Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZM8_LEIIN

TriTrypDb:

LINF_210014400

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZM8

PDB structure(s): 7ane_v

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.481
CLV_NRD_NRD_1	187	189	PF00675	0.479
CLV_NRD_NRD_1	60	62	PF00675	0.435
CLV_PCSK_KEX2_1	132	134	PF00082	0.481
CLV_PCSK_KEX2_1	187	189	PF00082	0.477
CLV_PCSK_KEX2_1	206	208	PF00082	0.349
CLV_PCSK_KEX2_1	60	62	PF00082	0.424
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.470
CLV_PCSK_SKI1_1	197	201	PF00082	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.520
DOC_CDC14_PxL_1	67	75	PF14671	0.490
DOC_CYCLIN_RxL_1	80	91	PF00134	0.520
DOC_USP7_MATH_1	33	37	PF00917	0.598
DOC_WW_Pin1_4	10	15	PF00397	0.514
DOC_WW_Pin1_4	73	78	PF00397	0.471
LIG_14-3-3_CanoR_1	132	142	PF00244	0.470
LIG_14-3-3_CanoR_1	32	38	PF00244	0.582
LIG_14-3-3_CanoR_1	60	67	PF00244	0.530
LIG_Actin_WH2_2	118	134	PF00022	0.431
LIG_AP2alpha_1	142	146	PF02296	0.443
LIG_BRCT_BRCA1_1	3	7	PF00533	0.509
LIG_BRCT_BRCA1_1	75	79	PF00533	0.446
LIG_eIF4E_1	169	175	PF01652	0.475
LIG_FHA_1	11	17	PF00498	0.530
LIG_FHA_1	41	47	PF00498	0.435
LIG_FHA_1	98	104	PF00498	0.431
LIG_FHA_2	50	56	PF00498	0.477
LIG_LIR_Apic_2	36	42	PF02991	0.455
LIG_LIR_Gen_1	36	45	PF02991	0.439
LIG_LIR_Gen_1	52	59	PF02991	0.405
LIG_LIR_Nem_3	164	168	PF02991	0.479
LIG_LIR_Nem_3	36	40	PF02991	0.447
LIG_LIR_Nem_3	52	57	PF02991	0.400
LIG_Pex14_1	165	169	PF04695	0.464
LIG_Pex14_2	142	146	PF04695	0.443
LIG_SH2_CRK	12	16	PF00017	0.595
LIG_SH2_CRK	37	41	PF00017	0.440
LIG_SH2_GRB2like	39	42	PF00017	0.473
LIG_SH2_SRC	39	42	PF00017	0.477
LIG_SH2_STAT3	168	171	PF00017	0.600
LIG_SH2_STAT5	12	15	PF00017	0.568
LIG_SH2_STAT5	198	201	PF00017	0.468
LIG_SH2_STAT5	39	42	PF00017	0.473
LIG_SH3_3	205	211	PF00018	0.466
LIG_SUMO_SIM_par_1	13	19	PF11976	0.571
LIG_TRFH_1	29	33	PF08558	0.445
MOD_CK1_1	69	75	PF00069	0.420
MOD_CK2_1	109	115	PF00069	0.487
MOD_Cter_Amidation	185	188	PF01082	0.496
MOD_Cter_Amidation	204	207	PF01082	0.349
MOD_GlcNHglycan	23	26	PF01048	0.461
MOD_GlcNHglycan	68	71	PF01048	0.445
MOD_GlcNHglycan	87	90	PF01048	0.454
MOD_GSK3_1	133	140	PF00069	0.566
MOD_GSK3_1	148	155	PF00069	0.281
MOD_GSK3_1	69	76	PF00069	0.418
MOD_N-GLC_1	148	153	PF02516	0.442
MOD_N-GLC_1	21	26	PF02516	0.587
MOD_NEK2_1	16	21	PF00069	0.604
MOD_PIKK_1	133	139	PF00454	0.575
MOD_PIKK_1	77	83	PF00454	0.470
MOD_PIKK_1	98	104	PF00454	0.543
MOD_PKA_2	115	121	PF00069	0.414
MOD_PKA_2	49	55	PF00069	0.459
MOD_PKA_2	59	65	PF00069	0.467
MOD_Plk_1	190	196	PF00069	0.571
MOD_Plk_1	98	104	PF00069	0.540
MOD_Plk_4	115	121	PF00069	0.505
MOD_ProDKin_1	10	16	PF00069	0.517
MOD_ProDKin_1	73	79	PF00069	0.479
MOD_SUMO_for_1	199	202	PF00179	0.511
TRG_DiLeu_BaEn_1	115	120	PF01217	0.549
TRG_ENDOCYTIC_2	12	15	PF00928	0.592
TRG_ENDOCYTIC_2	37	40	PF00928	0.443
TRG_ER_diArg_1	131	133	PF00400	0.484
TRG_ER_diArg_1	187	189	PF00400	0.498
TRG_ER_diArg_1	207	210	PF00400	0.291
TRG_ER_diArg_1	59	61	PF00400	0.458
TRG_NLS_MonoCore_2	205	210	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J8	Leptomonas seymouri	92%	100%
A0A0S4IQC1	Bodo saltans	66%	100%
A0A1X0NXP3	Trypanosomatidae	78%	98%
A0A3R7RD27	Trypanosoma rangeli	82%	100%
A0A3S7WWG7	Leishmania donovani	100%	100%
A4HBT3	Leishmania braziliensis	96%	100%
D0A1E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
E9AV53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
Q4QCC8	Leishmania major	100%	100%