Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZR1_LEIIN

TriTrypDb:

LINF_220008300

Length:

1089

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.693
CLV_C14_Caspase3-7	284	288	PF00656	0.637
CLV_C14_Caspase3-7	852	856	PF00656	0.674
CLV_NRD_NRD_1	153	155	PF00675	0.754
CLV_NRD_NRD_1	240	242	PF00675	0.690
CLV_NRD_NRD_1	320	322	PF00675	0.688
CLV_NRD_NRD_1	350	352	PF00675	0.667
CLV_NRD_NRD_1	440	442	PF00675	0.753
CLV_NRD_NRD_1	488	490	PF00675	0.584
CLV_NRD_NRD_1	597	599	PF00675	0.640
CLV_NRD_NRD_1	883	885	PF00675	0.609
CLV_PCSK_FUR_1	595	599	PF00082	0.643
CLV_PCSK_KEX2_1	153	155	PF00082	0.754
CLV_PCSK_KEX2_1	240	242	PF00082	0.690
CLV_PCSK_KEX2_1	320	322	PF00082	0.688
CLV_PCSK_KEX2_1	350	352	PF00082	0.588
CLV_PCSK_KEX2_1	440	442	PF00082	0.740
CLV_PCSK_KEX2_1	572	574	PF00082	0.635
CLV_PCSK_KEX2_1	595	597	PF00082	0.635
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.635
CLV_PCSK_SKI1_1	1001	1005	PF00082	0.576
CLV_PCSK_SKI1_1	153	157	PF00082	0.744
CLV_PCSK_SKI1_1	182	186	PF00082	0.581
CLV_PCSK_SKI1_1	36	40	PF00082	0.553
CLV_PCSK_SKI1_1	457	461	PF00082	0.766
CLV_PCSK_SKI1_1	634	638	PF00082	0.495
CLV_PCSK_SKI1_1	646	650	PF00082	0.472
CLV_PCSK_SKI1_1	85	89	PF00082	0.576
CLV_PCSK_SKI1_1	884	888	PF00082	0.736
CLV_PCSK_SKI1_1	911	915	PF00082	0.637
DEG_APCC_DBOX_1	349	357	PF00400	0.668
DEG_COP1_1	52	61	PF00400	0.531
DEG_Nend_UBRbox_2	1	3	PF02207	0.742
DEG_SCF_FBW7_1	155	160	PF00400	0.680
DEG_SPOP_SBC_1	157	161	PF00917	0.684
DEG_SPOP_SBC_1	478	482	PF00917	0.653
DEG_SPOP_SBC_1	738	742	PF00917	0.660
DOC_CKS1_1	459	464	PF01111	0.773
DOC_CKS1_1	833	838	PF01111	0.639
DOC_MAPK_DCC_7	911	921	PF00069	0.571
DOC_MAPK_FxFP_2	379	382	PF00069	0.703
DOC_MAPK_gen_1	320	329	PF00069	0.755
DOC_MAPK_MEF2A_6	218	225	PF00069	0.655
DOC_MAPK_MEF2A_6	323	331	PF00069	0.603
DOC_PP2B_LxvP_1	197	200	PF13499	0.577
DOC_PP2B_LxvP_1	465	468	PF13499	0.668
DOC_PP4_FxxP_1	325	328	PF00568	0.755
DOC_PP4_FxxP_1	379	382	PF00568	0.703
DOC_USP7_MATH_1	1015	1019	PF00917	0.635
DOC_USP7_MATH_1	1028	1032	PF00917	0.600
DOC_USP7_MATH_1	141	145	PF00917	0.651
DOC_USP7_MATH_1	148	152	PF00917	0.611
DOC_USP7_MATH_1	208	212	PF00917	0.692
DOC_USP7_MATH_1	261	265	PF00917	0.668
DOC_USP7_MATH_1	313	317	PF00917	0.653
DOC_USP7_MATH_1	330	334	PF00917	0.566
DOC_USP7_MATH_1	382	386	PF00917	0.606
DOC_USP7_MATH_1	449	453	PF00917	0.601
DOC_USP7_MATH_1	468	472	PF00917	0.785
DOC_USP7_MATH_1	503	507	PF00917	0.555
DOC_USP7_MATH_1	608	612	PF00917	0.687
DOC_USP7_MATH_1	714	718	PF00917	0.619
DOC_USP7_MATH_1	738	742	PF00917	0.719
DOC_USP7_MATH_1	796	800	PF00917	0.691
DOC_USP7_MATH_1	807	811	PF00917	0.644
DOC_USP7_MATH_1	822	826	PF00917	0.562
DOC_USP7_MATH_1	844	848	PF00917	0.687
DOC_USP7_MATH_1	854	858	PF00917	0.654
DOC_USP7_MATH_1	861	865	PF00917	0.541
DOC_USP7_MATH_1	92	96	PF00917	0.656
DOC_WW_Pin1_4	153	158	PF00397	0.681
DOC_WW_Pin1_4	184	189	PF00397	0.774
DOC_WW_Pin1_4	217	222	PF00397	0.654
DOC_WW_Pin1_4	265	270	PF00397	0.674
DOC_WW_Pin1_4	293	298	PF00397	0.770
DOC_WW_Pin1_4	301	306	PF00397	0.653
DOC_WW_Pin1_4	314	319	PF00397	0.572
DOC_WW_Pin1_4	37	42	PF00397	0.665
DOC_WW_Pin1_4	458	463	PF00397	0.770
DOC_WW_Pin1_4	532	537	PF00397	0.708
DOC_WW_Pin1_4	79	84	PF00397	0.687
DOC_WW_Pin1_4	825	830	PF00397	0.760
DOC_WW_Pin1_4	832	837	PF00397	0.591
DOC_WW_Pin1_4	914	919	PF00397	0.687
DOC_WW_Pin1_4	925	930	PF00397	0.563
DOC_WW_Pin1_4	931	936	PF00397	0.513
LIG_14-3-3_CanoR_1	177	182	PF00244	0.758
LIG_14-3-3_CanoR_1	240	249	PF00244	0.607
LIG_14-3-3_CanoR_1	320	326	PF00244	0.760
LIG_14-3-3_CanoR_1	36	41	PF00244	0.585
LIG_14-3-3_CanoR_1	393	397	PF00244	0.641
LIG_14-3-3_CanoR_1	440	448	PF00244	0.624
LIG_14-3-3_CanoR_1	49	58	PF00244	0.592
LIG_14-3-3_CanoR_1	5	14	PF00244	0.658
LIG_14-3-3_CanoR_1	547	553	PF00244	0.697
LIG_14-3-3_CanoR_1	838	843	PF00244	0.625
LIG_Actin_WH2_2	503	519	PF00022	0.624
LIG_Actin_WH2_2	630	648	PF00022	0.614
LIG_BIR_III_2	24	28	PF00653	0.642
LIG_BIR_III_2	982	986	PF00653	0.597
LIG_BRCT_BRCA1_1	1049	1053	PF00533	0.631
LIG_BRCT_BRCA1_1	321	325	PF00533	0.763
LIG_BRCT_BRCA1_1	362	366	PF00533	0.616
LIG_BRCT_BRCA1_1	809	813	PF00533	0.710
LIG_FHA_1	1083	1089	PF00498	0.742
LIG_FHA_1	121	127	PF00498	0.671
LIG_FHA_1	176	182	PF00498	0.625
LIG_FHA_1	218	224	PF00498	0.649
LIG_FHA_1	231	237	PF00498	0.592
LIG_FHA_1	355	361	PF00498	0.741
LIG_FHA_1	384	390	PF00498	0.715
LIG_FHA_1	480	486	PF00498	0.710
LIG_FHA_1	50	56	PF00498	0.683
LIG_FHA_1	557	563	PF00498	0.601
LIG_FHA_1	725	731	PF00498	0.658
LIG_FHA_1	866	872	PF00498	0.614
LIG_FHA_2	1031	1037	PF00498	0.684
LIG_FHA_2	105	111	PF00498	0.739
LIG_FHA_2	1081	1087	PF00498	0.612
LIG_FHA_2	11	17	PF00498	0.572
LIG_FHA_2	268	274	PF00498	0.576
LIG_FHA_2	282	288	PF00498	0.637
LIG_FHA_2	850	856	PF00498	0.672
LIG_LIR_Apic_2	322	328	PF02991	0.758
LIG_LIR_Apic_2	498	503	PF02991	0.539
LIG_LIR_Apic_2	902	908	PF02991	0.677
LIG_LIR_Gen_1	1050	1060	PF02991	0.590
LIG_LIR_Gen_1	13	21	PF02991	0.570
LIG_LIR_Gen_1	639	649	PF02991	0.504
LIG_LIR_Nem_3	1050	1056	PF02991	0.659
LIG_LIR_Nem_3	110	116	PF02991	0.709
LIG_LIR_Nem_3	13	17	PF02991	0.572
LIG_LIR_Nem_3	639	645	PF02991	0.512
LIG_LIR_Nem_3	810	816	PF02991	0.726
LIG_MYND_1	458	462	PF01753	0.768
LIG_MYND_1	764	768	PF01753	0.694
LIG_NRBOX	506	512	PF00104	0.553
LIG_PCNA_yPIPBox_3	893	901	PF02747	0.532
LIG_SH2_CRK	500	504	PF00017	0.532
LIG_SH2_NCK_1	1022	1026	PF00017	0.572
LIG_SH2_STAT5	487	490	PF00017	0.621
LIG_SH2_STAT5	955	958	PF00017	0.726
LIG_SH3_1	218	224	PF00018	0.654
LIG_SH3_3	122	128	PF00018	0.717
LIG_SH3_3	170	176	PF00018	0.682
LIG_SH3_3	218	224	PF00018	0.677
LIG_SH3_3	249	255	PF00018	0.698
LIG_SH3_3	263	269	PF00018	0.634
LIG_SH3_3	294	300	PF00018	0.635
LIG_SH3_3	456	462	PF00018	0.764
LIG_SH3_3	910	916	PF00018	0.664
LIG_SH3_3	929	935	PF00018	0.506
LIG_SUMO_SIM_par_1	977	982	PF11976	0.573
LIG_TRAF2_1	200	203	PF00917	0.756
LIG_TRAF2_1	235	238	PF00917	0.701
LIG_TRAF2_1	964	967	PF00917	0.636
LIG_WRC_WIRS_1	1053	1058	PF05994	0.639
LIG_WRC_WIRS_1	415	420	PF05994	0.693
MOD_CDC14_SPxK_1	82	85	PF00782	0.565
MOD_CDK_SPxK_1	314	320	PF00069	0.689
MOD_CDK_SPxK_1	79	85	PF00069	0.560
MOD_CDK_SPxK_1	832	838	PF00069	0.653
MOD_CDK_SPxxK_3	314	321	PF00069	0.772
MOD_CK1_1	1018	1024	PF00069	0.702
MOD_CK1_1	1052	1058	PF00069	0.607
MOD_CK1_1	1082	1088	PF00069	0.616
MOD_CK1_1	132	138	PF00069	0.646
MOD_CK1_1	139	145	PF00069	0.587
MOD_CK1_1	159	165	PF00069	0.552
MOD_CK1_1	187	193	PF00069	0.671
MOD_CK1_1	216	222	PF00069	0.756
MOD_CK1_1	244	250	PF00069	0.700
MOD_CK1_1	264	270	PF00069	0.535
MOD_CK1_1	333	339	PF00069	0.715
MOD_CK1_1	354	360	PF00069	0.689
MOD_CK1_1	383	389	PF00069	0.713
MOD_CK1_1	420	426	PF00069	0.695
MOD_CK1_1	444	450	PF00069	0.620
MOD_CK1_1	453	459	PF00069	0.637
MOD_CK1_1	479	485	PF00069	0.804
MOD_CK1_1	506	512	PF00069	0.553
MOD_CK1_1	515	521	PF00069	0.631
MOD_CK1_1	60	66	PF00069	0.654
MOD_CK1_1	683	689	PF00069	0.595
MOD_CK1_1	724	730	PF00069	0.586
MOD_CK1_1	755	761	PF00069	0.694
MOD_CK1_1	769	775	PF00069	0.663
MOD_CK1_1	812	818	PF00069	0.662
MOD_CK1_1	825	831	PF00069	0.741
MOD_CK1_1	847	853	PF00069	0.641
MOD_CK1_1	864	870	PF00069	0.675
MOD_CK1_1	928	934	PF00069	0.718
MOD_CK1_1	95	101	PF00069	0.748
MOD_CK2_1	10	16	PF00069	0.573
MOD_CK2_1	104	110	PF00069	0.738
MOD_CK2_1	1080	1086	PF00069	0.607
MOD_CK2_1	209	215	PF00069	0.679
MOD_CK2_1	240	246	PF00069	0.588
MOD_CK2_1	267	273	PF00069	0.576
MOD_CK2_1	739	745	PF00069	0.694
MOD_CK2_1	960	966	PF00069	0.739
MOD_DYRK1A_RPxSP_1	293	297	PF00069	0.690
MOD_GlcNHglycan	1006	1009	PF01048	0.610
MOD_GlcNHglycan	1036	1040	PF01048	0.592
MOD_GlcNHglycan	141	144	PF01048	0.643
MOD_GlcNHglycan	150	153	PF01048	0.574
MOD_GlcNHglycan	193	196	PF01048	0.638
MOD_GlcNHglycan	243	246	PF01048	0.701
MOD_GlcNHglycan	301	304	PF01048	0.667
MOD_GlcNHglycan	332	335	PF01048	0.720
MOD_GlcNHglycan	469	473	PF01048	0.732
MOD_GlcNHglycan	474	477	PF01048	0.767
MOD_GlcNHglycan	517	520	PF01048	0.640
MOD_GlcNHglycan	579	582	PF01048	0.650
MOD_GlcNHglycan	604	607	PF01048	0.701
MOD_GlcNHglycan	610	613	PF01048	0.676
MOD_GlcNHglycan	624	627	PF01048	0.529
MOD_GlcNHglycan	649	652	PF01048	0.593
MOD_GlcNHglycan	681	685	PF01048	0.548
MOD_GlcNHglycan	718	721	PF01048	0.705
MOD_GlcNHglycan	741	744	PF01048	0.624
MOD_GlcNHglycan	754	757	PF01048	0.577
MOD_GlcNHglycan	793	797	PF01048	0.585
MOD_GlcNHglycan	802	805	PF01048	0.535
MOD_GlcNHglycan	809	812	PF01048	0.739
MOD_GlcNHglycan	824	827	PF01048	0.597
MOD_GlcNHglycan	830	833	PF01048	0.650
MOD_GlcNHglycan	844	847	PF01048	0.562
MOD_GlcNHglycan	863	866	PF01048	0.748
MOD_GlcNHglycan	901	904	PF01048	0.617
MOD_GlcNHglycan	94	97	PF01048	0.671
MOD_GlcNHglycan	963	966	PF01048	0.695
MOD_GlcNHglycan	997	1000	PF01048	0.678
MOD_GSK3_1	1	8	PF00069	0.685
MOD_GSK3_1	1030	1037	PF00069	0.711
MOD_GSK3_1	1082	1089	PF00069	0.621
MOD_GSK3_1	131	138	PF00069	0.716
MOD_GSK3_1	153	160	PF00069	0.775
MOD_GSK3_1	183	190	PF00069	0.669
MOD_GSK3_1	209	216	PF00069	0.775
MOD_GSK3_1	240	247	PF00069	0.746
MOD_GSK3_1	257	264	PF00069	0.562
MOD_GSK3_1	277	284	PF00069	0.618
MOD_GSK3_1	295	302	PF00069	0.805
MOD_GSK3_1	303	310	PF00069	0.667
MOD_GSK3_1	352	359	PF00069	0.685
MOD_GSK3_1	383	390	PF00069	0.768
MOD_GSK3_1	416	423	PF00069	0.670
MOD_GSK3_1	447	454	PF00069	0.632
MOD_GSK3_1	468	475	PF00069	0.658
MOD_GSK3_1	476	483	PF00069	0.643
MOD_GSK3_1	49	56	PF00069	0.711
MOD_GSK3_1	502	509	PF00069	0.533
MOD_GSK3_1	585	592	PF00069	0.679
MOD_GSK3_1	604	611	PF00069	0.593
MOD_GSK3_1	618	625	PF00069	0.631
MOD_GSK3_1	680	687	PF00069	0.639
MOD_GSK3_1	696	703	PF00069	0.743
MOD_GSK3_1	710	717	PF00069	0.569
MOD_GSK3_1	74	81	PF00069	0.677
MOD_GSK3_1	750	757	PF00069	0.611
MOD_GSK3_1	792	799	PF00069	0.594
MOD_GSK3_1	828	835	PF00069	0.647
MOD_GSK3_1	838	845	PF00069	0.695
MOD_GSK3_1	861	868	PF00069	0.646
MOD_GSK3_1	90	97	PF00069	0.543
MOD_GSK3_1	921	928	PF00069	0.630
MOD_GSK3_1	970	977	PF00069	0.612
MOD_GSK3_1	99	106	PF00069	0.637
MOD_LATS_1	575	581	PF00433	0.633
MOD_N-GLC_1	157	162	PF02516	0.756
MOD_N-GLC_1	216	221	PF02516	0.612
MOD_N-GLC_1	420	425	PF02516	0.737
MOD_N-GLC_1	724	729	PF02516	0.539
MOD_N-GLC_1	79	84	PF02516	0.689
MOD_N-GLC_2	491	493	PF02516	0.706
MOD_NEK2_1	1	6	PF00069	0.669
MOD_NEK2_1	1003	1008	PF00069	0.621
MOD_NEK2_1	130	135	PF00069	0.703
MOD_NEK2_1	136	141	PF00069	0.647
MOD_NEK2_1	183	188	PF00069	0.665
MOD_NEK2_1	191	196	PF00069	0.569
MOD_NEK2_1	259	264	PF00069	0.774
MOD_NEK2_1	370	375	PF00069	0.631
MOD_NEK2_1	392	397	PF00069	0.683
MOD_NEK2_1	439	444	PF00069	0.775
MOD_NEK2_1	556	561	PF00069	0.707
MOD_NEK2_1	585	590	PF00069	0.647
MOD_NEK2_1	617	622	PF00069	0.667
MOD_NEK2_1	667	672	PF00069	0.681
MOD_NEK2_1	752	757	PF00069	0.674
MOD_NEK2_1	78	83	PF00069	0.646
MOD_NEK2_1	800	805	PF00069	0.619
MOD_NEK2_1	817	822	PF00069	0.712
MOD_NEK2_1	848	853	PF00069	0.669
MOD_NEK2_1	921	926	PF00069	0.690
MOD_OFUCOSY	279	285	PF10250	0.632
MOD_PIKK_1	1061	1067	PF00454	0.653
MOD_PIKK_1	261	267	PF00454	0.804
MOD_PIKK_1	5	11	PF00454	0.659
MOD_PIKK_1	537	543	PF00454	0.693
MOD_PIKK_1	556	562	PF00454	0.454
MOD_PK_1	838	844	PF00069	0.556
MOD_PKA_1	240	246	PF00069	0.693
MOD_PKA_2	1028	1034	PF00069	0.692
MOD_PKA_2	240	246	PF00069	0.600
MOD_PKA_2	319	325	PF00069	0.684
MOD_PKA_2	360	366	PF00069	0.688
MOD_PKA_2	392	398	PF00069	0.722
MOD_PKA_2	4	10	PF00069	0.726
MOD_PKA_2	439	445	PF00069	0.733
MOD_PKA_2	546	552	PF00069	0.697
MOD_PKA_2	586	592	PF00069	0.689
MOD_PKA_2	665	671	PF00069	0.699
MOD_Plk_1	15	21	PF00069	0.719
MOD_Plk_1	201	207	PF00069	0.674
MOD_Plk_1	272	278	PF00069	0.681
MOD_Plk_1	351	357	PF00069	0.734
MOD_Plk_1	758	764	PF00069	0.719
MOD_Plk_1	786	792	PF00069	0.546
MOD_Plk_1	796	802	PF00069	0.587
MOD_Plk_1	909	915	PF00069	0.704
MOD_Plk_4	10	16	PF00069	0.640
MOD_Plk_4	132	138	PF00069	0.529
MOD_Plk_4	244	250	PF00069	0.780
MOD_Plk_4	277	283	PF00069	0.695
MOD_Plk_4	392	398	PF00069	0.675
MOD_Plk_4	506	512	PF00069	0.560
MOD_Plk_4	53	59	PF00069	0.537
MOD_Plk_4	60	66	PF00069	0.577
MOD_Plk_4	688	694	PF00069	0.672
MOD_Plk_4	74	80	PF00069	0.665
MOD_Plk_4	812	818	PF00069	0.725
MOD_Plk_4	844	850	PF00069	0.764
MOD_Plk_4	928	934	PF00069	0.544
MOD_Plk_4	985	991	PF00069	0.717
MOD_ProDKin_1	153	159	PF00069	0.681
MOD_ProDKin_1	184	190	PF00069	0.773
MOD_ProDKin_1	217	223	PF00069	0.653
MOD_ProDKin_1	265	271	PF00069	0.672
MOD_ProDKin_1	293	299	PF00069	0.772
MOD_ProDKin_1	301	307	PF00069	0.653
MOD_ProDKin_1	314	320	PF00069	0.573
MOD_ProDKin_1	37	43	PF00069	0.663
MOD_ProDKin_1	458	464	PF00069	0.770
MOD_ProDKin_1	532	538	PF00069	0.703
MOD_ProDKin_1	79	85	PF00069	0.691
MOD_ProDKin_1	825	831	PF00069	0.761
MOD_ProDKin_1	832	838	PF00069	0.594
MOD_ProDKin_1	914	920	PF00069	0.686
MOD_ProDKin_1	925	931	PF00069	0.564
MOD_SUMO_for_1	706	709	PF00179	0.579
MOD_SUMO_rev_2	880	887	PF00179	0.617
TRG_DiLeu_BaEn_1	883	888	PF01217	0.736
TRG_DiLeu_BaEn_4	202	208	PF01217	0.664
TRG_ER_diArg_1	153	155	PF00400	0.751
TRG_ER_diArg_1	320	323	PF00400	0.686
TRG_ER_diArg_1	439	441	PF00400	0.751
TRG_ER_diArg_1	455	458	PF00400	0.536
TRG_ER_diArg_1	594	597	PF00400	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V1	Leptomonas seymouri	34%	100%
A0A3Q8IFD9	Leishmania donovani	100%	100%
A4HC83	Leishmania braziliensis	58%	98%
E9AVL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
Q4QBW2	Leishmania major	90%	100%