EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZR5_LEIIN

TriTrypDb:

LINF_220008700

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZR5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.591
CLV_C14_Caspase3-7	256	260	PF00656	0.487
CLV_C14_Caspase3-7	6	10	PF00656	0.344
CLV_PCSK_KEX2_1	71	73	PF00082	0.495
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.429
CLV_PCSK_SKI1_1	188	192	PF00082	0.447
CLV_PCSK_SKI1_1	40	44	PF00082	0.406
CLV_PCSK_SKI1_1	71	75	PF00082	0.408
DEG_APCC_DBOX_1	39	47	PF00400	0.399
DEG_Nend_UBRbox_1	1	4	PF02207	0.563
DEG_SPOP_SBC_1	154	158	PF00917	0.535
DOC_CKS1_1	160	165	PF01111	0.617
DOC_CYCLIN_RxL_1	37	45	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.392
DOC_PP1_RVXF_1	186	192	PF00149	0.431
DOC_PP1_RVXF_1	225	231	PF00149	0.409
DOC_PP2B_LxvP_1	81	84	PF13499	0.430
DOC_PP4_FxxP_1	47	50	PF00568	0.394
DOC_USP7_MATH_1	154	158	PF00917	0.560
DOC_USP7_MATH_1	167	171	PF00917	0.575
DOC_USP7_MATH_1	48	52	PF00917	0.473
DOC_USP7_MATH_1	73	77	PF00917	0.394
DOC_USP7_MATH_1	95	99	PF00917	0.617
DOC_WW_Pin1_4	159	164	PF00397	0.712
DOC_WW_Pin1_4	206	211	PF00397	0.518
DOC_WW_Pin1_4	46	51	PF00397	0.357
LIG_14-3-3_CanoR_1	153	163	PF00244	0.640
LIG_BIR_III_4	166	170	PF00653	0.571
LIG_CSL_BTD_1	81	84	PF09270	0.442
LIG_CtBP_PxDLS_1	85	89	PF00389	0.478
LIG_FHA_1	143	149	PF00498	0.616
LIG_FHA_1	156	162	PF00498	0.621
LIG_FHA_1	163	169	PF00498	0.548
LIG_FHA_1	215	221	PF00498	0.473
LIG_FHA_1	76	82	PF00498	0.365
LIG_FHA_2	108	114	PF00498	0.370
LIG_FHA_2	124	130	PF00498	0.582
LIG_FHA_2	254	260	PF00498	0.559
LIG_Integrin_isoDGR_2	31	33	PF01839	0.378
LIG_LIR_Apic_2	103	109	PF02991	0.501
LIG_LIR_Apic_2	45	50	PF02991	0.389
LIG_LIR_Gen_1	265	273	PF02991	0.377
LIG_LIR_Nem_3	197	203	PF02991	0.366
LIG_LIR_Nem_3	265	270	PF02991	0.373
LIG_NBox_RRM_1	7	17	PF00076	0.338
LIG_NRBOX	244	250	PF00104	0.405
LIG_NRBOX	7	13	PF00104	0.451
LIG_RPA_C_Fungi	166	178	PF08784	0.544
LIG_SH2_STAT5	106	109	PF00017	0.409
LIG_SH3_3	157	163	PF00018	0.697
LIG_SH3_3	207	213	PF00018	0.488
LIG_SH3_3	80	86	PF00018	0.467
LIG_TRAF2_1	195	198	PF00917	0.353
MOD_CK1_1	155	161	PF00069	0.684
MOD_CK1_1	49	55	PF00069	0.532
MOD_CK1_1	87	93	PF00069	0.598
MOD_CK2_1	107	113	PF00069	0.394
MOD_CK2_1	123	129	PF00069	0.526
MOD_CK2_1	192	198	PF00069	0.376
MOD_CK2_1	206	212	PF00069	0.429
MOD_GlcNHglycan	65	68	PF01048	0.505
MOD_GlcNHglycan	93	96	PF01048	0.731
MOD_GlcNHglycan	97	100	PF01048	0.705
MOD_GSK3_1	129	136	PF00069	0.639
MOD_GSK3_1	155	162	PF00069	0.632
MOD_GSK3_1	42	49	PF00069	0.448
MOD_GSK3_1	87	94	PF00069	0.563
MOD_NEK2_1	42	47	PF00069	0.388
MOD_NEK2_1	65	70	PF00069	0.455
MOD_PIKK_1	123	129	PF00454	0.562
MOD_PIKK_1	51	57	PF00454	0.541
MOD_PIKK_1	65	71	PF00454	0.367
MOD_PKA_2	152	158	PF00069	0.712
MOD_PKB_1	151	159	PF00069	0.621
MOD_Plk_1	141	147	PF00069	0.719
MOD_Plk_1	2	8	PF00069	0.448
MOD_Plk_2-3	3	9	PF00069	0.452
MOD_Plk_4	142	148	PF00069	0.637
MOD_Plk_4	3	9	PF00069	0.594
MOD_Plk_4	84	90	PF00069	0.630
MOD_ProDKin_1	159	165	PF00069	0.711
MOD_ProDKin_1	206	212	PF00069	0.522
MOD_ProDKin_1	46	52	PF00069	0.361
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.378
TRG_ENDOCYTIC_2	193	196	PF00928	0.382
TRG_ENDOCYTIC_2	200	203	PF00928	0.339
TRG_ER_diArg_1	151	154	PF00400	0.748
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB35	Leptomonas seymouri	39%	99%
A0A3S7WWY3	Leishmania donovani	99%	100%
A4HC86	Leishmania braziliensis	63%	100%
E9AVM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QBV8	Leishmania major	87%	100%