DUF4833 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZM6_LEIIN

TriTrypDb:

LINF_210014600

Length:

323

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.328
CLV_NRD_NRD_1	152	154	PF00675	0.281
CLV_NRD_NRD_1	60	62	PF00675	0.436
CLV_PCSK_KEX2_1	135	137	PF00082	0.336
CLV_PCSK_KEX2_1	60	62	PF00082	0.416
DOC_CDC14_PxL_1	215	223	PF14671	0.370
DOC_MAPK_gen_1	185	193	PF00069	0.359
DOC_MAPK_gen_1	82	90	PF00069	0.269
DOC_MAPK_MEF2A_6	186	195	PF00069	0.281
DOC_PP2B_LxvP_1	216	219	PF13499	0.342
DOC_USP7_MATH_1	103	107	PF00917	0.290
DOC_USP7_MATH_1	108	112	PF00917	0.278
DOC_USP7_MATH_1	207	211	PF00917	0.428
DOC_USP7_UBL2_3	284	288	PF12436	0.381
DOC_WW_Pin1_4	237	242	PF00397	0.750
DOC_WW_Pin1_4	24	29	PF00397	0.526
LIG_14-3-3_CanoR_1	168	175	PF00244	0.324
LIG_14-3-3_CanoR_1	265	269	PF00244	0.348
LIG_APCC_ABBA_1	76	81	PF00400	0.317
LIG_FHA_1	143	149	PF00498	0.287
LIG_FHA_1	25	31	PF00498	0.542
LIG_FHA_2	233	239	PF00498	0.687
LIG_LIR_Gen_1	167	178	PF02991	0.470
LIG_LIR_Gen_1	192	202	PF02991	0.370
LIG_LIR_Nem_3	167	173	PF02991	0.458
LIG_LIR_Nem_3	192	198	PF02991	0.384
LIG_LIR_Nem_3	315	321	PF02991	0.373
LIG_NRP_CendR_1	320	323	PF00754	0.427
LIG_SH2_CRK	296	300	PF00017	0.317
LIG_SH2_STAT5	286	289	PF00017	0.301
LIG_SH2_STAT5	51	54	PF00017	0.304
LIG_SH2_STAT5	79	82	PF00017	0.312
LIG_SUMO_SIM_anti_2	189	197	PF11976	0.331
MOD_CK1_1	111	117	PF00069	0.358
MOD_CK1_1	237	243	PF00069	0.756
MOD_CK1_1	310	316	PF00069	0.317
MOD_CK2_1	232	238	PF00069	0.678
MOD_CK2_1	313	319	PF00069	0.443
MOD_CK2_1	80	86	PF00069	0.291
MOD_CMANNOS	211	214	PF00535	0.445
MOD_GlcNHglycan	105	108	PF01048	0.314
MOD_GlcNHglycan	33	36	PF01048	0.689
MOD_GSK3_1	111	118	PF00069	0.351
MOD_GSK3_1	22	29	PF00069	0.601
MOD_GSK3_1	306	313	PF00069	0.342
MOD_N-GLC_1	55	60	PF02516	0.430
MOD_NEK2_1	55	60	PF00069	0.458
MOD_NEK2_1	95	100	PF00069	0.459
MOD_NEK2_2	17	22	PF00069	0.405
MOD_PKA_2	264	270	PF00069	0.442
MOD_Plk_1	111	117	PF00069	0.379
MOD_Plk_1	314	320	PF00069	0.389
MOD_Plk_1	55	61	PF00069	0.339
MOD_Plk_4	264	270	PF00069	0.335
MOD_Plk_4	277	283	PF00069	0.251
MOD_ProDKin_1	237	243	PF00069	0.743
MOD_ProDKin_1	24	30	PF00069	0.529
MOD_SUMO_for_1	299	302	PF00179	0.423
MOD_SUMO_rev_2	147	156	PF00179	0.365
MOD_SUMO_rev_2	289	295	PF00179	0.302
TRG_DiLeu_BaEn_1	189	194	PF01217	0.335
TRG_ENDOCYTIC_2	318	321	PF00928	0.369
TRG_ER_diArg_1	135	137	PF00400	0.384
TRG_ER_diArg_1	59	61	PF00400	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J1	Leptomonas seymouri	58%	100%
A0A0N0P3Y3	Leptomonas seymouri	34%	86%
A0A1X0NXM7	Trypanosomatidae	39%	100%
A0A3Q8IAB9	Leishmania donovani	35%	84%
A0A3Q8IF47	Leishmania donovani	100%	100%
A0A3R7N4N0	Trypanosoma rangeli	35%	100%
A4HBT1	Leishmania braziliensis	76%	96%
A4HZM7	Leishmania infantum	35%	84%
D0A1E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AV54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AV55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCC6	Leishmania major	91%	98%
Q4QCC7	Leishmania major	34%	100%
V5BDR4	Trypanosoma cruzi	35%	100%