Putative GPI transamidase component GAA1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase component GAA1 - putative

Species:

Leishmania infantum

UniProt:

A4HZI7_LEIIN

TriTrypDb:

LINF_210027900

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0008303	caspase complex	5	11
GO:0032991	protein-containing complex	1	11
GO:0042765	GPI-anchor transamidase complex	3	11
GO:0098796	membrane protein complex	2	11
GO:0140534	endoplasmic reticulum protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1905368	peptidase complex	3	11
GO:1905369	endopeptidase complex	4	11

Expansion

Sequence features

A4HZI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZI7

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016255	attachment of GPI anchor to protein	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.544
CLV_NRD_NRD_1	188	190	PF00675	0.450
CLV_NRD_NRD_1	3	5	PF00675	0.356
CLV_NRD_NRD_1	37	39	PF00675	0.597
CLV_NRD_NRD_1	77	79	PF00675	0.579
CLV_PCSK_FUR_1	75	79	PF00082	0.592
CLV_PCSK_KEX2_1	108	110	PF00082	0.547
CLV_PCSK_KEX2_1	188	190	PF00082	0.450
CLV_PCSK_KEX2_1	3	5	PF00082	0.381
CLV_PCSK_KEX2_1	77	79	PF00082	0.579
CLV_PCSK_SKI1_1	136	140	PF00082	0.482
CLV_PCSK_SKI1_1	4	8	PF00082	0.396
DEG_APCC_DBOX_1	429	437	PF00400	0.526
DEG_MDM2_SWIB_1	200	207	PF02201	0.317
DEG_Nend_Nbox_1	1	3	PF02207	0.563
DEG_ODPH_VHL_1	17	28	PF01847	0.349
DOC_CDC14_PxL_1	29	37	PF14671	0.404
DOC_CKS1_1	327	332	PF01111	0.349
DOC_CYCLIN_yCln2_LP_2	327	333	PF00134	0.349
DOC_MAPK_DCC_7	315	324	PF00069	0.534
DOC_MAPK_MEF2A_6	136	143	PF00069	0.236
DOC_MAPK_NFAT4_5	136	144	PF00069	0.331
DOC_MAPK_RevD_3	24	39	PF00069	0.349
DOC_MAPK_RevD_3	95	110	PF00069	0.344
DOC_PP2B_LxvP_1	429	432	PF13499	0.566
DOC_USP7_MATH_1	224	228	PF00917	0.300
DOC_USP7_MATH_1	232	236	PF00917	0.306
DOC_USP7_MATH_1	346	350	PF00917	0.356
DOC_USP7_MATH_1	415	419	PF00917	0.356
DOC_USP7_MATH_1	95	99	PF00917	0.354
DOC_WW_Pin1_4	317	322	PF00397	0.271
DOC_WW_Pin1_4	326	331	PF00397	0.271
DOC_WW_Pin1_4	76	81	PF00397	0.442
LIG_14-3-3_CanoR_1	108	114	PF00244	0.319
LIG_BRCT_BRCA1_1	241	245	PF00533	0.339
LIG_BRCT_BRCA1_1	348	352	PF00533	0.388
LIG_BRCT_BRCA1_1	439	443	PF00533	0.360
LIG_Clathr_ClatBox_1	433	437	PF01394	0.435
LIG_CSL_BTD_1	278	281	PF09270	0.236
LIG_eIF4E_1	134	140	PF01652	0.282
LIG_FHA_1	228	234	PF00498	0.328
LIG_FHA_1	323	329	PF00498	0.330
LIG_FHA_1	35	41	PF00498	0.488
LIG_FHA_1	58	64	PF00498	0.407
LIG_FHA_2	306	312	PF00498	0.292
LIG_GBD_Chelix_1	257	265	PF00786	0.517
LIG_GBD_Chelix_1	374	382	PF00786	0.314
LIG_LIR_Apic_2	125	131	PF02991	0.298
LIG_LIR_Apic_2	60	65	PF02991	0.412
LIG_LIR_Gen_1	252	262	PF02991	0.339
LIG_LIR_Gen_1	275	284	PF02991	0.317
LIG_LIR_Gen_1	320	331	PF02991	0.404
LIG_LIR_Gen_1	349	360	PF02991	0.358
LIG_LIR_Gen_1	370	379	PF02991	0.308
LIG_LIR_Gen_1	440	450	PF02991	0.404
LIG_LIR_Nem_3	116	122	PF02991	0.268
LIG_LIR_Nem_3	252	257	PF02991	0.325
LIG_LIR_Nem_3	275	280	PF02991	0.239
LIG_LIR_Nem_3	283	288	PF02991	0.232
LIG_LIR_Nem_3	306	312	PF02991	0.271
LIG_LIR_Nem_3	320	326	PF02991	0.271
LIG_LIR_Nem_3	349	355	PF02991	0.320
LIG_LIR_Nem_3	370	374	PF02991	0.290
LIG_LIR_Nem_3	440	446	PF02991	0.365
LIG_LYPXL_SIV_4	133	141	PF13949	0.282
LIG_LYPXL_SIV_4	205	213	PF13949	0.282
LIG_NRBOX	354	360	PF00104	0.292
LIG_NRBOX	458	464	PF00104	0.251
LIG_Pex14_2	200	204	PF04695	0.317
LIG_Pex14_2	352	356	PF04695	0.335
LIG_PTB_Apo_2	87	94	PF02174	0.326
LIG_PTB_Phospho_1	87	93	PF10480	0.361
LIG_SH2_GRB2like	167	170	PF00017	0.282
