LeishMANIAdb
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BAR domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
BAR domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZL6_LEIIN
TriTrypDb:
LINF_210005500
Length:
231

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 6
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 24
NetGPI no yes: 0, no: 24
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005886 plasma membrane 3 1
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0031253 cell projection membrane 4 1
GO:0060170 ciliary membrane 5 1
GO:0098588 bounding membrane of organelle 4 1
GO:0098590 plasma membrane region 3 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZL6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZL6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 166 170 PF00656 0.420
CLV_C14_Caspase3-7 73 77 PF00656 0.422
CLV_NRD_NRD_1 1 3 PF00675 0.416
CLV_NRD_NRD_1 148 150 PF00675 0.590
CLV_NRD_NRD_1 167 169 PF00675 0.423
CLV_NRD_NRD_1 223 225 PF00675 0.412
CLV_PCSK_KEX2_1 126 128 PF00082 0.556
CLV_PCSK_KEX2_1 167 169 PF00082 0.461
CLV_PCSK_KEX2_1 223 225 PF00082 0.580
CLV_PCSK_PC1ET2_1 126 128 PF00082 0.525
CLV_PCSK_PC1ET2_1 223 225 PF00082 0.563
CLV_PCSK_SKI1_1 180 184 PF00082 0.475
CLV_PCSK_SKI1_1 3 7 PF00082 0.463
CLV_PCSK_SKI1_1 9 13 PF00082 0.447
DEG_Nend_UBRbox_1 1 4 PF02207 0.497
DOC_MAPK_gen_1 223 231 PF00069 0.427
DOC_MAPK_MEF2A_6 91 100 PF00069 0.276
DOC_MAPK_RevD_3 111 127 PF00069 0.313
DOC_PP1_RVXF_1 15 22 PF00149 0.336
DOC_USP7_MATH_1 125 129 PF00917 0.411
DOC_USP7_MATH_1 206 210 PF00917 0.430
LIG_14-3-3_CanoR_1 48 55 PF00244 0.543
LIG_deltaCOP1_diTrp_1 20 23 PF00928 0.319
LIG_FHA_1 206 212 PF00498 0.544
LIG_FHA_2 101 107 PF00498 0.452
LIG_FHA_2 140 146 PF00498 0.566
LIG_FHA_2 183 189 PF00498 0.572
LIG_FHA_2 34 40 PF00498 0.516
LIG_FHA_2 54 60 PF00498 0.473
LIG_LIR_Gen_1 184 194 PF02991 0.414
LIG_LIR_Gen_1 84 92 PF02991 0.430
LIG_LIR_Nem_3 133 137 PF02991 0.435
LIG_LIR_Nem_3 184 189 PF02991 0.415
LIG_PCNA_PIPBox_1 198 207 PF02747 0.336
LIG_PDZ_Class_2 226 231 PF00595 0.584
LIG_SH2_STAP1 161 165 PF00017 0.455
LIG_SH2_STAT5 204 207 PF00017 0.540
LIG_UBA3_1 211 217 PF00899 0.473
LIG_UBA3_1 54 63 PF00899 0.338
MOD_CK1_1 57 63 PF00069 0.406
MOD_CK2_1 106 112 PF00069 0.494
MOD_CK2_1 139 145 PF00069 0.466
MOD_CK2_1 182 188 PF00069 0.449
MOD_CK2_1 39 45 PF00069 0.498
MOD_CK2_1 53 59 PF00069 0.401
MOD_GlcNHglycan 41 44 PF01048 0.530
MOD_GlcNHglycan 48 51 PF01048 0.498
MOD_GSK3_1 163 170 PF00069 0.494
MOD_GSK3_1 200 207 PF00069 0.462
MOD_GSK3_1 29 36 PF00069 0.466
MOD_GSK3_1 44 51 PF00069 0.496
MOD_GSK3_1 53 60 PF00069 0.425
MOD_N-GLC_1 33 38 PF02516 0.400
MOD_NEK2_1 155 160 PF00069 0.467
MOD_NEK2_1 182 187 PF00069 0.491
MOD_NEK2_1 205 210 PF00069 0.531
MOD_NEK2_1 211 216 PF00069 0.552
MOD_NEK2_1 219 224 PF00069 0.588
MOD_NEK2_1 5 10 PF00069 0.500
MOD_PIKK_1 206 212 PF00454 0.370
MOD_PIKK_1 48 54 PF00454 0.595
MOD_PKA_1 167 173 PF00069 0.471
MOD_PKA_2 167 173 PF00069 0.475
MOD_Plk_1 106 112 PF00069 0.470
MOD_Plk_1 33 39 PF00069 0.593
MOD_Plk_2-3 106 112 PF00069 0.552
MOD_Plk_4 200 206 PF00069 0.511
MOD_Plk_4 57 63 PF00069 0.424
MOD_SUMO_rev_2 122 128 PF00179 0.449
MOD_SUMO_rev_2 154 160 PF00179 0.527
MOD_SUMO_rev_2 179 185 PF00179 0.520
MOD_SUMO_rev_2 188 194 PF00179 0.499
MOD_SUMO_rev_2 20 27 PF00179 0.497
MOD_SUMO_rev_2 38 43 PF00179 0.340
MOD_SUMO_rev_2 95 103 PF00179 0.486
TRG_ENDOCYTIC_2 186 189 PF00928 0.359
TRG_NES_CRM1_1 52 66 PF08389 0.344
TRG_NLS_MonoExtC_3 148 153 PF00514 0.590
TRG_NLS_MonoExtN_4 191 196 PF00514 0.317

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4S1 Leptomonas seymouri 31% 97%
A0A0N1PD85 Leptomonas seymouri 45% 100%
A0A1X0NEE3 Trypanosomatidae 26% 84%
A0A1X0NFG5 Trypanosomatidae 26% 84%
A0A1X0NXA6 Trypanosomatidae 28% 76%
A0A1X0NXA8 Trypanosomatidae 40% 99%
A0A3Q8IKU7 Leishmania donovani 99% 100%
A0A3S5H792 Leishmania donovani 32% 94%
A0A3S5H7I1 Leishmania donovani 27% 68%
A0A422MZP2 Trypanosoma rangeli 29% 76%
A4HBJ9 Leishmania braziliensis 55% 100%
A4HBK0 Leishmania braziliensis 30% 100%
A4HFU7 Leishmania braziliensis 26% 68%
A4HZL5 Leishmania infantum 32% 100%
A4I2W4 Leishmania infantum 27% 68%
E9ADF0 Leishmania major 28% 68%
E9AUW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9AUW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AZ74 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 68%
Q4QCL3 Leishmania major 32% 100%
Q4QCL4 Leishmania major 92% 100%
V5BG41 Trypanosoma cruzi 34% 99%
V5BKK3 Trypanosoma cruzi 28% 76%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS