Dynamin_N domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase/Dynamin family - putative

Species:

Leishmania infantum

UniProt:

A4HZS6_LEIIN

TriTrypDb:

LINF_220010300

Length:

444

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	8
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HZS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZS6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	275	281	PF00089	0.313
CLV_MEL_PAP_1	422	428	PF00089	0.295
CLV_NRD_NRD_1	257	259	PF00675	0.335
CLV_NRD_NRD_1	424	426	PF00675	0.420
CLV_PCSK_KEX2_1	257	259	PF00082	0.335
CLV_PCSK_KEX2_1	40	42	PF00082	0.334
CLV_PCSK_KEX2_1	423	425	PF00082	0.410
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.334
CLV_PCSK_SKI1_1	159	163	PF00082	0.268
CLV_PCSK_SKI1_1	167	171	PF00082	0.234
CLV_PCSK_SKI1_1	197	201	PF00082	0.348
CLV_PCSK_SKI1_1	271	275	PF00082	0.279
CLV_PCSK_SKI1_1	290	294	PF00082	0.230
CLV_PCSK_SKI1_1	359	363	PF00082	0.460
CLV_Separin_Metazoa	381	385	PF03568	0.598
DEG_APCC_DBOX_1	378	386	PF00400	0.511
DEG_SPOP_SBC_1	207	211	PF00917	0.521
DEG_SPOP_SBC_1	230	234	PF00917	0.652
DOC_CKS1_1	101	106	PF01111	0.436
DOC_CKS1_1	95	100	PF01111	0.441
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.411
DOC_MAPK_gen_1	364	372	PF00069	0.586
DOC_MAPK_gen_1	376	385	PF00069	0.577
DOC_MAPK_JIP1_4	379	385	PF00069	0.535
DOC_USP7_MATH_1	132	136	PF00917	0.497
DOC_USP7_MATH_1	230	234	PF00917	0.635
DOC_USP7_MATH_1	311	315	PF00917	0.613
DOC_USP7_MATH_1	324	328	PF00917	0.209
DOC_USP7_MATH_1	329	333	PF00917	0.154
DOC_USP7_MATH_1	386	390	PF00917	0.551
DOC_USP7_MATH_1	399	403	PF00917	0.466
DOC_USP7_MATH_1	83	87	PF00917	0.454
DOC_USP7_UBL2_3	364	368	PF12436	0.601
DOC_WW_Pin1_4	100	105	PF00397	0.441
DOC_WW_Pin1_4	209	214	PF00397	0.547
DOC_WW_Pin1_4	226	231	PF00397	0.690
DOC_WW_Pin1_4	94	99	PF00397	0.437
LIG_14-3-3_CanoR_1	206	214	PF00244	0.505
LIG_14-3-3_CanoR_1	348	357	PF00244	0.569
LIG_14-3-3_CanoR_1	373	379	PF00244	0.620
LIG_14-3-3_CanoR_1	423	433	PF00244	0.582
LIG_BIR_III_4	47	51	PF00653	0.475
LIG_Clathr_ClatBox_1	139	143	PF01394	0.441
LIG_CtBP_PxDLS_1	89	93	PF00389	0.534
LIG_FHA_1	151	157	PF00498	0.430
LIG_FHA_1	230	236	PF00498	0.672
LIG_FHA_1	316	322	PF00498	0.285
LIG_FHA_1	365	371	PF00498	0.576
LIG_FHA_1	83	89	PF00498	0.432
LIG_FHA_2	147	153	PF00498	0.430
LIG_FHA_2	160	166	PF00498	0.436
LIG_FHA_2	262	268	PF00498	0.502
LIG_LIR_Gen_1	119	127	PF02991	0.464
LIG_LIR_Gen_1	176	185	PF02991	0.545
LIG_LIR_Gen_1	33	44	PF02991	0.426
LIG_LIR_Nem_3	119	125	PF02991	0.464
LIG_LIR_Nem_3	165	171	PF02991	0.454
LIG_LIR_Nem_3	176	181	PF02991	0.531
LIG_LIR_Nem_3	33	39	PF02991	0.430
LIG_Pex14_2	67	71	PF04695	0.432
LIG_PTB_Apo_2	53	60	PF02174	0.534
LIG_PTB_Phospho_1	53	59	PF10480	0.534
LIG_Rb_pABgroove_1	136	144	PF01858	0.472
LIG_REV1ctd_RIR_1	431	441	PF16727	0.578
LIG_SH2_CRK	122	126	PF00017	0.441
LIG_SH2_CRK	188	192	PF00017	0.476
LIG_SH2_CRK	295	299	PF00017	0.410
LIG_SH2_CRK	61	65	PF00017	0.534
LIG_SH2_STAP1	122	126	PF00017	0.441
LIG_SH2_STAP1	164	168	PF00017	0.475
LIG_SH2_STAP1	44	48	PF00017	0.445
LIG_SH2_STAT3	59	62	PF00017	0.441
LIG_SH2_STAT5	18	21	PF00017	0.454
LIG_SH2_STAT5	208	211	PF00017	0.509
LIG_SH2_STAT5	295	298	PF00017	0.334
LIG_SH2_STAT5	413	416	PF00017	0.502
LIG_SH3_3	141	147	PF00018	0.449
LIG_SH3_3	51	57	PF00018	0.454
LIG_SH3_3	92	98	PF00018	0.441
LIG_SUMO_SIM_anti_2	135	143	PF11976	0.436
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.419
LIG_SUMO_SIM_par_1	152	158	PF11976	0.461
LIG_SUMO_SIM_par_1	320	327	PF11976	0.352
LIG_SUMO_SIM_par_1	91	97	PF11976	0.534
MOD_CDK_SPxK_1	209	215	PF00069	0.553
MOD_CDK_SPxxK_3	209	216	PF00069	0.562
MOD_CK1_1	10	16	PF00069	0.586
MOD_CK1_1	313	319	PF00069	0.373
MOD_CK1_1	52	58	PF00069	0.497
MOD_CK1_1	70	76	PF00069	0.497
MOD_CK2_1	105	111	PF00069	0.451
MOD_CK2_1	146	152	PF00069	0.442
MOD_CK2_1	159	165	PF00069	0.499
MOD_CK2_1	17	23	PF00069	0.543
MOD_CK2_1	261	267	PF00069	0.500
MOD_GlcNHglycan	108	111	PF01048	0.339
MOD_GlcNHglycan	114	117	PF01048	0.320
MOD_GlcNHglycan	19	22	PF01048	0.244
MOD_GlcNHglycan	219	223	PF01048	0.539
MOD_GlcNHglycan	267	271	PF01048	0.421
MOD_GlcNHglycan	331	334	PF01048	0.336
MOD_GlcNHglycan	394	397	PF01048	0.363
MOD_GlcNHglycan	403	406	PF01048	0.345
MOD_GlcNHglycan	9	12	PF01048	0.243
MOD_GSK3_1	112	119	PF00069	0.564
MOD_GSK3_1	146	153	PF00069	0.430
MOD_GSK3_1	155	162	PF00069	0.447
MOD_GSK3_1	225	232	PF00069	0.667
MOD_GSK3_1	311	318	PF00069	0.491
MOD_GSK3_1	360	367	PF00069	0.650
MOD_GSK3_1	6	13	PF00069	0.429
MOD_LATS_1	390	396	PF00433	0.504
MOD_LATS_1	74	80	PF00433	0.534
MOD_N-GLC_1	193	198	PF02516	0.302
MOD_N-GLC_1	6	11	PF02516	0.265
MOD_NEK2_1	125	130	PF00069	0.430
MOD_NEK2_1	157	162	PF00069	0.445
MOD_NEK2_1	360	365	PF00069	0.635
MOD_NEK2_1	67	72	PF00069	0.553
MOD_NEK2_2	374	379	PF00069	0.560
MOD_PIKK_1	83	89	PF00454	0.474
MOD_PKA_1	40	46	PF00069	0.526
MOD_PKA_1	424	430	PF00069	0.525
MOD_PKA_2	277	283	PF00069	0.603
MOD_PKA_2	40	46	PF00069	0.484
MOD_PKA_2	424	430	PF00069	0.550
MOD_Plk_4	11	17	PF00069	0.486
MOD_Plk_4	317	323	PF00069	0.359
MOD_Plk_4	49	55	PF00069	0.534
MOD_ProDKin_1	209	215	PF00069	0.558
MOD_ProDKin_1	226	232	PF00069	0.688
MOD_ProDKin_1	94	100	PF00069	0.437
MOD_SUMO_rev_2	160	169	PF00179	0.430
TRG_DiLeu_BaEn_2	164	170	PF01217	0.475
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.501
TRG_ENDOCYTIC_2	122	125	PF00928	0.430
TRG_ENDOCYTIC_2	188	191	PF00928	0.477
TRG_ENDOCYTIC_2	295	298	PF00928	0.376
TRG_ENDOCYTIC_2	61	64	PF00928	0.534
TRG_ER_diArg_1	256	258	PF00400	0.555
TRG_ER_diArg_1	287	290	PF00400	0.534
TRG_ER_diArg_1	422	425	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0N6	Leptomonas seymouri	69%	70%
A0A0S4IRJ8	Bodo saltans	51%	86%
A0A1X0NTG9	Trypanosomatidae	49%	70%
A0A3R7N865	Trypanosoma rangeli	48%	73%
A0A3S7WX57	Leishmania donovani	100%	100%
A4HC94	Leishmania braziliensis	89%	100%
C9ZRK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	74%
E9AVN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QBU8	Leishmania major	96%	100%
V5DMH3	Trypanosoma cruzi	55%	88%