Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZJ6_LEIIN

TriTrypDb:

LINF_210006800

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	653	657	PF00656	0.474
CLV_NRD_NRD_1	189	191	PF00675	0.387
CLV_NRD_NRD_1	447	449	PF00675	0.480
CLV_NRD_NRD_1	599	601	PF00675	0.394
CLV_NRD_NRD_1	604	606	PF00675	0.377
CLV_NRD_NRD_1	666	668	PF00675	0.606
CLV_PCSK_FUR_1	187	191	PF00082	0.466
CLV_PCSK_KEX2_1	189	191	PF00082	0.387
CLV_PCSK_KEX2_1	281	283	PF00082	0.475
CLV_PCSK_KEX2_1	599	601	PF00082	0.358
CLV_PCSK_KEX2_1	604	606	PF00082	0.364
CLV_PCSK_KEX2_1	666	668	PF00082	0.606
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.493
CLV_PCSK_PC7_1	600	606	PF00082	0.384
CLV_PCSK_SKI1_1	129	133	PF00082	0.440
CLV_PCSK_SKI1_1	138	142	PF00082	0.363
CLV_PCSK_SKI1_1	213	217	PF00082	0.366
CLV_PCSK_SKI1_1	243	247	PF00082	0.348
CLV_PCSK_SKI1_1	253	257	PF00082	0.315
CLV_PCSK_SKI1_1	403	407	PF00082	0.324
CLV_PCSK_SKI1_1	49	53	PF00082	0.672
CLV_PCSK_SKI1_1	493	497	PF00082	0.306
DEG_APCC_DBOX_1	137	145	PF00400	0.335
DEG_Nend_UBRbox_1	1	4	PF02207	0.413
DEG_SCF_FBW7_1	395	402	PF00400	0.387
DEG_SPOP_SBC_1	117	121	PF00917	0.489
DEG_SPOP_SBC_1	361	365	PF00917	0.359
DOC_CKS1_1	396	401	PF01111	0.417
DOC_CKS1_1	435	440	PF01111	0.427
DOC_CYCLIN_RxL_1	186	196	PF00134	0.354
DOC_CYCLIN_RxL_1	400	411	PF00134	0.448
DOC_MAPK_gen_1	132	141	PF00069	0.459
DOC_MAPK_gen_1	16	25	PF00069	0.572
DOC_MAPK_gen_1	281	287	PF00069	0.464
DOC_MAPK_HePTP_8	13	25	PF00069	0.416
DOC_MAPK_MEF2A_6	16	25	PF00069	0.572
DOC_PP1_RVXF_1	187	194	PF00149	0.340
DOC_PP1_RVXF_1	241	247	PF00149	0.393
DOC_PP1_RVXF_1	251	257	PF00149	0.349
DOC_PP1_RVXF_1	293	300	PF00149	0.440
DOC_PP1_RVXF_1	401	408	PF00149	0.310
DOC_PP1_RVXF_1	481	488	PF00149	0.377
DOC_PP4_FxxP_1	375	378	PF00568	0.432
DOC_USP7_MATH_1	117	121	PF00917	0.526
DOC_USP7_MATH_1	173	177	PF00917	0.395
DOC_USP7_MATH_1	399	403	PF00917	0.345
DOC_USP7_MATH_1	56	60	PF00917	0.690
DOC_USP7_MATH_1	62	66	PF00917	0.434
DOC_WW_Pin1_4	218	223	PF00397	0.428
DOC_WW_Pin1_4	374	379	PF00397	0.461
DOC_WW_Pin1_4	395	400	PF00397	0.410
DOC_WW_Pin1_4	434	439	PF00397	0.414
DOC_WW_Pin1_4	499	504	PF00397	0.325
DOC_WW_Pin1_4	553	558	PF00397	0.364
DOC_WW_Pin1_4	60	65	PF00397	0.701
LIG_14-3-3_CanoR_1	143	152	PF00244	0.452
LIG_14-3-3_CanoR_1	16	22	PF00244	0.624
LIG_14-3-3_CanoR_1	272	276	PF00244	0.564
LIG_14-3-3_CanoR_1	324	330	PF00244	0.419
LIG_14-3-3_CanoR_1	427	432	PF00244	0.456
LIG_14-3-3_CanoR_1	49	57	PF00244	0.554
LIG_14-3-3_CanoR_1	647	652	PF00244	0.495
LIG_Actin_WH2_2	99	115	PF00022	0.596
LIG_BRCT_BRCA1_1	211	215	PF00533	0.345
LIG_CaM_IQ_9	121	137	PF13499	0.386
LIG_deltaCOP1_diTrp_1	180	188	PF00928	0.304
LIG_deltaCOP1_diTrp_1	468	474	PF00928	0.346
LIG_deltaCOP1_diTrp_1	486	492	PF00928	0.340
LIG_deltaCOP1_diTrp_1	540	548	PF00928	0.491
LIG_EVH1_2	325	329	PF00568	0.470
LIG_FHA_1	119	125	PF00498	0.550
LIG_FHA_1	145	151	PF00498	0.410
LIG_FHA_1	227	233	PF00498	0.353
LIG_FHA_1	250	256	PF00498	0.351
LIG_FHA_1	257	263	PF00498	0.332
LIG_FHA_1	338	344	PF00498	0.375
LIG_FHA_1	363	369	PF00498	0.344
LIG_FHA_1	396	402	PF00498	0.440
LIG_FHA_1	50	56	PF00498	0.554
LIG_FHA_1	61	67	PF00498	0.672
LIG_FHA_2	486	492	PF00498	0.454
LIG_FHA_2	517	523	PF00498	0.482
LIG_FHA_2	573	579	PF00498	0.509
LIG_FHA_2	628	634	PF00498	0.486
LIG_LIR_Apic_2	591	596	PF02991	0.365
LIG_LIR_Gen_1	180	188	PF02991	0.320
LIG_LIR_Gen_1	202	211	PF02991	0.328
LIG_LIR_Gen_1	430	439	PF02991	0.552
LIG_LIR_Gen_1	486	495	PF02991	0.400
LIG_LIR_Nem_3	180	185	PF02991	0.308
LIG_LIR_Nem_3	202	207	PF02991	0.428
LIG_LIR_Nem_3	430	435	PF02991	0.561
LIG_LIR_Nem_3	486	490	PF02991	0.353
LIG_LIR_Nem_3	491	495	PF02991	0.287
LIG_LIR_Nem_3	540	545	PF02991	0.409
LIG_NRP_CendR_1	672	674	PF00754	0.577
LIG_PCNA_PIPBox_1	330	339	PF02747	0.322
LIG_PCNA_yPIPBox_3	427	435	PF02747	0.551
LIG_Pex14_2	275	279	PF04695	0.484
LIG_REV1ctd_RIR_1	404	414	PF16727	0.376
LIG_SH2_CRK	251	255	PF00017	0.337
LIG_SH2_NCK_1	613	617	PF00017	0.533
LIG_SH2_PTP2	593	596	PF00017	0.360
LIG_SH2_STAP1	146	150	PF00017	0.467
LIG_SH2_STAP1	251	255	PF00017	0.313
LIG_SH2_STAP1	613	617	PF00017	0.438
LIG_SH2_STAT5	146	149	PF00017	0.502
LIG_SH2_STAT5	251	254	PF00017	0.317
LIG_SH2_STAT5	264	267	PF00017	0.367
LIG_SH2_STAT5	337	340	PF00017	0.318
LIG_SH2_STAT5	38	41	PF00017	0.665
LIG_SH2_STAT5	432	435	PF00017	0.461
LIG_SH2_STAT5	593	596	PF00017	0.372
LIG_SH2_STAT5	78	81	PF00017	0.554
LIG_SH3_3	319	325	PF00018	0.396
LIG_SH3_3	375	381	PF00018	0.347
LIG_SH3_3	386	392	PF00018	0.439
LIG_SH3_3	667	673	PF00018	0.579
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.429
LIG_SUMO_SIM_par_1	344	352	PF11976	0.359
LIG_SUMO_SIM_par_1	556	562	PF11976	0.340
LIG_TRAF2_1	120	123	PF00917	0.442
LIG_TRAF2_1	559	562	PF00917	0.527
LIG_TRAF2_2	89	94	PF00917	0.523
LIG_TYR_ITIM	249	254	PF00017	0.349
LIG_UBA3_1	651	655	PF00899	0.459
MOD_CDK_SPK_2	499	504	PF00069	0.325
MOD_CK1_1	223	229	PF00069	0.471
MOD_CK1_1	71	77	PF00069	0.607
MOD_CK2_1	116	122	PF00069	0.497
MOD_CK2_1	271	277	PF00069	0.610
MOD_CK2_1	356	362	PF00069	0.556
MOD_CK2_1	485	491	PF00069	0.460
MOD_CK2_1	572	578	PF00069	0.482
MOD_CK2_1	627	633	PF00069	0.580
MOD_GlcNHglycan	129	132	PF01048	0.609
MOD_GlcNHglycan	30	33	PF01048	0.711
MOD_GlcNHglycan	410	413	PF01048	0.321
MOD_GlcNHglycan	468	472	PF01048	0.452
MOD_GlcNHglycan	58	61	PF01048	0.581
MOD_GlcNHglycan	656	659	PF01048	0.596
MOD_GlcNHglycan	82	85	PF01048	0.586
MOD_GSK3_1	223	230	PF00069	0.376
MOD_GSK3_1	256	263	PF00069	0.340
MOD_GSK3_1	352	359	PF00069	0.530
MOD_GSK3_1	395	402	PF00069	0.378
MOD_GSK3_1	56	63	PF00069	0.619
MOD_GSK3_1	67	74	PF00069	0.584
MOD_GSK3_1	78	85	PF00069	0.579
MOD_N-GLC_1	427	432	PF02516	0.456
MOD_N-GLC_1	553	558	PF02516	0.425
MOD_NEK2_1	127	132	PF00069	0.561
MOD_NEK2_1	193	198	PF00069	0.411
MOD_NEK2_1	256	261	PF00069	0.312
MOD_NEK2_1	406	411	PF00069	0.339
MOD_NEK2_1	477	482	PF00069	0.425
MOD_NEK2_1	565	570	PF00069	0.346
MOD_NEK2_1	609	614	PF00069	0.403
MOD_NEK2_1	654	659	PF00069	0.470
MOD_NEK2_1	66	71	PF00069	0.618
MOD_NEK2_1	72	77	PF00069	0.585
MOD_NEK2_2	108	113	PF00069	0.476
MOD_NEK2_2	203	208	PF00069	0.436
MOD_PIKK_1	621	627	PF00454	0.544
MOD_PK_1	427	433	PF00069	0.455
MOD_PKA_2	271	277	PF00069	0.567
MOD_PKB_1	218	226	PF00069	0.434
MOD_Plk_1	399	405	PF00069	0.318
MOD_Plk_1	427	433	PF00069	0.455
MOD_Plk_1	485	491	PF00069	0.449
MOD_Plk_2-3	627	633	PF00069	0.488
MOD_Plk_4	220	226	PF00069	0.498
MOD_Plk_4	256	262	PF00069	0.327
MOD_Plk_4	427	433	PF00069	0.455
MOD_Plk_4	565	571	PF00069	0.362
MOD_Plk_4	589	595	PF00069	0.370
MOD_Plk_4	62	68	PF00069	0.584
MOD_Plk_4	647	653	PF00069	0.490
MOD_ProDKin_1	218	224	PF00069	0.421
MOD_ProDKin_1	374	380	PF00069	0.455
MOD_ProDKin_1	395	401	PF00069	0.402
MOD_ProDKin_1	434	440	PF00069	0.411
MOD_ProDKin_1	499	505	PF00069	0.321
MOD_ProDKin_1	553	559	PF00069	0.357
MOD_ProDKin_1	60	66	PF00069	0.703
MOD_SUMO_rev_2	502	511	PF00179	0.366
MOD_SUMO_rev_2	650	657	PF00179	0.482
TRG_DiLeu_BaEn_1	507	512	PF01217	0.345
TRG_DiLeu_BaEn_1	633	638	PF01217	0.450
TRG_DiLeu_BaEn_2	490	496	PF01217	0.309
TRG_DiLeu_BaEn_2	519	525	PF01217	0.364
TRG_DiLeu_BaEn_3	122	128	PF01217	0.431
TRG_DiLeu_BaEn_4	458	464	PF01217	0.450
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.387
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.313
TRG_ENDOCYTIC_2	251	254	PF00928	0.342
TRG_ENDOCYTIC_2	432	435	PF00928	0.552
TRG_ER_diArg_1	188	190	PF00400	0.372
TRG_ER_diArg_1	599	601	PF00400	0.378
TRG_ER_diArg_1	604	606	PF00400	0.357
TRG_ER_diArg_1	671	674	PF00400	0.708
TRG_NES_CRM1_1	578	591	PF08389	0.472
TRG_NLS_MonoExtN_4	445	452	PF00514	0.472
TRG_NLS_MonoExtN_4	543	550	PF00514	0.386
TRG_Pf-PMV_PEXEL_1	388	393	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X2	Leptomonas seymouri	72%	100%
A0A0S4IQX1	Bodo saltans	44%	100%
A0A1X0NXS1	Trypanosomatidae	64%	99%
A0A3S7WWA1	Leishmania donovani	100%	100%
A4HBL3	Leishmania braziliensis	93%	100%
D0A1K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AUY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QCK1	Leishmania major	98%	100%
V5DGX7	Trypanosoma cruzi	61%	100%