Translocon-associated protein subunit alpha

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translocon-associated protein (TRAP) - alpha subunit - putative

Species:

Leishmania infantum

UniProt:

A4HZQ3_LEIIN

TriTrypDb:

LINF_220007500

Length:

282

Annotations

Annotations by Jardim et al.

Translation, translocon-associated (TRAP), alpha subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HZQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZQ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	272	274	PF00675	0.466
CLV_NRD_NRD_1	5	7	PF00675	0.567
CLV_PCSK_FUR_1	270	274	PF00082	0.366
CLV_PCSK_KEX2_1	272	274	PF00082	0.487
CLV_PCSK_SKI1_1	125	129	PF00082	0.522
CLV_PCSK_SKI1_1	187	191	PF00082	0.437
CLV_PCSK_SKI1_1	214	218	PF00082	0.314
CLV_PCSK_SKI1_1	6	10	PF00082	0.529
CLV_PCSK_SKI1_1	61	65	PF00082	0.427
DOC_CYCLIN_RxL_1	55	69	PF00134	0.261
DOC_MAPK_gen_1	125	135	PF00069	0.322
DOC_MAPK_gen_1	6	13	PF00069	0.409
DOC_MAPK_MEF2A_6	80	87	PF00069	0.266
DOC_PP1_RVXF_1	59	65	PF00149	0.272
DOC_PP2B_LxvP_1	105	108	PF13499	0.314
DOC_USP7_MATH_1	171	175	PF00917	0.263
DOC_USP7_MATH_1	29	33	PF00917	0.510
DOC_USP7_MATH_1	57	61	PF00917	0.281
DOC_WW_Pin1_4	137	142	PF00397	0.197
DOC_WW_Pin1_4	274	279	PF00397	0.636
LIG_14-3-3_CanoR_1	187	193	PF00244	0.279
LIG_BIR_II_1	1	5	PF00653	0.414
LIG_BRCT_BRCA1_1	146	150	PF00533	0.345
LIG_BRCT_BRCA1_1	68	72	PF00533	0.300
LIG_EH1_1	98	106	PF00400	0.284
LIG_eIF4E_1	58	64	PF01652	0.266
LIG_FHA_1	130	136	PF00498	0.301
LIG_FHA_1	138	144	PF00498	0.283
LIG_FHA_1	164	170	PF00498	0.253
LIG_FHA_1	173	179	PF00498	0.251
LIG_FHA_2	241	247	PF00498	0.595
LIG_LIR_Gen_1	147	158	PF02991	0.216
LIG_LIR_Gen_1	191	198	PF02991	0.265
LIG_LIR_Nem_3	147	153	PF02991	0.216
LIG_LIR_Nem_3	191	196	PF02991	0.274
LIG_LIR_Nem_3	69	75	PF02991	0.302
LIG_Pex14_2	168	172	PF04695	0.223
LIG_Pex14_2	9	13	PF04695	0.421
LIG_SH2_GRB2like	249	252	PF00017	0.639
LIG_SH2_NCK_1	245	249	PF00017	0.655
LIG_SH2_SRC	245	248	PF00017	0.653
LIG_SH2_SRC	249	252	PF00017	0.639
LIG_SH2_SRC	46	49	PF00017	0.206
LIG_SH2_STAT5	137	140	PF00017	0.237
LIG_SH2_STAT5	157	160	PF00017	0.120
LIG_SH2_STAT5	167	170	PF00017	0.186
LIG_SH2_STAT5	192	195	PF00017	0.258
LIG_SH2_STAT5	204	207	PF00017	0.231
LIG_SH2_STAT5	249	252	PF00017	0.550
LIG_SH2_STAT5	36	39	PF00017	0.415
LIG_SH2_STAT5	58	61	PF00017	0.336
LIG_SUMO_SIM_par_1	174	180	PF11976	0.198
LIG_TRAF2_1	38	41	PF00917	0.542
LIG_TYR_ITIM	190	195	PF00017	0.264
LIG_UBA3_1	215	223	PF00899	0.484
LIG_WRC_WIRS_1	72	77	PF05994	0.232
MOD_CDC14_SPxK_1	277	280	PF00782	0.629
MOD_CDK_SPK_2	274	279	PF00069	0.682
MOD_CDK_SPxK_1	274	280	PF00069	0.648
MOD_CDK_SPxxK_3	274	281	PF00069	0.643
MOD_CK1_1	226	232	PF00069	0.499
MOD_CK1_1	68	74	PF00069	0.284
MOD_CK2_1	35	41	PF00069	0.464
MOD_GlcNHglycan	1	4	PF01048	0.589
MOD_GlcNHglycan	146	149	PF01048	0.550
MOD_GlcNHglycan	160	163	PF01048	0.388
MOD_GlcNHglycan	228	231	PF01048	0.281
MOD_GlcNHglycan	274	277	PF01048	0.537
MOD_GlcNHglycan	37	40	PF01048	0.711
MOD_GSK3_1	127	134	PF00069	0.231
MOD_GSK3_1	163	170	PF00069	0.234
MOD_GSK3_1	181	188	PF00069	0.152
MOD_GSK3_1	219	226	PF00069	0.510
MOD_GSK3_1	264	271	PF00069	0.644
MOD_LATS_1	221	227	PF00433	0.514
MOD_LATS_1	263	269	PF00433	0.675
MOD_N-GLC_1	116	121	PF02516	0.412
MOD_N-GLC_1	163	168	PF02516	0.436
MOD_N-GLC_1	172	177	PF02516	0.435
MOD_N-GLC_1	226	231	PF02516	0.272
MOD_N-GLC_1	65	70	PF02516	0.514
MOD_NEK2_1	17	22	PF00069	0.449
MOD_NEK2_1	172	177	PF00069	0.237
MOD_NEK2_1	219	224	PF00069	0.510
MOD_NEK2_1	266	271	PF00069	0.635
MOD_NEK2_1	65	70	PF00069	0.288
MOD_PIKK_1	66	72	PF00454	0.314
MOD_PIKK_1	92	98	PF00454	0.287
MOD_PKA_1	264	270	PF00069	0.615
MOD_PKA_1	272	278	PF00069	0.656
MOD_PKA_2	272	278	PF00069	0.683
MOD_PKB_1	270	278	PF00069	0.571
MOD_Plk_1	116	122	PF00069	0.223
MOD_Plk_1	163	169	PF00069	0.217
MOD_Plk_1	172	178	PF00069	0.205
MOD_Plk_1	92	98	PF00069	0.282
MOD_Plk_4	163	169	PF00069	0.233
MOD_Plk_4	17	23	PF00069	0.455
MOD_Plk_4	172	178	PF00069	0.204
MOD_Plk_4	188	194	PF00069	0.182
MOD_ProDKin_1	137	143	PF00069	0.197
MOD_ProDKin_1	274	280	PF00069	0.639
TRG_ENDOCYTIC_2	192	195	PF00928	0.264
TRG_ER_diArg_1	270	273	PF00400	0.677
TRG_ER_diLys_1	279	282	PF00400	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H4	Leptomonas seymouri	66%	100%
A0A0S4JN42	Bodo saltans	31%	100%
A0A1X0NT38	Trypanosomatidae	43%	100%
A0A3R7KKR8	Trypanosoma rangeli	44%	99%
A0A3S7WWZ6	Leishmania donovani	100%	100%
A4HC76	Leishmania braziliensis	73%	98%
C9ZSE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AVK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QBX0	Leishmania major	94%	100%
Q54R45	Dictyostelium discoideum	28%	100%
Q5R4X4	Pongo abelii	25%	97%
V5AVS0	Trypanosoma cruzi	42%	100%