Uncharacterized protein

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) family - putative

Species:

Leishmania infantum

UniProt:

A4HZS3_LEIIN

TriTrypDb:

LINF_220010000

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031248	protein acetyltransferase complex	3	1
GO:0031414	N-terminal protein acetyltransferase complex	4	1
GO:0031417	NatC complex	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HZS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZS3

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	10
GO:0006474	N-terminal protein amino acid acetylation	5	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0017196	N-terminal peptidyl-methionine acetylation	6	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018206	peptidyl-methionine modification	6	10
GO:0019538	protein metabolic process	3	10
GO:0031365	N-terminal protein amino acid modification	5	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043543	protein acylation	5	10
GO:0044238	primary metabolic process	2	10
GO:0051604	protein maturation	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004596	peptide alpha-N-acetyltransferase activity	8	10
GO:0008080	N-acetyltransferase activity	6	10
GO:0016407	acetyltransferase activity	5	10
GO:0016410	N-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0034212	peptide N-acetyltransferase activity	7	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.284
CLV_C14_Caspase3-7	258	262	PF00656	0.341
CLV_NRD_NRD_1	180	182	PF00675	0.271
CLV_PCSK_KEX2_1	8	10	PF00082	0.700
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.700
CLV_PCSK_SKI1_1	68	72	PF00082	0.423
CLV_Separin_Metazoa	216	220	PF03568	0.344
DOC_CKS1_1	228	233	PF01111	0.271
DOC_MAPK_gen_1	178	188	PF00069	0.383
DOC_MAPK_gen_1	219	228	PF00069	0.271
DOC_MAPK_MEF2A_6	209	217	PF00069	0.264
DOC_MAPK_MEF2A_6	236	244	PF00069	0.271
DOC_PP4_FxxP_1	145	148	PF00568	0.316
DOC_USP7_MATH_1	134	138	PF00917	0.354
DOC_USP7_MATH_1	163	167	PF00917	0.264
DOC_USP7_MATH_1	174	178	PF00917	0.255
DOC_USP7_UBL2_3	266	270	PF12436	0.411
DOC_USP7_UBL2_3	38	42	PF12436	0.503
DOC_USP7_UBL2_3	4	8	PF12436	0.592
DOC_WW_Pin1_4	159	164	PF00397	0.333
DOC_WW_Pin1_4	227	232	PF00397	0.271
LIG_14-3-3_CanoR_1	209	214	PF00244	0.318
LIG_BIR_III_2	271	275	PF00653	0.575
LIG_FHA_1	126	132	PF00498	0.366
LIG_FHA_1	212	218	PF00498	0.278
LIG_FHA_1	230	236	PF00498	0.280
LIG_FHA_1	247	253	PF00498	0.268
LIG_FHA_1	281	287	PF00498	0.557
LIG_FHA_2	159	165	PF00498	0.295
LIG_FHA_2	91	97	PF00498	0.481
LIG_KLC1_Yacidic_2	224	229	PF13176	0.271
LIG_LIR_Gen_1	132	143	PF02991	0.337
LIG_LIR_Gen_1	82	92	PF02991	0.453
LIG_LIR_Gen_1	96	107	PF02991	0.440
LIG_LIR_Nem_3	132	138	PF02991	0.359
LIG_LIR_Nem_3	139	145	PF02991	0.308
LIG_LIR_Nem_3	82	88	PF02991	0.485
LIG_LIR_Nem_3	96	102	PF02991	0.442
LIG_PDZ_Class_3	284	289	PF00595	0.647
LIG_Pex14_2	143	147	PF04695	0.306
LIG_PTB_Apo_2	240	247	PF02174	0.314
LIG_SH2_GRB2like	241	244	PF00017	0.314
LIG_SH2_GRB2like	85	88	PF00017	0.457
LIG_SH2_PTP2	85	88	PF00017	0.481
LIG_SH2_SRC	256	259	PF00017	0.401
LIG_SH2_SRC	85	88	PF00017	0.457
LIG_SH2_STAT5	107	110	PF00017	0.305
LIG_SH2_STAT5	142	145	PF00017	0.307
LIG_SH2_STAT5	191	194	PF00017	0.255
LIG_SH2_STAT5	227	230	PF00017	0.271
LIG_SH2_STAT5	241	244	PF00017	0.271
LIG_SH2_STAT5	251	254	PF00017	0.354
LIG_SH2_STAT5	256	259	PF00017	0.358
LIG_SH2_STAT5	61	64	PF00017	0.577
LIG_SH2_STAT5	85	88	PF00017	0.457
LIG_SH3_3	83	89	PF00018	0.482
LIG_SUMO_SIM_anti_2	214	220	PF11976	0.290
LIG_SUMO_SIM_par_1	208	214	PF11976	0.265
LIG_TRAF2_1	79	82	PF00917	0.651
LIG_TRAF2_1	93	96	PF00917	0.533
LIG_WRC_WIRS_1	135	140	PF05994	0.334
MOD_CK1_1	136	142	PF00069	0.323
MOD_CK1_1	159	165	PF00069	0.333
MOD_CK1_1	177	183	PF00069	0.290
MOD_CK2_1	113	119	PF00069	0.435
MOD_CK2_1	273	279	PF00069	0.524
MOD_CK2_1	90	96	PF00069	0.475
MOD_GSK3_1	125	132	PF00069	0.355
MOD_GSK3_1	158	165	PF00069	0.242
MOD_GSK3_1	205	212	PF00069	0.328
MOD_GSK3_1	273	280	PF00069	0.587
MOD_NEK2_1	150	155	PF00069	0.398
MOD_NEK2_1	246	251	PF00069	0.338
MOD_PIKK_1	40	46	PF00454	0.591
MOD_PKA_1	37	43	PF00069	0.519
MOD_PKA_2	177	183	PF00069	0.290
MOD_Plk_1	163	169	PF00069	0.260
MOD_Plk_1	21	27	PF00069	0.480
MOD_Plk_1	49	55	PF00069	0.608
MOD_Plk_2-3	21	27	PF00069	0.455
MOD_Plk_4	163	169	PF00069	0.402
MOD_ProDKin_1	159	165	PF00069	0.333
MOD_ProDKin_1	227	233	PF00069	0.271
MOD_SUMO_rev_2	43	53	PF00179	0.546
TRG_ENDOCYTIC_2	110	113	PF00928	0.335
TRG_ENDOCYTIC_2	135	138	PF00928	0.345
TRG_ENDOCYTIC_2	140	143	PF00928	0.304
TRG_ENDOCYTIC_2	191	194	PF00928	0.271
TRG_ENDOCYTIC_2	241	244	PF00928	0.271
TRG_ENDOCYTIC_2	85	88	PF00928	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R0	Leptomonas seymouri	77%	100%
A0A1X0NT56	Trypanosomatidae	62%	99%
A0A3S7WWZ5	Leishmania donovani	100%	100%
A0A422MXL6	Trypanosoma rangeli	60%	97%
C9ZRK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	94%
E9AVM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QBV1	Leishmania major	97%	100%
V5CKM9	Trypanosoma cruzi	60%	96%