LeishMANIAdb
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Putative serine/threonine-protein kinase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine/threonine-protein kinase
Gene product:
NIMA-related kinase - putative
Species:
Leishmania infantum
UniProt:
A4HZM2_LEIIN
TriTrypDb:
LINF_210024800
Length:
800

Annotations

Annotations by Jardim et al.

Protein kinase, serine/threonine- kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZM2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZM2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0004674 protein serine/threonine kinase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 372 376 PF00656 0.489
CLV_C14_Caspase3-7 514 518 PF00656 0.674
CLV_C14_Caspase3-7 693 697 PF00656 0.579
CLV_NRD_NRD_1 122 124 PF00675 0.382
CLV_NRD_NRD_1 276 278 PF00675 0.586
CLV_NRD_NRD_1 294 296 PF00675 0.550
CLV_NRD_NRD_1 300 302 PF00675 0.442
CLV_NRD_NRD_1 332 334 PF00675 0.565
CLV_NRD_NRD_1 340 342 PF00675 0.441
CLV_NRD_NRD_1 352 354 PF00675 0.268
CLV_NRD_NRD_1 364 366 PF00675 0.437
CLV_NRD_NRD_1 400 402 PF00675 0.530
CLV_NRD_NRD_1 439 441 PF00675 0.473
CLV_NRD_NRD_1 492 494 PF00675 0.618
CLV_NRD_NRD_1 512 514 PF00675 0.342
CLV_NRD_NRD_1 518 520 PF00675 0.582
CLV_NRD_NRD_1 588 590 PF00675 0.775
CLV_NRD_NRD_1 658 660 PF00675 0.496
CLV_NRD_NRD_1 677 679 PF00675 0.381
CLV_PCSK_KEX2_1 122 124 PF00082 0.382
CLV_PCSK_KEX2_1 245 247 PF00082 0.353
CLV_PCSK_KEX2_1 276 278 PF00082 0.616
CLV_PCSK_KEX2_1 294 296 PF00082 0.519
CLV_PCSK_KEX2_1 300 302 PF00082 0.454
CLV_PCSK_KEX2_1 331 333 PF00082 0.566
CLV_PCSK_KEX2_1 340 342 PF00082 0.490
CLV_PCSK_KEX2_1 354 356 PF00082 0.359
CLV_PCSK_KEX2_1 399 401 PF00082 0.520
CLV_PCSK_KEX2_1 439 441 PF00082 0.484
CLV_PCSK_KEX2_1 512 514 PF00082 0.530
CLV_PCSK_KEX2_1 657 659 PF00082 0.441
CLV_PCSK_PC1ET2_1 245 247 PF00082 0.396
CLV_PCSK_PC1ET2_1 354 356 PF00082 0.485
CLV_PCSK_SKI1_1 103 107 PF00082 0.276
CLV_PCSK_SKI1_1 122 126 PF00082 0.163
CLV_PCSK_SKI1_1 127 131 PF00082 0.263
CLV_PCSK_SKI1_1 214 218 PF00082 0.267
CLV_PCSK_SKI1_1 259 263 PF00082 0.414
CLV_PCSK_SKI1_1 354 358 PF00082 0.498
CLV_PCSK_SKI1_1 493 497 PF00082 0.627
CLV_PCSK_SKI1_1 520 524 PF00082 0.618
CLV_PCSK_SKI1_1 680 684 PF00082 0.663
CLV_PCSK_SKI1_1 699 703 PF00082 0.453
CLV_PCSK_SKI1_1 726 730 PF00082 0.357
DEG_APCC_DBOX_1 258 266 PF00400 0.323
DEG_Nend_UBRbox_2 1 3 PF02207 0.393
DEG_SCF_FBW7_1 480 487 PF00400 0.723
DEG_SCF_FBW7_2 630 635 PF00400 0.713
DEG_SPOP_SBC_1 484 488 PF00917 0.703
DOC_CKS1_1 481 486 PF01111 0.725
DOC_CYCLIN_yCln2_LP_2 612 615 PF00134 0.530
DOC_MAPK_gen_1 127 136 PF00069 0.261
DOC_MAPK_gen_1 273 282 PF00069 0.592
DOC_MAPK_gen_1 340 350 PF00069 0.522
DOC_MAPK_MEF2A_6 721 729 PF00069 0.374
DOC_MAPK_MEF2A_6 73 80 PF00069 0.279
DOC_PP2B_LxvP_1 569 572 PF13499 0.680
DOC_PP2B_LxvP_1 602 605 PF13499 0.496
DOC_PP2B_LxvP_1 612 615 PF13499 0.562
DOC_PP4_FxxP_1 707 710 PF00568 0.546
DOC_USP7_MATH_1 247 251 PF00917 0.277
DOC_USP7_MATH_1 485 489 PF00917 0.716
DOC_USP7_MATH_1 547 551 PF00917 0.786
DOC_USP7_MATH_1 564 568 PF00917 0.544
DOC_USP7_MATH_1 694 698 PF00917 0.595
DOC_USP7_MATH_1 710 714 PF00917 0.401
DOC_USP7_MATH_1 789 793 PF00917 0.559
DOC_USP7_MATH_2 42 48 PF00917 0.261
DOC_USP7_UBL2_3 373 377 PF12436 0.624
DOC_USP7_UBL2_3 581 585 PF12436 0.723
DOC_USP7_UBL2_3 675 679 PF12436 0.577
DOC_USP7_UBL2_3 8 12 PF12436 0.353
DOC_WW_Pin1_4 163 168 PF00397 0.261
DOC_WW_Pin1_4 411 416 PF00397 0.684
DOC_WW_Pin1_4 480 485 PF00397 0.619
DOC_WW_Pin1_4 493 498 PF00397 0.555
DOC_WW_Pin1_4 543 548 PF00397 0.693
DOC_WW_Pin1_4 591 596 PF00397 0.683
DOC_WW_Pin1_4 603 608 PF00397 0.580
DOC_WW_Pin1_4 628 633 PF00397 0.668
DOC_WW_Pin1_4 647 652 PF00397 0.648
LIG_14-3-3_CanoR_1 154 158 PF00244 0.261
LIG_14-3-3_CanoR_1 233 239 PF00244 0.339
LIG_14-3-3_CanoR_1 246 255 PF00244 0.204
LIG_14-3-3_CanoR_1 276 280 PF00244 0.579
LIG_14-3-3_CanoR_1 534 543 PF00244 0.556
LIG_Actin_WH2_2 145 162 PF00022 0.261
LIG_Actin_WH2_2 204 219 PF00022 0.277
LIG_Actin_WH2_2 28 43 PF00022 0.353
LIG_AP2alpha_1 682 686 PF02296 0.615
LIG_APCC_ABBA_1 725 730 PF00400 0.354
LIG_APCC_ABBAyCdc20_2 122 128 PF00400 0.254
LIG_BRCT_BRCA1_1 504 508 PF00533 0.639
LIG_FHA_1 129 135 PF00498 0.277
LIG_FHA_1 154 160 PF00498 0.291
LIG_FHA_1 62 68 PF00498 0.261
LIG_FHA_1 704 710 PF00498 0.447
LIG_FHA_1 713 719 PF00498 0.407
LIG_FHA_2 494 500 PF00498 0.581
LIG_FHA_2 535 541 PF00498 0.743
LIG_FHA_2 650 656 PF00498 0.584
LIG_LIR_Apic_2 166 172 PF02991 0.261
LIG_LIR_Apic_2 706 710 PF02991 0.536
LIG_LIR_Gen_1 2 10 PF02991 0.285
LIG_LIR_Gen_1 660 670 PF02991 0.402
LIG_LIR_Gen_1 75 83 PF02991 0.296
LIG_LIR_Nem_3 2 7 PF02991 0.261
LIG_LIR_Nem_3 660 666 PF02991 0.415
LIG_LIR_Nem_3 87 92 PF02991 0.261
LIG_LYPXL_S_1 219 223 PF13949 0.277
LIG_LYPXL_yS_3 220 223 PF13949 0.261
LIG_MAD2 214 222 PF02301 0.261
LIG_PCNA_yPIPBox_3 209 220 PF02747 0.282
LIG_PDZ_Class_2 795 800 PF00595 0.634
LIG_Pex14_2 15 19 PF04695 0.261
LIG_Pex14_2 682 686 PF04695 0.615
LIG_SH2_CRK 4 8 PF00017 0.321
LIG_SH2_CRK 89 93 PF00017 0.261
LIG_SH2_GRB2like 82 85 PF00017 0.296
LIG_SH2_SRC 66 69 PF00017 0.261
LIG_SH2_SRC 82 85 PF00017 0.261
LIG_SH2_STAP1 227 231 PF00017 0.277
LIG_SH2_STAT5 169 172 PF00017 0.278
LIG_SH2_STAT5 4 7 PF00017 0.266
LIG_SH2_STAT5 490 493 PF00017 0.625
LIG_SH2_STAT5 66 69 PF00017 0.261
LIG_SH3_3 216 222 PF00018 0.296
LIG_SH3_3 472 478 PF00018 0.662
LIG_SH3_3 530 536 PF00018 0.548
LIG_SH3_3 557 563 PF00018 0.678
LIG_SH3_3 608 614 PF00018 0.736
LIG_SH3_4 581 588 PF00018 0.657
LIG_SUMO_SIM_par_1 250 256 PF11976 0.268
LIG_SUMO_SIM_par_1 278 284 PF11976 0.590
LIG_TRAF2_1 281 284 PF00917 0.526
LIG_TRAF2_1 349 352 PF00917 0.522
LIG_TRAF2_1 496 499 PF00917 0.565
LIG_TRAF2_1 576 579 PF00917 0.639
LIG_UBA3_1 238 245 PF00899 0.333
LIG_WW_3 479 483 PF00397 0.729
MOD_CK1_1 14 20 PF00069 0.261
MOD_CK1_1 229 235 PF00069 0.291
MOD_CK1_1 278 284 PF00069 0.586
MOD_CK1_1 546 552 PF00069 0.752
MOD_CK1_1 556 562 PF00069 0.783
MOD_CK1_1 791 797 PF00069 0.613
MOD_CK2_1 278 284 PF00069 0.578
MOD_CK2_1 427 433 PF00069 0.563
MOD_CK2_1 493 499 PF00069 0.591
MOD_CK2_1 534 540 PF00069 0.745
MOD_CK2_1 647 653 PF00069 0.578
MOD_CK2_1 748 754 PF00069 0.570
MOD_GlcNHglycan 16 19 PF01048 0.261
MOD_GlcNHglycan 428 432 PF01048 0.521
MOD_GlcNHglycan 46 49 PF01048 0.261
MOD_GlcNHglycan 468 473 PF01048 0.701
MOD_GlcNHglycan 537 540 PF01048 0.689
MOD_GlcNHglycan 553 556 PF01048 0.706
MOD_GlcNHglycan 573 576 PF01048 0.447
MOD_GlcNHglycan 712 715 PF01048 0.556
MOD_GlcNHglycan 748 751 PF01048 0.545
MOD_GlcNHglycan 760 763 PF01048 0.543
MOD_GlcNHglycan 791 794 PF01048 0.659
MOD_GlcNHglycan 795 798 PF01048 0.673
MOD_GSK3_1 159 166 PF00069 0.261
MOD_GSK3_1 225 232 PF00069 0.282
MOD_GSK3_1 407 414 PF00069 0.735
MOD_GSK3_1 480 487 PF00069 0.723
MOD_GSK3_1 489 496 PF00069 0.682
MOD_GSK3_1 543 550 PF00069 0.757
MOD_GSK3_1 591 598 PF00069 0.701
MOD_GSK3_1 787 794 PF00069 0.553
MOD_N-GLC_1 181 186 PF02516 0.261
MOD_N-GLC_1 229 234 PF02516 0.296
MOD_N-GLC_1 247 252 PF02516 0.296
MOD_N-GLC_1 61 66 PF02516 0.261
MOD_N-GLC_1 710 715 PF02516 0.509
MOD_N-GLC_1 746 751 PF02516 0.507
MOD_NEK2_1 114 119 PF00069 0.379
MOD_NEK2_1 147 152 PF00069 0.261
MOD_NEK2_1 159 164 PF00069 0.261
MOD_NEK2_1 203 208 PF00069 0.362
MOD_NEK2_1 226 231 PF00069 0.329
MOD_NEK2_1 234 239 PF00069 0.285
MOD_NEK2_1 253 258 PF00069 0.422
MOD_NEK2_1 54 59 PF00069 0.396
MOD_NEK2_2 450 455 PF00069 0.574
MOD_PIKK_1 107 113 PF00454 0.277
MOD_PIKK_1 128 134 PF00454 0.267
MOD_PIKK_1 2 8 PF00454 0.344
MOD_PIKK_1 247 253 PF00454 0.296
MOD_PIKK_1 459 465 PF00454 0.683
MOD_PIKK_1 502 508 PF00454 0.613
MOD_PK_1 553 559 PF00069 0.542
MOD_PKA_2 153 159 PF00069 0.261
MOD_PKA_2 275 281 PF00069 0.596
MOD_PKA_2 44 50 PF00069 0.268
MOD_PKA_2 450 456 PF00069 0.657
MOD_Plk_1 194 200 PF00069 0.261
MOD_Plk_1 229 235 PF00069 0.346
MOD_Plk_1 247 253 PF00069 0.170
MOD_Plk_1 468 474 PF00069 0.541
MOD_Plk_1 61 67 PF00069 0.269
MOD_Plk_1 695 701 PF00069 0.568
MOD_Plk_4 114 120 PF00069 0.379
MOD_Plk_4 148 154 PF00069 0.277
MOD_Plk_4 234 240 PF00069 0.305
MOD_Plk_4 253 259 PF00069 0.318
MOD_Plk_4 450 456 PF00069 0.642
MOD_Plk_4 665 671 PF00069 0.424
MOD_Plk_4 72 78 PF00069 0.296
MOD_ProDKin_1 163 169 PF00069 0.261
MOD_ProDKin_1 411 417 PF00069 0.679
MOD_ProDKin_1 480 486 PF00069 0.620
MOD_ProDKin_1 493 499 PF00069 0.547
MOD_ProDKin_1 543 549 PF00069 0.694
MOD_ProDKin_1 591 597 PF00069 0.682
MOD_ProDKin_1 603 609 PF00069 0.580
MOD_ProDKin_1 628 634 PF00069 0.666
MOD_ProDKin_1 647 653 PF00069 0.642
MOD_SUMO_rev_2 347 356 PF00179 0.544
MOD_SUMO_rev_2 372 378 PF00179 0.487
MOD_SUMO_rev_2 573 583 PF00179 0.657
MOD_SUMO_rev_2 68 75 PF00179 0.379
MOD_SUMO_rev_2 697 707 PF00179 0.624
TRG_DiLeu_BaLyEn_6 230 235 PF01217 0.396
TRG_ENDOCYTIC_2 220 223 PF00928 0.261
TRG_ENDOCYTIC_2 4 7 PF00928 0.261
TRG_ENDOCYTIC_2 435 438 PF00928 0.481
TRG_ENDOCYTIC_2 663 666 PF00928 0.382
TRG_ENDOCYTIC_2 742 745 PF00928 0.372
TRG_ENDOCYTIC_2 89 92 PF00928 0.292
TRG_ER_diArg_1 122 124 PF00400 0.382
TRG_ER_diArg_1 299 301 PF00400 0.500
TRG_ER_diArg_1 331 333 PF00400 0.571
TRG_ER_diArg_1 340 342 PF00400 0.553
TRG_ER_diArg_1 399 401 PF00400 0.541
TRG_ER_diArg_1 438 440 PF00400 0.480
TRG_ER_diArg_1 511 513 PF00400 0.515
TRG_ER_diArg_1 657 659 PF00400 0.566
TRG_NES_CRM1_1 260 275 PF08389 0.436
TRG_NES_CRM1_1 716 730 PF08389 0.369
TRG_Pf-PMV_PEXEL_1 123 128 PF00026 0.274
TRG_Pf-PMV_PEXEL_1 333 337 PF00026 0.515
TRG_Pf-PMV_PEXEL_1 340 345 PF00026 0.466
TRG_Pf-PMV_PEXEL_1 355 359 PF00026 0.397
TRG_Pf-PMV_PEXEL_1 365 370 PF00026 0.477

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9W7 Leptomonas seymouri 65% 100%
A0A0S4JKY4 Bodo saltans 45% 100%
A0A1X0NHD4 Trypanosomatidae 48% 100%
A0A3Q8IBZ9 Leishmania donovani 100% 100%
A0A3R7M6Z7 Trypanosoma rangeli 47% 100%
A4HC09 Leishmania braziliensis 84% 100%
D0A118 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AVE6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QC33 Leishmania major 95% 100%
V5BLW4 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS