Zinc finger (CCCH type) motif-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger C-x8-C-x5-C-x3-H type (and similar) - putative

Species:

Leishmania infantum

UniProt:

A4HZP4_LEIIN

TriTrypDb:

LINF_220006600

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 38, 407

Expansion

Sequence features

A4HZP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZP4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.579
CLV_C14_Caspase3-7	344	348	PF00656	0.580
CLV_NRD_NRD_1	254	256	PF00675	0.301
DEG_Kelch_Keap1_1	191	196	PF01344	0.606
DOC_CKS1_1	139	144	PF01111	0.452
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.405
DOC_MAPK_MEF2A_6	215	222	PF00069	0.435
DOC_PP2B_LxvP_1	243	246	PF13499	0.497
DOC_PP2B_LxvP_1	84	87	PF13499	0.354
DOC_PP4_FxxP_1	139	142	PF00568	0.456
DOC_PP4_FxxP_1	303	306	PF00568	0.557
DOC_USP7_MATH_1	126	130	PF00917	0.422
DOC_USP7_MATH_1	188	192	PF00917	0.626
DOC_USP7_MATH_1	21	25	PF00917	0.587
DOC_USP7_MATH_1	275	279	PF00917	0.446
DOC_USP7_MATH_1	312	316	PF00917	0.592
DOC_USP7_MATH_1	365	369	PF00917	0.705
DOC_USP7_MATH_1	393	397	PF00917	0.657
DOC_USP7_MATH_1	403	407	PF00917	0.661
DOC_USP7_MATH_1	47	51	PF00917	0.650
DOC_USP7_MATH_1	69	73	PF00917	0.523
DOC_USP7_MATH_2	168	174	PF00917	0.498
DOC_WW_Pin1_4	1	6	PF00397	0.466
DOC_WW_Pin1_4	138	143	PF00397	0.457
DOC_WW_Pin1_4	286	291	PF00397	0.603
DOC_WW_Pin1_4	53	58	PF00397	0.603
LIG_14-3-3_CanoR_1	292	300	PF00244	0.564
LIG_14-3-3_CanoR_1	394	402	PF00244	0.611
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_BRCT_BRCA1_1	3	7	PF00533	0.431
LIG_FHA_1	13	19	PF00498	0.531
LIG_FHA_1	226	232	PF00498	0.342
LIG_FHA_2	200	206	PF00498	0.607
LIG_FHA_2	364	370	PF00498	0.590
LIG_IBAR_NPY_1	400	402	PF08397	0.507
LIG_LIR_Apic_2	137	142	PF02991	0.527
LIG_LIR_Apic_2	302	306	PF02991	0.560
LIG_LIR_Gen_1	264	275	PF02991	0.279
LIG_LIR_Nem_3	264	270	PF02991	0.302
LIG_MYND_1	376	380	PF01753	0.583
LIG_SH2_NCK_1	402	406	PF00017	0.584
LIG_SH2_SRC	402	405	PF00017	0.634
LIG_SH2_STAT5	67	70	PF00017	0.479
LIG_UBA3_1	241	249	PF00899	0.409
LIG_WW_3	166	170	PF00397	0.546
MOD_CDK_SPxK_1	286	292	PF00069	0.551
MOD_CK1_1	208	214	PF00069	0.539
MOD_CK1_1	308	314	PF00069	0.655
MOD_CK1_1	353	359	PF00069	0.559
MOD_CK1_1	38	44	PF00069	0.612
MOD_CK1_1	387	393	PF00069	0.715
MOD_CK1_1	72	78	PF00069	0.486
MOD_CK1_1	9	15	PF00069	0.595
MOD_CK2_1	126	132	PF00069	0.396
MOD_CK2_1	190	196	PF00069	0.648
MOD_CK2_1	230	236	PF00069	0.500
MOD_CK2_1	275	281	PF00069	0.537
MOD_CK2_1	363	369	PF00069	0.690
MOD_GlcNHglycan	172	175	PF01048	0.549
MOD_GlcNHglycan	186	189	PF01048	0.665
MOD_GlcNHglycan	19	22	PF01048	0.561
MOD_GlcNHglycan	207	210	PF01048	0.586
MOD_GlcNHglycan	277	280	PF01048	0.474
MOD_GlcNHglycan	293	296	PF01048	0.564
MOD_GlcNHglycan	312	315	PF01048	0.632
MOD_GlcNHglycan	40	43	PF01048	0.669
MOD_GlcNHglycan	74	77	PF01048	0.426
MOD_GSK3_1	17	24	PF00069	0.467
MOD_GSK3_1	184	191	PF00069	0.664
MOD_GSK3_1	282	289	PF00069	0.620
MOD_GSK3_1	301	308	PF00069	0.397
MOD_GSK3_1	319	326	PF00069	0.640
MOD_GSK3_1	333	340	PF00069	0.671
MOD_GSK3_1	346	353	PF00069	0.652
MOD_GSK3_1	359	366	PF00069	0.592
MOD_GSK3_1	47	54	PF00069	0.655
MOD_GSK3_1	72	79	PF00069	0.430
MOD_GSK3_1	8	15	PF00069	0.565
MOD_N-GLC_1	184	189	PF02516	0.721
MOD_N-GLC_1	341	346	PF02516	0.576
MOD_N-GLC_2	224	226	PF02516	0.456
MOD_N-GLC_2	263	265	PF02516	0.355
MOD_NEK2_1	199	204	PF00069	0.557
MOD_NEK2_1	230	235	PF00069	0.368
MOD_NEK2_1	284	289	PF00069	0.684
MOD_NEK2_1	291	296	PF00069	0.613
MOD_NEK2_1	333	338	PF00069	0.682
MOD_NEK2_1	346	351	PF00069	0.675
MOD_NEK2_1	58	63	PF00069	0.551
MOD_PIKK_1	319	325	PF00454	0.584
MOD_PIKK_1	337	343	PF00454	0.603
MOD_PIKK_1	350	356	PF00454	0.523
MOD_PIKK_1	58	64	PF00454	0.482
MOD_PKA_2	291	297	PF00069	0.592
MOD_PKA_2	393	399	PF00069	0.673
MOD_PKA_2	47	53	PF00069	0.660
MOD_Plk_1	263	269	PF00069	0.389
MOD_Plk_1	403	409	PF00069	0.568
MOD_Plk_4	126	132	PF00069	0.449
MOD_Plk_4	263	269	PF00069	0.384
MOD_Plk_4	334	340	PF00069	0.688
MOD_Plk_4	341	347	PF00069	0.656
MOD_Plk_4	40	46	PF00069	0.647
MOD_ProDKin_1	1	7	PF00069	0.464
MOD_ProDKin_1	138	144	PF00069	0.446
MOD_ProDKin_1	286	292	PF00069	0.605
MOD_ProDKin_1	53	59	PF00069	0.602
TRG_DiLeu_BaEn_1	40	45	PF01217	0.562
TRG_DiLeu_BaEn_1	98	103	PF01217	0.541
TRG_DiLeu_BaEn_3	236	242	PF01217	0.520
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.580
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.689
TRG_ER_diArg_1	45	48	PF00400	0.651
TRG_ER_FFAT_2	304	315	PF00635	0.461
TRG_NES_CRM1_1	100	112	PF08389	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY30	Leptomonas seymouri	59%	99%
A0A1X0NUJ7	Trypanosomatidae	36%	100%
A0A3R7MUT8	Trypanosoma rangeli	36%	100%
A0A3R7R5S5	Trypanosoma rangeli	27%	93%
A0A3S7WWZ1	Leishmania donovani	100%	100%
A4HC69	Leishmania braziliensis	73%	100%
E9AVK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QBX9	Leishmania major	94%	100%
V5DBU7	Trypanosoma cruzi	37%	100%