LIG_SH2_GRB2like	88	91	PF00017	0.258
LIG_SH2_NCK_1	134	138	PF00017	0.341
LIG_SH2_NCK_1	290	294	PF00017	0.236
LIG_SH2_SRC	206	209	PF00017	0.331
LIG_SH2_SRC	290	293	PF00017	0.267
LIG_SH2_SRC	62	65	PF00017	0.373
LIG_SH2_STAP1	134	138	PF00017	0.331
LIG_SH2_STAP1	167	171	PF00017	0.379
LIG_SH2_STAT3	184	187	PF00017	0.282
LIG_SH2_STAT5	120	123	PF00017	0.265
LIG_SH2_STAT5	134	137	PF00017	0.319
LIG_SH2_STAT5	167	170	PF00017	0.386
LIG_SH2_STAT5	184	187	PF00017	0.202
LIG_SH2_STAT5	206	209	PF00017	0.265
LIG_SH2_STAT5	287	290	PF00017	0.236
LIG_SH2_STAT5	41	44	PF00017	0.414
LIG_SH2_STAT5	424	427	PF00017	0.311
LIG_SH2_STAT5	62	65	PF00017	0.380
LIG_SH2_STAT5	88	91	PF00017	0.263
LIG_SH3_3	208	214	PF00018	0.271
LIG_SH3_3	275	281	PF00018	0.236
LIG_SH3_3	444	450	PF00018	0.404
LIG_SH3_3	64	70	PF00018	0.403
LIG_SH3_5	163	167	PF00018	0.282
LIG_SUMO_SIM_par_1	229	236	PF11976	0.249
LIG_SUMO_SIM_par_1	324	329	PF11976	0.378
LIG_TRAF2_1	124	127	PF00917	0.409
LIG_TYR_ITIM	421	426	PF00017	0.404
LIG_UBA3_1	103	111	PF00899	0.286
LIG_UBA3_1	31	39	PF00899	0.403
LIG_WRC_WIRS_1	368	373	PF05994	0.442
LIG_WRC_WIRS_1	443	448	PF05994	0.289
MOD_CAAXbox	461	464	PF01239	0.387
MOD_CK1_1	227	233	PF00069	0.311
MOD_CK1_1	303	309	PF00069	0.271
MOD_CK1_1	79	85	PF00069	0.332
MOD_CK2_1	121	127	PF00069	0.393
MOD_CK2_1	305	311	PF00069	0.300
MOD_CMANNOS	201	204	PF00535	0.531
MOD_Cter_Amidation	75	78	PF01082	0.568
MOD_GlcNHglycan	348	351	PF01048	0.329
MOD_GlcNHglycan	364	367	PF01048	0.279
MOD_GlcNHglycan	418	421	PF01048	0.333
MOD_GlcNHglycan	52	55	PF01048	0.573
MOD_GSK3_1	227	234	PF00069	0.264
MOD_GSK3_1	300	307	PF00069	0.276
MOD_GSK3_1	322	329	PF00069	0.480
MOD_GSK3_1	346	353	PF00069	0.339
MOD_N-GLC_1	122	127	PF02516	0.510
MOD_N-GLC_1	141	146	PF02516	0.350
MOD_NEK2_1	141	146	PF00069	0.306
MOD_NEK2_1	207	212	PF00069	0.302
MOD_NEK2_1	240	245	PF00069	0.265
MOD_NEK2_1	272	277	PF00069	0.261
MOD_NEK2_1	300	305	PF00069	0.287
MOD_NEK2_1	322	327	PF00069	0.346
MOD_NEK2_1	367	372	PF00069	0.527
MOD_NEK2_1	442	447	PF00069	0.309
MOD_PIKK_1	245	251	PF00454	0.251
MOD_PK_1	315	321	PF00069	0.482
MOD_PKA_1	109	115	PF00069	0.312
MOD_PKA_2	109	115	PF00069	0.312
MOD_PKA_2	190	196	PF00069	0.347
MOD_Plk_1	141	147	PF00069	0.236
MOD_Plk_1	207	213	PF00069	0.333
MOD_Plk_4	142	148	PF00069	0.296
MOD_Plk_4	180	186	PF00069	0.331
MOD_Plk_4	240	246	PF00069	0.359
MOD_Plk_4	273	279	PF00069	0.281
MOD_Plk_4	280	286	PF00069	0.331
MOD_Plk_4	300	306	PF00069	0.190
MOD_Plk_4	322	328	PF00069	0.371
MOD_Plk_4	396	402	PF00069	0.320
MOD_Plk_4	442	448	PF00069	0.349
MOD_ProDKin_1	317	323	PF00069	0.271
MOD_ProDKin_1	326	332	PF00069	0.271
MOD_ProDKin_1	76	82	PF00069	0.443
MOD_SUMO_rev_2	264	272	PF00179	0.327
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.292
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.299
TRG_ENDOCYTIC_2	423	426	PF00928	0.404
TRG_ER_diArg_1	107	110	PF00400	0.347
TRG_ER_diArg_1	188	191	PF00400	0.251
TRG_ER_diArg_1	2	4	PF00400	0.605
TRG_ER_diArg_1	35	38	PF00400	0.382
TRG_ER_diArg_1	74	77	PF00400	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W7	Leptomonas seymouri	66%	100%
A0A1X0NIY4	Trypanosomatidae	39%	100%
A0A3R7N823	Trypanosoma rangeli	39%	99%
A0A3S7WWY8	Leishmania donovani	100%	100%
A4HLC3	Leishmania braziliensis	83%	100%
D0A0Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AVH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QC02	Leishmania major	95%	100%
V5DID2	Trypanosoma cruzi	37%	96%