LeishMANIAdb
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TRAF3-interacting protein 1

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TRAF3-interacting protein 1
Gene product:
Microtubule-binding protein MIP-T3 - putative
Species:
Leishmania infantum
UniProt:
A4HZM1_LEIIN
TriTrypDb:
LINF_210024900
Length:
485

Annotations

Annotations by Jardim et al.

Structural Proteins, Microtubule-binding MIP-T3

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005813 centrosome 3 1
GO:0005815 microtubule organizing center 2 1
GO:0005930 axoneme 2 1
GO:0030992 intraciliary transport particle B 2 1
GO:0032991 protein-containing complex 1 1
GO:0036064 ciliary basal body 3 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZM1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZM1

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006996 organelle organization 4 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
GO:0010970 transport along microtubule 4 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0030705 cytoskeleton-dependent intracellular transport 4 1
GO:0031503 protein-containing complex localization 2 1
GO:0032886 regulation of microtubule-based process 4 1
GO:0033043 regulation of organelle organization 5 1
GO:0042073 intraciliary transport 3 1
GO:0044782 cilium organization 5 1
GO:0046907 intracellular transport 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051128 regulation of cellular component organization 4 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051493 regulation of cytoskeleton organization 6 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0060271 cilium assembly 6 1
GO:0065007 biological regulation 1 1
GO:0070507 regulation of microtubule cytoskeleton organization 5 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0099111 microtubule-based transport 4 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0005515 protein binding 2 6
GO:0008017 microtubule binding 5 6
GO:0008092 cytoskeletal protein binding 3 6
GO:0015631 tubulin binding 4 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 401 405 PF00656 0.475
CLV_C14_Caspase3-7 55 59 PF00656 0.475
CLV_NRD_NRD_1 125 127 PF00675 0.480
CLV_NRD_NRD_1 167 169 PF00675 0.558
CLV_NRD_NRD_1 174 176 PF00675 0.469
CLV_NRD_NRD_1 223 225 PF00675 0.620
CLV_NRD_NRD_1 239 241 PF00675 0.540
CLV_NRD_NRD_1 333 335 PF00675 0.300
CLV_NRD_NRD_1 428 430 PF00675 0.275
CLV_PCSK_FUR_1 164 168 PF00082 0.537
CLV_PCSK_FUR_1 172 176 PF00082 0.482
CLV_PCSK_KEX2_1 166 168 PF00082 0.558
CLV_PCSK_KEX2_1 172 174 PF00082 0.484
CLV_PCSK_KEX2_1 180 182 PF00082 0.395
CLV_PCSK_KEX2_1 225 227 PF00082 0.641
CLV_PCSK_KEX2_1 273 275 PF00082 0.676
CLV_PCSK_KEX2_1 325 327 PF00082 0.293
CLV_PCSK_KEX2_1 333 335 PF00082 0.258
CLV_PCSK_KEX2_1 428 430 PF00082 0.275
CLV_PCSK_PC1ET2_1 166 168 PF00082 0.558
CLV_PCSK_PC1ET2_1 180 182 PF00082 0.395
CLV_PCSK_PC1ET2_1 225 227 PF00082 0.651
CLV_PCSK_PC1ET2_1 273 275 PF00082 0.676
CLV_PCSK_PC1ET2_1 325 327 PF00082 0.275
CLV_PCSK_PC7_1 168 174 PF00082 0.548
CLV_PCSK_PC7_1 221 227 PF00082 0.661
CLV_PCSK_SKI1_1 314 318 PF00082 0.275
CLV_PCSK_SKI1_1 65 69 PF00082 0.275
DEG_APCC_DBOX_1 378 386 PF00400 0.547
DEG_Nend_UBRbox_2 1 3 PF02207 0.502
DOC_MAPK_gen_1 65 71 PF00069 0.475
DOC_MAPK_RevD_3 311 326 PF00069 0.475
DOC_PP1_RVXF_1 66 72 PF00149 0.475
DOC_USP7_MATH_1 115 119 PF00917 0.455
DOC_USP7_MATH_1 142 146 PF00917 0.648
DOC_USP7_MATH_1 235 239 PF00917 0.646
DOC_USP7_MATH_1 89 93 PF00917 0.412
DOC_USP7_UBL2_3 61 65 PF12436 0.475
DOC_WW_Pin1_4 260 265 PF00397 0.501
DOC_WW_Pin1_4 82 87 PF00397 0.457
LIG_14-3-3_CanoR_1 20 26 PF00244 0.376
LIG_14-3-3_CanoR_1 428 435 PF00244 0.475
LIG_Actin_WH2_2 446 462 PF00022 0.535
LIG_BIR_III_2 261 265 PF00653 0.637
LIG_FHA_1 101 107 PF00498 0.457
LIG_FHA_1 20 26 PF00498 0.475
LIG_FHA_1 227 233 PF00498 0.595
LIG_FHA_1 247 253 PF00498 0.490
LIG_FHA_1 261 267 PF00498 0.490
LIG_FHA_1 302 308 PF00498 0.629
LIG_FHA_1 405 411 PF00498 0.539
LIG_FHA_1 454 460 PF00498 0.475
LIG_FHA_2 158 164 PF00498 0.538
LIG_FHA_2 196 202 PF00498 0.593
LIG_FHA_2 277 283 PF00498 0.604
LIG_FHA_2 6 12 PF00498 0.475
LIG_LIR_Gen_1 105 115 PF02991 0.475
LIG_LIR_Gen_1 287 296 PF02991 0.599
LIG_LIR_Nem_3 105 110 PF02991 0.475
LIG_LIR_Nem_3 287 292 PF02991 0.598
LIG_PCNA_yPIPBox_3 7 16 PF02747 0.475
LIG_SH2_STAT5 33 36 PF00017 0.475
LIG_SH3_1 240 246 PF00018 0.644
LIG_SH3_3 240 246 PF00018 0.644
LIG_TRAF2_1 156 159 PF00917 0.575
LIG_TRAF2_1 160 163 PF00917 0.506
LIG_TRAF2_1 198 201 PF00917 0.639
LIG_TRAF2_1 434 437 PF00917 0.475
LIG_TRAF2_1 96 99 PF00917 0.475
LIG_WRC_WIRS_1 38 43 PF05994 0.439
LIG_WW_3 242 246 PF00397 0.642
MOD_CK1_1 150 156 PF00069 0.580
MOD_CK1_1 212 218 PF00069 0.592
MOD_CK1_1 357 363 PF00069 0.474
MOD_CK2_1 143 149 PF00069 0.650
MOD_CK2_1 157 163 PF00069 0.451
MOD_CK2_1 195 201 PF00069 0.614
MOD_CK2_1 276 282 PF00069 0.606
MOD_CK2_1 431 437 PF00069 0.475
MOD_CK2_1 5 11 PF00069 0.475
MOD_Cter_Amidation 271 274 PF01082 0.656
MOD_GlcNHglycan 117 120 PF01048 0.496
MOD_GlcNHglycan 128 131 PF01048 0.472
MOD_GlcNHglycan 149 152 PF01048 0.586
MOD_GlcNHglycan 211 214 PF01048 0.613
MOD_GlcNHglycan 237 240 PF01048 0.647
MOD_GlcNHglycan 58 61 PF01048 0.239
MOD_GSK3_1 143 150 PF00069 0.586
MOD_GSK3_1 195 202 PF00069 0.614
MOD_GSK3_1 231 238 PF00069 0.642
MOD_GSK3_1 353 360 PF00069 0.475
MOD_GSK3_1 85 92 PF00069 0.376
MOD_NEK2_1 42 47 PF00069 0.474
MOD_NEK2_1 459 464 PF00069 0.441
MOD_NEK2_1 473 478 PF00069 0.475
MOD_NEK2_1 5 10 PF00069 0.341
MOD_PIKK_1 5 11 PF00454 0.475
MOD_PKA_1 126 132 PF00069 0.503
MOD_PKA_1 147 153 PF00069 0.578
MOD_PKA_1 225 231 PF00069 0.625
MOD_PKA_1 428 434 PF00069 0.475
MOD_PKA_2 19 25 PF00069 0.376
MOD_PKA_2 225 231 PF00069 0.625
MOD_PKA_2 428 434 PF00069 0.475
MOD_PKA_2 459 465 PF00069 0.475
MOD_PKA_2 89 95 PF00069 0.412
MOD_PKB_1 224 232 PF00069 0.574
MOD_Plk_1 431 437 PF00069 0.502
MOD_Plk_2-3 278 284 PF00069 0.654
MOD_Plk_4 37 43 PF00069 0.475
MOD_Plk_4 459 465 PF00069 0.475
MOD_Plk_4 473 479 PF00069 0.475
MOD_ProDKin_1 260 266 PF00069 0.503
MOD_ProDKin_1 82 88 PF00069 0.457
MOD_SUMO_rev_2 146 156 PF00179 0.578
MOD_SUMO_rev_2 294 301 PF00179 0.646
MOD_SUMO_rev_2 309 316 PF00179 0.475
MOD_SUMO_rev_2 58 67 PF00179 0.475
TRG_DiLeu_BaEn_1 380 385 PF01217 0.457
TRG_ER_diArg_1 172 175 PF00400 0.547
TRG_NES_CRM1_1 401 416 PF08389 0.475
TRG_NLS_MonoExtC_3 272 278 PF00514 0.656
TRG_NLS_MonoExtN_4 270 277 PF00514 0.653
TRG_Pf-PMV_PEXEL_1 32 36 PF00026 0.275

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WWV8 Leishmania donovani 100% 100%
A4HC10 Leishmania braziliensis 79% 99%
E9AVE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QC32 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS