Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZL3_LEIIN

TriTrypDb:

LINF_210005800

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZL3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006720	isoprenoid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	412	416	PF00656	0.455
CLV_NRD_NRD_1	12	14	PF00675	0.449
CLV_NRD_NRD_1	246	248	PF00675	0.560
CLV_NRD_NRD_1	376	378	PF00675	0.507
CLV_PCSK_KEX2_1	12	14	PF00082	0.461
CLV_PCSK_KEX2_1	376	378	PF00082	0.521
CLV_PCSK_SKI1_1	158	162	PF00082	0.456
CLV_PCSK_SKI1_1	21	25	PF00082	0.438
CLV_PCSK_SKI1_1	351	355	PF00082	0.388
CLV_PCSK_SKI1_1	64	68	PF00082	0.351
DEG_APCC_DBOX_1	262	270	PF00400	0.531
DOC_ANK_TNKS_1	410	417	PF00023	0.537
DOC_CKS1_1	438	443	PF01111	0.524
DOC_CYCLIN_RxL_1	61	70	PF00134	0.416
DOC_MAPK_gen_1	247	253	PF00069	0.495
DOC_MAPK_gen_1	376	384	PF00069	0.523
DOC_MAPK_MEF2A_6	17	26	PF00069	0.373
DOC_PP1_RVXF_1	156	163	PF00149	0.479
DOC_PP1_RVXF_1	84	90	PF00149	0.515
DOC_USP7_MATH_1	30	34	PF00917	0.458
DOC_WW_Pin1_4	300	305	PF00397	0.709
DOC_WW_Pin1_4	437	442	PF00397	0.526
LIG_14-3-3_CanoR_1	189	199	PF00244	0.527
LIG_14-3-3_CanoR_1	230	235	PF00244	0.472
LIG_14-3-3_CanoR_1	263	267	PF00244	0.490
LIG_14-3-3_CanoR_1	270	278	PF00244	0.470
LIG_14-3-3_CanoR_1	308	313	PF00244	0.639
LIG_14-3-3_CanoR_1	404	410	PF00244	0.570
LIG_14-3-3_CanoR_1	437	441	PF00244	0.594
LIG_14-3-3_CanoR_1	91	95	PF00244	0.614
LIG_Actin_WH2_2	62	79	PF00022	0.432
LIG_Actin_WH2_2	99	117	PF00022	0.608
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BRCT_BRCA1_1	255	259	PF00533	0.460
LIG_BRCT_BRCA1_1	487	491	PF00533	0.426
LIG_eIF4E_1	19	25	PF01652	0.551
LIG_eIF4E_1	365	371	PF01652	0.368
LIG_FHA_1	109	115	PF00498	0.543
LIG_FHA_1	118	124	PF00498	0.654
LIG_FHA_1	164	170	PF00498	0.493
LIG_FHA_1	185	191	PF00498	0.517
LIG_FHA_1	2	8	PF00498	0.591
LIG_FHA_1	329	335	PF00498	0.536
LIG_FHA_1	358	364	PF00498	0.432
LIG_FHA_1	366	372	PF00498	0.326
LIG_FHA_1	42	48	PF00498	0.470
LIG_FHA_1	82	88	PF00498	0.414
LIG_FHA_1	98	104	PF00498	0.565
LIG_FHA_2	29	35	PF00498	0.581
LIG_FHA_2	333	339	PF00498	0.489
LIG_FHA_2	373	379	PF00498	0.527
LIG_FXI_DFP_1	283	287	PF00024	0.464
LIG_LIR_Apic_2	436	441	PF02991	0.479
LIG_LIR_Gen_1	256	266	PF02991	0.440
LIG_LIR_Gen_1	366	373	PF02991	0.426
LIG_LIR_Nem_3	137	142	PF02991	0.454
LIG_LIR_Nem_3	256	262	PF02991	0.403
LIG_LIR_Nem_3	311	316	PF02991	0.524
LIG_LIR_Nem_3	347	353	PF02991	0.410
LIG_LIR_Nem_3	366	370	PF02991	0.216
LIG_LIR_Nem_3	387	393	PF02991	0.446
LIG_LYPXL_SIV_4	18	26	PF13949	0.575
LIG_Pex14_1	85	89	PF04695	0.400
LIG_Pex14_2	349	353	PF04695	0.468
LIG_SH2_CRK	313	317	PF00017	0.447
LIG_SH2_CRK	367	371	PF00017	0.419
LIG_SH2_SRC	168	171	PF00017	0.374
LIG_SH2_SRC	313	316	PF00017	0.567
LIG_SH2_STAP1	19	23	PF00017	0.548
LIG_SH2_STAP1	365	369	PF00017	0.376
LIG_SH2_STAT5	168	171	PF00017	0.531
LIG_SH2_STAT5	315	318	PF00017	0.437
LIG_SH2_STAT5	367	370	PF00017	0.382
LIG_SH2_STAT5	390	393	PF00017	0.454
LIG_SH2_STAT5	419	422	PF00017	0.511
LIG_SH3_3	281	287	PF00018	0.446
LIG_SH3_3	301	307	PF00018	0.608
LIG_SH3_CIN85_PxpxPR_1	59	64	PF14604	0.597
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.546
LIG_SUMO_SIM_anti_2	216	224	PF11976	0.445
LIG_SxIP_EBH_1	387	400	PF03271	0.573
LIG_UBA3_1	66	74	PF00899	0.488
LIG_WW_3	14	18	PF00397	0.364
LIG_WW_3	305	309	PF00397	0.665
MOD_CDC14_SPxK_1	305	308	PF00782	0.673
MOD_CDK_SPxK_1	302	308	PF00069	0.678
MOD_CK1_1	2	8	PF00069	0.520
MOD_CK1_1	33	39	PF00069	0.672
MOD_CK1_1	386	392	PF00069	0.513
MOD_CK1_1	422	428	PF00069	0.455
MOD_CK1_1	90	96	PF00069	0.565
MOD_CK2_1	255	261	PF00069	0.502
MOD_CK2_1	28	34	PF00069	0.535
MOD_CK2_1	332	338	PF00069	0.562
MOD_CK2_1	372	378	PF00069	0.528
MOD_CK2_1	464	470	PF00069	0.475
MOD_GlcNHglycan	154	157	PF01048	0.448
MOD_GlcNHglycan	254	258	PF01048	0.467
MOD_GlcNHglycan	275	278	PF01048	0.568
MOD_GlcNHglycan	308	311	PF01048	0.604
MOD_GlcNHglycan	316	319	PF01048	0.458
MOD_GlcNHglycan	412	415	PF01048	0.557
MOD_GlcNHglycan	77	80	PF01048	0.465
MOD_GSK3_1	109	116	PF00069	0.601
MOD_GSK3_1	249	256	PF00069	0.444
MOD_GSK3_1	287	294	PF00069	0.495
MOD_GSK3_1	29	36	PF00069	0.577
MOD_GSK3_1	296	303	PF00069	0.680
MOD_GSK3_1	328	335	PF00069	0.481
MOD_GSK3_1	37	44	PF00069	0.601
MOD_GSK3_1	394	401	PF00069	0.548
MOD_GSK3_1	405	412	PF00069	0.481
MOD_GSK3_1	415	422	PF00069	0.523
MOD_GSK3_1	485	492	PF00069	0.446
MOD_NEK2_1	213	218	PF00069	0.396
MOD_NEK2_1	220	225	PF00069	0.547
MOD_NEK2_1	253	258	PF00069	0.464
MOD_NEK2_1	291	296	PF00069	0.507
MOD_NEK2_1	396	401	PF00069	0.533
MOD_NEK2_1	405	410	PF00069	0.524
MOD_NEK2_1	67	72	PF00069	0.432
MOD_NEK2_1	87	92	PF00069	0.229
MOD_PIKK_1	221	227	PF00454	0.453
MOD_PIKK_1	33	39	PF00454	0.657
MOD_PIKK_1	332	338	PF00454	0.484
MOD_PIKK_1	394	400	PF00454	0.608
MOD_PK_1	308	314	PF00069	0.645
MOD_PKA_2	262	268	PF00069	0.543
MOD_PKA_2	410	416	PF00069	0.606
MOD_PKA_2	422	428	PF00069	0.487
MOD_PKA_2	436	442	PF00069	0.567
MOD_PKA_2	90	96	PF00069	0.555
MOD_Plk_1	108	114	PF00069	0.651
MOD_Plk_1	127	133	PF00069	0.581
MOD_Plk_1	365	371	PF00069	0.391
MOD_Plk_4	109	115	PF00069	0.674
MOD_Plk_4	128	134	PF00069	0.566
MOD_Plk_4	255	261	PF00069	0.433
MOD_Plk_4	308	314	PF00069	0.586
MOD_Plk_4	386	392	PF00069	0.514
MOD_Plk_4	415	421	PF00069	0.605
MOD_Plk_4	422	428	PF00069	0.437
MOD_Plk_4	474	480	PF00069	0.631
MOD_ProDKin_1	300	306	PF00069	0.709
MOD_ProDKin_1	437	443	PF00069	0.531
TRG_DiLeu_BaEn_1	20	25	PF01217	0.551
TRG_DiLeu_BaEn_1	6	11	PF01217	0.577
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.591
TRG_ENDOCYTIC_2	139	142	PF00928	0.543
TRG_ENDOCYTIC_2	19	22	PF00928	0.512
TRG_ENDOCYTIC_2	313	316	PF00928	0.439
TRG_ENDOCYTIC_2	350	353	PF00928	0.358
TRG_ENDOCYTIC_2	367	370	PF00928	0.362
TRG_ENDOCYTIC_2	393	396	PF00928	0.541
TRG_ER_diArg_1	11	13	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWC8	Leptomonas seymouri	46%	97%
A0A1X0NXR3	Trypanosomatidae	29%	92%
A0A3Q8IBT1	Leishmania donovani	99%	100%
A0A3R7K7L8	Trypanosoma rangeli	28%	94%
A4HBK2	Leishmania braziliensis	81%	100%
D0A1J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	96%
E9AUX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCL1	Leishmania major	95%	100%
V5BQ24	Trypanosoma cruzi	26%	100%