA1_1	243	247	PF00533	0.524
LIG_BRCT_BRCA1_1	300	304	PF00533	0.694
LIG_BRCT_BRCA1_1	95	99	PF00533	0.443
LIG_deltaCOP1_diTrp_1	523	527	PF00928	0.296
LIG_eIF4E_1	506	512	PF01652	0.296
LIG_FHA_1	111	117	PF00498	0.509
LIG_FHA_1	243	249	PF00498	0.616
LIG_FHA_1	473	479	PF00498	0.296
LIG_FHA_1	689	695	PF00498	0.355
LIG_FHA_1	724	730	PF00498	0.315
LIG_FHA_2	223	229	PF00498	0.791
LIG_FHA_2	254	260	PF00498	0.558
LIG_FHA_2	545	551	PF00498	0.296
LIG_FHA_2	691	697	PF00498	0.326
LIG_FHA_2	698	704	PF00498	0.321
LIG_FHA_2	722	728	PF00498	0.296
LIG_FHA_2	743	749	PF00498	0.355
LIG_FHA_2	810	816	PF00498	0.356
LIG_Integrin_isoDGR_2	800	802	PF01839	0.402
LIG_LIR_Apic_2	503	509	PF02991	0.296
LIG_LIR_Apic_2	680	685	PF02991	0.323
LIG_LIR_Gen_1	301	312	PF02991	0.515
LIG_LIR_Gen_1	430	440	PF02991	0.340
LIG_LIR_Gen_1	703	714	PF02991	0.296
LIG_LIR_Gen_1	73	81	PF02991	0.470
LIG_LIR_Gen_1	96	107	PF02991	0.471
LIG_LIR_Nem_3	16	21	PF02991	0.411
LIG_LIR_Nem_3	174	178	PF02991	0.396
LIG_LIR_Nem_3	276	281	PF02991	0.360
LIG_LIR_Nem_3	301	307	PF02991	0.568
LIG_LIR_Nem_3	430	435	PF02991	0.386
LIG_LIR_Nem_3	510	516	PF02991	0.296
LIG_LIR_Nem_3	526	530	PF02991	0.296
LIG_LIR_Nem_3	554	559	PF02991	0.357
LIG_LIR_Nem_3	700	705	PF02991	0.309
LIG_LIR_Nem_3	73	77	PF02991	0.484
LIG_LIR_Nem_3	85	90	PF02991	0.461
LIG_LIR_Nem_3	96	102	PF02991	0.456
LIG_MLH1_MIPbox_1	15	19	PF16413	0.393
LIG_Pex14_1	716	720	PF04695	0.296
LIG_Pex14_2	105	109	PF04695	0.473
LIG_Pex14_2	755	759	PF04695	0.353
LIG_REV1ctd_RIR_1	102	106	PF16727	0.452
LIG_SH2_CRK	164	168	PF00017	0.441
LIG_SH2_CRK	706	710	PF00017	0.296
LIG_SH2_NCK_1	281	285	PF00017	0.464
LIG_SH2_NCK_1	819	823	PF00017	0.441
LIG_SH2_STAP1	197	201	PF00017	0.486
LIG_SH2_STAP1	819	823	PF00017	0.382
LIG_SH2_STAT5	169	172	PF00017	0.401
LIG_SH2_STAT5	278	281	PF00017	0.357
LIG_SH2_STAT5	342	345	PF00017	0.329
LIG_SH2_STAT5	349	352	PF00017	0.331
LIG_SH2_STAT5	356	359	PF00017	0.399
LIG_SH2_STAT5	361	364	PF00017	0.436
LIG_SH2_STAT5	500	503	PF00017	0.321
LIG_SH2_STAT5	819	822	PF00017	0.393
LIG_SH2_STAT5	87	90	PF00017	0.490
LIG_SH3_1	86	92	PF00018	0.455
LIG_SH3_2	28	33	PF14604	0.464
LIG_SH3_3	104	110	PF00018	0.412
LIG_SH3_3	211	217	PF00018	0.643
LIG_SH3_3	25	31	PF00018	0.449
LIG_SH3_3	330	336	PF00018	0.547
LIG_SH3_3	400	406	PF00018	0.669
LIG_SH3_3	45	51	PF00018	0.432
LIG_SH3_3	747	753	PF00018	0.355
LIG_SH3_3	86	92	PF00018	0.455
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.385
LIG_SUMO_SIM_anti_2	726	734	PF11976	0.299
LIG_SUMO_SIM_par_1	126	131	PF11976	0.541
LIG_SUMO_SIM_par_1	176	183	PF11976	0.353
LIG_SUMO_SIM_par_1	270	276	PF11976	0.344
LIG_TRAF2_1	492	495	PF00917	0.355
LIG_TRAF2_1	618	621	PF00917	0.323
LIG_TRAF2_1	701	704	PF00917	0.355
LIG_UBA3_1	555	564	PF00899	0.296
LIG_WRC_WIRS_1	524	529	PF05994	0.296
LIG_WRC_WIRS_1	71	76	PF05994	0.483
MOD_CDK_SPK_2	402	407	PF00069	0.666
MOD_CDK_SPK_2	77	82	PF00069	0.457
MOD_CK1_1	118	124	PF00069	0.669
MOD_CK1_1	131	137	PF00069	0.708
MOD_CK1_1	138	144	PF00069	0.579
MOD_CK1_1	157	163	PF00069	0.722
MOD_CK1_1	243	249	PF00069	0.610
MOD_CK1_1	251	257	PF00069	0.531
MOD_CK1_1	306	312	PF00069	0.530
MOD_CK1_1	32	38	PF00069	0.475
MOD_CK1_1	320	326	PF00069	0.603
MOD_CK1_1	374	380	PF00069	0.606
MOD_CK1_1	416	422	PF00069	0.637
MOD_CK1_1	589	595	PF00069	0.243
MOD_CK1_1	59	65	PF00069	0.518
MOD_CK1_1	654	660	PF00069	0.385
MOD_CK1_1	666	672	PF00069	0.226
MOD_CK1_1	779	785	PF00069	0.612
MOD_CK1_1	94	100	PF00069	0.443
MOD_CK2_1	560	566	PF00069	0.296
MOD_CK2_1	697	703	PF00069	0.355
MOD_CK2_1	721	727	PF00069	0.296
MOD_CK2_1	742	748	PF00069	0.355
MOD_CK2_1	781	787	PF00069	0.584
MOD_CK2_1	809	815	PF00069	0.349
MOD_GlcNHglycan	133	136	PF01048	0.669
MOD_GlcNHglycan	137	140	PF01048	0.603
MOD_GlcNHglycan	248	251	PF01048	0.651
MOD_GlcNHglycan	300	303	PF01048	0.693
MOD_GlcNHglycan	319	322	PF01048	0.596
MOD_GlcNHglycan	333	336	PF01048	0.554
MOD_GlcNHglycan	390	393	PF01048	0.709
MOD_GlcNHglycan	426	429	PF01048	0.637
MOD_GlcNHglycan	484	487	PF01048	0.296
MOD_GlcNHglycan	537	540	PF01048	0.316
MOD_GlcNHglycan	58	61	PF01048	0.489
MOD_GlcNHglycan	595	598	PF01048	0.469
MOD_GlcNHglycan	656	659	PF01048	0.296
MOD_GlcNHglycan	682	685	PF01048	0.355
MOD_GlcNHglycan	759	762	PF01048	0.497
MOD_GlcNHglycan	778	781	PF01048	0.482
MOD_GlcNHglycan	792	795	PF01048	0.404
MOD_GSK3_1	131	138	PF00069	0.712
MOD_GSK3_1	148	155	PF00069	0.649
MOD_GSK3_1	222	229	PF00069	0.806
MOD_GSK3_1	242	249	PF00069	0.532
MOD_GSK3_1	32	39	PF00069	0.472
MOD_GSK3_1	320	327	PF00069	0.654
MOD_GSK3_1	366	373	PF00069	0.444
MOD_GSK3_1	374	381	PF00069	0.563
MOD_GSK3_1	415	422	PF00069	0.673
MOD_GSK3_1	496	503	PF00069	0.296
MOD_GSK3_1	52	59	PF00069	0.477
MOD_GSK3_1	589	596	PF00069	0.243
MOD_GSK3_1	650	657	PF00069	0.325
MOD_GSK3_1	663	670	PF00069	0.244
MOD_GSK3_1	680	687	PF00069	0.213
MOD_GSK3_1	772	779	PF00069	0.619
MOD_GSK3_1	88	95	PF00069	0.456
MOD_N-GLC_1	413	418	PF02516	0.650
MOD_N-GLC_1	496	501	PF02516	0.296
MOD_NEK2_1	128	133	PF00069	0.657
MOD_NEK2_1	13	18	PF00069	0.365
MOD_NEK2_1	145	150	PF00069	0.555
MOD_NEK2_1	248	253	PF00069	0.699
MOD_NEK2_1	345	350	PF00069	0.437
MOD_NEK2_1	370	375	PF00069	0.643
MOD_NEK2_1	535	540	PF00069	0.301
MOD_NEK2_1	578	583	PF00069	0.296
MOD_NEK2_1	731	736	PF00069	0.355
MOD_NEK2_1	93	98	PF00069	0.450
MOD_NMyristoyl	1	7	PF02799	0.381
MOD_PIKK_1	154	160	PF00454	0.636
MOD_PIKK_1	36	42	PF00454	0.463
MOD_PIKK_1	651	657	PF00454	0.355
MOD_PK_1	126	132	PF00069	0.544
MOD_PKA_1	52	58	PF00069	0.478
MOD_PKA_1	742	748	PF00069	0.296
MOD_PKA_2	131	137	PF00069	0.657
MOD_PKA_2	171	177	PF00069	0.412
MOD_PKA_2	240	246	PF00069	0.635
MOD_PKA_2	32	38	PF00069	0.475
MOD_PKA_2	419	425	PF00069	0.618
MOD_PKA_2	52	58	PF00069	0.447
MOD_PKA_2	535	541	PF00069	0.296
MOD_PKA_2	742	748	PF00069	0.296
MOD_PKA_2	770	776	PF00069	0.508
MOD_PKB_1	70	78	PF00069	0.480
MOD_Plk_1	118	124	PF00069	0.530
MOD_Plk_1	230	236	PF00069	0.574
MOD_Plk_1	496	502	PF00069	0.296
MOD_Plk_4	208	214	PF00069	0.415
MOD_Plk_4	222	228	PF00069	0.710
MOD_Plk_4	243	249	PF00069	0.640
MOD_Plk_4	345	351	PF00069	0.323
MOD_Plk_4	366	372	PF00069	0.378
MOD_Plk_4	496	502	PF00069	0.296
MOD_Plk_4	731	737	PF00069	0.427
MOD_Plk_4	804	810	PF00069	0.462
MOD_ProDKin_1	152	158	PF00069	0.566
MOD_ProDKin_1	24	30	PF00069	0.443
MOD_ProDKin_1	372	378	PF00069	0.770
MOD_ProDKin_1	402	408	PF00069	0.760
MOD_ProDKin_1	656	662	PF00069	0.296
MOD_ProDKin_1	663	669	PF00069	0.296
MOD_ProDKin_1	697	703	PF00069	0.330
MOD_ProDKin_1	721	727	PF00069	0.296
MOD_ProDKin_1	77	83	PF00069	0.461
MOD_ProDKin_1	781	787	PF00069	0.636
MOD_ProDKin_1	88	94	PF00069	0.436
MOD_SUMO_rev_2	674	681	PF00179	0.333
TRG_DiLeu_BaEn_1	727	732	PF01217	0.296
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.359
TRG_ENDOCYTIC_2	164	167	PF00928	0.443
TRG_ENDOCYTIC_2	342	345	PF00928	0.364
TRG_ENDOCYTIC_2	349	352	PF00928	0.404
TRG_ENDOCYTIC_2	361	364	PF00928	0.436
TRG_ENDOCYTIC_2	705	708	PF00928	0.296
TRG_ENDOCYTIC_2	87	90	PF00928	0.471
TRG_ER_diArg_1	122	125	PF00400	0.639
TRG_ER_diArg_1	44	47	PF00400	0.469
TRG_ER_diArg_1	51	53	PF00400	0.459
TRG_ER_diArg_1	579	582	PF00400	0.355
TRG_ER_diArg_1	716	718	PF00400	0.355
TRG_Pf-PMV_PEXEL_1	816	821	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU16	Leptomonas seymouri	51%	100%
A0A3Q8IC49	Leishmania donovani	99%	100%
E9AVN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBU7	Leishmania major	93%	100%