LeishMANIAdb
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60S ribosomal protein L32

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
60S ribosomal protein L32
Gene product:
60S ribosomal protein L32
Species:
Leishmania infantum
UniProt:
A4HZH8_LEIIN
TriTrypDb:
LINF_210027000
Length:
133

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L32 RPL32

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 21
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 20
GO:0032991 protein-containing complex 1 22
GO:0043226 organelle 2 21
GO:0043228 non-membrane-bounded organelle 3 21
GO:0043229 intracellular organelle 3 21
GO:0043232 intracellular non-membrane-bounded organelle 4 21
GO:0110165 cellular anatomical entity 1 21
GO:1990904 ribonucleoprotein complex 2 22
GO:0015934 large ribosomal subunit 4 2
GO:0022625 cytosolic large ribosomal subunit 5 2
GO:0044391 ribosomal subunit 3 2
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZH8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZH8

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 22
GO:0006518 peptide metabolic process 4 22
GO:0006807 nitrogen compound metabolic process 2 22
GO:0008152 metabolic process 1 22
GO:0009058 biosynthetic process 2 22
GO:0009059 macromolecule biosynthetic process 4 22
GO:0009987 cellular process 1 22
GO:0019538 protein metabolic process 3 22
GO:0034641 cellular nitrogen compound metabolic process 3 22
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 22
GO:0043043 peptide biosynthetic process 5 22
GO:0043170 macromolecule metabolic process 3 22
GO:0043603 amide metabolic process 3 22
GO:0043604 amide biosynthetic process 4 22
GO:0044237 cellular metabolic process 2 22
GO:0044238 primary metabolic process 2 22
GO:0044249 cellular biosynthetic process 3 22
GO:0044260 obsolete cellular macromolecule metabolic process 3 22
GO:0044271 cellular nitrogen compound biosynthetic process 4 22
GO:0071704 organic substance metabolic process 2 22
GO:1901564 organonitrogen compound metabolic process 3 22
GO:1901566 organonitrogen compound biosynthetic process 4 22
GO:1901576 organic substance biosynthetic process 3 22
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 22
GO:0005198 structural molecule activity 1 22

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 103 105 PF00675 0.265
CLV_NRD_NRD_1 110 112 PF00675 0.087
CLV_NRD_NRD_1 127 129 PF00675 0.453
CLV_NRD_NRD_1 33 35 PF00675 0.265
CLV_NRD_NRD_1 45 47 PF00675 0.265
CLV_NRD_NRD_1 90 92 PF00675 0.265
CLV_PCSK_FUR_1 14 18 PF00082 0.364
CLV_PCSK_KEX2_1 105 107 PF00082 0.379
CLV_PCSK_KEX2_1 13 15 PF00082 0.407
CLV_PCSK_KEX2_1 16 18 PF00082 0.272
CLV_PCSK_KEX2_1 44 46 PF00082 0.265
CLV_PCSK_PC1ET2_1 105 107 PF00082 0.379
CLV_PCSK_PC1ET2_1 13 15 PF00082 0.407
CLV_PCSK_PC1ET2_1 16 18 PF00082 0.272
CLV_PCSK_SKI1_1 16 20 PF00082 0.273
CLV_PCSK_SKI1_1 65 69 PF00082 0.281
DOC_CKS1_1 66 71 PF01111 0.282
DOC_MAPK_gen_1 111 118 PF00069 0.265
DOC_MAPK_MEF2A_6 111 120 PF00069 0.265
DOC_MAPK_NFAT4_5 111 119 PF00069 0.394
DOC_USP7_MATH_1 4 8 PF00917 0.493
DOC_USP7_UBL2_3 8 12 PF12436 0.405
DOC_WW_Pin1_4 38 43 PF00397 0.265
DOC_WW_Pin1_4 65 70 PF00397 0.282
LIG_Actin_WH2_2 113 130 PF00022 0.232
LIG_FHA_1 62 68 PF00498 0.265
LIG_LIR_Apic_2 30 36 PF02991 0.266
LIG_LIR_Apic_2 64 69 PF02991 0.266
LIG_LIR_Gen_1 81 88 PF02991 0.266
LIG_LIR_Nem_3 24 29 PF02991 0.265
LIG_LIR_Nem_3 70 75 PF02991 0.260
LIG_LIR_Nem_3 81 87 PF02991 0.252
LIG_PTB_Apo_2 52 59 PF02174 0.265
LIG_PTB_Apo_2 87 94 PF02174 0.265
LIG_PTB_Phospho_1 52 58 PF10480 0.265
LIG_PTB_Phospho_1 87 93 PF10480 0.265
LIG_SH2_CRK 84 88 PF00017 0.265
LIG_SH2_CRK 93 97 PF00017 0.265
LIG_SH2_PTP2 66 69 PF00017 0.292
LIG_SH2_STAT3 47 50 PF00017 0.265
LIG_SH2_STAT5 66 69 PF00017 0.292
LIG_TRFH_1 23 27 PF08558 0.379
LIG_UBA3_1 85 92 PF00899 0.262
MOD_CDC14_SPxK_1 41 44 PF00782 0.265
MOD_CDK_SPxK_1 38 44 PF00069 0.265
MOD_CDK_SPxxK_3 38 45 PF00069 0.265
MOD_GlcNHglycan 69 72 PF01048 0.265
MOD_GSK3_1 12 19 PF00069 0.265
MOD_GSK3_1 57 64 PF00069 0.265
MOD_GSK3_1 67 74 PF00069 0.265
MOD_NEK2_1 29 34 PF00069 0.292
MOD_PKA_1 12 18 PF00069 0.265
MOD_PKA_2 16 22 PF00069 0.364
MOD_PKA_2 61 67 PF00069 0.265
MOD_ProDKin_1 38 44 PF00069 0.265
MOD_ProDKin_1 65 71 PF00069 0.282
TRG_ENDOCYTIC_2 23 26 PF00928 0.348
TRG_ENDOCYTIC_2 84 87 PF00928 0.265
TRG_ENDOCYTIC_2 93 96 PF00928 0.265
TRG_ER_diArg_1 20 23 PF00400 0.379
TRG_ER_diArg_1 43 46 PF00400 0.265
TRG_NLS_Bipartite_1 16 38 PF00514 0.265
TRG_NLS_Bipartite_1 91 109 PF00514 0.379
TRG_NLS_MonoCore_2 103 108 PF00514 0.362
TRG_NLS_MonoCore_2 33 38 PF00514 0.265
TRG_NLS_MonoExtC_3 11 16 PF00514 0.404
TRG_NLS_MonoExtC_3 33 39 PF00514 0.292
TRG_NLS_MonoExtN_4 104 109 PF00514 0.362
TRG_NLS_MonoExtN_4 12 17 PF00514 0.408

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P415 Leptomonas seymouri 93% 100%
A0A0N0P7H7 Leptomonas seymouri 90% 100%
A0A0S4J1B6 Bodo saltans 81% 100%
A0A0S4JEW7 Bodo saltans 80% 100%
A0A0S4JID9 Bodo saltans 80% 100%
A0A1D8PPN6 Candida albicans (strain SC5314 / ATCC MYA-2876) 42% 100%
A0A1X0P652 Trypanosomatidae 85% 100%
A0A3Q8IBA2 Leishmania donovani 99% 100%
A0A3R7M160 Trypanosoma rangeli 87% 100%
A0A3S7X954 Leishmania donovani 89% 100%
A0A422N8T9 Trypanosoma rangeli 83% 100%
A4FWA4 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 33% 99%
A4HC36 Leishmania braziliensis 89% 100%
A4HMM5 Leishmania braziliensis 89% 100%
A4IBA3 Leishmania infantum 89% 100%
A6UQ61 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 31% 99%
A6VH02 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 32% 99%
A9A9P7 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 32% 99%
B6YSN1 Thermococcus onnurineus (strain NA1) 34% 100%
C3MQ76 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 32% 96%
C3MVJ5 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 32% 96%
C3N5U4 Sulfolobus islandicus (strain M.16.27) 32% 96%
C3NEG0 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 32% 96%
C3NH92 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 32% 96%
C4KHH3 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 32% 96%
C5A268 Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) 35% 100%
C6A177 Thermococcus sibiricus (strain DSM 12597 / MM 739) 34% 100%
C9ZZN2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 86% 100%
D0A0Z5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 85% 100%
E2RKA8 Canis lupus familiaris 48% 99%
E9AF27 Leishmania major 91% 100%
E9AVG8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9B683 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
O05638 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 32% 100%
O26128 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 36% 100%
O28371 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 36% 100%
O42935 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 50% 100%
O59435 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 35% 100%
O94008 Candida albicans 42% 100%
P04359 Drosophila melanogaster 49% 99%
P14549 Methanococcus vannielii 31% 99%
P17932 Mus musculus 44% 99%
P34040 Trichoderma harzianum 43% 97%
P38061 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 41% 100%
P49211 Arabidopsis thaliana 45% 100%
P54010 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 34% 91%
P61127 Drosophila yakuba 49% 99%
P61128 Drosophila simulans 49% 99%
P62910 Homo sapiens 48% 99%
P62911 Mus musculus 48% 99%
P62912 Rattus norvegicus 48% 99%
P79015 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 48% 100%
P84311 Drosophila subobscura 48% 99%
P84312 Drosophila bifasciata 48% 99%
P84313 Drosophila madeirensis 48% 99%
P84314 Drosophila guanche 48% 99%
P84323 Drosophila pseudoobscura pseudoobscura 48% 99%
P84324 Drosophila affinis 48% 99%
P84325 Drosophila azteca 48% 99%
P84326 Drosophila miranda 48% 99%
P84327 Drosophila persimilis 48% 99%
Q236T0 Tetrahymena thermophila (strain SB210) 50% 99%
Q3SZQ6 Bos taurus 48% 99%
Q4QC11 Leishmania major 98% 100%
Q55AB5 Dictyostelium discoideum 51% 100%
Q5JJG5 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 34% 100%
Q6FS03 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 40% 100%
Q6L1B0 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) 34% 99%
Q6LXD6 Methanococcus maripaludis (strain S2 / LL) 34% 99%
Q6QAT0 Sus scrofa 48% 99%
Q74MV8 Nanoarchaeum equitans (strain Kin4-M) 37% 99%
Q751I7 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 39% 100%
Q76KA3 Macaca fascicularis 48% 99%
Q7RXY1 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 47% 100%
Q8PV33 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 30% 100%
Q8SS18 Encephalitozoon cuniculi (strain GB-M1) 42% 96%
Q8TRT0 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 32% 100%
Q8TW13 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 34% 100%
Q8WRF3 Apis mellifera 45% 99%
Q8ZVV9 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 35% 88%
Q90YT6 Ictalurus punctatus 44% 99%
Q94460 Drosophila acanthoptera 50% 99%
Q962T1 Spodoptera frugiperda 48% 99%
Q975J7 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 32% 100%
Q97BV9 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 31% 100%
Q9FHG2 Arabidopsis thaliana 43% 100%
Q9HH82 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 32% 100%
Q9HIS4 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 35% 100%
Q9UX90 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 31% 96%
Q9V1V2 Pyrococcus abyssi (strain GE5 / Orsay) 34% 100%
Q9YF92 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 31% 92%
V5ATH5 Trypanosoma cruzi 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS