Putative cytochrome c oxidase subunit VI

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase subunit VI - putative

Species:

Leishmania infantum

UniProt:

A4HZH7_LEIIN

TriTrypDb:

LINF_210026900

Length:

157

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), cytochrome c oxidase subunit VI COX6

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0045277	respiratory chain complex IV	4	11
GO:0070069	cytochrome complex	3	11
GO:0098796	membrane protein complex	2	11
GO:0098803	respiratory chain complex	3	11
GO:0110165	cellular anatomical entity	1	11
GO:1902494	catalytic complex	2	11
GO:0005737	cytoplasm	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HZH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZH7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016491	oxidoreductase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.523
CLV_PCSK_KEX2_1	83	85	PF00082	0.395
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.395
CLV_PCSK_SKI1_1	83	87	PF00082	0.397
DEG_APCC_DBOX_1	12	20	PF00400	0.574
DOC_PP4_FxxP_1	25	28	PF00568	0.483
DOC_USP7_UBL2_3	111	115	PF12436	0.523
DOC_USP7_UBL2_3	4	8	PF12436	0.485
DOC_USP7_UBL2_3	79	83	PF12436	0.381
LIG_deltaCOP1_diTrp_1	119	126	PF00928	0.462
LIG_deltaCOP1_diTrp_1	74	80	PF00928	0.386
LIG_FHA_2	73	79	PF00498	0.482
LIG_LIR_Apic_2	23	28	PF02991	0.488
LIG_LIR_Nem_3	104	110	PF02991	0.485
LIG_LIR_Nem_3	123	129	PF02991	0.451
LIG_SH2_CRK	107	111	PF00017	0.475
LIG_SH2_SRC	107	110	PF00017	0.462
LIG_SH2_STAP1	118	122	PF00017	0.449
LIG_SH2_STAP1	130	134	PF00017	0.522
LIG_SH2_STAT3	9	12	PF00017	0.567
LIG_SH2_STAT5	67	70	PF00017	0.376
LIG_SH3_3	14	20	PF00018	0.536
LIG_UBA3_1	143	152	PF00899	0.472
LIG_ULM_U2AF65_1	62	67	PF00076	0.386
MOD_CK2_1	72	78	PF00069	0.430
MOD_Cter_Amidation	150	153	PF01082	0.482
MOD_NEK2_1	30	35	PF00069	0.464
MOD_NEK2_1	72	77	PF00069	0.424
MOD_NEK2_1	89	94	PF00069	0.354
MOD_Plk_1	56	62	PF00069	0.424
MOD_Plk_1	89	95	PF00069	0.527
MOD_Plk_4	72	78	PF00069	0.430
MOD_Plk_4	89	95	PF00069	0.458
MOD_SUMO_rev_2	78	85	PF00179	0.393
TRG_DiLeu_BaEn_4	81	87	PF01217	0.393
TRG_ENDOCYTIC_2	107	110	PF00928	0.462
TRG_ENDOCYTIC_2	45	48	PF00928	0.331
TRG_NLS_MonoExtC_3	110	115	PF00514	0.590
TRG_NLS_MonoExtN_4	109	115	PF00514	0.582
TRG_NLS_MonoExtN_4	4	11	PF00514	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4F6	Leptomonas seymouri	93%	99%
A0A0S4IU45	Bodo saltans	81%	99%
A0A1X0NHC1	Trypanosomatidae	86%	99%
A0A3Q8IE33	Leishmania donovani	99%	100%
A0A3R7LRC1	Trypanosoma rangeli	84%	99%
A4HC35	Leishmania braziliensis	93%	100%
D0A0Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	99%
E9AVG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QC12	Leishmania major	97%	100%