Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZK9_LEIIN

TriTrypDb:

LINF_210006300

Length:

151

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZK9

PDB structure(s): 7aih_V , 7am2_V , 7ane_V

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.466
CLV_NRD_NRD_1	22	24	PF00675	0.515
CLV_NRD_NRD_1	65	67	PF00675	0.453
CLV_PCSK_FUR_1	63	67	PF00082	0.474
CLV_PCSK_KEX2_1	103	105	PF00082	0.541
CLV_PCSK_KEX2_1	143	145	PF00082	0.472
CLV_PCSK_KEX2_1	22	24	PF00082	0.490
CLV_PCSK_KEX2_1	63	65	PF00082	0.447
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.648
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.472
CLV_PCSK_SKI1_1	23	27	PF00082	0.579
DEG_MDM2_SWIB_1	51	58	PF02201	0.421
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DEG_ODPH_VHL_1	138	150	PF01847	0.495
DOC_AGCK_PIF_3	148	151	PF00069	0.531
DOC_MAPK_gen_1	103	110	PF00069	0.502
DOC_MAPK_gen_1	63	73	PF00069	0.470
DOC_PP2B_LxvP_1	138	141	PF13499	0.503
DOC_PP4_MxPP_1	47	50	PF00568	0.434
LIG_14-3-3_CanoR_1	128	134	PF00244	0.577
LIG_FHA_2	111	117	PF00498	0.474
LIG_LIR_Gen_1	52	62	PF02991	0.429
LIG_LIR_Gen_1	84	95	PF02991	0.424
LIG_LIR_Nem_3	145	151	PF02991	0.468
LIG_LIR_Nem_3	52	58	PF02991	0.405
LIG_LIR_Nem_3	84	90	PF02991	0.425
LIG_Pex14_1	40	44	PF04695	0.419
LIG_Pex14_2	51	55	PF04695	0.426
LIG_SH2_CRK	87	91	PF00017	0.420
LIG_SH2_STAT3	31	34	PF00017	0.460
LIG_SH2_STAT5	31	34	PF00017	0.435
LIG_SH3_1	79	85	PF00018	0.418
LIG_SH3_3	22	28	PF00018	0.583
LIG_SH3_3	79	85	PF00018	0.418
MOD_CK2_1	119	125	PF00069	0.502
MOD_NEK2_1	110	115	PF00069	0.283
MOD_NEK2_1	90	95	PF00069	0.424
MOD_PKA_2	110	116	PF00069	0.470
MOD_PKA_2	127	133	PF00069	0.468
TRG_ENDOCYTIC_2	87	90	PF00928	0.425
TRG_ER_diArg_1	108	111	PF00400	0.469
TRG_ER_diArg_1	22	24	PF00400	0.490
TRG_ER_diArg_1	62	65	PF00400	0.450
TRG_ER_diArg_1	94	97	PF00400	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIX3	Leptomonas seymouri	86%	100%
A0A1X0NXY7	Trypanosomatidae	80%	100%
A0A3R7M8D8	Trypanosoma rangeli	80%	100%
A0A3S7WW87	Leishmania donovani	99%	100%
A4HBK7	Leishmania braziliensis	93%	100%
D0A1K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	83%
E9AUX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QCK6	Leishmania major	98%	100%