Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZM4_LEIIN

TriTrypDb:

LINF_210014800

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	5
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HZM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.542
CLV_NRD_NRD_1	223	225	PF00675	0.342
CLV_NRD_NRD_1	229	231	PF00675	0.403
CLV_NRD_NRD_1	281	283	PF00675	0.370
CLV_NRD_NRD_1	32	34	PF00675	0.632
CLV_NRD_NRD_1	8	10	PF00675	0.693
CLV_PCSK_FUR_1	202	206	PF00082	0.546
CLV_PCSK_FUR_1	279	283	PF00082	0.370
CLV_PCSK_FUR_1	39	43	PF00082	0.635
CLV_PCSK_KEX2_1	204	206	PF00082	0.469
CLV_PCSK_KEX2_1	223	225	PF00082	0.342
CLV_PCSK_KEX2_1	228	230	PF00082	0.398
CLV_PCSK_KEX2_1	264	266	PF00082	0.450
CLV_PCSK_KEX2_1	281	283	PF00082	0.370
CLV_PCSK_KEX2_1	32	34	PF00082	0.632
CLV_PCSK_KEX2_1	41	43	PF00082	0.593
CLV_PCSK_KEX2_1	7	9	PF00082	0.656
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.469
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.401
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.450
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.638
CLV_PCSK_PC7_1	224	230	PF00082	0.417
CLV_PCSK_PC7_1	4	10	PF00082	0.651
CLV_PCSK_SKI1_1	121	125	PF00082	0.603
CLV_PCSK_SKI1_1	159	163	PF00082	0.544
CLV_PCSK_SKI1_1	187	191	PF00082	0.575
CLV_PCSK_SKI1_1	205	209	PF00082	0.304
CLV_PCSK_SKI1_1	9	13	PF00082	0.663
DEG_APCC_DBOX_1	186	194	PF00400	0.374
DOC_CYCLIN_RxL_1	224	238	PF00134	0.616
DOC_MAPK_gen_1	228	234	PF00069	0.623
DOC_MAPK_RevD_3	208	224	PF00069	0.304
DOC_PP1_RVXF_1	202	209	PF00149	0.269
DOC_USP7_MATH_1	314	318	PF00917	0.589
DOC_USP7_MATH_1	72	76	PF00917	0.533
DOC_WW_Pin1_4	243	248	PF00397	0.639
DOC_WW_Pin1_4	65	70	PF00397	0.531
DOC_WW_Pin1_4	82	87	PF00397	0.429
LIG_14-3-3_CanoR_1	121	129	PF00244	0.399
LIG_14-3-3_CanoR_1	268	274	PF00244	0.627
LIG_14-3-3_CanoR_1	32	40	PF00244	0.413
LIG_14-3-3_CanoR_1	8	17	PF00244	0.474
LIG_BRCT_BRCA1_1	18	22	PF00533	0.443
LIG_BRCT_BRCA1_1	75	79	PF00533	0.508
LIG_FHA_1	166	172	PF00498	0.351
LIG_FHA_2	122	128	PF00498	0.368
LIG_FHA_2	132	138	PF00498	0.374
LIG_FHA_2	21	27	PF00498	0.430
LIG_FHA_2	270	276	PF00498	0.593
LIG_FHA_2	305	311	PF00498	0.575
LIG_LIR_Gen_1	212	222	PF02991	0.352
LIG_LIR_Gen_1	241	249	PF02991	0.683
LIG_LIR_Nem_3	212	217	PF02991	0.352
LIG_Pex14_1	214	218	PF04695	0.304
LIG_SH2_STAP1	104	108	PF00017	0.421
LIG_SH2_STAT5	226	229	PF00017	0.576
LIG_TRAF2_1	35	38	PF00917	0.388
LIG_WRC_WIRS_1	146	151	PF05994	0.404
MOD_CK1_1	73	79	PF00069	0.648
MOD_CK1_1	96	102	PF00069	0.803
MOD_CK2_1	121	127	PF00069	0.593
MOD_CK2_1	131	137	PF00069	0.404
MOD_CK2_1	251	257	PF00069	0.729
MOD_CK2_1	269	275	PF00069	0.417
MOD_CK2_1	304	310	PF00069	0.451
MOD_CK2_1	32	38	PF00069	0.504
MOD_CK2_1	75	81	PF00069	0.643
MOD_GlcNHglycan	18	21	PF01048	0.542
MOD_GlcNHglycan	70	73	PF01048	0.759
MOD_GlcNHglycan	86	89	PF01048	0.751
MOD_GlcNHglycan	96	99	PF01048	0.768
MOD_GSK3_1	16	23	PF00069	0.563
MOD_GSK3_1	165	172	PF00069	0.417
MOD_GSK3_1	243	250	PF00069	0.559
MOD_GSK3_1	68	75	PF00069	0.770
MOD_GSK3_1	80	87	PF00069	0.526
MOD_GSK3_1	89	96	PF00069	0.635
MOD_NEK2_1	10	15	PF00069	0.580
MOD_NEK2_1	128	133	PF00069	0.475
MOD_NEK2_1	169	174	PF00069	0.405
MOD_NEK2_1	269	274	PF00069	0.544
MOD_NEK2_1	3	8	PF00069	0.571
MOD_NEK2_1	74	79	PF00069	0.669
MOD_NEK2_1	89	94	PF00069	0.516
MOD_PIKK_1	169	175	PF00454	0.432
MOD_PIKK_1	304	310	PF00454	0.451
MOD_PKA_1	32	38	PF00069	0.504
MOD_PKA_2	113	119	PF00069	0.489
MOD_PKA_2	267	273	PF00069	0.572
MOD_PKA_2	3	9	PF00069	0.564
MOD_PKA_2	32	38	PF00069	0.504
MOD_PKB_1	7	15	PF00069	0.575
MOD_Plk_1	165	171	PF00069	0.415
MOD_Plk_4	209	215	PF00069	0.304
MOD_Plk_4	75	81	PF00069	0.601
MOD_ProDKin_1	243	249	PF00069	0.544
MOD_ProDKin_1	65	71	PF00069	0.666
MOD_ProDKin_1	82	88	PF00069	0.528
TRG_ENDOCYTIC_2	120	123	PF00928	0.438
TRG_ENDOCYTIC_2	146	149	PF00928	0.417
TRG_ER_diArg_1	132	135	PF00400	0.442
TRG_ER_diArg_1	222	224	PF00400	0.396
TRG_ER_diArg_1	7	9	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIJ9	Leptomonas seymouri	59%	100%
A0A3S7WWJ0	Leishmania donovani	100%	100%
A4HBT5	Leishmania braziliensis	80%	100%
E9AV57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCC4	Leishmania major	96%	100%