Mediator complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZR4_LEIIN

TriTrypDb:

LINF_220008600

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.642
CLV_NRD_NRD_1	145	147	PF00675	0.574
CLV_NRD_NRD_1	157	159	PF00675	0.400
CLV_NRD_NRD_1	187	189	PF00675	0.451
CLV_NRD_NRD_1	292	294	PF00675	0.766
CLV_NRD_NRD_1	93	95	PF00675	0.480
CLV_PCSK_KEX2_1	144	146	PF00082	0.631
CLV_PCSK_KEX2_1	157	159	PF00082	0.461
CLV_PCSK_KEX2_1	187	189	PF00082	0.451
CLV_PCSK_KEX2_1	269	271	PF00082	0.660
CLV_PCSK_KEX2_1	292	294	PF00082	0.766
CLV_PCSK_KEX2_1	93	95	PF00082	0.480
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.548
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.660
CLV_PCSK_PC7_1	265	271	PF00082	0.637
CLV_PCSK_SKI1_1	188	192	PF00082	0.417
CLV_PCSK_SKI1_1	77	81	PF00082	0.581
CLV_Separin_Metazoa	53	57	PF03568	0.538
DEG_APCC_DBOX_1	156	164	PF00400	0.607
DEG_APCC_DBOX_1	55	63	PF00400	0.565
DOC_CYCLIN_RxL_1	72	83	PF00134	0.570
DOC_MAPK_DCC_7	165	173	PF00069	0.406
DOC_MAPK_gen_1	306	314	PF00069	0.630
DOC_MAPK_gen_1	72	81	PF00069	0.439
DOC_MAPK_gen_1	93	101	PF00069	0.475
DOC_USP7_MATH_1	211	215	PF00917	0.715
DOC_USP7_UBL2_3	228	232	PF12436	0.721
DOC_WW_Pin1_4	293	298	PF00397	0.690
DOC_WW_Pin1_4	46	51	PF00397	0.648
LIG_14-3-3_CanoR_1	157	161	PF00244	0.445
LIG_14-3-3_CanoR_1	179	186	PF00244	0.435
LIG_14-3-3_CanoR_1	187	191	PF00244	0.485
LIG_14-3-3_CanoR_1	282	290	PF00244	0.724
LIG_14-3-3_CanoR_1	292	296	PF00244	0.623
LIG_14-3-3_CanoR_1	56	60	PF00244	0.633
LIG_14-3-3_CanoR_1	75	80	PF00244	0.382
LIG_Actin_WH2_2	52	69	PF00022	0.525
LIG_APCC_ABBAyCdc20_2	188	194	PF00400	0.555
LIG_BRCT_BRCA1_1	103	107	PF00533	0.367
LIG_FHA_1	24	30	PF00498	0.655
LIG_FHA_1	262	268	PF00498	0.528
LIG_FHA_1	49	55	PF00498	0.561
LIG_FHA_1	76	82	PF00498	0.574
LIG_FHA_1	87	93	PF00498	0.388
LIG_FHA_2	136	142	PF00498	0.570
LIG_FHA_2	179	185	PF00498	0.347
LIG_LIR_Gen_1	206	215	PF02991	0.636
LIG_LIR_Nem_3	167	172	PF02991	0.448
LIG_LIR_Nem_3	175	180	PF02991	0.419
LIG_LIR_Nem_3	206	210	PF02991	0.622
LIG_LYPXL_S_1	168	172	PF13949	0.371
LIG_LYPXL_yS_3	169	172	PF13949	0.373
LIG_PDZ_Class_2	338	343	PF00595	0.537
LIG_REV1ctd_RIR_1	175	183	PF16727	0.550
LIG_SH2_SRC	98	101	PF00017	0.478
LIG_SH2_STAP1	331	335	PF00017	0.607
LIG_SH2_STAT3	259	262	PF00017	0.662
LIG_SH2_STAT5	98	101	PF00017	0.478
LIG_SH3_2	258	263	PF14604	0.467
LIG_SH3_3	255	261	PF00018	0.459
LIG_SH3_3	297	303	PF00018	0.651
LIG_SUMO_SIM_anti_2	239	246	PF11976	0.612
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.437
LIG_SUMO_SIM_par_1	169	175	PF11976	0.483
LIG_SUMO_SIM_par_1	77	83	PF11976	0.529
LIG_TRAF2_1	140	143	PF00917	0.562
LIG_TRAF2_1	50	53	PF00917	0.594
LIG_TYR_ITIM	96	101	PF00017	0.472
LIG_WRC_WIRS_1	204	209	PF05994	0.608
MOD_CDK_SPxxK_3	295	302	PF00069	0.653
MOD_CK1_1	20	26	PF00069	0.728
MOD_CK1_1	206	212	PF00069	0.604
MOD_CK1_1	298	304	PF00069	0.713
MOD_CK1_1	48	54	PF00069	0.603
MOD_CK2_1	135	141	PF00069	0.613
MOD_CK2_1	178	184	PF00069	0.345
MOD_CK2_1	46	52	PF00069	0.715
MOD_Cter_Amidation	267	270	PF01082	0.636
MOD_Cter_Amidation	290	293	PF01082	0.663
MOD_GlcNHglycan	17	20	PF01048	0.691
MOD_GlcNHglycan	213	216	PF01048	0.653
MOD_GlcNHglycan	276	279	PF01048	0.612
MOD_GlcNHglycan	331	334	PF01048	0.637
MOD_GlcNHglycan	9	12	PF01048	0.635
MOD_GSK3_1	152	159	PF00069	0.577
MOD_GSK3_1	20	27	PF00069	0.692
MOD_GSK3_1	274	281	PF00069	0.627
MOD_GSK3_1	291	298	PF00069	0.541
MOD_GSK3_1	41	48	PF00069	0.690
MOD_GSK3_1	71	78	PF00069	0.599
MOD_NEK2_1	108	113	PF00069	0.553
MOD_NEK2_1	135	140	PF00069	0.566
MOD_NEK2_1	178	183	PF00069	0.350
MOD_NEK2_1	24	29	PF00069	0.609
MOD_NEK2_1	40	45	PF00069	0.663
MOD_NEK2_1	66	71	PF00069	0.521
MOD_NEK2_1	7	12	PF00069	0.619
MOD_NEK2_2	152	157	PF00069	0.573
MOD_PIKK_1	301	307	PF00454	0.669
MOD_PIKK_1	66	72	PF00454	0.522
MOD_PKA_2	135	141	PF00069	0.506
MOD_PKA_2	15	21	PF00069	0.711
MOD_PKA_2	156	162	PF00069	0.542
MOD_PKA_2	178	184	PF00069	0.431
MOD_PKA_2	186	192	PF00069	0.488
MOD_PKA_2	281	287	PF00069	0.595
MOD_PKA_2	291	297	PF00069	0.630
MOD_PKA_2	301	307	PF00069	0.462
MOD_PKA_2	55	61	PF00069	0.588
MOD_PKA_2	66	72	PF00069	0.459
MOD_PKA_2	7	13	PF00069	0.626
MOD_Plk_1	152	158	PF00069	0.521
MOD_Plk_1	24	30	PF00069	0.661
MOD_Plk_1	41	47	PF00069	0.623
MOD_Plk_4	2	8	PF00069	0.583
MOD_Plk_4	203	209	PF00069	0.602
MOD_Plk_4	24	30	PF00069	0.615
MOD_ProDKin_1	293	299	PF00069	0.688
MOD_ProDKin_1	46	52	PF00069	0.638
TRG_ENDOCYTIC_2	169	172	PF00928	0.373
TRG_ENDOCYTIC_2	98	101	PF00928	0.401
TRG_ER_diArg_1	156	158	PF00400	0.630
TRG_ER_diArg_1	186	188	PF00400	0.453
TRG_ER_diArg_1	92	94	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVH6	Leptomonas seymouri	44%	98%
A0A3S7WX10	Leishmania donovani	98%	100%
A4HC85	Leishmania braziliensis	70%	100%
E9AVM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QBV9	Leishmania major	91%	100%