LeishMANIAdb
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Condensin complex subunit 1

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Condensin complex subunit 1
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZQ8_LEIIN
TriTrypDb:
LINF_220008000
Length:
561

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZQ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZQ8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 122 124 PF00675 0.456
CLV_NRD_NRD_1 247 249 PF00675 0.413
CLV_NRD_NRD_1 4 6 PF00675 0.563
CLV_NRD_NRD_1 411 413 PF00675 0.449
CLV_NRD_NRD_1 538 540 PF00675 0.739
CLV_NRD_NRD_1 553 555 PF00675 0.711
CLV_NRD_NRD_1 556 558 PF00675 0.609
CLV_PCSK_FUR_1 554 558 PF00082 0.624
CLV_PCSK_KEX2_1 4 6 PF00082 0.563
CLV_PCSK_KEX2_1 413 415 PF00082 0.396
CLV_PCSK_KEX2_1 482 484 PF00082 0.443
CLV_PCSK_KEX2_1 504 506 PF00082 0.579
CLV_PCSK_KEX2_1 529 531 PF00082 0.651
CLV_PCSK_KEX2_1 540 542 PF00082 0.688
CLV_PCSK_KEX2_1 553 555 PF00082 0.665
CLV_PCSK_KEX2_1 556 558 PF00082 0.572
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.563
CLV_PCSK_PC1ET2_1 413 415 PF00082 0.396
CLV_PCSK_PC1ET2_1 482 484 PF00082 0.443
CLV_PCSK_PC1ET2_1 504 506 PF00082 0.579
CLV_PCSK_PC1ET2_1 529 531 PF00082 0.614
CLV_PCSK_PC1ET2_1 540 542 PF00082 0.677
CLV_PCSK_SKI1_1 124 128 PF00082 0.303
CLV_PCSK_SKI1_1 181 185 PF00082 0.476
CLV_PCSK_SKI1_1 205 209 PF00082 0.389
CLV_PCSK_SKI1_1 356 360 PF00082 0.317
CLV_PCSK_SKI1_1 363 367 PF00082 0.311
CLV_PCSK_SKI1_1 473 477 PF00082 0.365
DEG_APCC_DBOX_1 204 212 PF00400 0.409
DEG_APCC_DBOX_1 482 490 PF00400 0.514
DEG_SPOP_SBC_1 57 61 PF00917 0.439
DOC_CDC14_PxL_1 328 336 PF14671 0.359
DOC_CKS1_1 95 100 PF01111 0.457
DOC_CYCLIN_RxL_1 479 488 PF00134 0.500
DOC_MAPK_RevD_3 398 414 PF00069 0.417
DOC_PP1_RVXF_1 100 106 PF00149 0.292
DOC_PP1_RVXF_1 208 215 PF00149 0.301
DOC_PP1_RVXF_1 441 448 PF00149 0.423
DOC_PP4_MxPP_1 514 517 PF00568 0.668
DOC_USP7_MATH_1 192 196 PF00917 0.351
DOC_USP7_MATH_1 203 207 PF00917 0.302
DOC_USP7_MATH_1 452 456 PF00917 0.426
DOC_USP7_MATH_1 465 469 PF00917 0.476
DOC_USP7_MATH_1 91 95 PF00917 0.516
DOC_USP7_UBL2_3 6 10 PF12436 0.651
DOC_WW_Pin1_4 136 141 PF00397 0.369
DOC_WW_Pin1_4 9 14 PF00397 0.720
DOC_WW_Pin1_4 94 99 PF00397 0.419
LIG_14-3-3_CanoR_1 123 133 PF00244 0.446
LIG_14-3-3_CanoR_1 248 258 PF00244 0.523
LIG_14-3-3_CanoR_1 265 271 PF00244 0.238
LIG_14-3-3_CanoR_1 280 287 PF00244 0.427
LIG_14-3-3_CanoR_1 379 385 PF00244 0.462
LIG_14-3-3_CanoR_1 389 398 PF00244 0.404
LIG_14-3-3_CanoR_1 412 419 PF00244 0.470
LIG_14-3-3_CanoR_1 530 537 PF00244 0.705
LIG_Actin_WH2_2 109 125 PF00022 0.424
LIG_BIR_II_1 1 5 PF00653 0.549
LIG_BIR_III_2 182 186 PF00653 0.414
LIG_BRCT_BRCA1_1 200 204 PF00533 0.399
LIG_BRCT_BRCA1_1 324 328 PF00533 0.339
LIG_Clathr_ClatBox_1 397 401 PF01394 0.409
LIG_FHA_1 125 131 PF00498 0.316
LIG_FHA_1 137 143 PF00498 0.326
LIG_FHA_1 237 243 PF00498 0.404
LIG_FHA_1 26 32 PF00498 0.591
LIG_FHA_1 267 273 PF00498 0.406
LIG_FHA_1 280 286 PF00498 0.487
LIG_FHA_1 352 358 PF00498 0.367
LIG_FHA_1 392 398 PF00498 0.473
LIG_FHA_1 58 64 PF00498 0.315
LIG_FHA_1 95 101 PF00498 0.420
LIG_FHA_2 338 344 PF00498 0.432
LIG_FHA_2 472 478 PF00498 0.427
LIG_LIR_Apic_2 255 261 PF02991 0.460
LIG_LIR_Gen_1 160 171 PF02991 0.325
LIG_LIR_Gen_1 274 283 PF02991 0.292
LIG_LIR_Gen_1 61 71 PF02991 0.316
LIG_LIR_Nem_3 160 166 PF02991 0.345
LIG_LIR_Nem_3 201 207 PF02991 0.292
LIG_LIR_Nem_3 274 278 PF02991 0.291
LIG_LIR_Nem_3 325 331 PF02991 0.421
LIG_LIR_Nem_3 371 377 PF02991 0.309
LIG_LIR_Nem_3 440 445 PF02991 0.398
LIG_LIR_Nem_3 61 67 PF02991 0.327
LIG_LRP6_Inhibitor_1 467 473 PF00058 0.384
LIG_LYPXL_S_1 330 334 PF13949 0.294
LIG_LYPXL_S_1 373 377 PF13949 0.415
LIG_LYPXL_yS_3 331 334 PF13949 0.300
LIG_LYPXL_yS_3 374 377 PF13949 0.420
LIG_MYND_3 294 298 PF01753 0.414
LIG_NRBOX 207 213 PF00104 0.412
LIG_NRP_CendR_1 560 561 PF00754 0.668
LIG_PCNA_yPIPBox_3 117 126 PF02747 0.436
LIG_PCNA_yPIPBox_3 291 300 PF02747 0.441
LIG_RPA_C_Fungi 407 419 PF08784 0.379
LIG_SH2_CRK 378 382 PF00017 0.335
LIG_SH2_CRK 442 446 PF00017 0.404
LIG_SH2_CRK 64 68 PF00017 0.338
LIG_SH2_SRC 258 261 PF00017 0.455
LIG_SH2_STAT3 81 84 PF00017 0.439
LIG_SH2_STAT5 165 168 PF00017 0.291
LIG_SH2_STAT5 300 303 PF00017 0.411
LIG_SH2_STAT5 376 379 PF00017 0.428
LIG_SH2_STAT5 81 84 PF00017 0.439
LIG_SH3_3 47 53 PF00018 0.605
LIG_SH3_3 512 518 PF00018 0.565
LIG_SH3_3 92 98 PF00018 0.346
LIG_SUMO_SIM_anti_2 313 319 PF11976 0.290
LIG_SUMO_SIM_par_1 154 160 PF11976 0.346
LIG_SUMO_SIM_par_1 268 274 PF11976 0.347
LIG_SUMO_SIM_par_1 356 362 PF11976 0.465
LIG_SUMO_SIM_par_1 380 387 PF11976 0.337
LIG_SUMO_SIM_par_1 396 401 PF11976 0.376
LIG_TRAF2_1 14 17 PF00917 0.661
LIG_TRFH_1 328 332 PF08558 0.313
MOD_CK1_1 195 201 PF00069 0.399
MOD_CK1_1 236 242 PF00069 0.382
MOD_CK1_1 348 354 PF00069 0.506
MOD_CK1_1 383 389 PF00069 0.415
MOD_CK1_1 430 436 PF00069 0.459
MOD_CK1_1 69 75 PF00069 0.502
MOD_CK1_1 9 15 PF00069 0.697
MOD_CK1_1 94 100 PF00069 0.484
MOD_CK2_1 471 477 PF00069 0.415
MOD_CK2_1 56 62 PF00069 0.428
MOD_Cter_Amidation 526 529 PF01082 0.603
MOD_Cter_Amidation 558 561 PF01082 0.609
MOD_GlcNHglycan 201 204 PF01048 0.436
MOD_GlcNHglycan 414 417 PF01048 0.467
MOD_GlcNHglycan 429 432 PF01048 0.420
MOD_GlcNHglycan 461 464 PF01048 0.422
MOD_GSK3_1 195 202 PF00069 0.319
MOD_GSK3_1 344 351 PF00069 0.539
MOD_GSK3_1 359 366 PF00069 0.366
MOD_GSK3_1 423 430 PF00069 0.453
MOD_GSK3_1 58 65 PF00069 0.455
MOD_N-GLC_1 25 30 PF02516 0.599
MOD_N-GLC_1 427 432 PF02516 0.478
MOD_NEK2_1 199 204 PF00069 0.377
MOD_NEK2_1 233 238 PF00069 0.270
MOD_NEK2_1 359 364 PF00069 0.445
MOD_NEK2_1 388 393 PF00069 0.468
MOD_NEK2_1 427 432 PF00069 0.461
MOD_PIKK_1 243 249 PF00454 0.415
MOD_PIKK_1 252 258 PF00454 0.393
MOD_PIKK_1 530 536 PF00454 0.727
MOD_PIKK_1 62 68 PF00454 0.455
MOD_PKA_1 412 418 PF00069 0.465
MOD_PKA_1 528 534 PF00069 0.724
MOD_PKA_2 236 242 PF00069 0.461
MOD_PKA_2 279 285 PF00069 0.468
MOD_PKA_2 388 394 PF00069 0.480
MOD_PKA_2 529 535 PF00069 0.586
MOD_PKA_2 552 558 PF00069 0.726
MOD_Plk_1 252 258 PF00069 0.416
MOD_Plk_1 32 38 PF00069 0.469
MOD_Plk_1 423 429 PF00069 0.482
MOD_Plk_4 125 131 PF00069 0.316
MOD_Plk_4 154 160 PF00069 0.326
MOD_Plk_4 380 386 PF00069 0.415
MOD_Plk_4 66 72 PF00069 0.389
MOD_ProDKin_1 136 142 PF00069 0.360
MOD_ProDKin_1 9 15 PF00069 0.721
MOD_ProDKin_1 94 100 PF00069 0.422
MOD_SUMO_rev_2 532 542 PF00179 0.639
TRG_DiLeu_BaEn_1 96 101 PF01217 0.380
TRG_DiLeu_BaLyEn_6 237 242 PF01217 0.332
TRG_DiLeu_BaLyEn_6 258 263 PF01217 0.449
TRG_DiLeu_BaLyEn_6 292 297 PF01217 0.312
TRG_ENDOCYTIC_2 331 334 PF00928 0.363
TRG_ENDOCYTIC_2 374 377 PF00928 0.327
TRG_ENDOCYTIC_2 378 381 PF00928 0.325
TRG_ENDOCYTIC_2 442 445 PF00928 0.405
TRG_ENDOCYTIC_2 64 67 PF00928 0.332
TRG_ER_diArg_1 101 104 PF00400 0.279
TRG_ER_diArg_1 553 556 PF00400 0.663
TRG_NES_CRM1_1 260 274 PF08389 0.415
TRG_NES_CRM1_1 277 290 PF08389 0.274
TRG_NLS_Bipartite_1 528 544 PF00514 0.693
TRG_NLS_MonoExtC_3 411 417 PF00514 0.461
TRG_NLS_MonoExtC_3 539 545 PF00514 0.655
TRG_NLS_MonoExtN_4 3 8 PF00514 0.530
TRG_NLS_MonoExtN_4 537 544 PF00514 0.642

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4V0 Leptomonas seymouri 65% 95%
A0A0S4JSH7 Bodo saltans 30% 100%
A0A1X0NTF0 Trypanosomatidae 41% 99%
A0A3Q8IC40 Leishmania donovani 100% 100%
A0A3R7NVM0 Trypanosoma rangeli 42% 100%
A4HC80 Leishmania braziliensis 84% 100%
C9ZSF1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AVL4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QBW5 Leishmania major 95% 100%
V5BFQ6 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS