LeishMANIAdb
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Putative calpain

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative calpain
Gene product:
cysteine peptidase - Clan CA - family C2 - putative
Species:
Leishmania infantum
UniProt:
A4HZK7_LEIIN
TriTrypDb:
LINF_210006500
Length:
747

Annotations

Annotations by Jardim et al.

Proteases, calpain (Fragment)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Cellular components
Term Name Level Count
GO:0005929 cilium 4 3
GO:0042995 cell projection 2 3
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0110165 cellular anatomical entity 1 3
GO:0120025 plasma membrane bounded cell projection 3 3

Expansion

Sequence features

A4HZK7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZK7

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0019538 protein metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004175 endopeptidase activity 4 1
GO:0004197 cysteine-type endopeptidase activity 5 1
GO:0004198 calcium-dependent cysteine-type endopeptidase activity 6 1
GO:0008233 peptidase activity 3 1
GO:0008234 cysteine-type peptidase activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 178 180 PF00675 0.583
CLV_NRD_NRD_1 364 366 PF00675 0.400
CLV_NRD_NRD_1 39 41 PF00675 0.467
CLV_NRD_NRD_1 441 443 PF00675 0.338
CLV_NRD_NRD_1 571 573 PF00675 0.582
CLV_NRD_NRD_1 664 666 PF00675 0.614
CLV_NRD_NRD_1 678 680 PF00675 0.414
CLV_NRD_NRD_1 703 705 PF00675 0.562
CLV_PCSK_KEX2_1 177 179 PF00082 0.668
CLV_PCSK_KEX2_1 364 366 PF00082 0.400
CLV_PCSK_KEX2_1 39 41 PF00082 0.464
CLV_PCSK_KEX2_1 50 52 PF00082 0.431
CLV_PCSK_KEX2_1 587 589 PF00082 0.621
CLV_PCSK_KEX2_1 678 680 PF00082 0.659
CLV_PCSK_KEX2_1 703 705 PF00082 0.562
CLV_PCSK_PC1ET2_1 50 52 PF00082 0.539
CLV_PCSK_PC1ET2_1 587 589 PF00082 0.621
CLV_PCSK_PC7_1 174 180 PF00082 0.676
CLV_PCSK_SKI1_1 236 240 PF00082 0.549
CLV_PCSK_SKI1_1 488 492 PF00082 0.486
CLV_PCSK_SKI1_1 498 502 PF00082 0.535
CLV_PCSK_SKI1_1 557 561 PF00082 0.802
CLV_PCSK_SKI1_1 704 708 PF00082 0.651
CLV_Separin_Metazoa 432 436 PF03568 0.600
DEG_APCC_DBOX_1 703 711 PF00400 0.662
DOC_CKS1_1 428 433 PF01111 0.600
DOC_MAPK_DCC_7 74 82 PF00069 0.443
DOC_MAPK_gen_1 230 240 PF00069 0.444
DOC_MAPK_gen_1 442 450 PF00069 0.600
DOC_MAPK_gen_1 584 594 PF00069 0.603
DOC_MAPK_gen_1 84 94 PF00069 0.587
DOC_MAPK_MEF2A_6 442 450 PF00069 0.600
DOC_MAPK_MEF2A_6 587 594 PF00069 0.570
DOC_MAPK_MEF2A_6 74 82 PF00069 0.443
DOC_MAPK_NFAT4_5 443 451 PF00069 0.600
DOC_PP1_RVXF_1 194 200 PF00149 0.575
DOC_PP1_RVXF_1 234 240 PF00149 0.554
DOC_PP1_RVXF_1 305 312 PF00149 0.434
DOC_PP4_FxxP_1 450 453 PF00568 0.600
DOC_PP4_FxxP_1 460 463 PF00568 0.516
DOC_PP4_FxxP_1 627 630 PF00568 0.545
DOC_PP4_FxxP_1 730 733 PF00568 0.745
DOC_USP7_MATH_1 209 213 PF00917 0.582
DOC_USP7_MATH_1 26 30 PF00917 0.645
DOC_USP7_MATH_1 348 352 PF00917 0.600
DOC_USP7_MATH_1 436 440 PF00917 0.600
DOC_USP7_MATH_1 532 536 PF00917 0.592
DOC_USP7_MATH_1 593 597 PF00917 0.545
DOC_USP7_MATH_1 617 621 PF00917 0.488
DOC_USP7_MATH_1 656 660 PF00917 0.517
DOC_USP7_MATH_2 402 408 PF00917 0.600
DOC_WW_Pin1_4 189 194 PF00397 0.732
DOC_WW_Pin1_4 3 8 PF00397 0.782
DOC_WW_Pin1_4 427 432 PF00397 0.600
DOC_WW_Pin1_4 56 61 PF00397 0.643
DOC_WW_Pin1_4 563 568 PF00397 0.638
DOC_WW_Pin1_4 595 600 PF00397 0.560
LIG_14-3-3_CanoR_1 194 200 PF00244 0.688
LIG_14-3-3_CanoR_1 39 45 PF00244 0.599
LIG_14-3-3_CanoR_1 435 445 PF00244 0.499
LIG_14-3-3_CanoR_1 496 501 PF00244 0.529
LIG_14-3-3_CanoR_1 582 590 PF00244 0.535
LIG_14-3-3_CanoR_1 709 718 PF00244 0.662
LIG_14-3-3_CanoR_1 724 730 PF00244 0.536
LIG_BRCT_BRCA1_1 446 450 PF00533 0.600
LIG_BRCT_BRCA1_1 482 486 PF00533 0.555
LIG_BRCT_BRCA1_1 647 651 PF00533 0.435
LIG_BRCT_BRCA1_1 726 730 PF00533 0.769
LIG_CaM_IQ_9 157 173 PF13499 0.611
LIG_Clathr_ClatBox_1 238 242 PF01394 0.550
LIG_EH1_1 262 270 PF00400 0.587
LIG_EVH1_2 737 741 PF00568 0.693
LIG_FAT_LD_1 132 140 PF03623 0.579
LIG_FHA_1 117 123 PF00498 0.497
LIG_FHA_1 270 276 PF00498 0.460
LIG_FHA_1 389 395 PF00498 0.506
LIG_FHA_1 414 420 PF00498 0.525
LIG_FHA_1 428 434 PF00498 0.492
LIG_FHA_1 471 477 PF00498 0.522
LIG_FHA_1 640 646 PF00498 0.389
LIG_FHA_1 655 661 PF00498 0.474
LIG_FHA_1 71 77 PF00498 0.514
LIG_FHA_1 724 730 PF00498 0.770
LIG_FHA_1 84 90 PF00498 0.481
LIG_FHA_2 15 21 PF00498 0.698
LIG_FHA_2 320 326 PF00498 0.692
LIG_FHA_2 7 13 PF00498 0.792
LIG_GBD_Chelix_1 265 273 PF00786 0.592
LIG_Integrin_isoDGR_2 676 678 PF01839 0.644
LIG_LIR_Apic_2 220 225 PF02991 0.553
LIG_LIR_Apic_2 447 453 PF02991 0.600
LIG_LIR_Apic_2 458 463 PF02991 0.516
LIG_LIR_Apic_2 6 11 PF02991 0.786
LIG_LIR_Apic_2 727 733 PF02991 0.636
LIG_LIR_Gen_1 22 31 PF02991 0.685
LIG_LIR_Gen_1 293 303 PF02991 0.513
LIG_LIR_Gen_1 310 317 PF02991 0.448
LIG_LIR_Gen_1 325 336 PF02991 0.539
LIG_LIR_Gen_1 444 453 PF02991 0.600
LIG_LIR_Gen_1 477 487 PF02991 0.629
LIG_LIR_Gen_1 601 610 PF02991 0.591
LIG_LIR_LC3C_4 271 275 PF02991 0.585
LIG_LIR_Nem_3 212 218 PF02991 0.568
LIG_LIR_Nem_3 310 314 PF02991 0.446
LIG_LIR_Nem_3 32 37 PF02991 0.409
LIG_LIR_Nem_3 325 331 PF02991 0.550
LIG_LIR_Nem_3 444 448 PF02991 0.600
LIG_LIR_Nem_3 477 482 PF02991 0.628
LIG_LIR_Nem_3 601 605 PF02991 0.564
LIG_NRBOX 134 140 PF00104 0.569
LIG_PCNA_yPIPBox_3 39 53 PF02747 0.482
LIG_Pex14_2 491 495 PF04695 0.452
LIG_PTB_Apo_2 221 228 PF02174 0.546
LIG_PTB_Phospho_1 221 227 PF10480 0.545
LIG_SH2_CRK 497 501 PF00017 0.461
LIG_SH2_GRB2like 403 406 PF00017 0.600
LIG_SH2_STAP1 215 219 PF00017 0.475
LIG_SH2_STAP1 227 231 PF00017 0.411
LIG_SH2_STAP1 338 342 PF00017 0.578
LIG_SH2_STAP1 474 478 PF00017 0.600
LIG_SH2_STAP1 602 606 PF00017 0.484
LIG_SH2_STAP1 641 645 PF00017 0.538
LIG_SH2_STAP1 711 715 PF00017 0.694
LIG_SH2_STAT5 109 112 PF00017 0.448
LIG_SH2_STAT5 187 190 PF00017 0.713
LIG_SH2_STAT5 215 218 PF00017 0.525
LIG_SH2_STAT5 296 299 PF00017 0.404
LIG_SH2_STAT5 34 37 PF00017 0.406
LIG_SH2_STAT5 52 55 PF00017 0.371
LIG_SH2_STAT5 641 644 PF00017 0.496
LIG_SH2_STAT5 70 73 PF00017 0.497
LIG_SH2_STAT5 8 11 PF00017 0.794
LIG_SH3_3 294 300 PF00018 0.538
LIG_SUMO_SIM_anti_2 58 65 PF11976 0.623
LIG_SUMO_SIM_par_1 271 278 PF11976 0.467
LIG_SUMO_SIM_par_1 58 65 PF11976 0.523
LIG_SUMO_SIM_par_1 641 650 PF11976 0.544
LIG_SUMO_SIM_par_1 90 95 PF11976 0.481
LIG_TRAF2_1 322 325 PF00917 0.701
LIG_TRAF2_1 553 556 PF00917 0.769
LIG_TRAF2_1 562 565 PF00917 0.482
LIG_UBA3_1 76 84 PF00899 0.439
LIG_WW_1 599 602 PF00397 0.489
MOD_CDK_SPK_2 189 194 PF00069 0.732
MOD_CDK_SPxxK_3 189 196 PF00069 0.728
MOD_CK1_1 232 238 PF00069 0.447
MOD_CK1_1 480 486 PF00069 0.521
MOD_CK1_1 598 604 PF00069 0.533
MOD_CK1_1 6 12 PF00069 0.789
MOD_CK1_1 608 614 PF00069 0.431
MOD_CK1_1 647 653 PF00069 0.442
MOD_CK2_1 14 20 PF00069 0.787
MOD_CK2_1 205 211 PF00069 0.591
MOD_CK2_1 26 32 PF00069 0.414
MOD_CK2_1 274 280 PF00069 0.585
MOD_CK2_1 319 325 PF00069 0.527
MOD_CK2_1 461 467 PF00069 0.500
MOD_CK2_1 550 556 PF00069 0.715
MOD_CK2_1 56 62 PF00069 0.641
MOD_CK2_1 583 589 PF00069 0.657
MOD_CK2_1 598 604 PF00069 0.523
MOD_Cter_Amidation 676 679 PF01082 0.648
MOD_GlcNHglycan 207 210 PF01048 0.486
MOD_GlcNHglycan 211 214 PF01048 0.426
MOD_GlcNHglycan 40 43 PF01048 0.586
MOD_GlcNHglycan 46 49 PF01048 0.485
MOD_GlcNHglycan 488 491 PF01048 0.577
MOD_GlcNHglycan 552 555 PF01048 0.666
MOD_GlcNHglycan 607 610 PF01048 0.483
MOD_GlcNHglycan 612 616 PF01048 0.473
MOD_GlcNHglycan 65 69 PF01048 0.480
MOD_GlcNHglycan 672 675 PF01048 0.636
MOD_GSK3_1 183 190 PF00069 0.707
MOD_GSK3_1 201 208 PF00069 0.521
MOD_GSK3_1 209 216 PF00069 0.475
MOD_GSK3_1 225 232 PF00069 0.271
MOD_GSK3_1 309 316 PF00069 0.454
MOD_GSK3_1 369 376 PF00069 0.491
MOD_GSK3_1 384 391 PF00069 0.237
MOD_GSK3_1 444 451 PF00069 0.391
MOD_GSK3_1 468 475 PF00069 0.500
MOD_GSK3_1 546 553 PF00069 0.648
MOD_GSK3_1 6 13 PF00069 0.790
MOD_GSK3_1 635 642 PF00069 0.563
MOD_GSK3_1 88 95 PF00069 0.581
MOD_N-GLC_1 141 146 PF02516 0.535
MOD_N-GLC_1 153 158 PF02516 0.473
MOD_N-GLC_1 404 409 PF02516 0.500
MOD_N-GLC_1 420 425 PF02516 0.219
MOD_NEK2_1 14 19 PF00069 0.721
MOD_NEK2_1 167 172 PF00069 0.620
MOD_NEK2_1 231 236 PF00069 0.457
MOD_NEK2_1 269 274 PF00069 0.608
MOD_NEK2_1 292 297 PF00069 0.500
MOD_NEK2_1 313 318 PF00069 0.544
MOD_NEK2_1 388 393 PF00069 0.500
MOD_NEK2_1 448 453 PF00069 0.386
MOD_NEK2_1 486 491 PF00069 0.464
MOD_NEK2_1 515 520 PF00069 0.513
MOD_NEK2_1 53 58 PF00069 0.561
MOD_NEK2_1 605 610 PF00069 0.591
MOD_NEK2_1 645 650 PF00069 0.521
MOD_NEK2_1 92 97 PF00069 0.571
MOD_NEK2_2 116 121 PF00069 0.562
MOD_NEK2_2 225 230 PF00069 0.549
MOD_NEK2_2 474 479 PF00069 0.500
MOD_NEK2_2 725 730 PF00069 0.768
MOD_OFUCOSY 591 597 PF10250 0.543
MOD_PIKK_1 654 660 PF00454 0.589
MOD_PKA_2 195 201 PF00069 0.661
MOD_PKA_2 232 238 PF00069 0.460
MOD_PKA_2 38 44 PF00069 0.594
MOD_PKA_2 434 440 PF00069 0.362
MOD_PKA_2 441 447 PF00069 0.324
MOD_PKA_2 468 474 PF00069 0.468
MOD_PKA_2 583 589 PF00069 0.552
MOD_PKA_2 723 729 PF00069 0.764
MOD_PKB_1 496 504 PF00069 0.573
MOD_PKB_1 580 588 PF00069 0.672
MOD_Plk_1 141 147 PF00069 0.547
MOD_Plk_1 275 281 PF00069 0.594
MOD_Plk_1 292 298 PF00069 0.559
MOD_Plk_1 309 315 PF00069 0.451
MOD_Plk_1 545 551 PF00069 0.748
MOD_Plk_1 611 617 PF00069 0.593
MOD_Plk_2-3 141 147 PF00069 0.540
MOD_Plk_2-3 413 419 PF00069 0.383
MOD_Plk_4 183 189 PF00069 0.707
MOD_Plk_4 217 223 PF00069 0.452
MOD_Plk_4 269 275 PF00069 0.564
MOD_Plk_4 292 298 PF00069 0.459
MOD_Plk_4 384 390 PF00069 0.399
MOD_Plk_4 441 447 PF00069 0.500
MOD_Plk_4 532 538 PF00069 0.574
MOD_Plk_4 647 653 PF00069 0.559
MOD_Plk_4 725 731 PF00069 0.648
MOD_ProDKin_1 189 195 PF00069 0.734
MOD_ProDKin_1 3 9 PF00069 0.784
MOD_ProDKin_1 427 433 PF00069 0.500
MOD_ProDKin_1 56 62 PF00069 0.641
MOD_ProDKin_1 563 569 PF00069 0.629
MOD_ProDKin_1 595 601 PF00069 0.566
MOD_SUMO_rev_2 553 559 PF00179 0.735
MOD_SUMO_rev_2 565 574 PF00179 0.694
TRG_DiLeu_BaEn_2 455 461 PF01217 0.500
TRG_DiLeu_BaEn_3 701 707 PF01217 0.661
TRG_DiLeu_BaLyEn_6 423 428 PF01217 0.500
TRG_ENDOCYTIC_2 296 299 PF00928 0.346
TRG_ENDOCYTIC_2 497 500 PF00928 0.456
TRG_ENDOCYTIC_2 602 605 PF00928 0.473
TRG_ER_diArg_1 177 179 PF00400 0.668
TRG_ER_diArg_1 193 196 PF00400 0.489
TRG_ER_diArg_1 363 365 PF00400 0.500
TRG_ER_diArg_1 579 582 PF00400 0.565
TRG_ER_diArg_1 662 665 PF00400 0.599
TRG_Pf-PMV_PEXEL_1 51 55 PF00026 0.503
TRG_Pf-PMV_PEXEL_1 513 517 PF00026 0.601
TRG_Pf-PMV_PEXEL_1 704 708 PF00026 0.651

Homologs

Protein Taxonomy Sequence identity Coverage
A0A422N796 Trypanosoma rangeli 36% 88%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS