LeishMANIAdb
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tRNA N(3)-methylcytidine methyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
tRNA N(3)-methylcytidine methyltransferase
Gene product:
Methyltransferase domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HZL8_LEIIN
TriTrypDb:
LINF_210005200
Length:
345

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZL8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZL8

Function

Biological processes
Term Name Level Count
GO:0001510 RNA methylation 4 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006396 RNA processing 6 5
GO:0006399 tRNA metabolic process 7 5
GO:0006400 tRNA modification 6 5
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008033 tRNA processing 8 5
GO:0008152 metabolic process 1 12
GO:0009451 RNA modification 5 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0030488 tRNA methylation 5 5
GO:0032259 methylation 2 12
GO:0034470 ncRNA processing 7 5
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 5
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0043414 macromolecule methylation 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0008168 methyltransferase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016741 transferase activity, transferring one-carbon groups 3 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 268 272 PF00656 0.480
CLV_NRD_NRD_1 106 108 PF00675 0.353
CLV_NRD_NRD_1 12 14 PF00675 0.511
CLV_NRD_NRD_1 323 325 PF00675 0.364
CLV_PCSK_KEX2_1 106 108 PF00082 0.353
CLV_PCSK_SKI1_1 239 243 PF00082 0.251
DEG_APCC_DBOX_1 162 170 PF00400 0.422
DEG_Nend_UBRbox_2 1 3 PF02207 0.576
DOC_MAPK_DCC_7 163 173 PF00069 0.499
DOC_MAPK_gen_1 242 253 PF00069 0.381
DOC_MAPK_gen_1 324 335 PF00069 0.317
DOC_MAPK_MEF2A_6 129 138 PF00069 0.407
DOC_MAPK_MEF2A_6 215 224 PF00069 0.512
DOC_USP7_MATH_1 207 211 PF00917 0.517
DOC_USP7_UBL2_3 239 243 PF12436 0.511
DOC_USP7_UBL2_3 269 273 PF12436 0.488
DOC_USP7_UBL2_3 325 329 PF12436 0.351
DOC_WW_Pin1_4 106 111 PF00397 0.472
DOC_WW_Pin1_4 130 135 PF00397 0.426
DOC_WW_Pin1_4 141 146 PF00397 0.402
LIG_14-3-3_CanoR_1 163 169 PF00244 0.436
LIG_14-3-3_CanoR_1 19 26 PF00244 0.340
LIG_Actin_WH2_2 227 244 PF00022 0.479
LIG_Actin_WH2_2 86 103 PF00022 0.396
LIG_APCC_ABBA_1 250 255 PF00400 0.438
LIG_Clathr_ClatBox_1 304 308 PF01394 0.315
LIG_deltaCOP1_diTrp_1 73 80 PF00928 0.378
LIG_FHA_1 183 189 PF00498 0.502
LIG_FHA_1 196 202 PF00498 0.412
LIG_FHA_1 283 289 PF00498 0.418
LIG_FHA_1 336 342 PF00498 0.345
LIG_FHA_2 130 136 PF00498 0.536
LIG_FHA_2 178 184 PF00498 0.561
LIG_FHA_2 203 209 PF00498 0.485
LIG_FHA_2 39 45 PF00498 0.394
LIG_LIR_Apic_2 255 259 PF02991 0.262
LIG_LIR_Gen_1 64 72 PF02991 0.578
LIG_LIR_LC3C_4 198 201 PF02991 0.424
LIG_LIR_Nem_3 135 141 PF02991 0.424
LIG_LIR_Nem_3 260 266 PF02991 0.380
LIG_LIR_Nem_3 64 68 PF02991 0.541
LIG_Pex14_1 76 80 PF04695 0.342
LIG_Pex14_2 290 294 PF04695 0.286
LIG_PTAP_UEV_1 183 188 PF05743 0.407
LIG_PTB_Apo_2 273 280 PF02174 0.415
LIG_PTB_Apo_2 333 340 PF02174 0.268
LIG_REV1ctd_RIR_1 261 269 PF16727 0.373
LIG_REV1ctd_RIR_1 287 296 PF16727 0.365
LIG_SH2_NCK_1 256 260 PF00017 0.268
LIG_SH2_SRC 92 95 PF00017 0.383
LIG_SH2_STAT5 160 163 PF00017 0.510
LIG_SH2_STAT5 92 95 PF00017 0.330
LIG_SH3_3 181 187 PF00018 0.507
LIG_SH3_3 69 75 PF00018 0.448
LIG_SUMO_SIM_anti_2 217 223 PF11976 0.435
LIG_SUMO_SIM_par_1 169 177 PF11976 0.467
LIG_SUMO_SIM_par_1 197 202 PF11976 0.424
LIG_SUMO_SIM_par_1 303 309 PF11976 0.317
LIG_TRFH_1 339 343 PF08558 0.366
LIG_UBA3_1 234 243 PF00899 0.416
MOD_CK1_1 146 152 PF00069 0.450
MOD_CK1_1 177 183 PF00069 0.465
MOD_CK1_1 312 318 PF00069 0.313
MOD_CK1_1 64 70 PF00069 0.581
MOD_CK2_1 38 44 PF00069 0.390
MOD_CK2_1 64 70 PF00069 0.538
MOD_Cter_Amidation 104 107 PF01082 0.326
MOD_Cter_Amidation 326 329 PF01082 0.375
MOD_GlcNHglycan 145 148 PF01048 0.237
MOD_GlcNHglycan 180 183 PF01048 0.226
MOD_GlcNHglycan 225 228 PF01048 0.267
MOD_GlcNHglycan 235 238 PF01048 0.273
MOD_GlcNHglycan 299 302 PF01048 0.409
MOD_GlcNHglycan 80 83 PF01048 0.536
MOD_GSK3_1 14 21 PF00069 0.477
MOD_GSK3_1 146 153 PF00069 0.460
MOD_GSK3_1 173 180 PF00069 0.449
MOD_GSK3_1 182 189 PF00069 0.433
MOD_GSK3_1 223 230 PF00069 0.413
MOD_GSK3_1 57 64 PF00069 0.408
MOD_N-GLC_1 195 200 PF02516 0.220
MOD_N-GLC_1 312 317 PF02516 0.240
MOD_N-GLC_1 335 340 PF02516 0.299
MOD_NEK2_1 223 228 PF00069 0.406
MOD_NEK2_1 78 83 PF00069 0.511
MOD_NEK2_1 99 104 PF00069 0.353
MOD_PIKK_1 283 289 PF00454 0.426
MOD_PKA_2 18 24 PF00069 0.564
MOD_Plk_1 195 201 PF00069 0.506
MOD_Plk_1 207 213 PF00069 0.387
MOD_Plk_1 312 318 PF00069 0.240
MOD_Plk_1 38 44 PF00069 0.403
MOD_Plk_4 120 126 PF00069 0.416
MOD_Plk_4 164 170 PF00069 0.433
MOD_Plk_4 195 201 PF00069 0.420
MOD_ProDKin_1 106 112 PF00069 0.466
MOD_ProDKin_1 130 136 PF00069 0.426
MOD_ProDKin_1 141 147 PF00069 0.402
MOD_SUMO_rev_2 268 274 PF00179 0.455
MOD_SUMO_rev_2 30 38 PF00179 0.358
TRG_DiLeu_BaEn_1 195 200 PF01217 0.387
TRG_DiLeu_BaLyEn_6 95 100 PF01217 0.302
TRG_ENDOCYTIC_2 291 294 PF00928 0.254
TRG_ER_diArg_1 10 13 PF00400 0.583
TRG_Pf-PMV_PEXEL_1 45 49 PF00026 0.384

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4J3 Leptomonas seymouri 26% 97%
A0A0N1I1R8 Leptomonas seymouri 65% 99%
A0A0S4ISJ6 Bodo saltans 32% 78%
A0A1X0NXB7 Trypanosomatidae 45% 99%
A0A3Q8IDT0 Leishmania donovani 98% 100%
A0A3R7M2M3 Trypanosoma rangeli 27% 100%
A0A3S7X9Q3 Leishmania donovani 25% 89%
A0A422MZQ7 Trypanosoma rangeli 44% 100%
A4HBJ6 Leishmania braziliensis 71% 100%
A4HN30 Leishmania braziliensis 24% 100%
A4IBP9 Leishmania infantum 25% 89%
A8KBL7 Danio rerio 26% 98%
C9ZYX5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A1J3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AUW5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9B6N9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
O74386 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
Q0P5B2 Bos taurus 28% 91%
Q4QCL7 Leishmania major 90% 100%
Q5RDV8 Pongo abelii 26% 100%
Q6AXU8 Rattus norvegicus 28% 100%
Q8BVH9 Mus musculus 28% 100%
Q8TCB7 Homo sapiens 26% 100%
Q9P7L6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
V5BCV4 Trypanosoma cruzi 26% 100%
V5DGW7 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS