Peroxisomal membrane protein PEX14

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxin 14 - putative

Species:

Leishmania infantum

UniProt:

A4HZJ0_LEIIN

TriTrypDb:

LINF_210028200

Length:

464

Annotations

Annotations by Jardim et al.

Glycosome membrane, peroxin 14 PEX14

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0031903	microbody membrane	5	9
GO:0042579	microbody	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0098588	bounding membrane of organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0032991	protein-containing complex	1	1
GO:1990351	transporter complex	2	1
GO:1990429	peroxisomal importomer complex	3	1

Expansion

Sequence features

A4HZJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZJ0

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	9
GO:0009987	cellular process	1	9
GO:0016560	protein import into peroxisome matrix, docking	5	9
GO:0033036	macromolecule localization	2	9
GO:0051179	localization	1	9
GO:0051641	cellular localization	2	9
GO:0070727	cellular macromolecule localization	3	9

Molecular functions
Term	Name	Level	Count
GO:0005102	signaling receptor binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.673
CLV_C14_Caspase3-7	26	30	PF00656	0.569
CLV_NRD_NRD_1	182	184	PF00675	0.546
CLV_NRD_NRD_1	268	270	PF00675	0.529
CLV_NRD_NRD_1	47	49	PF00675	0.331
CLV_PCSK_FUR_1	45	49	PF00082	0.438
CLV_PCSK_KEX2_1	182	184	PF00082	0.546
CLV_PCSK_KEX2_1	252	254	PF00082	0.435
CLV_PCSK_KEX2_1	47	49	PF00082	0.412
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.435
CLV_PCSK_SKI1_1	262	266	PF00082	0.518
CLV_PCSK_SKI1_1	56	60	PF00082	0.368
CLV_PCSK_SKI1_1	69	73	PF00082	0.338
CLV_PCSK_SKI1_1	77	81	PF00082	0.449
DOC_ANK_TNKS_1	152	159	PF00023	0.432
DOC_CDC14_PxL_1	374	382	PF14671	0.452
DOC_CYCLIN_yCln2_LP_2	380	386	PF00134	0.467
DOC_MAPK_gen_1	269	277	PF00069	0.428
DOC_PP1_RVXF_1	146	153	PF00149	0.488
DOC_PP2B_LxvP_1	13	16	PF13499	0.604
DOC_PP2B_LxvP_1	225	228	PF13499	0.552
DOC_PP2B_LxvP_1	380	383	PF13499	0.455
DOC_USP7_MATH_1	23	27	PF00917	0.528
DOC_USP7_MATH_1	235	239	PF00917	0.673
DOC_USP7_MATH_1	50	54	PF00917	0.343
DOC_USP7_UBL2_3	184	188	PF12436	0.613
DOC_WW_Pin1_4	103	108	PF00397	0.757
DOC_WW_Pin1_4	121	126	PF00397	0.482
DOC_WW_Pin1_4	134	139	PF00397	0.533
DOC_WW_Pin1_4	174	179	PF00397	0.467
DOC_WW_Pin1_4	213	218	PF00397	0.738
DOC_WW_Pin1_4	240	245	PF00397	0.533
DOC_WW_Pin1_4	351	356	PF00397	0.629
DOC_WW_Pin1_4	422	427	PF00397	0.635
DOC_WW_Pin1_4	456	461	PF00397	0.722
DOC_WW_Pin1_4	46	51	PF00397	0.283
LIG_14-3-3_CanoR_1	145	151	PF00244	0.589
LIG_14-3-3_CanoR_1	182	191	PF00244	0.632
LIG_14-3-3_CanoR_1	295	303	PF00244	0.531
LIG_14-3-3_CanoR_1	77	84	PF00244	0.500
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BRCT_BRCA1_1	337	341	PF00533	0.628
LIG_EABR_CEP55_1	332	341	PF12180	0.504
LIG_EVH1_1	225	229	PF00568	0.604
LIG_FHA_1	103	109	PF00498	0.678
LIG_FHA_1	128	134	PF00498	0.689
LIG_FHA_1	145	151	PF00498	0.522
LIG_FHA_1	246	252	PF00498	0.471
LIG_FHA_1	295	301	PF00498	0.533
LIG_FHA_1	395	401	PF00498	0.701
LIG_FHA_2	254	260	PF00498	0.506
LIG_FHA_2	322	328	PF00498	0.564
LIG_FHA_2	344	350	PF00498	0.692
LIG_FHA_2	434	440	PF00498	0.563
LIG_LIR_Nem_3	149	155	PF02991	0.473
LIG_LIR_Nem_3	165	170	PF02991	0.392
LIG_LIR_Nem_3	338	344	PF02991	0.630
LIG_MLH1_MIPbox_1	337	341	PF16413	0.628
LIG_MYND_1	223	227	PF01753	0.538
LIG_MYND_1	414	418	PF01753	0.469
LIG_MYND_3	377	381	PF01753	0.447
LIG_SH2_NCK_1	427	431	PF00017	0.485
LIG_SH2_SRC	427	430	PF00017	0.539
LIG_SH2_STAP1	129	133	PF00017	0.675
LIG_SH2_STAP1	427	431	PF00017	0.485
LIG_SH2_STAT5	129	132	PF00017	0.678
LIG_SH2_STAT5	340	343	PF00017	0.628
LIG_SH3_3	132	138	PF00018	0.656
LIG_SH3_3	17	23	PF00018	0.697
LIG_SH3_3	220	226	PF00018	0.572
LIG_SH3_3	3	9	PF00018	0.573
LIG_SH3_3	331	337	PF00018	0.693
LIG_SH3_3	369	375	PF00018	0.694
LIG_SH3_3	387	393	PF00018	0.673
LIG_SH3_3	411	417	PF00018	0.595
LIG_SH3_3	437	443	PF00018	0.726
LIG_SH3_3	84	90	PF00018	0.531
LIG_WW_2	223	226	PF00397	0.542
MOD_CDK_SPxK_1	213	219	PF00069	0.608
MOD_CK1_1	165	171	PF00069	0.491
MOD_CK1_1	206	212	PF00069	0.646
MOD_CK1_1	240	246	PF00069	0.525
MOD_CK1_1	343	349	PF00069	0.666
MOD_CK1_1	359	365	PF00069	0.657
MOD_CK2_1	174	180	PF00069	0.510
MOD_CK2_1	204	210	PF00069	0.586
MOD_CK2_1	21	27	PF00069	0.644
MOD_CK2_1	321	327	PF00069	0.557
MOD_CK2_1	343	349	PF00069	0.751
MOD_CK2_1	433	439	PF00069	0.605
MOD_CK2_1	46	52	PF00069	0.342
MOD_GlcNHglycan	108	111	PF01048	0.639
MOD_GlcNHglycan	164	167	PF01048	0.459
MOD_GlcNHglycan	200	203	PF01048	0.646
MOD_GlcNHglycan	206	209	PF01048	0.699
MOD_GlcNHglycan	239	242	PF01048	0.567
MOD_GlcNHglycan	277	280	PF01048	0.507
MOD_GlcNHglycan	315	318	PF01048	0.533
MOD_GlcNHglycan	35	38	PF01048	0.304
MOD_GlcNHglycan	361	364	PF01048	0.680
MOD_GlcNHglycan	405	408	PF01048	0.572
MOD_GSK3_1	182	189	PF00069	0.593
MOD_GSK3_1	194	201	PF00069	0.582
MOD_GSK3_1	204	211	PF00069	0.627
MOD_GSK3_1	29	36	PF00069	0.437
MOD_GSK3_1	336	343	PF00069	0.606
MOD_GSK3_1	351	358	PF00069	0.556
MOD_GSK3_1	361	368	PF00069	0.645
MOD_GSK3_1	46	53	PF00069	0.286
MOD_GSK3_1	99	106	PF00069	0.619
MOD_NEK2_1	275	280	PF00069	0.413
MOD_NEK2_1	41	46	PF00069	0.302
MOD_NEK2_2	129	134	PF00069	0.643
MOD_PIKK_1	127	133	PF00454	0.643
MOD_PIKK_1	294	300	PF00454	0.456
MOD_PIKK_1	319	325	PF00454	0.603
MOD_PIKK_1	50	56	PF00454	0.377
MOD_PK_1	83	89	PF00069	0.528
MOD_PKA_1	182	188	PF00069	0.623
MOD_PKA_2	144	150	PF00069	0.567
MOD_PKA_2	182	188	PF00069	0.604
MOD_PKA_2	192	198	PF00069	0.553
MOD_PKA_2	294	300	PF00069	0.535
MOD_Plk_1	30	36	PF00069	0.326
MOD_Plk_1	355	361	PF00069	0.591
MOD_Plk_4	129	135	PF00069	0.644
MOD_Plk_4	336	342	PF00069	0.587
MOD_ProDKin_1	103	109	PF00069	0.760
MOD_ProDKin_1	121	127	PF00069	0.483
MOD_ProDKin_1	134	140	PF00069	0.530
MOD_ProDKin_1	174	180	PF00069	0.471
MOD_ProDKin_1	213	219	PF00069	0.743
MOD_ProDKin_1	240	246	PF00069	0.525
MOD_ProDKin_1	351	357	PF00069	0.628
MOD_ProDKin_1	422	428	PF00069	0.632
MOD_ProDKin_1	456	462	PF00069	0.722
MOD_ProDKin_1	46	52	PF00069	0.283
MOD_SUMO_rev_2	180	189	PF00179	0.586
MOD_SUMO_rev_2	249	254	PF00179	0.483
MOD_SUMO_rev_2	257	264	PF00179	0.455
TRG_DiLeu_BaEn_4	249	255	PF01217	0.511
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.593
TRG_ENDOCYTIC_2	170	173	PF00928	0.519
TRG_ER_diArg_1	181	183	PF00400	0.535
TRG_ER_diArg_1	45	48	PF00400	0.274
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA53	Leptomonas seymouri	57%	95%
A0A1X0NHT0	Trypanosomatidae	34%	100%
A0A3S7WWU5	Leishmania donovani	100%	100%
A4HLC6	Leishmania braziliensis	71%	100%
D0A0Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AVI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QBZ9	Leishmania major	92%	100%