LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Putative tRNA binding domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HZS5_LEIIN
TriTrypDb:
LINF_220010200
Length:
415

Annotations

Annotations by Jardim et al.

tRNA synthetase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 3
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HZS5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZS5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000049 tRNA binding 5 11
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0005488 binding 1 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003824 catalytic activity 1 3
GO:0004812 aminoacyl-tRNA ligase activity 4 3
GO:0016874 ligase activity 2 3
GO:0016875 ligase activity, forming carbon-oxygen bonds 3 3
GO:0140098 catalytic activity, acting on RNA 3 3
GO:0140101 catalytic activity, acting on a tRNA 4 3
GO:0140640 catalytic activity, acting on a nucleic acid 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 248 252 PF00656 0.565
CLV_C14_Caspase3-7 383 387 PF00656 0.540
CLV_MEL_PAP_1 255 261 PF00089 0.385
CLV_NRD_NRD_1 211 213 PF00675 0.581
CLV_NRD_NRD_1 266 268 PF00675 0.384
CLV_NRD_NRD_1 58 60 PF00675 0.608
CLV_PCSK_KEX2_1 210 212 PF00082 0.583
CLV_PCSK_KEX2_1 266 268 PF00082 0.363
CLV_PCSK_KEX2_1 330 332 PF00082 0.380
CLV_PCSK_KEX2_1 58 60 PF00082 0.639
CLV_PCSK_PC1ET2_1 330 332 PF00082 0.380
CLV_PCSK_SKI1_1 243 247 PF00082 0.810
CLV_PCSK_SKI1_1 349 353 PF00082 0.448
CLV_PCSK_SKI1_1 67 71 PF00082 0.551
CLV_Separin_Metazoa 207 211 PF03568 0.592
DEG_Nend_UBRbox_3 1 3 PF02207 0.522
DOC_ANK_TNKS_1 38 45 PF00023 0.492
DOC_MAPK_gen_1 313 320 PF00069 0.606
DOC_MAPK_gen_1 330 337 PF00069 0.508
DOC_MAPK_RevD_3 196 212 PF00069 0.639
DOC_PP1_RVXF_1 347 353 PF00149 0.567
DOC_PP2B_LxvP_1 23 26 PF13499 0.562
DOC_USP7_MATH_1 101 105 PF00917 0.599
DOC_USP7_MATH_1 173 177 PF00917 0.595
DOC_USP7_MATH_1 18 22 PF00917 0.557
DOC_USP7_MATH_1 196 200 PF00917 0.696
DOC_USP7_MATH_1 229 233 PF00917 0.624
DOC_USP7_UBL2_3 215 219 PF12436 0.568
DOC_USP7_UBL2_3 243 247 PF12436 0.758
DOC_WW_Pin1_4 231 236 PF00397 0.737
DOC_WW_Pin1_4 60 65 PF00397 0.616
LIG_14-3-3_CanoR_1 133 137 PF00244 0.476
LIG_14-3-3_CanoR_1 39 43 PF00244 0.559
LIG_14-3-3_CanoR_1 58 64 PF00244 0.464
LIG_Actin_WH2_2 43 60 PF00022 0.553
LIG_FHA_1 150 156 PF00498 0.569
LIG_FHA_1 283 289 PF00498 0.559
LIG_FHA_1 302 308 PF00498 0.563
LIG_FHA_1 373 379 PF00498 0.475
LIG_FHA_2 127 133 PF00498 0.517
LIG_FHA_2 192 198 PF00498 0.659
LIG_FHA_2 246 252 PF00498 0.638
LIG_FHA_2 381 387 PF00498 0.478
LIG_KLC1_Yacidic_2 272 277 PF13176 0.563
LIG_LIR_Apic_2 168 173 PF02991 0.498
LIG_LIR_Apic_2 197 203 PF02991 0.765
LIG_LIR_LC3C_4 304 309 PF02991 0.612
LIG_LIR_Nem_3 46 50 PF02991 0.573
LIG_PCNA_PIPBox_1 374 383 PF02747 0.499
LIG_SH2_NCK_1 110 114 PF00017 0.600
LIG_SH2_NCK_1 142 146 PF00017 0.538
LIG_SH2_PTP2 200 203 PF00017 0.735
LIG_SH2_STAP1 142 146 PF00017 0.538
LIG_SH2_STAP1 356 360 PF00017 0.602
LIG_SH2_STAT5 127 130 PF00017 0.574
LIG_SH2_STAT5 170 173 PF00017 0.500
LIG_SH2_STAT5 200 203 PF00017 0.735
LIG_SH2_STAT5 275 278 PF00017 0.525
LIG_SH2_STAT5 296 299 PF00017 0.558
LIG_SH3_3 95 101 PF00018 0.587
LIG_SUMO_SIM_anti_2 72 81 PF11976 0.598
LIG_TRAF2_1 203 206 PF00917 0.600
MOD_CAAXbox 412 415 PF01239 0.560
MOD_CDK_SPxxK_3 231 238 PF00069 0.763
MOD_CDK_SPxxK_3 60 67 PF00069 0.614
MOD_CK1_1 149 155 PF00069 0.622
MOD_CK1_1 21 27 PF00069 0.534
MOD_CK2_1 108 114 PF00069 0.618
MOD_CK2_1 126 132 PF00069 0.340
MOD_CK2_1 191 197 PF00069 0.845
MOD_CK2_1 201 207 PF00069 0.542
MOD_Cter_Amidation 241 244 PF01082 0.821
MOD_GlcNHglycan 148 151 PF01048 0.522
MOD_GlcNHglycan 176 179 PF01048 0.568
MOD_GlcNHglycan 185 188 PF01048 0.730
MOD_GlcNHglycan 231 234 PF01048 0.724
MOD_GlcNHglycan 235 238 PF01048 0.776
MOD_GlcNHglycan 289 292 PF01048 0.332
MOD_GlcNHglycan 369 372 PF01048 0.474
MOD_GlcNHglycan 399 402 PF01048 0.649
MOD_GSK3_1 118 125 PF00069 0.624
MOD_GSK3_1 128 135 PF00069 0.449
MOD_GSK3_1 174 181 PF00069 0.571
MOD_GSK3_1 229 236 PF00069 0.753
MOD_GSK3_1 245 252 PF00069 0.580
MOD_GSK3_1 372 379 PF00069 0.556
MOD_N-GLC_1 146 151 PF02516 0.554
MOD_N-GLC_1 183 188 PF02516 0.656
MOD_N-GLC_1 5 10 PF02516 0.505
MOD_NEK2_1 117 122 PF00069 0.562
MOD_NEK2_1 146 151 PF00069 0.553
MOD_NEK2_1 250 255 PF00069 0.603
MOD_NEK2_1 301 306 PF00069 0.537
MOD_NEK2_1 318 323 PF00069 0.575
MOD_NEK2_1 57 62 PF00069 0.525
MOD_PIKK_1 245 251 PF00454 0.542
MOD_PIKK_1 301 307 PF00454 0.636
MOD_PIKK_1 319 325 PF00454 0.612
MOD_PKA_1 243 249 PF00069 0.735
MOD_PKA_2 132 138 PF00069 0.468
MOD_PKA_2 174 180 PF00069 0.558
MOD_PKA_2 38 44 PF00069 0.590
MOD_PKA_2 57 63 PF00069 0.298
MOD_Plk_1 196 202 PF00069 0.674
MOD_Plk_1 250 256 PF00069 0.579
MOD_Plk_1 5 11 PF00069 0.500
MOD_Plk_2-3 132 138 PF00069 0.593
MOD_Plk_4 18 24 PF00069 0.473
MOD_Plk_4 196 202 PF00069 0.784
MOD_Plk_4 313 319 PF00069 0.552
MOD_Plk_4 6 12 PF00069 0.528
MOD_Plk_4 75 81 PF00069 0.598
MOD_ProDKin_1 231 237 PF00069 0.739
MOD_ProDKin_1 60 66 PF00069 0.611
MOD_SUMO_for_1 218 221 PF00179 0.671
MOD_SUMO_rev_2 236 245 PF00179 0.819
MOD_SUMO_rev_2 332 338 PF00179 0.580
TRG_DiLeu_BaEn_1 75 80 PF01217 0.582
TRG_DiLeu_BaEn_2 64 70 PF01217 0.605
TRG_ENDOCYTIC_2 110 113 PF00928 0.570
TRG_ER_diArg_1 209 212 PF00400 0.581
TRG_ER_diArg_1 265 267 PF00400 0.584
TRG_ER_diArg_1 57 59 PF00400 0.617

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P301 Leptomonas seymouri 66% 98%
A0A0S4IJF4 Bodo saltans 39% 99%
A0A1X0NUW2 Trypanosomatidae 45% 100%
A0A3R7KNR3 Trypanosoma rangeli 44% 100%
A0A3S7WX09 Leishmania donovani 100% 100%
A4HC93 Leishmania braziliensis 77% 100%
C9ZRK5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 98%
E9AVN0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4QBU9 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS