LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
SEP domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HZR0_LEIIN
TriTrypDb:
LINF_220008200
Length:
351

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HZR0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZR0

Function

Biological processes
Term Name Level Count
GO:0000045 autophagosome assembly 6 1
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006996 organelle organization 4 1
GO:0007030 Golgi organization 5 1
GO:0007033 vacuole organization 5 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0016043 cellular component organization 3 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0022607 cellular component assembly 4 1
GO:0030163 protein catabolic process 4 1
GO:0031468 nuclear membrane reassembly 6 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0061024 membrane organization 4 1
GO:0061025 membrane fusion 5 1
GO:0070925 organelle assembly 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0071709 membrane assembly 5 1
GO:0071763 nuclear membrane organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:1905037 autophagosome organization 6 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0032182 ubiquitin-like protein binding 3 1
GO:0043130 ubiquitin binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 110 114 PF00656 0.679
CLV_C14_Caspase3-7 20 24 PF00656 0.580
CLV_NRD_NRD_1 286 288 PF00675 0.488
CLV_NRD_NRD_1 325 327 PF00675 0.564
CLV_NRD_NRD_1 48 50 PF00675 0.648
CLV_NRD_NRD_1 99 101 PF00675 0.577
CLV_PCSK_KEX2_1 286 288 PF00082 0.608
CLV_PCSK_KEX2_1 325 327 PF00082 0.564
CLV_PCSK_SKI1_1 25 29 PF00082 0.503
DEG_Nend_UBRbox_2 1 3 PF02207 0.625
DOC_CKS1_1 255 260 PF01111 0.511
DOC_MAPK_gen_1 13 21 PF00069 0.544
DOC_MAPK_gen_1 148 157 PF00069 0.439
DOC_MAPK_gen_1 283 291 PF00069 0.602
DOC_MAPK_gen_1 340 348 PF00069 0.507
DOC_MAPK_MEF2A_6 13 21 PF00069 0.567
DOC_MAPK_MEF2A_6 148 157 PF00069 0.438
DOC_PP2B_LxvP_1 229 232 PF13499 0.667
DOC_PP4_MxPP_1 71 74 PF00568 0.576
DOC_USP7_MATH_1 107 111 PF00917 0.692
DOC_USP7_MATH_1 149 153 PF00917 0.580
DOC_USP7_MATH_1 171 175 PF00917 0.499
DOC_USP7_MATH_1 230 234 PF00917 0.589
DOC_USP7_MATH_1 235 239 PF00917 0.598
DOC_USP7_MATH_1 74 78 PF00917 0.716
DOC_USP7_MATH_2 74 80 PF00917 0.528
DOC_WW_Pin1_4 137 142 PF00397 0.500
DOC_WW_Pin1_4 245 250 PF00397 0.672
DOC_WW_Pin1_4 251 256 PF00397 0.678
LIG_14-3-3_CanoR_1 132 142 PF00244 0.529
LIG_14-3-3_CanoR_1 148 154 PF00244 0.434
LIG_14-3-3_CanoR_1 295 299 PF00244 0.414
LIG_BRCT_BRCA1_1 165 169 PF00533 0.540
LIG_CaM_NSCaTE_8 33 40 PF13499 0.558
LIG_CtBP_PxDLS_1 190 194 PF00389 0.560
LIG_FHA_1 201 207 PF00498 0.531
LIG_FHA_1 272 278 PF00498 0.478
LIG_FHA_2 114 120 PF00498 0.735
LIG_FHA_2 18 24 PF00498 0.546
LIG_FHA_2 280 286 PF00498 0.530
LIG_FHA_2 295 301 PF00498 0.408
LIG_LIR_Apic_2 185 191 PF02991 0.560
LIG_LIR_Apic_2 213 217 PF02991 0.519
LIG_LIR_Gen_1 274 280 PF02991 0.485
LIG_LIR_Nem_3 14 19 PF02991 0.527
LIG_LIR_Nem_3 166 172 PF02991 0.524
LIG_LIR_Nem_3 218 222 PF02991 0.522
LIG_LIR_Nem_3 274 279 PF02991 0.486
LIG_SH2_PTP2 188 191 PF00017 0.516
LIG_SH2_PTP2 214 217 PF00017 0.516
LIG_SH2_SRC 188 191 PF00017 0.516
LIG_SH2_SRC 214 217 PF00017 0.516
LIG_SH2_SRC 260 263 PF00017 0.587
LIG_SH2_STAT5 135 138 PF00017 0.564
LIG_SH2_STAT5 142 145 PF00017 0.551
LIG_SH2_STAT5 188 191 PF00017 0.513
LIG_SH2_STAT5 214 217 PF00017 0.499
LIG_SH2_STAT5 219 222 PF00017 0.513
LIG_SH2_STAT5 57 60 PF00017 0.544
LIG_SH3_3 252 258 PF00018 0.672
LIG_SH3_3 307 313 PF00018 0.557
LIG_SH3_3 67 73 PF00018 0.625
LIG_SUMO_SIM_anti_2 274 282 PF11976 0.446
LIG_SUMO_SIM_par_1 274 282 PF11976 0.509
LIG_UBA3_1 94 101 PF00899 0.542
LIG_WW_1 216 219 PF00397 0.517
LIG_WW_3 322 326 PF00397 0.477
MOD_CK1_1 248 254 PF00069 0.730
MOD_CK1_1 330 336 PF00069 0.511
MOD_CK1_1 79 85 PF00069 0.704
MOD_CK1_1 8 14 PF00069 0.510
MOD_CK2_1 113 119 PF00069 0.744
MOD_CK2_1 279 285 PF00069 0.515
MOD_GlcNHglycan 109 112 PF01048 0.647
MOD_GlcNHglycan 233 236 PF01048 0.592
MOD_GlcNHglycan 238 241 PF01048 0.621
MOD_GlcNHglycan 53 56 PF01048 0.576
MOD_GlcNHglycan 65 68 PF01048 0.520
MOD_GlcNHglycan 80 84 PF01048 0.696
MOD_GlcNHglycan 86 89 PF01048 0.588
MOD_GSK3_1 133 140 PF00069 0.504
MOD_GSK3_1 149 156 PF00069 0.334
MOD_GSK3_1 231 238 PF00069 0.561
MOD_GSK3_1 256 263 PF00069 0.650
MOD_GSK3_1 267 274 PF00069 0.470
MOD_GSK3_1 328 335 PF00069 0.550
MOD_GSK3_1 4 11 PF00069 0.595
MOD_GSK3_1 86 93 PF00069 0.578
MOD_N-GLC_1 33 38 PF02516 0.480
MOD_NEK2_1 133 138 PF00069 0.510
MOD_NEK2_1 279 284 PF00069 0.539
MOD_NEK2_1 327 332 PF00069 0.586
MOD_PIKK_1 330 336 PF00454 0.488
MOD_PK_1 5 11 PF00069 0.557
MOD_PKA_2 294 300 PF00069 0.424
MOD_Plk_1 200 206 PF00069 0.498
MOD_Plk_1 271 277 PF00069 0.555
MOD_Plk_1 33 39 PF00069 0.477
MOD_Plk_2-3 267 273 PF00069 0.611
MOD_Plk_2-3 294 300 PF00069 0.570
MOD_Plk_4 215 221 PF00069 0.505
MOD_Plk_4 272 278 PF00069 0.533
MOD_Plk_4 90 96 PF00069 0.461
MOD_ProDKin_1 137 143 PF00069 0.498
MOD_ProDKin_1 245 251 PF00069 0.677
MOD_ProDKin_1 254 260 PF00069 0.649
TRG_DiLeu_BaEn_2 175 181 PF01217 0.542
TRG_DiLeu_BaEn_2 271 277 PF01217 0.544
TRG_DiLeu_BaEn_2 310 316 PF01217 0.543
TRG_ENDOCYTIC_2 219 222 PF00928 0.511
TRG_ER_diArg_1 12 15 PF00400 0.561
TRG_ER_diArg_1 324 326 PF00400 0.586
TRG_NES_CRM1_1 201 213 PF08389 0.542
TRG_Pf-PMV_PEXEL_1 25 29 PF00026 0.518

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P591 Leptomonas seymouri 66% 100%
A0A0S4JV00 Bodo saltans 34% 95%
A0A1X0NTT3 Trypanosomatidae 38% 100%
A0A3Q8IAL1 Leishmania donovani 99% 100%
A0A422NSS0 Trypanosoma rangeli 38% 100%
A4HC82 Leishmania braziliensis 79% 100%
C9ZRJ0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AVL6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O35987 Rattus norvegicus 24% 95%
P0C627 Rattus norvegicus 20% 100%
Q14CS0 Homo sapiens 21% 100%
Q3SZC4 Bos taurus 24% 95%
Q4QBW3 Leishmania major 94% 100%
Q5RBG3 Pongo abelii 25% 95%
Q5ZK10 Gallus gallus 24% 95%
Q9CZ44 Mus musculus 24% 95%
Q9SUG6 Arabidopsis thaliana 28% 100%
Q9UNZ2 Homo sapiens 25% 95%
V5AVR5 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS