V-type proton ATPase proteolipid subunit

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar ATP synthase - putative

Species:

Leishmania infantum

UniProt:

A4HZI5_LEIIN

TriTrypDb:

LINF_210027800

Length:

187

Annotations

Annotations by Jardim et al.

Acidocalcisome, vacuolar ATP synthase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 20
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0005774	vacuolar membrane	5	30
GO:0016020	membrane	2	30
GO:0031090	organelle membrane	3	30
GO:0032991	protein-containing complex	1	30
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3	30
GO:0033179	proton-transporting V-type ATPase, V0 domain	4	30
GO:0098588	bounding membrane of organelle	4	30
GO:0098796	membrane protein complex	2	30
GO:0110165	cellular anatomical entity	1	30

Expansion

Sequence features

A4HZI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZI5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0005215	transporter activity	1	30
GO:0008324	monoatomic cation transmembrane transporter activity	4	30
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	30
GO:0015075	monoatomic ion transmembrane transporter activity	3	30
GO:0015078	proton transmembrane transporter activity	5	30
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	30
GO:0015399	primary active transmembrane transporter activity	4	30
GO:0016787	hydrolase activity	2	19
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	30
GO:0022804	active transmembrane transporter activity	3	30
GO:0022853	active monoatomic ion transmembrane transporter activity	4	30
GO:0022857	transmembrane transporter activity	2	30
GO:0022890	inorganic cation transmembrane transporter activity	4	30
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	30
GO:0042626	ATPase-coupled transmembrane transporter activity	2	30
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	30
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	30
GO:0140657	ATP-dependent activity	1	30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_1	1	4	PF02207	0.551
DOC_MAPK_DCC_7	71	81	PF00069	0.426
DOC_MAPK_gen_1	146	156	PF00069	0.427
DOC_MAPK_gen_1	71	79	PF00069	0.426
DOC_MAPK_MEF2A_6	146	154	PF00069	0.426
DOC_MAPK_MEF2A_6	74	81	PF00069	0.426
DOC_USP7_MATH_1	19	23	PF00917	0.487
DOC_USP7_MATH_1	28	32	PF00917	0.307
LIG_APCC_ABBA_1	157	162	PF00400	0.267
LIG_BRCT_BRCA1_1	29	33	PF00533	0.293
LIG_LIR_Gen_1	104	114	PF02991	0.279
LIG_LIR_Gen_1	148	159	PF02991	0.427
LIG_LIR_Nem_3	104	110	PF02991	0.330
LIG_LRP6_Inhibitor_1	95	101	PF00058	0.316
LIG_MLH1_MIPbox_1	30	34	PF16413	0.267
LIG_SH2_CRK	167	171	PF00017	0.247
LIG_SH2_CRK	88	92	PF00017	0.267
LIG_SH2_SRC	3	6	PF00017	0.595
LIG_SH2_STAP1	107	111	PF00017	0.353
LIG_SH2_STAT3	144	147	PF00017	0.427
LIG_SH2_STAT5	113	116	PF00017	0.285
MOD_GlcNHglycan	107	110	PF01048	0.470
MOD_GlcNHglycan	30	33	PF01048	0.495
MOD_GlcNHglycan	40	43	PF01048	0.280
MOD_GlcNHglycan	49	52	PF01048	0.173
MOD_GlcNHglycan	56	59	PF01048	0.224
MOD_GSK3_1	47	54	PF00069	0.307
MOD_N-GLC_1	175	180	PF02516	0.366
MOD_NEK2_1	175	180	PF00069	0.403
MOD_NEK2_1	33	38	PF00069	0.210
MOD_NEK2_1	90	95	PF00069	0.316
MOD_NEK2_2	137	142	PF00069	0.442
MOD_Plk_1	103	109	PF00069	0.388
MOD_Plk_1	137	143	PF00069	0.476
MOD_Plk_4	4	10	PF00069	0.565
MOD_Plk_4	90	96	PF00069	0.315
TRG_ENDOCYTIC_2	107	110	PF00928	0.290
TRG_ENDOCYTIC_2	113	116	PF00928	0.268
TRG_ENDOCYTIC_2	167	170	PF00928	0.247
TRG_ENDOCYTIC_2	88	91	PF00928	0.267
TRG_NES_CRM1_1	148	162	PF08389	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3G9	Leptomonas seymouri	29%	83%
A0A0N0P7K0	Leptomonas seymouri	74%	95%
A0A0N1HSG6	Leptomonas seymouri	91%	99%
A0A0N1I3H6	Leptomonas seymouri	63%	100%
A0A0S4IU71	Bodo saltans	90%	100%
A0A0S4JFM4	Bodo saltans	66%	100%
A0A0S4JKG0	Bodo saltans	29%	72%
A0A0S4KKA5	Bodo saltans	71%	96%
A0A1X0NGC8	Trypanosomatidae	69%	100%
A0A1X0NHL5	Trypanosomatidae	92%	98%
A0A1X0NZ73	Trypanosomatidae	72%	100%
A0A1X0P179	Trypanosomatidae	26%	83%
A0A3Q8II19	Leishmania donovani	72%	93%
A0A3Q8II88	Leishmania donovani	27%	83%
A0A3Q8ILV9	Leishmania donovani	64%	100%
A0A3R7MQK8	Trypanosoma rangeli	27%	83%
A0A3R7RFU6	Trypanosoma rangeli	92%	96%
A0A3S7WX01	Leishmania donovani	100%	100%
A0A422N304	Trypanosoma rangeli	73%	94%
A0A422NW00	Trypanosoma rangeli	66%	100%
A2ZBW5	Oryza sativa subsp. indica	58%	100%
A4HCM7	Leishmania braziliensis	66%	100%
A4HGG2	Leishmania braziliensis	74%	100%
A4HIV2	Leishmania braziliensis	28%	100%
A4HLC1	Leishmania braziliensis	95%	100%
A4I051	Leishmania infantum	64%	100%
A4I3J4	Leishmania infantum	72%	93%
A4I657	Leishmania infantum	27%	83%
C0HLB3	Caenorhabditis elegans	50%	100%
C0HLB4	Caenorhabditis elegans	50%	100%
C0HLB5	Caenorhabditis briggsae	51%	100%
C0HLB6	Caenorhabditis briggsae	51%	100%
C9ZRH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	83%
D0A0Y8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	91%	98%
D0A7U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	74%
E9AVH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AW14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9AZT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9B1E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
G5EDB8	Caenorhabditis elegans	27%	87%
O14046	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	94%
O16110	Aedes aegypti	52%	100%
O18882	Ovis aries	53%	100%
O22552	Vigna radiata var. radiata	57%	100%
O24011	Solanum lycopersicum	57%	100%
P0DH92	Arabidopsis thaliana	57%	100%
P0DH93	Arabidopsis thaliana	57%	100%
P0DH94	Arabidopsis thaliana	57%	100%
P23380	Drosophila melanogaster	54%	100%
P23956	Bos taurus	53%	100%
P23957	Avena sativa	57%	100%
P25515	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
P27449	Homo sapiens	53%	100%
P31403	Manduca sexta	56%	100%
P31413	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	57%	100%
P32842	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
P50515	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	100%
P54642	Dictyostelium discoideum	45%	95%
P55277	Heliothis virescens	57%	100%
P59228	Arabidopsis thaliana	57%	100%
P59229	Arabidopsis thaliana	57%	100%
P63081	Rattus norvegicus	55%	100%
P63082	Mus musculus	55%	100%
P68161	Mesembryanthemum crystallinum	57%	100%
P68162	Beta vulgaris	57%	100%
Q00607	Candida tropicalis	51%	100%
Q03105	Torpedo marmorata	55%	100%
Q0IUB5	Oryza sativa subsp. japonica	58%	100%
Q17046	Ascaris suum	50%	100%
Q21898	Caenorhabditis elegans	51%	100%
Q24808	Entamoeba dispar	48%	100%
Q24810	Entamoeba histolytica	47%	100%
Q26250	Nephrops norvegicus	54%	100%
Q2TA24	Bos taurus	32%	91%
Q40585	Nicotiana tabacum	57%	100%
Q43362	Chrysotila carterae	59%	100%
Q43434	Gossypium hirsutum	57%	100%
Q4Q6S2	Leishmania major	27%	100%
Q4Q8F0	Leishmania major	73%	100%
Q4QBG2	Leishmania major	64%	100%
Q4QC03	Leishmania major	99%	100%
Q6BSB9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	49%	100%
Q6CT28	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	46%	100%
Q6FUY5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	48%	100%
Q755G4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	47%	100%
Q91V37	Mus musculus	30%	91%
Q96473	Kalanchoe daigremontiana	57%	100%
Q99437	Homo sapiens	32%	91%
Q9SLA2	Arabidopsis thaliana	30%	100%
Q9SZY7	Arabidopsis thaliana	30%	100%
Q9URZ8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
Q9Y874	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	47%	100%