Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZH9_LEIIN

TriTrypDb:

LINF_210027100

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.591
CLV_NRD_NRD_1	11	13	PF00675	0.584
CLV_NRD_NRD_1	130	132	PF00675	0.541
CLV_NRD_NRD_1	25	27	PF00675	0.486
CLV_NRD_NRD_1	66	68	PF00675	0.455
CLV_PCSK_KEX2_1	121	123	PF00082	0.599
CLV_PCSK_KEX2_1	130	132	PF00082	0.517
CLV_PCSK_KEX2_1	27	29	PF00082	0.591
CLV_PCSK_KEX2_1	55	57	PF00082	0.535
CLV_PCSK_KEX2_1	68	70	PF00082	0.406
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.599
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.591
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.535
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.406
CLV_PCSK_SKI1_1	121	125	PF00082	0.629
CLV_PCSK_SKI1_1	151	155	PF00082	0.643
CLV_PCSK_SKI1_1	31	35	PF00082	0.624
DEG_APCC_DBOX_1	40	48	PF00400	0.488
DOC_MAPK_gen_1	31	39	PF00069	0.462
DOC_PP1_RVXF_1	29	36	PF00149	0.624
DOC_PP2B_LxvP_1	123	126	PF13499	0.667
DOC_PP4_FxxP_1	59	62	PF00568	0.484
DOC_USP7_MATH_1	8	12	PF00917	0.635
DOC_USP7_MATH_1	99	103	PF00917	0.741
DOC_USP7_UBL2_3	13	17	PF12436	0.705
DOC_USP7_UBL2_3	132	136	PF12436	0.734
DOC_USP7_UBL2_3	27	31	PF12436	0.528
DOC_WW_Pin1_4	87	92	PF00397	0.775
DOC_WW_Pin1_4	93	98	PF00397	0.769
LIG_Actin_WH2_2	40	57	PF00022	0.603
LIG_BRCT_BRCA1_1	10	14	PF00533	0.715
LIG_FHA_1	34	40	PF00498	0.608
LIG_FHA_1	88	94	PF00498	0.749
LIG_FHA_2	1	7	PF00498	0.730
LIG_REV1ctd_RIR_1	107	116	PF16727	0.643
LIG_SH3_4	132	139	PF00018	0.651
LIG_TRAF2_1	86	89	PF00917	0.713
LIG_WRC_WIRS_1	163	168	PF05994	0.669
MOD_GSK3_1	162	169	PF00069	0.672
MOD_GSK3_1	33	40	PF00069	0.576
MOD_NEK2_1	166	171	PF00069	0.667
MOD_NEK2_1	33	38	PF00069	0.547
MOD_PKA_2	37	43	PF00069	0.575
MOD_Plk_2-3	101	107	PF00069	0.752
MOD_Plk_2-3	162	168	PF00069	0.556
MOD_Plk_4	111	117	PF00069	0.624
MOD_Plk_4	162	168	PF00069	0.672
MOD_ProDKin_1	87	93	PF00069	0.774
MOD_SUMO_for_1	47	50	PF00179	0.374
MOD_SUMO_rev_2	118	123	PF00179	0.691
MOD_SUMO_rev_2	77	86	PF00179	0.684
TRG_DiLeu_BaEn_1	66	71	PF01217	0.467
TRG_ER_diArg_1	129	131	PF00400	0.520
TRG_ER_diArg_1	56	59	PF00400	0.598
TRG_ER_diArg_1	67	70	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NH88	Trypanosomatidae	34%	97%
A0A3S7WWT3	Leishmania donovani	99%	100%
A0A422N8U7	Trypanosoma rangeli	34%	98%
A4HC37	Leishmania braziliensis	74%	99%
D0A0Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	82%
E9AVG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QC10	Leishmania major	88%	100%