LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Methionine aminopeptidase 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Methionine aminopeptidase 2
Gene product:
metallo-peptidase - Clan MG - Family M24
Species:
Leishmania infantum
UniProt:
A4HZM5_LEIIN
TriTrypDb:
LINF_210014700
Length:
465

Annotations

Annotations by Jardim et al.

Proteases, Methionine aminopeptidase 2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4HZM5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZM5

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044238 primary metabolic process 2 12
GO:0070084 protein initiator methionine removal 5 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0016485 protein processing 5 1
GO:0035551 protein initiator methionine removal involved in protein maturation 6 1
GO:0051604 protein maturation 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004177 aminopeptidase activity 5 12
GO:0005488 binding 1 12
GO:0008233 peptidase activity 3 12
GO:0008235 metalloexopeptidase activity 5 12
GO:0008237 metallopeptidase activity 4 12
GO:0008238 exopeptidase activity 4 12
GO:0016787 hydrolase activity 2 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0070006 metalloaminopeptidase activity 6 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 25 29 PF00656 0.528
CLV_C14_Caspase3-7 43 47 PF00656 0.484
CLV_NRD_NRD_1 135 137 PF00675 0.563
CLV_NRD_NRD_1 403 405 PF00675 0.269
CLV_PCSK_KEX2_1 135 137 PF00082 0.447
CLV_PCSK_KEX2_1 141 143 PF00082 0.376
CLV_PCSK_KEX2_1 58 60 PF00082 0.693
CLV_PCSK_PC1ET2_1 141 143 PF00082 0.403
CLV_PCSK_PC1ET2_1 58 60 PF00082 0.693
CLV_PCSK_SKI1_1 141 145 PF00082 0.458
CLV_PCSK_SKI1_1 226 230 PF00082 0.265
CLV_PCSK_SKI1_1 268 272 PF00082 0.271
CLV_PCSK_SKI1_1 456 460 PF00082 0.302
DEG_ODPH_VHL_1 320 333 PF01847 0.363
DOC_MAPK_MEF2A_6 174 181 PF00069 0.414
DOC_MAPK_MEF2A_6 276 284 PF00069 0.281
DOC_MAPK_MEF2A_6 430 437 PF00069 0.413
DOC_PP1_RVXF_1 234 240 PF00149 0.269
DOC_PP1_SILK_1 197 202 PF00149 0.396
DOC_USP7_MATH_1 145 149 PF00917 0.438
DOC_USP7_MATH_1 3 7 PF00917 0.708
DOC_USP7_MATH_1 69 73 PF00917 0.439
DOC_USP7_UBL2_3 10 14 PF12436 0.719
DOC_USP7_UBL2_3 391 395 PF12436 0.334
DOC_USP7_UBL2_3 4 8 PF12436 0.758
DOC_WW_Pin1_4 216 221 PF00397 0.274
LIG_14-3-3_CanoR_1 100 104 PF00244 0.372
LIG_14-3-3_CanoR_1 135 144 PF00244 0.414
LIG_14-3-3_CanoR_1 146 152 PF00244 0.415
LIG_14-3-3_CanoR_1 163 169 PF00244 0.284
LIG_BRCT_BRCA1_1 110 114 PF00533 0.457
LIG_deltaCOP1_diTrp_1 249 256 PF00928 0.269
LIG_FHA_1 105 111 PF00498 0.369
LIG_FHA_1 181 187 PF00498 0.296
LIG_FHA_1 446 452 PF00498 0.273
LIG_FHA_2 100 106 PF00498 0.366
LIG_FHA_2 220 226 PF00498 0.303
LIG_FHA_2 338 344 PF00498 0.333
LIG_FHA_2 452 458 PF00498 0.310
LIG_IBAR_NPY_1 89 91 PF08397 0.402
LIG_Integrin_isoDGR_2 244 246 PF01839 0.319
LIG_LIR_Apic_2 102 106 PF02991 0.407
LIG_LIR_Apic_2 171 175 PF02991 0.269
LIG_LIR_Apic_2 448 453 PF02991 0.450
LIG_LIR_Gen_1 30 40 PF02991 0.517
LIG_LIR_Gen_1 396 402 PF02991 0.377
LIG_LIR_Nem_3 269 275 PF02991 0.332
LIG_LIR_Nem_3 396 400 PF02991 0.297
LIG_LYPXL_yS_3 431 434 PF13949 0.284
LIG_Pex14_1 252 256 PF04695 0.269
LIG_Pex14_2 256 260 PF04695 0.334
LIG_Pex14_2 402 406 PF04695 0.269
LIG_PTB_Apo_2 254 261 PF02174 0.414
LIG_SH2_CRK 397 401 PF00017 0.284
LIG_SH2_SRC 231 234 PF00017 0.248
LIG_SH2_SRC 323 326 PF00017 0.284
LIG_SH2_STAP1 231 235 PF00017 0.248
LIG_SH2_STAP1 397 401 PF00017 0.386
LIG_SH2_STAP1 441 445 PF00017 0.264
LIG_SH2_STAT3 441 444 PF00017 0.243
LIG_SH2_STAT3 98 101 PF00017 0.464
LIG_SH2_STAT5 218 221 PF00017 0.292
LIG_SH2_STAT5 323 326 PF00017 0.313
LIG_SH2_STAT5 441 444 PF00017 0.272
LIG_SH2_STAT5 450 453 PF00017 0.340
LIG_SH3_3 122 128 PF00018 0.536
LIG_SH3_3 75 81 PF00018 0.505
LIG_SH3_3 84 90 PF00018 0.401
LIG_SUMO_SIM_anti_2 178 184 PF11976 0.412
LIG_SUMO_SIM_par_1 105 111 PF11976 0.433
LIG_TRAF2_1 137 140 PF00917 0.426
LIG_TRAF2_1 290 293 PF00917 0.269
LIG_TYR_ITIM 229 234 PF00017 0.269
LIG_UBA3_1 259 268 PF00899 0.390
LIG_UBA3_1 389 395 PF00899 0.313
LIG_WRC_WIRS_1 350 355 PF05994 0.269
MOD_CK1_1 327 333 PF00069 0.316
MOD_CK1_1 396 402 PF00069 0.428
MOD_CK2_1 134 140 PF00069 0.457
MOD_CK2_1 219 225 PF00069 0.414
MOD_CK2_1 337 343 PF00069 0.333
MOD_CK2_1 451 457 PF00069 0.310
MOD_CK2_1 99 105 PF00069 0.378
MOD_Cter_Amidation 56 59 PF01082 0.650
MOD_GlcNHglycan 315 318 PF01048 0.331
MOD_GlcNHglycan 326 329 PF01048 0.263
MOD_GlcNHglycan 5 8 PF01048 0.654
MOD_GlcNHglycan 82 85 PF01048 0.508
MOD_GSK3_1 104 111 PF00069 0.467
MOD_GSK3_1 164 171 PF00069 0.414
MOD_GSK3_1 349 356 PF00069 0.269
MOD_GSK3_1 63 70 PF00069 0.559
MOD_N-GLC_1 313 318 PF02516 0.335
MOD_N-GLC_1 40 45 PF02516 0.717
MOD_N-GLC_1 49 54 PF02516 0.747
MOD_N-GLC_1 63 68 PF02516 0.645
MOD_NEK2_1 353 358 PF00069 0.273
MOD_NEK2_1 365 370 PF00069 0.290
MOD_NEK2_2 445 450 PF00069 0.290
MOD_PIKK_1 23 29 PF00454 0.718
MOD_PKA_1 135 141 PF00069 0.558
MOD_PKA_1 58 64 PF00069 0.807
MOD_PKA_2 134 140 PF00069 0.420
MOD_PKA_2 145 151 PF00069 0.420
MOD_PKA_2 58 64 PF00069 0.777
MOD_PKA_2 99 105 PF00069 0.378
MOD_Plk_1 268 274 PF00069 0.342
MOD_Plk_1 365 371 PF00069 0.269
MOD_Plk_1 445 451 PF00069 0.269
MOD_Plk_4 104 110 PF00069 0.434
MOD_Plk_4 168 174 PF00069 0.269
MOD_Plk_4 175 181 PF00069 0.269
MOD_Plk_4 445 451 PF00069 0.269
MOD_ProDKin_1 216 222 PF00069 0.274
MOD_SUMO_rev_2 137 143 PF00179 0.423
MOD_SUMO_rev_2 184 190 PF00179 0.291
TRG_DiLeu_BaEn_1 105 110 PF01217 0.431
TRG_DiLeu_BaEn_4 139 145 PF01217 0.447
TRG_DiLeu_BaLyEn_6 259 264 PF01217 0.363
TRG_ENDOCYTIC_2 231 234 PF00928 0.269
TRG_ENDOCYTIC_2 272 275 PF00928 0.342
TRG_ENDOCYTIC_2 397 400 PF00928 0.302
TRG_ENDOCYTIC_2 431 434 PF00928 0.284
TRG_ER_diArg_1 134 136 PF00400 0.558
TRG_Pf-PMV_PEXEL_1 188 192 PF00026 0.284
TRG_Pf-PMV_PEXEL_1 71 76 PF00026 0.507

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2W6 Leptomonas seymouri 86% 100%
A0A0S4IME4 Bodo saltans 68% 100%
A0A1X0NXP2 Trypanosomatidae 73% 98%
A0A3Q8IBA7 Leishmania donovani 25% 100%
A0A3R7MCJ4 Trypanosoma rangeli 71% 99%
A0A3S7WWI2 Leishmania donovani 100% 100%
A1CCP2 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 50% 97%
A1CH02 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 57% 100%
A1CXT5 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 58% 100%
A1CYM1 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 49% 100%
A1DA84 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 51% 100%
A2QAF9 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 49% 98%
A2QHX0 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 58% 100%
A4H9X3 Leishmania braziliensis 24% 100%
A4HBT2 Leishmania braziliensis 91% 100%
A4RDI6 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 55% 100%
A5DR89 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 53% 100%
A5E5I9 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 52% 98%
A6RGC8 Ajellomyces capsulatus (strain NAm1 / WU24) 45% 100%
A6RTU0 Botryotinia fuckeliana (strain B05.10) 57% 100%
A6ZKL2 Saccharomyces cerevisiae (strain YJM789) 54% 100%
A7EZ86 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 57% 100%
A8QBZ2 Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) 52% 100%
B0CRL4 Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) 53% 100%
B0XTJ7 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 49% 96%
B0Y5N4 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 58% 99%
B0YAX5 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 50% 100%
B2B738 Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) 56% 100%
B2VW14 Pyrenophora tritici-repentis (strain Pt-1C-BFP) 46% 100%
B2W1N6 Pyrenophora tritici-repentis (strain Pt-1C-BFP) 56% 100%
B3LNM2 Saccharomyces cerevisiae (strain RM11-1a) 54% 100%
B5VDQ0 Saccharomyces cerevisiae (strain AWRI1631) 54% 100%
B6H5L5 Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) 47% 100%
B6HTQ4 Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) 56% 100%
B6Q1N3 Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) 58% 100%
B6QD96 Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) 49% 100%
B8LUH2 Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) 59% 100%
B8M990 Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) 49% 100%
B8NA06 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) 58% 100%
B8NLL0 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) 49% 99%
B9WJA2 Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) 53% 100%
C0NIQ4 Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) 56% 100%
C0NX86 Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) 46% 100%
C0SIM8 Paracoccidioides brasiliensis (strain Pb03) 58% 100%
C1GLM4 Paracoccidioides brasiliensis (strain Pb18) 58% 100%
C1HAB2 Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) 59% 100%
C4JSX6 Uncinocarpus reesii (strain UAMH 1704) 55% 100%
C4R2P3 Komagataella phaffii (strain GS115 / ATCC 20864) 55% 100%
C4Y1F8 Clavispora lusitaniae (strain ATCC 42720) 56% 100%
C4YSA9 Candida albicans (strain WO-1) 54% 100%
C5DE35 Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) 55% 100%
C5FEJ1 Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) 46% 100%
C5FF46 Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) 55% 100%
C5GCN0 Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) 57% 100%
C5GLJ6 Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) 46% 100%
C5JW60 Blastomyces gilchristii (strain SLH14081) 57% 100%
C5JYZ5 Blastomyces gilchristii (strain SLH14081) 46% 100%
C5M8M4 Candida tropicalis (strain ATCC MYA-3404 / T1) 55% 100%
C5P8Q4 Coccidioides posadasii (strain C735) 55% 100%
C6HI66 Ajellomyces capsulatus (strain H143) 46% 100%
C7GSF3 Saccharomyces cerevisiae (strain JAY291) 54% 100%
C7YS77 Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4) 56% 100%
C7Z7V7 Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4) 49% 100%
C8Z3V4 Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) 54% 100%
C9SB49 Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) 55% 100%
D0A1D9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
D1ZEN1 Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) 59% 100%
D4B2G3 Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) 55% 100%
D4DE65 Trichophyton verrucosum (strain HKI 0517) 55% 100%
D8PR70 Schizophyllum commune (strain H4-8 / FGSC 9210) 53% 100%
E3L3Q8 Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) 54% 100%
E3QDQ4 Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) 47% 100%
E3QW41 Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) 55% 100%
E3RCY7 Pyrenophora teres f. teres (strain 0-1) 56% 100%
E3RD74 Pyrenophora teres f. teres (strain 0-1) 46% 100%
E4ZYY3 Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) 47% 100%
E5R278 Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) 46% 100%
E5R3Z8 Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) 55% 100%
E5R4J3 Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) 57% 100%
E9AGR8 Leishmania infantum 25% 100%
E9ARW7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AV56 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
H1UBK1 Caenorhabditis elegans 55% 99%
M1CZC0 Solanum tuberosum 23% 100%
O08663 Mus musculus 58% 97%
O60085 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 59% 100%
P38062 Rattus norvegicus 57% 97%
P38174 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 54% 100%
P50579 Homo sapiens 57% 97%
Q09184 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
Q0C838 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 47% 100%
Q0CL94 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 58% 100%
Q0UTI9 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 55% 100%
Q2GSJ7 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 48% 100%
Q2GYA8 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 55% 100%
Q2U6H2 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 49% 99%
Q3ZC89 Bos taurus 58% 97%
Q4QCC5 Leishmania major 97% 100%
Q4QDK5 Leishmania major 24% 100%
Q4WAY7 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 50% 100%
Q4WII3 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 49% 96%
Q4WNT9 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 58% 99%
Q55C21 Dictyostelium discoideum 59% 100%
Q56Y85 Arabidopsis thaliana 63% 100%
Q59LF9 Candida albicans (strain SC5314 / ATCC MYA-2876) 54% 100%
Q5B4X6 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 57% 100%
Q5BGG1 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 49% 100%
Q6BVB8 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 55% 100%
Q6CA79 Yarrowia lipolytica (strain CLIB 122 / E 150) 53% 99%
Q6CP80 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 55% 100%
Q7S7L7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 58% 100%
Q96327 Arabidopsis thaliana 24% 100%
Q9FV49 Arabidopsis thaliana 59% 100%
V5BMW9 Trypanosoma cruzi 71% 98%
V5BS99 Trypanosoma cruzi 26% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS