Methylenetetrahydrofolate dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetrahydrofolate dehydrogenase/cyclohydrolase - catalytic domain/Tetrahydrofolate dehydrogenase/cyclohydrolase - NAD(P)-binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HZR2_LEIIN

TriTrypDb:

LINF_220008400

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZR2

Function

Biological processes
Term	Name	Level	Count
GO:0006730	one-carbon metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0044237	cellular metabolic process	2	8
GO:0044281	small molecule metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	5	8
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	6	8
GO:0016491	oxidoreductase activity	2	8
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	8
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	8
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.561
CLV_C14_Caspase3-7	68	72	PF00656	0.317
CLV_NRD_NRD_1	27	29	PF00675	0.721
CLV_NRD_NRD_1	291	293	PF00675	0.409
CLV_NRD_NRD_1	389	391	PF00675	0.341
CLV_NRD_NRD_1	56	58	PF00675	0.309
CLV_NRD_NRD_1	80	82	PF00675	0.293
CLV_PCSK_KEX2_1	27	29	PF00082	0.708
CLV_PCSK_KEX2_1	291	293	PF00082	0.409
CLV_PCSK_KEX2_1	56	58	PF00082	0.282
CLV_PCSK_KEX2_1	79	81	PF00082	0.291
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.317
CLV_PCSK_SKI1_1	133	137	PF00082	0.249
CLV_PCSK_SKI1_1	211	215	PF00082	0.458
CLV_PCSK_SKI1_1	223	227	PF00082	0.252
DEG_APCC_DBOX_1	132	140	PF00400	0.238
DEG_APCC_DBOX_1	161	169	PF00400	0.549
DEG_APCC_DBOX_1	290	298	PF00400	0.317
DEG_Nend_UBRbox_4	1	3	PF02207	0.441
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.317
DOC_CYCLIN_yCln2_LP_2	467	473	PF00134	0.546
DOC_MAPK_gen_1	131	139	PF00069	0.292
DOC_MAPK_gen_1	291	299	PF00069	0.370
DOC_MAPK_gen_1	56	64	PF00069	0.344
DOC_MAPK_HePTP_8	54	66	PF00069	0.317
DOC_MAPK_JIP1_4	133	139	PF00069	0.259
DOC_MAPK_MEF2A_6	461	469	PF00069	0.575
DOC_MAPK_MEF2A_6	56	65	PF00069	0.261
DOC_PP1_RVXF_1	221	228	PF00149	0.293
DOC_PP2B_LxvP_1	122	125	PF13499	0.259
DOC_PP2B_LxvP_1	467	470	PF13499	0.592
DOC_USP7_MATH_1	12	16	PF00917	0.441
DOC_USP7_MATH_1	170	174	PF00917	0.582
DOC_USP7_MATH_1	175	179	PF00917	0.530
DOC_USP7_MATH_1	195	199	PF00917	0.716
DOC_USP7_MATH_1	242	246	PF00917	0.597
DOC_USP7_MATH_1	258	262	PF00917	0.568
DOC_USP7_MATH_1	280	284	PF00917	0.715
DOC_WW_Pin1_4	256	261	PF00397	0.693
DOC_WW_Pin1_4	267	272	PF00397	0.700
DOC_WW_Pin1_4	410	415	PF00397	0.299
LIG_14-3-3_CanoR_1	106	112	PF00244	0.473
LIG_14-3-3_CanoR_1	164	169	PF00244	0.511
LIG_14-3-3_CanoR_1	27	35	PF00244	0.577
LIG_14-3-3_CanoR_1	281	290	PF00244	0.690
LIG_14-3-3_CanoR_1	326	331	PF00244	0.300
LIG_14-3-3_CanoR_1	47	55	PF00244	0.142
LIG_BRCT_BRCA1_1	7	11	PF00533	0.446
LIG_EVH1_1	124	128	PF00568	0.375
LIG_FHA_1	21	27	PF00498	0.572
LIG_FHA_1	263	269	PF00498	0.639
LIG_FHA_1	307	313	PF00498	0.259
LIG_FHA_1	446	452	PF00498	0.553
LIG_FHA_1	50	56	PF00498	0.375
LIG_LIR_Gen_1	224	234	PF02991	0.452
LIG_LIR_Gen_1	440	451	PF02991	0.528
LIG_LIR_Nem_3	224	230	PF02991	0.419
LIG_LIR_Nem_3	233	239	PF02991	0.551
LIG_LIR_Nem_3	440	446	PF02991	0.568
LIG_Pex14_2	353	357	PF04695	0.317
LIG_RPA_C_Fungi	23	35	PF08784	0.432
LIG_SH2_CRK	443	447	PF00017	0.592
LIG_SH2_GRB2like	75	78	PF00017	0.375
LIG_SH2_NCK_1	443	447	PF00017	0.566
LIG_SH2_SRC	75	78	PF00017	0.317
LIG_SH2_STAP1	447	451	PF00017	0.545
LIG_SH2_STAT5	229	232	PF00017	0.415
LIG_SH2_STAT5	447	450	PF00017	0.545
LIG_SH2_STAT5	75	78	PF00017	0.259
LIG_SH3_3	122	128	PF00018	0.375
LIG_SH3_3	248	254	PF00018	0.667
LIG_SH3_3	268	274	PF00018	0.433
LIG_SH3_3	302	308	PF00018	0.259
LIG_SUMO_SIM_par_1	62	68	PF11976	0.317
LIG_UBA3_1	136	143	PF00899	0.259
LIG_UBA3_1	426	431	PF00899	0.352
LIG_WW_3	288	292	PF00397	0.505
MOD_CDK_SPxxK_3	270	277	PF00069	0.604
MOD_CK1_1	15	21	PF00069	0.613
MOD_CK1_1	173	179	PF00069	0.662
MOD_CK1_1	22	28	PF00069	0.624
MOD_CK1_1	270	276	PF00069	0.745
MOD_CK1_1	282	288	PF00069	0.540
MOD_CK1_1	329	335	PF00069	0.435
MOD_CK2_1	246	252	PF00069	0.737
MOD_CK2_1	269	275	PF00069	0.596
MOD_GlcNHglycan	14	17	PF01048	0.563
MOD_GlcNHglycan	172	175	PF01048	0.599
MOD_GlcNHglycan	197	200	PF01048	0.620
MOD_GlcNHglycan	201	204	PF01048	0.750
MOD_GlcNHglycan	247	251	PF01048	0.706
MOD_GlcNHglycan	262	265	PF01048	0.570
MOD_GlcNHglycan	282	285	PF01048	0.488
MOD_GlcNHglycan	30	33	PF01048	0.379
MOD_GlcNHglycan	35	38	PF01048	0.256
MOD_GlcNHglycan	387	390	PF01048	0.364
MOD_GlcNHglycan	403	406	PF01048	0.325
MOD_GlcNHglycan	7	10	PF01048	0.640
MOD_GlcNHglycan	95	98	PF01048	0.354
MOD_GSK3_1	1	8	PF00069	0.441
MOD_GSK3_1	11	18	PF00069	0.458
MOD_GSK3_1	160	167	PF00069	0.540
MOD_GSK3_1	169	176	PF00069	0.644
MOD_GSK3_1	195	202	PF00069	0.620
MOD_GSK3_1	22	29	PF00069	0.671
MOD_GSK3_1	221	228	PF00069	0.419
MOD_GSK3_1	242	249	PF00069	0.693
MOD_GSK3_1	252	259	PF00069	0.657
MOD_GSK3_1	279	286	PF00069	0.621
MOD_GSK3_1	315	322	PF00069	0.414
MOD_N-GLC_1	299	304	PF02516	0.259
MOD_NEK2_1	1	6	PF00069	0.451
MOD_NEK2_1	104	109	PF00069	0.317
MOD_NEK2_1	11	16	PF00069	0.628
MOD_NEK2_1	19	24	PF00069	0.606
MOD_NEK2_1	26	31	PF00069	0.520
MOD_NEK2_1	262	267	PF00069	0.663
MOD_NEK2_1	319	324	PF00069	0.282
MOD_NEK2_1	353	358	PF00069	0.394
MOD_NEK2_1	420	425	PF00069	0.280
MOD_NEK2_1	95	100	PF00069	0.330
MOD_PIKK_1	283	289	PF00454	0.610
MOD_PKA_2	26	32	PF00069	0.506
MOD_PKA_2	280	286	PF00069	0.685
MOD_PKA_2	48	54	PF00069	0.397
MOD_PKB_1	162	170	PF00069	0.508
MOD_PKB_1	45	53	PF00069	0.274
MOD_Plk_1	246	252	PF00069	0.725
MOD_Plk_1	299	305	PF00069	0.259
MOD_Plk_1	353	359	PF00069	0.375
MOD_Plk_4	164	170	PF00069	0.671
MOD_Plk_4	175	181	PF00069	0.668
MOD_Plk_4	50	56	PF00069	0.422
MOD_ProDKin_1	256	262	PF00069	0.693
MOD_ProDKin_1	267	273	PF00069	0.700
MOD_ProDKin_1	410	416	PF00069	0.299
MOD_SUMO_rev_2	270	279	PF00179	0.564
TRG_DiLeu_BaEn_2	209	215	PF01217	0.385
TRG_ENDOCYTIC_2	443	446	PF00928	0.571
TRG_ENDOCYTIC_2	447	450	PF00928	0.551
TRG_ER_diArg_1	130	133	PF00400	0.292
TRG_ER_diArg_1	162	165	PF00400	0.505
TRG_ER_diArg_1	204	207	PF00400	0.640
TRG_ER_diArg_1	26	28	PF00400	0.587
TRG_ER_diArg_1	290	292	PF00400	0.617
TRG_ER_diArg_1	44	47	PF00400	0.277
TRG_ER_diArg_1	55	57	PF00400	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAR1	Leptomonas seymouri	55%	92%
A0A1X0NT48	Trypanosomatidae	43%	100%
A0A3Q8IB41	Leishmania donovani	99%	100%
A0A422NSL2	Trypanosoma rangeli	41%	100%
E9AVL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BK74	Trypanosoma cruzi	40%	100%